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Sirolimus: Community, Culture, Applications & Research

Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa). It has immunosuppressant functions in humans and is…

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Sirolimus topic overview

The analysis highlights Community, Culture, Applications and Research as prominent areas in the source structure around Sirolimus.

Related topics
149
Source areas
9
Connected nodes
158
Extracted relationships
159
Concept neighborhoods
34
Bridge connections
158

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Research · 32 topics
Chemistry · 26 topics
Adverse effects · 24 topics
Medical uses · 23 topics
Overview · 21 topics
Pharmacology · 11 topics
Veterinary uses · 6 topics
Interactions · 4 topics
Society and culture · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
L04AH01 (WHO) L01EG04 (WHO), S01XA23 (WHO), QC01EB90 (WHO)
Bioavailability
14% (oral solution), lower with high-fat meals; 18% (tablet), higher with high-fat meals
CAS Number
53123–88–9 Y
ChEBI
CHEBI:9168 Y
ChEMBL
ChEMBL413 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Interactions

Pharmacology

Chemistry

Society and culture

Research

Veterinary uses

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Sirolimus connects Entity context

The extracted context around Sirolimus shows recurring relationship patterns in the source. For example, Sirolimus → CYP2C8, CYP3A4, CYP3A5, Dose-corrected, Drug, However, In, It, P-glycoprotein, P-gp, PK, SRL, TAC, The, This Another extracted example is Sirolimus → August, Committee, European Medicines Agency, European Union, GmbH, Human Use, Hyftor, In February, May, Medicinal Products, Plusultra, Rapamune, The, United States. Use these groups to spot repeated connection types before inspecting the individual relationships.

Sirolimus

Top relations

related to Pharmacokinetics · 15
Sirolimus → CYP2C8, CYP3A4, CYP3A5, Dose-corrected, Drug, However, In, It, P-glycoprotein, P-gp, PK, SRL, TAC, The, This
related to Legal status · 14
Sirolimus → August, Committee, European Medicines Agency, European Union, GmbH, Human Use, Hyftor, In February, May, Medicinal Products, Plusultra, Rapamune, The, United States
has prevention · 11
Sirolimus → FDA, However, Impaired, In, It, Its, October, The, Transplant, US, Wyeth
related to Pharmacodynamics · 9
Sirolimus → Ciclosporin, Complex, FK-binding, FKBP12, IL-2, PP2B, Target Of Rapamycin, The, Unlike
has effect · 8
Sirolimus → However, In, NIH, Novartis, The, This, Two, Ultimately
related to Lymphangioleiomyomatosis · 8
Sirolimus → FDA, In May, LAM, Loss, Serious, The, This, TSC2
related to Angiofibromas · 7
Sirolimus → English-language, Facial, FDA, In April, Reported, The, TSC
related to Cancer · 7
Sirolimus → CCI-779, However, Kaposi's, Other, RAD001, The, When
related to Medical uses · 7
Sirolimus → EU, Fyarro, Hyftor, In, PEComa, Rapamune, US
related to Tuberous sclerosis complex · 7
Sirolimus → After, Novartis's RAD001, Numerous, TSC, United States, US, Wyeth's Rapamune

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

rapamycin treatment mtor patients use disease clinical also studies may effects transplant drug risk first complex calcineurin used however approved

