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RHEB

RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.

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Function

13 related topics

Interactions

8 related topics

Structure

2 related topics

Regulation

1 related topics

Key facts & relationships

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Aliases
RHEB, RHEB2, Ras homolog enriched in brain, Ras homolog, mTORC1 binding
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1XTQ, 1XTR, 1XTS, 3SEA, 3T5G
Band
7q36.1 · 5|5 A3
Bgee
ventricular zone · ganglionic eminence · smooth muscle tissue · Brodmann area 9 · gastric mucosa
BioGPS
More reference expression data
Chr.
Chromosome 7 (human) · Chromosome 5 (mouse)

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Overview

Structure

Function

Regulation

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

RHEB

Nodes35
Edges34
Triples167
Avg. degree1.94
Density0.057143
Components1

How this topic connects Entity context

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RHEB

Top relations

Gene ontology · 29
RHEB → cytoplasm, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular exosome, GDP binding, Golgi apparatus, Golgi membrane, GTP binding, GTPase activity, lysosomal membrane, magnesium ion binding, membrane, metal ion binding, negative regulation of cold-induced thermogenesis, nucleotide binding, plasma membrane, positive regulation of oligodendrocyte differentiation, positive regulation of TOR signaling
Bgee · 20
RHEB → anterior cingulate cortex, Brodmann area 9, cingulate gyrus, condyle, Epithelium of choroid plexus, facial motor nucleus, ganglionic eminence, gastric mucosa, left adrenal cortex, medial ganglionic eminence, muscle layer of sigmoid colon, nucleus of stria terminalis, otic placode, otic vesicle, Region I of hippocampus proper, right frontal lobe, saccule, smooth muscle tissue, ventricular zone, vestibular sensory epithelium
RNA expression pattern · 20
RHEB → anterior cingulate cortex, Brodmann area 9, cingulate gyrus, condyle, Epithelium of choroid plexus, facial motor nucleus, ganglionic eminence, gastric mucosa, left adrenal cortex, medial ganglionic eminence, muscle layer of sigmoid colon, nucleus of stria terminalis, otic placode, otic vesicle, Region I of hippocampus proper, right frontal lobe, saccule, smooth muscle tissue, ventricular zone, vestibular sensory epithelium
related to Interactions · 17
RHEB → AMP-activated, AMPK, Ataxia, ATM, ATR, C-Raf, CAD, Phospholipase D1, PLD1, Rad3, RAF, Rapamycin Complex, Regulatory-associated, RPTOR, Target, TSC, Tuberous
related to Differences from Ras superfamily · 10
RHEB → Asp65, GDP-bound, GTP, GTP-bound, GTPase, However, II, Ras, Similar, Such
related to Structure · 10
RHEB → Also, C-terminus, CAAX, GDP-bound, GTP-bound, GTPase, II, N-terminus, RAS-related GTP-binding, The
related to Activation of mTORC1 · 7
RHEB → GTP-bound, GTP-bound RHEB, Mechanistic Target, Rag7, Ragulator-Rag, Rapamycin Complex, TOR/S6K
related to mTORC1 independent functions · 7
RHEB → AMPK, An, CAD, For, In, Phospholipase D1, PLD1
related to Regulation · 7
RHEB → GTP, GTP-bound, Its, Specifically, TSC, TSC2, Tuberin
related to External links · 6
RHEB → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library

Important terminology Word statistics

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Important terminology

ras cell protein mtorc1 human mtor bp pathway complex chr band within proteins chromosome superfamily function regulation also growth tuberous

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
RHEBAliasesRHEB, RHEB2, Ras homolog enriched in brain, Ras homolog, mTORC1 binding1.00infobox
RHEBAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1XTQ, 1XTR, 1XTS, 3SEA, 3T5G1.00infobox
RHEBBand7q36.11.00infobox
RHEBBand5|5 A31.00infobox
RHEBBgeeventricular zone1.00infobox
RHEBBgeeganglionic eminence1.00infobox
RHEBBgeesmooth muscle tissue1.00infobox
RHEBBgeeBrodmann area 91.00infobox
RHEBBgeegastric mucosa1.00infobox
RHEBBgeecingulate gyrus1.00infobox
RHEBBgeeanterior cingulate cortex1.00infobox
RHEBBgeemuscle layer of sigmoid colon1.00infobox
RHEBBgeeleft adrenal cortex1.00infobox
RHEBBgeeright frontal lobe1.00infobox
RHEBBgeeotic vesicle1.00infobox
RHEBBgeeEpithelium of choroid plexus1.00infobox
RHEBBgeesaccule1.00infobox
RHEBBgeeRegion I of hippocampus proper1.00infobox
RHEBBgeeotic placode1.00infobox
RHEBBgeefacial motor nucleus1.00infobox
RHEBBgeecondyle1.00infobox
RHEBBgeevestibular sensory epithelium1.00infobox
RHEBBgeenucleus of stria terminalis1.00infobox
RHEBBgeemedial ganglionic eminence1.00infobox
RHEBBioGPSMore reference expression data1.00infobox
RHEBChr.Chromosome 7 (human)1.00infobox
RHEBChr.Chromosome 5 (mouse)1.00infobox
RHEBDatabasesNCBI: entry; OMA: entry1.00infobox
RHEBEnd151,520,120 bp1.00infobox
RHEBEnd25,047,622 bp1.00infobox

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