Insulin receptor

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Insulin receptor topic overview

The analysis highlights Ligand binding, Signal transduction pathway and Function as prominent areas in the source structure around Insulin receptor.

Related topics: 78
Source areas: 7
Connected nodes: 85
Extracted relationships: 216
Related term clusters: 26
Bridge connections: 85

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Ligand binding · 15 topics

Signal transduction pathway · 12 topics

Function · 11 topics

Overview · 11 topics

Pathology · 10 topics

Structure · 10 topics

Interactions · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.1: ↗
Aliases: INSR, CD220, HHF5, insulin receptor
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GAG, 1I44, 1IR3, 1IRK, 1P14, 1RQQ, 2AUH, 2B4S, 2HR7, 3BU3, 3BU5, 3BU6, 3EKK, 3EKN, 3ETA, 3W11, 3W12, 3W13,…
Band: 19p13.2 · 8 A1.1|8 1.82 cM
Bgee: buccal mucosa cell · palpebral conjunctiva · visceral pleura · middle temporal gyrus · kidney tubule
BioGPS: More reference expression data

Start with your topic. Discover where to go next.

Explore different angles and find fresh ideas to shape your next piece of content.

Insulin receptor

11Transmembrane receptor · Insulin · IGF-I

3Endocytosis · Insulin degrading enzyme · Liver

11Tyrosine kinase receptor · Autophosphorylation · Insulin receptor substrate

6Donohue syndrome · Autosomal recessive · Rabson-Mendenhall syndrome

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Ligand binding

Signal transduction pathway

Function

Pathology

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Insulin receptor connects Entity context

The extracted context around Insulin receptor shows recurring relationship patterns in the source. For example, Insulin receptor → activation of protein kinase activity, activation of protein kinase B activity, adrenal gland development, amyloid-beta binding, amyloid-beta clearance, anatomical structure development, animal organ morphogenesis, ATP binding, axon, carbohydrate metabolic process, cargo receptor activity, caveola, cellular response to growth factor stimulus, cellular response to insulin stimulus, dendrite membrane, dendritic spine maintenance, endosome membrane, epidermis development, exocrine pancreas development, external side of plasma membrane Another extracted example is Insulin receptor → body of pancreas, buccal mucosa cell, ciliary body, digastric muscle, epithelium of nasopharynx, kidney tubule, lacrimal gland, left lobe of liver, middle temporal gyrus, palpebral conjunctiva, Paneth cell, parotid gland, renal medulla, retinal pigment epithelium, seminal vesicula, sternocleidomastoid muscle, substantia nigra, tibia, triceps brachii muscle, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 89

Insulin receptor → activation of protein kinase activity, activation of protein kinase B activity, adrenal gland development, amyloid-beta binding, amyloid-beta clearance, anatomical structure development, animal organ morphogenesis, ATP binding, axon, carbohydrate metabolic process, cargo receptor activity, caveola, cellular response to growth factor stimulus, cellular response to insulin stimulus, dendrite membrane, dendritic spine maintenance, endosome membrane, epidermis development, exocrine pancreas development, external side of plasma membrane

Bgee · 20

Insulin receptor → body of pancreas, buccal mucosa cell, ciliary body, digastric muscle, epithelium of nasopharynx, kidney tubule, lacrimal gland, left lobe of liver, middle temporal gyrus, palpebral conjunctiva, Paneth cell, parotid gland, renal medulla, retinal pigment epithelium, seminal vesicula, sternocleidomastoid muscle, substantia nigra, tibia, triceps brachii muscle, visceral pleura

RNA expression pattern · 20

related to Ligand binding · 18

Insulin receptor → APS, Binding, EM, Furthermore, IGF-I, IGF-II, IR, IR-ligand, IRS, PTP1B, Scatchard, SH2-B, Src Homology, Strictly, T-shaped, TK, Using, V-shape

related to Signal transduction pathway · 14

Insulin receptor → Akt, Effect, Glut-4, GLUT4, Insulin, IRS-1, Phosphatidylinositol, PI3K, PIP2, PIP3, PKB, Signal, SNARE, Therefore

related to Stimulation of glycogen synthesis · 13

Insulin receptor → Akt, Glycogen, GSK-3, IRS-1, Now, P-Tyr, PI-3, PI-3K, PIP2, PIP3, PKB, SH2, When GSK-3

related to Interactions · 8

Insulin receptor → ENPP1, GRB10, GRB7, Insulin, IRS1, MAD2L1, PRKCD, PTPN11

related to Immune system · 5

Insulin receptor → Besides, Indeed, Insulin, T-cell, TCR

Band · 2

Insulin receptor → 19p13.2, 8 A1.1|8 1.82 cM

Chr. · 2

Insulin receptor → Chromosome 19 (human), Chromosome 8 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

insulin receptor glucose binding ligand ir gene kinase activation glycogen site protein transmembrane cells bp domain domains upon insr monomer

