Insulin receptor

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Export map as:

Research this topic

Explore the main themes, entities and connections around Insulin receptor. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Ligand binding

Cryo-EM Adapter proteins SH2-B Src APS

16 related topics

Signal transduction pathway

Tyrosine kinase receptor Autophosphorylation Insulin receptor substrate Phosphoinositide 3-kinase Phosphatidylinositol 4,5-bisphosphate

12 related topics

Function

SH2 domain Grb2 G protein MAPK Elk1

11 related topics

Structure

Transcription Translated Exon Furin Proteolytic cleavage

10 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.1: ↗
Aliases: INSR, CD220, HHF5, insulin receptor
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GAG, 1I44, 1IR3, 1IRK, 1P14, 1RQQ, 2AUH, 2B4S, 2HR7, 3BU3, 3BU5, 3BU6, 3EKK, 3EKN, 3ETA, 3W11, 3W12, 3W13,…
Band: 19p13.2 · 8 A1.1|8 1.82 cM
Bgee: buccal mucosa cell · palpebral conjunctiva · visceral pleura · middle temporal gyrus · kidney tubule
BioGPS: More reference expression data

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Structure

Transcription Transcription (genetics)
Translated Translation (genetics)
Exon
Furin
Proteolytic cleavage Proteolysis
C-terminus
Ligand
Monomer
Fibronectin type III domains Fibronectin type III domain
Ectodomain

Ligand binding

Cryo-EM Transmission electron cryomicroscopy
Adapter proteins Signal transducing adaptor protein
SH2-B SHB (gene)
Src Src (gene)
APS APS (gene)?action=edit&redlink=1
PTP1B
Scatchard plots Scatchard plot
Cooperative binding
'crosslinking' Cross-link
Conformation Conformational change
Molecular dynamics
Nanodiscs Nanodisc
4548-G05
Insulin-like growth factor 1
Mecasermin
Small-molecule

Signal transduction pathway

Tyrosine kinase receptor
Autophosphorylation
Insulin receptor substrate
Phosphoinositide 3-kinase
Phosphatidylinositol 4,5-bisphosphate
Phosphatidylinositol 3,4,5-trisphosphate Phosphatidylinositol (3,4,5)-trisphosphate
Protein kinase B
GLUT4
SNARE SNARE (protein)
Glycogen synthase kinase Glycogen synthase kinase 3
Glycogen synthase
PIP2

Function

SH2 domain
Grb2
G protein
MAPK
Elk1
Phosphatidylinositol 4,5-bisphosphate Phosphatidylinositol (4,5)-bisphosphate
Akt
Endocytosis
Insulin degrading enzyme
Liver
T-cell receptor

Pathology

Interactions

Interact Protein–protein interaction
ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase 1
GRB10
GRB7
IRS1
MAD2L1
PRKCD
PTPN11
SH2B1

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes87

Edges86

Triples237

Avg. degree1.98

Density0.022989

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Insulin receptor

Top relations

Gene ontology · 89

Insulin receptor → activation of protein kinase activity, activation of protein kinase B activity, adrenal gland development, amyloid-beta binding, amyloid-beta clearance, anatomical structure development, animal organ morphogenesis, ATP binding, axon, carbohydrate metabolic process, cargo receptor activity, caveola, cellular response to growth factor stimulus, cellular response to insulin stimulus, dendrite membrane, dendritic spine maintenance, endosome membrane, epidermis development, exocrine pancreas development, external side of plasma membrane

related to Ligand binding · 21

Insulin receptor → APS, Binding, EM, Furthermore, IGF-I, IGF-II, IR, IR-ligand, IRS, PTP1B, Scatchard, SH2-B, Src Homology, Strictly, T-shaped, The, These, This, TK, Using

Bgee · 20

Insulin receptor → body of pancreas, buccal mucosa cell, ciliary body, digastric muscle, epithelium of nasopharynx, kidney tubule, lacrimal gland, left lobe of liver, middle temporal gyrus, palpebral conjunctiva, Paneth cell, parotid gland, renal medulla, retinal pigment epithelium, seminal vesicula, sternocleidomastoid muscle, substantia nigra, tibia, triceps brachii muscle, visceral pleura

