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TPCN2: Structure, Filoviral infections & Overview

Two pore segment channel 2 (TPC2) is a protein which in humans is encoded by the TPCN2 gene. TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).

Language: English [EN]
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TPCN2 topic overview

The analysis highlights Structure, Filoviral infections and Overview as prominent areas in the source structure around TPCN2.

Related topics
15
Source areas
3
Connected nodes
18
Extracted relationships
86
Related term clusters
12
Bridge connections
18

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Filoviral infections · 5 topics
Overview · 5 topics
Structure · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TPCN2, SHEP10, TPC2, two pore segment channel 2
Band
11q13.3 · 7|7 F5
Bgee
pancreatic ductal cell · mucosa of ileum · gastric mucosa · muscle layer of sigmoid colon · body of uterus
BioGPS
n/a
Chr.
Chromosome 11 (human) · Chromosome 7 (mouse)
Databases
NCBI: entry; OMA: entry

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TPCN2
5Protein · Gene · Ion channel
5Ortholog · Arabidopsis thaliana · X-ray crystallography
5Two-pore channel · TPC1 · TPC2

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Filoviral infections

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How TPCN2 connects Entity context

The extracted context around TPCN2 shows recurring relationship patterns in the source. For example, TPCN2 → calcium channel activity, calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, cellular calcium ion homeostasis, endosome membrane, identical protein binding, integral component of membrane, ion channel activity, ion transmembrane transport, ion transport, lysosomal membrane, lysosome, lysosome organization, membrane, membrane depolarization during action potential, NAADP-sensitive calcium-release channel activity, plasma membrane, protein binding, protein kinase binding Another extracted example is TPCN2 → blastocyst, body of uterus, embryo, gastric mucosa, granulocyte, inner renal medulla, left uterine tube, lip, monocyte, mucosa of ileum, muscle layer of sigmoid colon, pancreatic ductal cell, right hemisphere of cerebellum, right lobe of liver, spermatid, stroma of bone marrow, tibialis anterior muscle, ventricular zone, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

TPCN2

Top relations

Gene ontology · 28
TPCN2 → calcium channel activity, calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, cellular calcium ion homeostasis, endosome membrane, identical protein binding, integral component of membrane, ion channel activity, ion transmembrane transport, ion transport, lysosomal membrane, lysosome, lysosome organization, membrane, membrane depolarization during action potential, NAADP-sensitive calcium-release channel activity, plasma membrane, protein binding, protein kinase binding
Bgee · 19
TPCN2 → blastocyst, body of uterus, embryo, gastric mucosa, granulocyte, inner renal medulla, left uterine tube, lip, monocyte, mucosa of ileum, muscle layer of sigmoid colon, pancreatic ductal cell, right hemisphere of cerebellum, right lobe of liver, spermatid, stroma of bone marrow, tibialis anterior muscle, ventricular zone, yolk sac
RNA expression pattern · 19
TPCN2 → blastocyst, body of uterus, embryo, gastric mucosa, granulocyte, inner renal medulla, left uterine tube, lip, monocyte, mucosa of ileum, muscle layer of sigmoid colon, pancreatic ductal cell, right hemisphere of cerebellum, right lobe of liver, spermatid, stroma of bone marrow, tibialis anterior muscle, ventricular zone, yolk sac
Band · 2
TPCN2 → 11q13.3, 7|7 F5
Chr. · 2
TPCN2 → Chromosome 11 (human), Chromosome 7 (mouse)
End · 2
TPCN2 → 144,837,748 bp, 69,136,316 bp
Aliases · 1
TPCN2 → TPCN2, SHEP10, TPC2, two pore segment channel 2
BioGPS · 1
TPCN2 → n/a
Databases · 1
TPCN2 → NCBI: entry; OMA: entry
Ensembl · 1
TPCN2 → ENSG00000162341

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

channel bp tpc2 human chr band gene two chromosome 11 protein ion location tpc1 calcium mouse pore segment transmembrane external