Insulin receptor relationships Subject–Predicate–Object triples

TTTA extracted 216 structured relationships around Insulin receptor. Examples in this analysis include Insulin receptor → 2.7.10.1 → ↗ and Insulin receptor → Aliases → INSR, CD220, HHF5, insulin receptor. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Insulin receptor	2.7.10.1	↗	1.00	infobox
Insulin receptor	Aliases	INSR, CD220, HHF5, insulin receptor	1.00	infobox
Insulin receptor	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GAG, 1I44, 1IR3, 1IRK, 1P14, 1RQQ, 2AUH, 2B4S, 2HR7, 3BU3, 3BU5, 3BU6, 3EKK, 3EKN, 3ETA, 3W11, 3W12, 3W13,…	1.00	infobox
Insulin receptor	Band	19p13.2	1.00	infobox
Insulin receptor	Band	8 A1.1\|8 1.82 cM	1.00	infobox
Insulin receptor	Bgee	buccal mucosa cell	1.00	infobox
Insulin receptor	Bgee	palpebral conjunctiva	1.00	infobox
Insulin receptor	Bgee	visceral pleura	1.00	infobox
Insulin receptor	Bgee	middle temporal gyrus	1.00	infobox
Insulin receptor	Bgee	kidney tubule	1.00	infobox
Insulin receptor	Bgee	renal medulla	1.00	infobox
Insulin receptor	Bgee	tibia	1.00	infobox
Insulin receptor	Bgee	seminal vesicula	1.00	infobox
Insulin receptor	Bgee	epithelium of nasopharynx	1.00	infobox
Insulin receptor	Bgee	body of pancreas	1.00	infobox
Insulin receptor	Bgee	retinal pigment epithelium	1.00	infobox
Insulin receptor	Bgee	Paneth cell	1.00	infobox
Insulin receptor	Bgee	ciliary body	1.00	infobox
Insulin receptor	Bgee	lacrimal gland	1.00	infobox
Insulin receptor	Bgee	left lobe of liver	1.00	infobox
Insulin receptor	Bgee	parotid gland	1.00	infobox
Insulin receptor	Bgee	substantia nigra	1.00	infobox
Insulin receptor	Bgee	digastric muscle	1.00	infobox
Insulin receptor	Bgee	triceps brachii muscle	1.00	infobox
Insulin receptor	Bgee	sternocleidomastoid muscle	1.00	infobox
Insulin receptor	BioGPS	More reference expression data	1.00	infobox
Insulin receptor	Chr.	Chromosome 19 (human)	1.00	infobox
Insulin receptor	Chr.	Chromosome 8 (mouse)	1.00	infobox
Insulin receptor	Databases	NCBI: entry; OMA: entry	1.00	infobox
Insulin receptor	End	7,294,414 bp	1.00	infobox

Related concept clusters Related term clusters

The concept neighborhoods around Insulin receptor bring nearby vocabulary together. In this analysis, examples include Receptor, Binding and Glucose. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Insulin receptor
- Receptor
- Binding
- Glucose
- Cells
- Activation
- Downstream
- Ir
- May
- Tyrosine
- Via
- Gene
- Transmembrane
insulin receptor
- Receptor
- Binding
- Glucose
- Cells
- Activation
- Phosphorylation
- Tyrosine
- Gene
- Upon
- Ligand
- Insr
- Result
transmembrane receptor
- Tyrosine
- Domain
- Downstream
- Domains
- Glucose
- Binding
- Activation
- Phosphorylation
- Gene
- Upon
- Ligand
- Insr
insulin
- Receptor
- Binding
- Glucose
- Cells
- Activation
- Ir
- May
- Tyrosine
- Via
- Gene
- Transmembrane
- Upon
receptor tyrosine kinase
- Transmembrane
- Kinase
- Pkb
- Tyrosine
- Domain
- Protein
- Binding
- Ligand
- Phosphorylation
- Ectodomain
- Ir
- Glucose
glucose homeostasis
- Activation
- Membrane
- Receptor
- Insulin
- Result
- Cell
- Phosphorylation
- Tyrosine
- Cells
- Glycogen
- Protein
- Binding
cooperative binding
- Ligand
- Site
- Ir
- Ectodomain
- Structure
- Tyrosine
- Insulin
- Monomer
- Phosphorylation
- Receptor
- Via
- Upon
tyrosine kinase receptor
- Transmembrane
- Kinase
- Pkb
- Tyrosine
- Domain
- Protein
- Binding
- Ligand
- Phosphorylation
- Ectodomain
- Ir
- Glucose

Connections between topic areas Semantic bridges

For Insulin receptor, one of the stronger structural bridges in this analysis connects Insulin receptor with Ligand binding. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Insulin receptor — Ligand binding · splits 70 ⟂ 16

Insulin receptor — Signal transduction pathway · splits 73 ⟂ 13

Insulin receptor — Overview · splits 74 ⟂ 12

Insulin receptor — Function · splits 74 ⟂ 12

Insulin receptor — Structure · splits 75 ⟂ 11

Insulin receptor — Pathology · splits 75 ⟂ 11

Insulin receptor — Interactions · splits 76 ⟂ 10

Map overview Semantic statistics

Insulin receptor

Nodes86

Edges85

Triples216

Avg. degree1.98

Density0.023256

Components1

Source & methodology

TTTA analyzes the structure around Insulin receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Ligand binding, Signal transduction pathway & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Insulin receptor · EN edition · Analysis: TopicsToTalkAbout

Insulin receptor: Ligand binding, Signal transduction pathway & Function

Insulin receptor topic overview

What this topic covers Research coverage

Key facts & relationships

Start with your topic. Discover where to go next.

Questions to explore

Explore all related topics Closing gaps

Overview

Structure

Ligand binding

Signal transduction pathway

Function

Pathology

Interactions

For the semantics nerds

Advanced semantic analysis

How Insulin receptor connects Entity context

Insulin receptor

Top relations

Important terminology

Important terminology

Insulin receptor relationships Subject–Predicate–Object triples

Related concept clusters Related term clusters

Connections between topic areas Semantic bridges

Map overview Semantic statistics

Insulin receptor

Source & methodology