Sirolimus relationships Subject–Predicate–Object triples

TTTA extracted 159 structured relationships around Sirolimus. Examples in this analysis include Sirolimus → 3D model (JSmol) → Interactive image and Sirolimus → ATC code → L04AH01 (WHO) L01EG04 (WHO), S01XA23 (WHO), QC01EB90 (WHO). The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Sirolimus3D model (JSmol)Interactive image1.00infobox
SirolimusATC codeL04AH01 (WHO) L01EG04 (WHO), S01XA23 (WHO), QC01EB90 (WHO)1.00infobox
SirolimusBioavailability14% (oral solution), lower with high-fat meals; 18% (tablet), higher with high-fat meals1.00infobox
SirolimusCAS Number53123–88–9 Y1.00infobox
SirolimusChEBICHEBI:9168 Y1.00infobox
SirolimusChEMBLChEMBL413 Y1.00infobox
SirolimusChemSpider10482078 Y1.00infobox
SirolimusCompTox Dashboard (EPA)DTXSID50235821.00infobox
SirolimusDrugBankDB00877 Y1.00infobox
SirolimusECHA InfoCard100.107.1471.00infobox
SirolimusElimination half-life57–63 hours1.00infobox
SirolimusExcretionMostly fecal1.00infobox
SirolimusFormulaC51H79NO131.00infobox
SirolimusKEGGD00753 Y1.00infobox
SirolimusLegal statusUS: ℞-only1.00infobox
SirolimusLegal statusEU: Rx-only1.00infobox
SirolimusLicense dataUS DailyMed: Sirolimus1.00infobox
SirolimusMetabolismLiver1.00infobox
SirolimusMolar mass914.187 g·mol−11.00infobox
SirolimusOther namesRapamycin, ABI-0091.00infobox
SirolimusPDB ligandRAP (PDBe, RCSB PDB)1.00infobox
SirolimusPregnancy categoryAU: C1.00infobox
SirolimusProtein binding92%1.00infobox
SirolimusPubChem CID52846161.00infobox
SirolimusRoutes of administrationBy mouth, intravenous, topical1.00infobox
SirolimusSolubility in water0.00261.00infobox
SirolimusTrade namesRapamune, others1.00infobox
SirolimusUNIIW36ZG6FT641.00infobox
Sirolimusis arelatively new medical therapy for the treatment of vascular malformations in recent years0.90text
Sirolimusis anatural product and macrocyclic lactone.BiosynthesisThe biosynthesis of the rapamycin core is accomplished by a type I polyketide synthase0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Sirolimus bring nearby vocabulary together. In this analysis, examples include Treatment, Transplant and Risk. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Sirolimus
    • Treatment
    • Transplant
    • Risk
    • Drug
    • Effects
    • May
    • Studies
    • Mtor
    • Use
    • Patients
    • Approved
    • Complex
  • sirolimus
    • Treatment
    • Transplant
    • Risk
    • Drug
    • Effects
    • May
    • Studies
    • Mtor
    • Use
    • Patients
    • Approved
    • Complex
  • organ transplant rejection
    • Lymphangioleiomyomatosis
    • Transplant
    • Lung
    • Effects
    • Disease
    • Cell
    • Risk
    • Patients
    • Immunosuppressive
    • Complex
    • Us
    • Calcineurin
  • perivascular epithelioid cell tumour
    • Lymphangioleiomyomatosis
    • Name
    • Rapamune
    • Rejection
    • Disease
    • Medical
    • Lung
    • Rapamycin
    • Transplant
    • Effects
    • Treatment
    • Mtor
  • mammalian target of rapamycin
    • Cells
    • Clinical
    • Mtor
    • Protein
    • Cell
    • Treatment
    • Name
    • Needed
    • Used
    • Effects
    • Disease
    • Studies
  • food and drug administration
    • Us
    • Drug
    • Lymphangioleiomyomatosis
    • Name
    • Rapamune
    • Topical
    • Angiofibromas
    • Needed
    • Patients
    • Rejection
    • Sirolimus
    • Medical
  • tuberous sclerosis complex
    • Rapamune
    • Lung
    • Mtor
    • First
    • Lymphangioleiomyomatosis
    • Name
    • Topical
    • Rejection
    • Us
    • Protein
    • Transplant
    • Risk
  • mantle cell lymphoma
    • Lymphangioleiomyomatosis
    • Name
    • Rapamune
    • Rejection
    • Disease
    • Medical
    • Lung
    • Rapamycin
    • Transplant
    • Effects
    • Treatment
    • Mtor

Connections between topic areas Semantic bridges

For Sirolimus, one of the stronger structural bridges in this analysis connects Sirolimus with Research. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Sirolimus — Research · splits 126 ⟂ 33
Sirolimus — Chemistry · splits 132 ⟂ 27
Sirolimus — Adverse effects · splits 134 ⟂ 25
Sirolimus — Medical uses · splits 135 ⟂ 24
Sirolimus — Overview · splits 137 ⟂ 22
Sirolimus — Pharmacology · splits 147 ⟂ 12
Sirolimus — Veterinary uses · splits 152 ⟂ 7
Sirolimus — Interactions · splits 154 ⟂ 5
Sirolimus — Society and culture · splits 156 ⟂ 3

Map overview Semantic statistics

Sirolimus

Nodes159
Edges158
Triples159
Avg. degree1.99
Density0.012579
Components1

Source & methodology

TTTA analyzes the structure around Sirolimus to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Community, Culture, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Sirolimus · EN edition · Analysis: TopicsToTalkAbout

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