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Insulin receptor: Ligand binding, Signal transduction pathway & Function

The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis; a functional process that under degenerate conditions may result in a range of clinical manifestations…

Language: English [EN]
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Insulin receptor topic overview

The analysis highlights Ligand binding, Signal transduction pathway and Function as prominent areas in the source structure around Insulin receptor.

Related topics
79
Source areas
7
Connected nodes
86
Extracted relationships
237
Concept neighborhoods
26
Bridge connections
86

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Ligand binding · 16 topics
Signal transduction pathway · 12 topics
Function · 11 topics
Overview · 11 topics
Pathology · 10 topics
Structure · 10 topics
Interactions · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.1
Aliases
INSR, CD220, HHF5, insulin receptor
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GAG, 1I44, 1IR3, 1IRK, 1P14, 1RQQ, 2AUH, 2B4S, 2HR7, 3BU3, 3BU5, 3BU6, 3EKK, 3EKN, 3ETA, 3W11, 3W12, 3W13,…
Band
19p13.2 · 8 A1.1|8 1.82 cM
Bgee
buccal mucosa cell · palpebral conjunctiva · visceral pleura · middle temporal gyrus · kidney tubule
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Ligand binding

Signal transduction pathway

Function

Pathology

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Insulin receptor connects Entity context

The extracted context around Insulin receptor shows recurring relationship patterns in the source. For example, Insulin receptor → activation of protein kinase activity, activation of protein kinase B activity, adrenal gland development, amyloid-beta binding, amyloid-beta clearance, anatomical structure development, animal organ morphogenesis, ATP binding, axon, carbohydrate metabolic process, cargo receptor activity, caveola, cellular response to growth factor stimulus, cellular response to insulin stimulus, dendrite membrane, dendritic spine maintenance, endosome membrane, epidermis development, exocrine pancreas development, external side of plasma membrane Another extracted example is Insulin receptor → APS, Binding, EM, Furthermore, IGF-I, IGF-II, IR, IR-ligand, IRS, PTP1B, Scatchard, SH2-B, Src Homology, Strictly, T-shaped, The, These, This, TK, Using. Use these groups to spot repeated connection types before inspecting the individual relationships.

Insulin receptor

Top relations

Gene ontology · 89
Insulin receptor → activation of protein kinase activity, activation of protein kinase B activity, adrenal gland development, amyloid-beta binding, amyloid-beta clearance, anatomical structure development, animal organ morphogenesis, ATP binding, axon, carbohydrate metabolic process, cargo receptor activity, caveola, cellular response to growth factor stimulus, cellular response to insulin stimulus, dendrite membrane, dendritic spine maintenance, endosome membrane, epidermis development, exocrine pancreas development, external side of plasma membrane
related to Ligand binding · 21
Insulin receptor → APS, Binding, EM, Furthermore, IGF-I, IGF-II, IR, IR-ligand, IRS, PTP1B, Scatchard, SH2-B, Src Homology, Strictly, T-shaped, The, These, This, TK, Using
Bgee · 20
Insulin receptor → body of pancreas, buccal mucosa cell, ciliary body, digastric muscle, epithelium of nasopharynx, kidney tubule, lacrimal gland, left lobe of liver, middle temporal gyrus, palpebral conjunctiva, Paneth cell, parotid gland, renal medulla, retinal pigment epithelium, seminal vesicula, sternocleidomastoid muscle, substantia nigra, tibia, triceps brachii muscle, visceral pleura
RNA expression pattern · 20
Insulin receptor → body of pancreas, buccal mucosa cell, ciliary body, digastric muscle, epithelium of nasopharynx, kidney tubule, lacrimal gland, left lobe of liver, middle temporal gyrus, palpebral conjunctiva, Paneth cell, parotid gland, renal medulla, retinal pigment epithelium, seminal vesicula, sternocleidomastoid muscle, substantia nigra, tibia, triceps brachii muscle, visceral pleura
related to Signal transduction pathway · 18
Insulin receptor → Akt, At, Effect, Glut-4, GLUT4, Insulin, IRS-1, Phosphatidylinositol, PI3K, PIP2, PIP3, PKB, Signal, SNARE, The, Therefore, These, This
related to Stimulation of glycogen synthesis · 15
Insulin receptor → Akt, Glycogen, GSK-3, In, IRS-1, Now, P-Tyr, PI-3, PI-3K, PIP2, PIP3, PKB, SH2, This, When GSK-3
related to External links · 9
Insulin receptor → Insulin, Medicine Medical Subject Headings, MeSH, National Library, Overview, P06213, PDB, PDBe-KB, UniProt
related to Interactions · 8
Insulin receptor → ENPP1, GRB10, GRB7, Insulin, IRS1, MAD2L1, PRKCD, PTPN11
related to Immune system · 6
Insulin receptor → Besides, Indeed, Insulin, On, T-cell, TCR
related to Pathology · 3
Insulin receptor → For, Patients, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

insulin receptor glucose binding ligand ir gene kinase activation glycogen site protein transmembrane cells bp domain domains upon insr monomer

