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MTORC2

mTOR Complex 2 (mTORC2) is an acutely rapamycin-insensitive protein complex formed by serine/threonine kinase mTOR that regulates cell proliferation and survival, cell migration and cytoskeletal remodeling. The complex itself is rather large, consisting of seven protein subunits. The catalytic mTOR subunit, DEP domain containing mTOR-interacting protein…

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Key facts & relationships

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Alt. symbols
FRAP, FRAP2, FRAP1
Domains
InterPro
EC number
2.7.11.1
HGNC
3942
Locus
Chr. 1 p36
NCBI gene
2475

Topics to explore

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Overview

Function

Regulation and signaling

Role in disease

Advanced semantic analysis

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Map overview Semantic statistics

MTORC2

Nodes73
Edges72
Triples74
Avg. degree1.97
Density0.027397
Components1

How this topic connects Entity context

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MTORC2

Top relations

related to Function · 23
MTORC2 → Akt, Akt/PKB, Cdc42, Curcumin, F-actin, IGF-IR, In, InsR, Moreover, PDK1, Phosphorylation, PI3K-dependent, PKCα, Rac1, RhoA, S450, S473, SGK, T308, The
related to Upstream signaling · 12
MTORC2 → Additionally, Akt, Grb10, IGF-1, PH, PI3K, PI3K-generated PIP3, Ric-8B, Similar, The, This, What
related to Role in disease · 9
MTORC2 → Akt, Although, By, Deregulation, In, On, Since, Torin1, Warburg
related to Downstream signaling · 8
MTORC2 → AGC, Akt, HDACs, PI3K, PKA/PKG/PKC, PKC, PKCα, SGK1
related to Regulation and signaling · 7
MTORC2 → Akt, However, In, Originally, TORC1, TORC2, Torin-1
Alt. symbols · 1
MTORC2 → FRAP, FRAP2, FRAP1
Domains · 1
MTORC2 → InterPro
EC number · 1
MTORC2 → 2.7.11.1
HGNC · 1
MTORC2 → 3942
Locus · 1
MTORC2 → Chr. 1 p36

Important terminology Word statistics

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Important terminology

akt protein mtor insulin kinase rictor complex activity role also regulation signaling mtorc1 activation cell serine phosphorylation glucose rapamycin plays

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MTORC2Alt. symbolsFRAP, FRAP2, FRAP11.00infobox
MTORC2DomainsInterPro1.00infobox
MTORC2EC number2.7.11.11.00infobox
MTORC2HGNC39421.00infobox
MTORC2LocusChr. 1 p361.00infobox
MTORC2NCBI gene24751.00infobox
MTORC2OMIM6012311.00infobox
MTORC2RefSeqNM_0049581.00infobox
MTORC2Search forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
MTORC2StructuresSwiss-model1.00infobox
MTORC2SymbolMTOR1.00infobox
MTORC2UniProtP423451.00infobox

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    Min side: 3
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