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Sirolimus

Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa). It has immunosuppressant functions in humans and is…

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3D model (JSmol)
Interactive image
ATC code
L04AH01 (WHO) L01EG04 (WHO), S01XA23 (WHO), QC01EB90 (WHO)
Bioavailability
14% (oral solution), lower with high-fat meals; 18% (tablet), higher with high-fat meals
CAS Number
53123–88–9 Y
ChEBI
CHEBI:9168 Y
ChEMBL
ChEMBL413 Y

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Overview

Medical uses

Adverse effects

Interactions

Pharmacology

Chemistry

Society and culture

Research

Veterinary uses

Advanced semantic analysis

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Map overview Semantic statistics

Sirolimus

Nodes159
Edges158
Triples159
Avg. degree1.99
Density0.012579
Components1

How this topic connects Entity context

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Sirolimus

Top relations

related to Pharmacokinetics · 15
Sirolimus → CYP2C8, CYP3A4, CYP3A5, Dose-corrected, Drug, However, In, It, P-glycoprotein, P-gp, PK, SRL, TAC, The, This
related to Legal status · 14
Sirolimus → August, Committee, European Medicines Agency, European Union, GmbH, Human Use, Hyftor, In February, May, Medicinal Products, Plusultra, Rapamune, The, United States
has prevention · 11
Sirolimus → FDA, However, Impaired, In, It, Its, October, The, Transplant, US, Wyeth
related to Pharmacodynamics · 9
Sirolimus → Ciclosporin, Complex, FK-binding, FKBP12, IL-2, PP2B, Target Of Rapamycin, The, Unlike
has effect · 8
Sirolimus → However, In, NIH, Novartis, The, This, Two, Ultimately
related to Lymphangioleiomyomatosis · 8
Sirolimus → FDA, In May, LAM, Loss, Serious, The, This, TSC2
related to Angiofibromas · 7
Sirolimus → English-language, Facial, FDA, In April, Reported, The, TSC
related to Cancer · 7
Sirolimus → CCI-779, However, Kaposi's, Other, RAD001, The, When
related to Medical uses · 7
Sirolimus → EU, Fyarro, Hyftor, In, PEComa, Rapamune, US
related to Tuberous sclerosis complex · 7
Sirolimus → After, Novartis's RAD001, Numerous, TSC, United States, US, Wyeth's Rapamune

Important terminology Word statistics

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Important terminology

rapamycin treatment mtor patients use disease clinical also studies may effects transplant drug risk first complex calcineurin used however approved

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Sirolimus3D model (JSmol)Interactive image1.00infobox
SirolimusATC codeL04AH01 (WHO) L01EG04 (WHO), S01XA23 (WHO), QC01EB90 (WHO)1.00infobox
SirolimusBioavailability14% (oral solution), lower with high-fat meals; 18% (tablet), higher with high-fat meals1.00infobox
SirolimusCAS Number53123–88–9 Y1.00infobox
SirolimusChEBICHEBI:9168 Y1.00infobox
SirolimusChEMBLChEMBL413 Y1.00infobox
SirolimusChemSpider10482078 Y1.00infobox
SirolimusCompTox Dashboard (EPA)DTXSID50235821.00infobox
SirolimusDrugBankDB00877 Y1.00infobox
SirolimusECHA InfoCard100.107.1471.00infobox
SirolimusElimination half-life57–63 hours1.00infobox
SirolimusExcretionMostly fecal1.00infobox
SirolimusFormulaC51H79NO131.00infobox
SirolimusKEGGD00753 Y1.00infobox
SirolimusLegal statusUS: ℞-only1.00infobox
SirolimusLegal statusEU: Rx-only1.00infobox
SirolimusLicense dataUS DailyMed: Sirolimus1.00infobox
SirolimusMetabolismLiver1.00infobox
SirolimusMolar mass914.187 g·mol−11.00infobox
SirolimusOther namesRapamycin, ABI-0091.00infobox
SirolimusPDB ligandRAP (PDBe, RCSB PDB)1.00infobox
SirolimusPregnancy categoryAU: C1.00infobox
SirolimusProtein binding92%1.00infobox
SirolimusPubChem CID52846161.00infobox
SirolimusRoutes of administrationBy mouth, intravenous, topical1.00infobox
SirolimusSolubility in water0.00261.00infobox
SirolimusTrade namesRapamune, others1.00infobox
SirolimusUNIIW36ZG6FT641.00infobox
Sirolimusis arelatively new medical therapy for the treatment of vascular malformations in recent years0.90text
Sirolimusis anatural product and macrocyclic lactone.BiosynthesisThe biosynthesis of the rapamycin core is accomplished by a type I polyketide synthase0.90text

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