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BECN1

Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.

Interactions, Role in disease & Modulators

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Interactions

6 related topics

Role in disease

5 related topics

Modulators

1 related topics

Overview

9 related topics

Key facts & relationships

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Aliases
BECN1, ATG6, VPS30, beclin1, beclin 1
Available structures
Available structuresPDBOrtholog search: K7ER46 PDBe K7ER46 RCSB List of PDB id codes2P1L, 2PON, 3DVU, 4DDP, 4MI8
Band
17q21.31 · 11|11 D
Bgee
rectum · epithelium of colon · monocyte · Achilles tendon · gastric mucosa
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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Overview

Role in disease

Interactions

Modulators

Advanced semantic analysis

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Map overview Semantic statistics

BECN1

Nodes26
Edges25
Triples154
Avg. degree1.92
Density0.076923
Components1

How this topic connects Entity context

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BECN1

Top relations

Gene ontology · 82
BECN1 → ageing, amyloid-beta metabolic process, apoptotic process, autophagosome, autophagosome assembly, autophagy, autophagy of mitochondrion, autophagy of nucleus, cell cycle, cell division, cellular defense response, cellular response to aluminum ion, cellular response to amino acid starvation, cellular response to copper ion, cellular response to epidermal growth factor stimulus, cellular response to glucose starvation, cellular response to hydrogen peroxide, cellular response to nitrogen starvation, cytokinesis, cytoplasm
Bgee · 20
BECN1 → Achilles tendon, aortic valve, ascending aorta, blood, ciliary body, endocardial cushion, endothelial cell of lymphatic vessel, epithelium of colon, gastric mucosa, gastrocnemius muscle, hair follicle, medullary collecting duct, monocyte, muscle layer of sigmoid colon, olfactory zone of nasal mucosa, Paneth cell, rectum, retinal pigment epithelium, Skeletal muscle tissue of rectus abdominis, stromal cell of endometrium
RNA expression pattern · 20
BECN1 → Achilles tendon, aortic valve, ascending aorta, blood, ciliary body, endocardial cushion, endothelial cell of lymphatic vessel, epithelium of colon, gastric mucosa, gastrocnemius muscle, hair follicle, medullary collecting duct, monocyte, muscle layer of sigmoid colon, olfactory zone of nasal mucosa, Paneth cell, rectum, retinal pigment epithelium, Skeletal muscle tissue of rectus abdominis, stromal cell of endometrium
related to External links · 8
BECN1 → Beclin-1, Human BECN1, Overview, PDB, PDBe-KB, Q14457, UCSC Genome Browser, UniProt
Band · 2
BECN1 → 11|11 D, 17q21.31
Chr. · 2
BECN1 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
BECN1 → 101,193,112 bp, 42,833,350 bp
Aliases · 1
BECN1 → BECN1, ATG6, VPS30, beclin1, beclin 1
Available structures · 1
BECN1 → Available structuresPDBOrtholog search: K7ER46 PDBe K7ER46 RCSB List of PDB id codes2P1L, 2PON, 3DVU, 4DDP, 4MI8
BioGPS · 1
BECN1 → More reference expression data

Important terminology Word statistics

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Important terminology

gene bp human chr band beclin-1 autophagy protein chromosome 17 cell death location role ortholog mouse bcl-2 atg6 class iii

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
BECN1AliasesBECN1, ATG6, VPS30, beclin1, beclin 11.00infobox
BECN1Available structuresAvailable structuresPDBOrtholog search: K7ER46 PDBe K7ER46 RCSB List of PDB id codes2P1L, 2PON, 3DVU, 4DDP, 4MI81.00infobox
BECN1Band17q21.311.00infobox
BECN1Band11|11 D1.00infobox
BECN1Bgeerectum1.00infobox
BECN1Bgeeepithelium of colon1.00infobox
BECN1Bgeemonocyte1.00infobox
BECN1BgeeAchilles tendon1.00infobox
BECN1Bgeegastric mucosa1.00infobox
BECN1BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
BECN1Bgeegastrocnemius muscle1.00infobox
BECN1Bgeeolfactory zone of nasal mucosa1.00infobox
BECN1Bgeemuscle layer of sigmoid colon1.00infobox
BECN1Bgeestromal cell of endometrium1.00infobox
BECN1Bgeemedullary collecting duct1.00infobox
BECN1BgeePaneth cell1.00infobox
BECN1Bgeeblood1.00infobox
BECN1Bgeeendothelial cell of lymphatic vessel1.00infobox
BECN1Bgeeretinal pigment epithelium1.00infobox
BECN1Bgeeendocardial cushion1.00infobox
BECN1Bgeeaortic valve1.00infobox
BECN1Bgeeascending aorta1.00infobox
BECN1Bgeehair follicle1.00infobox
BECN1Bgeeciliary body1.00infobox
BECN1BioGPSMore reference expression data1.00infobox
BECN1Chr.Chromosome 17 (human)1.00infobox
BECN1Chr.Chromosome 11 (mouse)1.00infobox
BECN1DatabasesNCBI: entry; OMA: entry1.00infobox
BECN1End42,833,350 bp1.00infobox
BECN1End101,193,112 bp1.00infobox

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