Insulin receptor relationships Subject–Predicate–Object triples

TTTA extracted 237 structured relationships around Insulin receptor. Examples in this analysis include Insulin receptor → 2.7.10.1 → ↗ and Insulin receptor → Aliases → INSR, CD220, HHF5, insulin receptor. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Insulin receptor2.7.10.11.00infobox
Insulin receptorAliasesINSR, CD220, HHF5, insulin receptor1.00infobox
Insulin receptorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GAG, 1I44, 1IR3, 1IRK, 1P14, 1RQQ, 2AUH, 2B4S, 2HR7, 3BU3, 3BU5, 3BU6, 3EKK, 3EKN, 3ETA, 3W11, 3W12, 3W13,…1.00infobox
Insulin receptorBand19p13.21.00infobox
Insulin receptorBand8 A1.1|8 1.82 cM1.00infobox
Insulin receptorBgeebuccal mucosa cell1.00infobox
Insulin receptorBgeepalpebral conjunctiva1.00infobox
Insulin receptorBgeevisceral pleura1.00infobox
Insulin receptorBgeemiddle temporal gyrus1.00infobox
Insulin receptorBgeekidney tubule1.00infobox
Insulin receptorBgeerenal medulla1.00infobox
Insulin receptorBgeetibia1.00infobox
Insulin receptorBgeeseminal vesicula1.00infobox
Insulin receptorBgeeepithelium of nasopharynx1.00infobox
Insulin receptorBgeebody of pancreas1.00infobox
Insulin receptorBgeeretinal pigment epithelium1.00infobox
Insulin receptorBgeePaneth cell1.00infobox
Insulin receptorBgeeciliary body1.00infobox
Insulin receptorBgeelacrimal gland1.00infobox
Insulin receptorBgeeleft lobe of liver1.00infobox
Insulin receptorBgeeparotid gland1.00infobox
Insulin receptorBgeesubstantia nigra1.00infobox
Insulin receptorBgeedigastric muscle1.00infobox
Insulin receptorBgeetriceps brachii muscle1.00infobox
Insulin receptorBgeesternocleidomastoid muscle1.00infobox
Insulin receptorBioGPSMore reference expression data1.00infobox
Insulin receptorChr.Chromosome 19 (human)1.00infobox
Insulin receptorChr.Chromosome 8 (mouse)1.00infobox
Insulin receptorDatabasesNCBI: entry; OMA: entry1.00infobox
Insulin receptorEnd7,294,414 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Insulin receptor bring nearby vocabulary together. In this analysis, examples include Receptor, Binding and Glucose. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Insulin receptor
    • Receptor
    • Binding
    • Glucose
    • Cells
    • Activation
    • Downstream
    • Ir
    • May
    • Tyrosine
    • Via
    • Gene
    • Transmembrane
  • insulin receptor
    • Receptor
    • Binding
    • Glucose
    • Cells
    • Activation
    • Phosphorylation
    • Tyrosine
    • Gene
    • Upon
    • Ligand
    • Insr
    • Result
  • transmembrane receptor
    • Tyrosine
    • Domain
    • Downstream
    • Domains
    • Glucose
    • Binding
    • Activation
    • Phosphorylation
    • Gene
    • Upon
    • Ligand
    • Insr
  • insulin
    • Receptor
    • Binding
    • Glucose
    • Cells
    • Activation
    • Ir
    • May
    • Tyrosine
    • Via
    • Gene
    • Transmembrane
    • Upon
  • receptor tyrosine kinase
    • Transmembrane
    • Kinase
    • Pkb
    • Tyrosine
    • Domain
    • Protein
    • Binding
    • Ligand
    • Phosphorylation
    • Ectodomain
    • Ir
    • Glucose
  • glucose homeostasis
    • Activation
    • Membrane
    • Receptor
    • Insulin
    • Result
    • Cell
    • Phosphorylation
    • Tyrosine
    • Cells
    • Glycogen
    • Protein
    • Binding
  • cooperative binding
    • Ligand
    • Site
    • Ir
    • Ectodomain
    • Structure
    • Tyrosine
    • Insulin
    • Monomer
    • Phosphorylation
    • Receptor
    • Via
    • Upon
  • tyrosine kinase receptor
    • Transmembrane
    • Kinase
    • Pkb
    • Tyrosine
    • Domain
    • Protein
    • Binding
    • Ligand
    • Phosphorylation
    • Ectodomain
    • Ir
    • Glucose

Connections between topic areas Semantic bridges

For Insulin receptor, one of the stronger structural bridges in this analysis connects Insulin receptor with Ligand binding. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Insulin receptorLigand binding · splits 70 ⟂ 17
Insulin receptorSignal transduction pathway · splits 74 ⟂ 13
Insulin receptorOverview · splits 75 ⟂ 12
Insulin receptorFunction · splits 75 ⟂ 12
Insulin receptorStructure · splits 76 ⟂ 11
Insulin receptorPathology · splits 76 ⟂ 11
Insulin receptorInteractions · splits 77 ⟂ 10

Map overview Semantic statistics

Insulin receptor

Nodes87
Edges86
Triples237
Avg. degree1.98
Density0.022989
Components1

Source & methodology

TTTA analyzes the structure around Insulin receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Ligand binding, Signal transduction pathway & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Insulin receptor · EN edition · Analysis: TopicsToTalkAbout

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