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Philadelphia chromosome

The Philadelphia chromosome or Philadelphia translocation (Ph) is an abnormal version of chromosome 22 where a part of the Abelson murine leukemia 1 (ABL1) gene on chromosome 9 breaks off and attaches to the breakpoint cluster region (BCR) gene in chromosome 22. The balanced reciprocal translocation between the long arms of 9 and 22 chromosomes [t (9…

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Specialty
Oncology

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Molecular biology

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History

General Interest

  • ISBN ISBN (identifier)

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Philadelphia chromosome

Nodes152
Edges151
Triples57
Avg. degree1.99
Density0.013158
Components1

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Philadelphia chromosome

Top relations

related to history · 19
Philadelphia chromosome → Boveri's, CML, David Hungerford, Giemsa, Hungerford, Janet Rowley, Medicine, Nowell, Pennsylvania School, Peter Nowell, Ph, Philadelphia, Rowley, The, The Philadelphia, This, Through, University, While
related to Molecular biology · 13
Philadelphia chromosome → Abelson, ABL, ABL1, BCR, BCR-ABL1, DNA, Herbert, It, Philadelphia, The, The ABL, The BCR, This
related to Nomenclature · 11
Philadelphia chromosome → ABL1, BCR, Cells, Hence, Human Cytogenomic Nomenclature, International System, It, Ph, Ph-like, Some, The Philadelphia
related to General Interest · 9
Philadelphia chromosome → Cure Cancer, Genetic Level, ISBN, Jessica, Mutant Gene, Quest, The Experiment, The Philadelphia Chromosome, Wapner
Specialty · 1
Philadelphia chromosome → Oncology

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Important terminology

abl1 bcr gene cells pathway patients cell protein chromosome leukemia kinase ph fusion cml tyrosine tkis apoptosis also survival philadelphia

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Philadelphia chromosomeSpecialtyOncology1.00infobox
Sanger sequencinginstance ofwhich falls under mixed-phenotype acute leukemias.Detection of these variants is carried out using methods0.80text
reverse transcription polymerase chain reactioninstance ofwhich falls under mixed-phenotype acute leukemias.Detection of these variants is carried out using methods0.80text
stem cell transplantationinstance ofand allogeneic treatments0.80text
Allogeneic Stem Cell Transplantationinstance ofother treatment options0.80text
Philadelphia chromosomerelated to General InterestWapner0.60section
Philadelphia chromosomerelated to General InterestJessica0.60section
Philadelphia chromosomerelated to General InterestThe Philadelphia Chromosome0.60section
Philadelphia chromosomerelated to General InterestMutant Gene0.60section
Philadelphia chromosomerelated to General InterestQuest0.60section
Philadelphia chromosomerelated to General InterestCure Cancer0.60section
Philadelphia chromosomerelated to General InterestGenetic Level0.60section

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