Interleukin 1-alpha

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Explore the main themes, entities and connections around Interleukin 1-alpha. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Production and cellular sources

Epithelial cells Epidermis Stratum corneum Keratinocytes Skin

29 related topics

Biological activity

Collagenase Cytoskeletal IL-6 GCSF Cyclooxygenase

31 related topics

Interactions

Interact HAX1 NDN TNF TNF-α

16 related topics

Synthesis and structure

Signal peptide IL-18 Proteases Calpain Microtubules

9 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha, IL-1 alpha, IL-1α
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ILA, 2KKI, 2L5X
Band: 2q14.1 · 2 F1|2 62.9 cM
Bgee: periodontal fiber · oral cavity · buccal mucosa cell · mucosa of urinary bladder · testicle
BioGPS: More reference expression data
Chr.: Chromosome 2 (human) · Chromosome 2 (mouse)

Topics to explore

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Overview

Discovery

Interleukin-1 beta IL1B

Synthesis and structure

Signal peptide
IL-18 Interleukin 18
Proteases Protease
Calpain
Microtubules Microtubule
Ribosomes Ribosome
Endoplasmic reticulum
Beta-pleated Beta sheet
Binding sites Binding site

Production and cellular sources

Interactions

Interact Protein-protein interaction
HAX1
NDN NDN (gene)
TNF
TNF-α Tumor necrosis factor
Shwartzman reaction Shwartzman phenomenon
PGE2
Nitric oxide
Nerve growth factor
Insulin
IL-8 Interleukin 8
Chemokine
MRNA Messenger RNA
MTOR
NF-κB
Positive feedback loop Positive feedback

Regulatory molecules

IL-1Ra IL1ra
IL-10 Interleukin 10

Biological activity

Applications

Advanced semantic analysis

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Map overview Semantic statistics

Nodes108

Edges107

Triples97

Avg. degree1.98

Density0.018519

Components1

How this topic connects Entity context

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Interleukin 1-alpha

Top relations

Gene ontology · 33

Interleukin 1-alpha → apoptotic process, cell population proliferation, cellular response to heat, connective tissue replacement involved in inflammatory response wound healing, copper ion binding, cytokine activity, cytokine-mediated signaling pathway, cytoplasm, cytosol, ectopic germ cell programmed cell death, extracellular region, extracellular space, extrinsic apoptotic signaling pathway in absence of ligand, fever generation, immune response, inflammatory response, interleukin-1 receptor binding, interleukin-1-mediated signaling pathway, negative regulation of cell population proliferation, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Bgee · 20

Interleukin 1-alpha → buccal mucosa cell, cornea, corneal stroma, embryo, epidermis, esophagus, gingival epithelium, gums, islet of Langerhans, left testis, lip, liver, mucosa of urinary bladder, oral cavity, periodontal fiber, placenta, right testis, skin of back, spermatocyte, testicle

RNA expression pattern · 20

Band · 2

Interleukin 1-alpha → 2 F1|2 62.9 cM, 2q14.1

Chr. · 2

Interleukin 1-alpha → Chromosome 2 (human), Chromosome 2 (mouse)

End · 2

Interleukin 1-alpha → 112,784,493 bp, 129,151,892 bp

Aliases · 1

Interleukin 1-alpha → IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha, IL-1 alpha, IL-1α

Available structures · 1

Interleukin 1-alpha → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ILA, 2KKI, 2L5X

BioGPS · 1

Interleukin 1-alpha → More reference expression data

Databases · 1

Interleukin 1-alpha → NCBI: entry; OMA: entry

Important terminology Word statistics

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Important terminology

il-1α cells production human activity interleukin bp chr band gene keratinocytes interleukin-1 fever precursor chromosome cytokine synthesis endothelial immune skin

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Interleukin 1-alpha	Aliases	IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha, IL-1 alpha, IL-1α	1.00	infobox
Interleukin 1-alpha	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ILA, 2KKI, 2L5X	1.00	infobox
Interleukin 1-alpha	Band	2q14.1	1.00	infobox
Interleukin 1-alpha	Band	2 F1\|2 62.9 cM	1.00	infobox
Interleukin 1-alpha	Bgee	periodontal fiber	1.00	infobox
Interleukin 1-alpha	Bgee	oral cavity	1.00	infobox
Interleukin 1-alpha	Bgee	buccal mucosa cell	1.00	infobox
Interleukin 1-alpha	Bgee	mucosa of urinary bladder	1.00	infobox
Interleukin 1-alpha	Bgee	testicle	1.00	infobox
Interleukin 1-alpha	Bgee	gums	1.00	infobox
Interleukin 1-alpha	Bgee	right testis	1.00	infobox
Interleukin 1-alpha	Bgee	left testis	1.00	infobox
Interleukin 1-alpha	Bgee	gingival epithelium	1.00	infobox
Interleukin 1-alpha	Bgee	islet of Langerhans	1.00	infobox
Interleukin 1-alpha	Bgee	esophagus	1.00	infobox
Interleukin 1-alpha	Bgee	skin of back	1.00	infobox
Interleukin 1-alpha	Bgee	embryo	1.00	infobox
Interleukin 1-alpha	Bgee	epidermis	1.00	infobox
Interleukin 1-alpha	Bgee	cornea	1.00	infobox
Interleukin 1-alpha	Bgee	spermatocyte	1.00	infobox
Interleukin 1-alpha	Bgee	liver	1.00	infobox
Interleukin 1-alpha	Bgee	corneal stroma	1.00	infobox
Interleukin 1-alpha	Bgee	lip	1.00	infobox
Interleukin 1-alpha	Bgee	placenta	1.00	infobox
Interleukin 1-alpha	BioGPS	More reference expression data	1.00	infobox
Interleukin 1-alpha	Chr.	Chromosome 2 (human)	1.00	infobox
Interleukin 1-alpha	Chr.	Chromosome 2 (mouse)	1.00	infobox
Interleukin 1-alpha	Databases	NCBI: entry; OMA: entry	1.00	infobox
Interleukin 1-alpha	End	112,784,493 bp	1.00	infobox
Interleukin 1-alpha	End	129,151,892 bp	1.00	infobox

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