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Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa). It has immunosuppressant functions in humans and is…
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| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Sirolimus | 3D model (JSmol) | Interactive image | 1.00 | infobox |
| Sirolimus | ATC code | L04AH01 (WHO) L01EG04 (WHO), S01XA23 (WHO), QC01EB90 (WHO) | 1.00 | infobox |
| Sirolimus | Bioavailability | 14% (oral solution), lower with high-fat meals; 18% (tablet), higher with high-fat meals | 1.00 | infobox |
| Sirolimus | CAS Number | 53123–88–9 Y | 1.00 | infobox |
| Sirolimus | ChEBI | CHEBI:9168 Y | 1.00 | infobox |
| Sirolimus | ChEMBL | ChEMBL413 Y | 1.00 | infobox |
| Sirolimus | ChemSpider | 10482078 Y | 1.00 | infobox |
| Sirolimus | CompTox Dashboard (EPA) | DTXSID5023582 | 1.00 | infobox |
| Sirolimus | DrugBank | DB00877 Y | 1.00 | infobox |
| Sirolimus | ECHA InfoCard | 100.107.147 | 1.00 | infobox |
| Sirolimus | Elimination half-life | 57–63 hours | 1.00 | infobox |
| Sirolimus | Excretion | Mostly fecal | 1.00 | infobox |
| Sirolimus | Formula | C51H79NO13 | 1.00 | infobox |
| Sirolimus | KEGG | D00753 Y | 1.00 | infobox |
| Sirolimus | Legal status | US: ℞-only | 1.00 | infobox |
| Sirolimus | Legal status | EU: Rx-only | 1.00 | infobox |
| Sirolimus | License data | US DailyMed: Sirolimus | 1.00 | infobox |
| Sirolimus | Metabolism | Liver | 1.00 | infobox |
| Sirolimus | Molar mass | 914.187 g·mol−1 | 1.00 | infobox |
| Sirolimus | Other names | Rapamycin, ABI-009 | 1.00 | infobox |
| Sirolimus | PDB ligand | RAP (PDBe, RCSB PDB) | 1.00 | infobox |
| Sirolimus | Pregnancy category | AU: C | 1.00 | infobox |
| Sirolimus | Protein binding | 92% | 1.00 | infobox |
| Sirolimus | PubChem CID | 5284616 | 1.00 | infobox |
| Sirolimus | Routes of administration | By mouth, intravenous, topical | 1.00 | infobox |
| Sirolimus | Solubility in water | 0.0026 | 1.00 | infobox |
| Sirolimus | Trade names | Rapamune, others | 1.00 | infobox |
| Sirolimus | UNII | W36ZG6FT64 | 1.00 | infobox |
| Sirolimus | is a | relatively new medical therapy for the treatment of vascular malformations in recent years | 0.90 | text |
| Sirolimus | is a | natural product and macrocyclic lactone.BiosynthesisThe biosynthesis of the rapamycin core is accomplished by a type I polyketide synthase | 0.90 | text |
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