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Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.
Interactions, Role in disease & Modulators
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gene bp human chr band beclin-1 autophagy protein chromosome 17 cell death location role ortholog mouse bcl-2 atg6 class iii
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| BECN1 | Aliases | BECN1, ATG6, VPS30, beclin1, beclin 1 | 1.00 | infobox |
| BECN1 | Available structures | Available structuresPDBOrtholog search: K7ER46 PDBe K7ER46 RCSB List of PDB id codes2P1L, 2PON, 3DVU, 4DDP, 4MI8 | 1.00 | infobox |
| BECN1 | Band | 17q21.31 | 1.00 | infobox |
| BECN1 | Band | 11|11 D | 1.00 | infobox |
| BECN1 | Bgee | rectum | 1.00 | infobox |
| BECN1 | Bgee | epithelium of colon | 1.00 | infobox |
| BECN1 | Bgee | monocyte | 1.00 | infobox |
| BECN1 | Bgee | Achilles tendon | 1.00 | infobox |
| BECN1 | Bgee | gastric mucosa | 1.00 | infobox |
| BECN1 | Bgee | Skeletal muscle tissue of rectus abdominis | 1.00 | infobox |
| BECN1 | Bgee | gastrocnemius muscle | 1.00 | infobox |
| BECN1 | Bgee | olfactory zone of nasal mucosa | 1.00 | infobox |
| BECN1 | Bgee | muscle layer of sigmoid colon | 1.00 | infobox |
| BECN1 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| BECN1 | Bgee | medullary collecting duct | 1.00 | infobox |
| BECN1 | Bgee | Paneth cell | 1.00 | infobox |
| BECN1 | Bgee | blood | 1.00 | infobox |
| BECN1 | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| BECN1 | Bgee | retinal pigment epithelium | 1.00 | infobox |
| BECN1 | Bgee | endocardial cushion | 1.00 | infobox |
| BECN1 | Bgee | aortic valve | 1.00 | infobox |
| BECN1 | Bgee | ascending aorta | 1.00 | infobox |
| BECN1 | Bgee | hair follicle | 1.00 | infobox |
| BECN1 | Bgee | ciliary body | 1.00 | infobox |
| BECN1 | BioGPS | More reference expression data | 1.00 | infobox |
| BECN1 | Chr. | Chromosome 17 (human) | 1.00 | infobox |
| BECN1 | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| BECN1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| BECN1 | End | 42,833,350 bp | 1.00 | infobox |
| BECN1 | End | 101,193,112 bp | 1.00 | infobox |
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