TPCN2 relationships Subject–Predicate–Object triples

TTTA extracted 86 structured relationships around TPCN2. Examples in this analysis include TPCN2 → Aliases → TPCN2, SHEP10, TPC2, two pore segment channel 2 and TPCN2 → Band → 11q13.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TPCN2AliasesTPCN2, SHEP10, TPC2, two pore segment channel 21.00infobox
TPCN2Band11q13.31.00infobox
TPCN2Band7|7 F51.00infobox
TPCN2Bgeepancreatic ductal cell1.00infobox
TPCN2Bgeemucosa of ileum1.00infobox
TPCN2Bgeegastric mucosa1.00infobox
TPCN2Bgeemuscle layer of sigmoid colon1.00infobox
TPCN2Bgeebody of uterus1.00infobox
TPCN2Bgeemonocyte1.00infobox
TPCN2Bgeeright hemisphere of cerebellum1.00infobox
TPCN2Bgeetibialis anterior muscle1.00infobox
TPCN2Bgeeleft uterine tube1.00infobox
TPCN2Bgeeright lobe of liver1.00infobox
TPCN2Bgeegranulocyte1.00infobox
TPCN2Bgeeinner renal medulla1.00infobox
TPCN2Bgeestroma of bone marrow1.00infobox
TPCN2Bgeelip1.00infobox
TPCN2Bgeeventricular zone1.00infobox
TPCN2Bgeespermatid1.00infobox
TPCN2Bgeeyolk sac1.00infobox
TPCN2Bgeeembryo1.00infobox
TPCN2Bgeeblastocyst1.00infobox
TPCN2BioGPSn/a1.00infobox
TPCN2Chr.Chromosome 11 (human)1.00infobox
TPCN2Chr.Chromosome 7 (mouse)1.00infobox
TPCN2DatabasesNCBI: entry; OMA: entry1.00infobox
TPCN2End69,136,316 bp1.00infobox
TPCN2End144,837,748 bp1.00infobox
TPCN2EnsemblENSG000001623411.00infobox
TPCN2Entrez2199311.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around TPCN2 bring nearby vocabulary together. In this analysis, examples include Gene, Human and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Location
    • Chromosome
    • Tpcn2
    • Bp
    • Chr
    • End
    • Human
    • Mouse
    • Pore
    • Segment
    • Tpc2
    • Protein
  • ion channel
    • Calcium
    • Homologous
    • Tpcn2
    • Transmembrane
    • Voltage-gated
    • Tpc2
    • Ion
    • Protein
    • Gene
    • Two
    • Human
    • Contrast
  • calcium
    • Homologous
    • Transmembrane
    • Ion
    • Contrast
    • Domains
    • Four
    • Sodium
    • Tpc2
    • Channel
    • Channels
    • End
    • Mouse
  • voltage-gated ion channel
    • Calcium
    • Homologous
    • Ion
    • Tpcn2
    • Transmembrane
    • Voltage-gated
    • Tpc2
    • Protein
    • Gene
    • Two
    • Human
    • Channel
  • tpc2
    • Gene
    • Tpcn2
    • Two
    • Calcium
    • Channels
    • Homologous
    • Transmembrane
    • Ion
    • Location
    • Protein
    • Tpc1
    • Chromosome
  • protein
    • Tpcn2
    • Gene
    • Encoded
    • Human
    • Humans
    • Tpc2
    • Calcium
    • End
    • Homologous
    • Mouse
    • Segment
    • Transmembrane
  • TPCN2
    • Gene
    • Human
    • Location
    • Chromosome
    • Two
    • Bp
    • Chr
    • External
    • Calcium
    • End
    • Homologous
    • Mouse
  • tpcn2
    • Gene
    • Human
    • Location
    • Chromosome
    • Two
    • Bp
    • Chr
    • External
    • Calcium
    • End
    • Homologous
    • Mouse

Connections between topic areas Semantic bridges

For TPCN2, one of the stronger structural bridges in this analysis connects TPCN2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TPCN2 — Overview · splits 13 ⟂ 6
TPCN2 — Structure · splits 13 ⟂ 6
TPCN2 — Filoviral infections · splits 13 ⟂ 6

Map overview Semantic statistics

TPCN2

Nodes19
Edges18
Triples86
Avg. degree1.89
Density0.105263
Components1

Source & methodology

TTTA analyzes the structure around TPCN2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Filoviral infections & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TPCN2 · EN edition · Analysis: TopicsToTalkAbout

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