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MTORC2: Measurement & Products

mTOR Complex 2 (mTORC2) is an acutely rapamycin-insensitive protein complex formed by serine/threonine kinase mTOR that regulates cell proliferation and survival, cell migration and cytoskeletal remodeling. The complex itself is rather large, consisting of seven protein subunits. The catalytic mTOR subunit, DEP domain containing mTOR-interacting protein…

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MTORC2 topic overview

The analysis highlights Measurement and Products as prominent areas in the source structure around MTORC2.

Related topics
68
Source areas
4
Connected nodes
72
Extracted relationships
74
Concept neighborhoods
28
Bridge connections
72

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 29 topics
Overview · 14 topics
Role in disease · 14 topics
Regulation and signaling · 11 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Alt. symbols
FRAP, FRAP2, FRAP1
Domains
InterPro
EC number
2.7.11.1
HGNC
3942
Locus
Chr. 1 p36
NCBI gene
2475

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Regulation and signaling

Role in disease

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MTORC2 connects Entity context

The extracted context around MTORC2 shows recurring relationship patterns in the source. For example, MTORC2 → Akt, Akt/PKB, Cdc42, Curcumin, F-actin, IGF-IR, In, InsR, Moreover, PDK1, Phosphorylation, PI3K-dependent, PKCα, Rac1, RhoA, S450, S473, SGK, T308, The Another extracted example is MTORC2 → Additionally, Akt, Grb10, IGF-1, PH, PI3K, PI3K-generated PIP3, Ric-8B, Similar, The, This, What. Use these groups to spot repeated connection types before inspecting the individual relationships.

MTORC2

Top relations

related to Function · 23
MTORC2 → Akt, Akt/PKB, Cdc42, Curcumin, F-actin, IGF-IR, In, InsR, Moreover, PDK1, Phosphorylation, PI3K-dependent, PKCα, Rac1, RhoA, S450, S473, SGK, T308, The
related to Upstream signaling · 12
MTORC2 → Additionally, Akt, Grb10, IGF-1, PH, PI3K, PI3K-generated PIP3, Ric-8B, Similar, The, This, What
related to Role in disease · 9
MTORC2 → Akt, Although, By, Deregulation, In, On, Since, Torin1, Warburg
related to Downstream signaling · 8
MTORC2 → AGC, Akt, HDACs, PI3K, PKA/PKG/PKC, PKC, PKCα, SGK1
related to Regulation and signaling · 7
MTORC2 → Akt, However, In, Originally, TORC1, TORC2, Torin-1
Alt. symbols · 1
MTORC2 → FRAP, FRAP2, FRAP1
Domains · 1
MTORC2 → InterPro
EC number · 1
MTORC2 → 2.7.11.1
HGNC · 1
MTORC2 → 3942
Locus · 1
MTORC2 → Chr. 1 p36

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

akt protein mtor insulin kinase rictor complex activity role also regulation signaling mtorc1 activation cell serine phosphorylation glucose rapamycin plays

MTORC2 relationships Subject–Predicate–Object triples

TTTA extracted 74 structured relationships around MTORC2. Examples in this analysis include MTORC2 → Alt. symbols → FRAP, FRAP2, FRAP1 and MTORC2 → Domains → InterPro. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MTORC2Alt. symbolsFRAP, FRAP2, FRAP11.00infobox
MTORC2DomainsInterPro1.00infobox
MTORC2EC number2.7.11.11.00infobox
MTORC2HGNC39421.00infobox
MTORC2LocusChr. 1 p361.00infobox
MTORC2NCBI gene24751.00infobox
MTORC2OMIM6012311.00infobox
MTORC2RefSeqNM_0049581.00infobox
MTORC2Search forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
MTORC2StructuresSwiss-model1.00infobox
MTORC2SymbolMTOR1.00infobox
MTORC2UniProtP423451.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MTORC2 bring nearby vocabulary together. In this analysis, examples include Insulin, Activity and Akt. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • MTORC2
    • Insulin
    • Activity
    • Akt
    • Rictor
    • Role
    • Glucose
    • Protein
    • Regulation
    • Mice
    • Plays
    • Activation
    • Also
  • mtorc2
    • Insulin
    • Activity
    • Akt
    • Rictor
    • Role
    • Glucose
    • Protein
    • Regulation
    • Mice
    • Plays
    • Activation
    • Also
  • protein complex
    • Proliferation
    • Regulates
    • Protein
    • Also
    • Mammalian
    • Actin
    • Rapamycin-insensitive
    • Survival
    • Threonine
    • Serine
    • Akt
    • Plays
  • serine/threonine kinase
    • Serine
    • Threonine
    • Proliferation
    • Regulates
    • Survival
    • Protein
    • Cell
    • Activation
    • Phosphorylation
    • Mtor
    • Actin
    • Complex
  • mtor
    • Mammalian
    • Kinase
    • Protein
    • Rapamycin-insensitive
    • Cell
    • Mtorc2
    • Regulation
    • Rictor
    • Signaling
    • Role
    • Insulin
    • Chronic
  • cell proliferation
    • Regulates
    • Survival
    • Actin
    • Threonine
    • Protein
    • Serine
    • Kinase
    • Plays
    • Proliferation
    • Shown
    • Also
    • Cells
  • cell migration
    • Survival
    • Kinase
    • Proliferation
    • Regulates
    • Shown
    • Cells
    • Activation
    • Mtor
    • Protein
    • Activity
    • Actin
    • Akt
  • akt
    • Phosphorylation
    • Also
    • Mtorc1
    • Mtorc2
    • Complex
    • Kinase
    • Activity
    • Actin
    • Proliferation
    • Regulates
    • Survival
    • Threonine

Connections between topic areas Semantic bridges

For MTORC2, one of the stronger structural bridges in this analysis connects MTORC2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MTORC2 — Function · splits 43 ⟂ 30
MTORC2 — Overview · splits 58 ⟂ 15
MTORC2 — Role in disease · splits 58 ⟂ 15
MTORC2 — Regulation and signaling · splits 61 ⟂ 12

Map overview Semantic statistics

MTORC2

Nodes73
Edges72
Triples74
Avg. degree1.97
Density0.027397
Components1

Source & methodology

TTTA analyzes the structure around MTORC2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MTORC2 · EN edition · Analysis: TopicsToTalkAbout

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