Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

PGC-1α: Regions & Standards

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is also known as human accelerated region 20 (HAR20). It may, therefore, have played a key role in differentiating humans from apes.

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

PGC-1α topic overview

The analysis highlights Regions and Standards as prominent areas in the source structure around PGC-1α.

Related topics
71
Source areas
5
Connected nodes
76
Extracted relationships
45
Concept neighborhoods
27
Bridge connections
76

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Regulation · 17 topics
Function · 16 topics
Interactions · 16 topics
Clinical significance · 15 topics
Overview · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1, PGC-1alpha, PPARG coactivator 1 alpha, PGC-1α
Band
4p15.2 · 5|5 C1
Chr.
Chromosome 4 (human) · Chromosome 5 (mouse)
Databases
NCBI: entry; OMA: entry
End
23,904,089 bp · 51,725,068 bp
Ensembl
ENSG00000109819

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Regulation

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PGC-1α connects Entity context

The extracted context around PGC-1α shows recurring relationship patterns in the source. For example, PGC-1α → Akt, CREB, Fasting, It, NRF1, NRF2, PI3K, PIP3, Protein, Reactive, SIRT1, The Akt Another extracted example is PGC-1α → CREB, Endurance, Exercise-induced PGC-1α, It, NRFs, PPAR-γ, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

PGC-1α

Top relations

related to Regulation · 12
PGC-1α → Akt, CREB, Fasting, It, NRF1, NRF2, PI3K, PIP3, Protein, Reactive, SIRT1, The Akt
related to Function · 7
PGC-1α → CREB, Endurance, Exercise-induced PGC-1α, It, NRFs, PPAR-γ, This
Band · 2
PGC-1α → 4p15.2, 5|5 C1
Chr. · 2
PGC-1α → Chromosome 4 (human), Chromosome 5 (mouse)
End · 2
PGC-1α → 23,904,089 bp, 51,725,068 bp
is a · 2
PGC-1α → master regulator of mitochondrial biogenesis, transcriptional coactivator that regulates the genes involved in energy metabolism
Aliases · 1
PGC-1α → PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1, PGC-1alpha, PPARG coactivator 1 alpha, PGC-1α
Databases · 1
PGC-1α → NCBI: entry; OMA: entry
Ensembl · 1
PGC-1α → ENSG00000109819
Entrez · 1
PGC-1α → 10891

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein human ppargc1a also bp mitochondrial chr band receptor akt coactivator external muscle shown gamma expression chromosome alpha nf-kappa-b

PGC-1α relationships Subject–Predicate–Object triples

TTTA extracted 45 structured relationships around PGC-1α. Examples in this analysis include PGC-1α → Aliases → PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1, PGC-1alpha, PPARG coactivator 1 alpha, PGC-1α and PGC-1α → Band → 4p15.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PGC-1αAliasesPPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1, PGC-1alpha, PPARG coactivator 1 alpha, PGC-1α1.00infobox
PGC-1αBand4p15.21.00infobox
PGC-1αBand5|5 C11.00infobox
PGC-1αChr.Chromosome 4 (human)1.00infobox
PGC-1αChr.Chromosome 5 (mouse)1.00infobox
PGC-1αDatabasesNCBI: entry; OMA: entry1.00infobox
PGC-1αEnd23,904,089 bp1.00infobox
PGC-1αEnd51,725,068 bp1.00infobox
PGC-1αEnsemblENSG000001098191.00infobox
PGC-1αEntrez108911.00infobox
PGC-1αExternal IDsOMIM: 604517; MGI: 1342774; GeneCards: PPARGC1A1.00infobox
PGC-1αGene location (Human)Gene location (Human)Chr.Chromosome 4 (human)Band4p15.2Start23,755,041 bpEnd23,904,089 bp1.00infobox
PGC-1αGene location (Mouse)Gene location (Mouse)Chr.Chromosome 5 (mouse)Band5|5 C1Start51,611,592 bpEnd51,725,068 bp1.00infobox
PGC-1αLocation (UCSC)Chr 4: 23.76 – 23.9 Mb1.00infobox
PGC-1αOrthologsOrthologsDatabasesNCBI: entry; OMA: entrySpeciesHumanMouseEntrez1089119017EnsemblENSG00000109819ENSMUSG00000029167UniProtn aO70343RefSeq (mRNA)NM_013261NM_008904RefSeq (protein)…1.00infobox
PGC-1αRefSeq (mRNA)NM_0132611.00infobox
PGC-1αRefSeq (protein)n/a1.00infobox
PGC-1αSpeciesHuman1.00infobox
PGC-1αUniProtn a1.00infobox
PGC-1αis amaster regulator of mitochondrial biogenesis0.90text
PGC-1αis atranscriptional coactivator that regulates the genes involved in energy metabolism0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around PGC-1α bring nearby vocabulary together. In this analysis, examples include Protein, Expression and Muscle. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PGC-1α
    • Protein
    • Expression
    • Muscle
    • Shown
    • Also
    • External
    • Effects
    • Increase
    • Mitochondrial
    • Human
    • Ppargc1a
    • Increased
  • pgc-1α
    • Protein
    • Expression
    • Muscle
    • Shown
    • Also
    • External
    • Effects
    • Increase
    • Mitochondrial
    • Human
    • Ppargc1a
    • Increased
  • gene
    • Human
    • Location
    • Mouse
    • Chromosome
    • Bp
    • Chr
    • Pgc-1α
    • Also
    • Ppargc1a
    • Band
    • Effects
    • Expression
  • gene expression
    • Human
    • Increased
    • Location
    • Mouse
    • Chromosome
    • Bp
    • Chr
    • Pgc-1α
    • Also
    • Ppargc1a
    • Band
    • Effects
  • estrogen-related receptor alpha
    • Beta
    • Receptor
    • Ppargc1a
    • Gamma
    • Human
    • Protein
    • Location
    • Peroxisome
    • Proliferator-activated
    • Chromosome
    • Coactivator
    • External
  • retinoid x receptor alpha
    • Beta
    • Receptor
    • Ppargc1a
    • Gamma
    • Human
    • Protein
    • Location
    • Peroxisome
    • Proliferator-activated
    • Chromosome
    • Coactivator
    • External
  • coactivator
    • Peroxisome
    • Proliferator-activated
    • Gamma
    • Receptor
    • Ppargc1a
    • Humans
    • Gene
    • Location
    • Chromosome
    • External
    • Alpha
    • Bp
  • protein
    • Receptor
    • Akt
    • Alpha
    • Beta
    • Human
    • Location
    • Mouse
    • Upregulated
    • Band
    • Chromosome
    • Signals
    • Bp

Connections between topic areas Semantic bridges

For PGC-1α, one of the stronger structural bridges in this analysis connects PGC-1α with Regulation. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PGC-1α — Regulation · splits 59 ⟂ 18
PGC-1α — Function · splits 60 ⟂ 17
PGC-1α — Interactions · splits 60 ⟂ 17
PGC-1α — Clinical significance · splits 61 ⟂ 16
PGC-1α — Overview · splits 69 ⟂ 8

Map overview Semantic statistics

PGC-1α

Nodes77
Edges76
Triples45
Avg. degree1.97
Density0.025974
Components1

Source & methodology

TTTA analyzes the structure around PGC-1α to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PGC-1α · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.