RNA expression pattern · 20

related to Signal transduction pathway · 18

Insulin receptor → Akt, At, Effect, Glut-4, GLUT4, Insulin, IRS-1, Phosphatidylinositol, PI3K, PIP2, PIP3, PKB, Signal, SNARE, The, Therefore, These, This

related to Stimulation of glycogen synthesis · 15

Insulin receptor → Akt, Glycogen, GSK-3, In, IRS-1, Now, P-Tyr, PI-3, PI-3K, PIP2, PIP3, PKB, SH2, This, When GSK-3

related to External links · 9

Insulin receptor → Insulin, Medicine Medical Subject Headings, MeSH, National Library, Overview, P06213, PDB, PDBe-KB, UniProt

related to Interactions · 8

Insulin receptor → ENPP1, GRB10, GRB7, Insulin, IRS1, MAD2L1, PRKCD, PTPN11

related to Immune system · 6

Insulin receptor → Besides, Indeed, Insulin, On, T-cell, TCR

related to Pathology · 3

Insulin receptor → For, Patients, The

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

insulin receptor glucose binding ligand ir gene kinase activation glycogen site protein transmembrane cells bp domain domains upon insr monomer

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Insulin receptor	2.7.10.1	↗	1.00	infobox
Insulin receptor	Aliases	INSR, CD220, HHF5, insulin receptor	1.00	infobox
Insulin receptor	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GAG, 1I44, 1IR3, 1IRK, 1P14, 1RQQ, 2AUH, 2B4S, 2HR7, 3BU3, 3BU5, 3BU6, 3EKK, 3EKN, 3ETA, 3W11, 3W12, 3W13,…	1.00	infobox
Insulin receptor	Band	19p13.2	1.00	infobox
Insulin receptor	Band	8 A1.1\|8 1.82 cM	1.00	infobox
Insulin receptor	Bgee	buccal mucosa cell	1.00	infobox
Insulin receptor	Bgee	palpebral conjunctiva	1.00	infobox
Insulin receptor	Bgee	visceral pleura	1.00	infobox
Insulin receptor	Bgee	middle temporal gyrus	1.00	infobox
Insulin receptor	Bgee	kidney tubule	1.00	infobox
Insulin receptor	Bgee	renal medulla	1.00	infobox
Insulin receptor	Bgee	tibia	1.00	infobox
Insulin receptor	Bgee	seminal vesicula	1.00	infobox
Insulin receptor	Bgee	epithelium of nasopharynx	1.00	infobox
Insulin receptor	Bgee	body of pancreas	1.00	infobox
Insulin receptor	Bgee	retinal pigment epithelium	1.00	infobox
Insulin receptor	Bgee	Paneth cell	1.00	infobox
Insulin receptor	Bgee	ciliary body	1.00	infobox
Insulin receptor	Bgee	lacrimal gland	1.00	infobox
Insulin receptor	Bgee	left lobe of liver	1.00	infobox
Insulin receptor	Bgee	parotid gland	1.00	infobox
Insulin receptor	Bgee	substantia nigra	1.00	infobox
Insulin receptor	Bgee	digastric muscle	1.00	infobox
Insulin receptor	Bgee	triceps brachii muscle	1.00	infobox
Insulin receptor	Bgee	sternocleidomastoid muscle	1.00	infobox
Insulin receptor	BioGPS	More reference expression data	1.00	infobox
Insulin receptor	Chr.	Chromosome 19 (human)	1.00	infobox
Insulin receptor	Chr.	Chromosome 8 (mouse)	1.00	infobox
Insulin receptor	Databases	NCBI: entry; OMA: entry	1.00	infobox
Insulin receptor	End	7,294,414 bp	1.00	infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

Connections between topic areas Semantic bridges

Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

Min side: 3