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BECN1: Interactions, Role in disease & Modulators

Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.

Language: English [EN]
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BECN1 topic overview

The analysis highlights Interactions, Role in disease and Modulators as prominent areas in the source structure around BECN1.

Related topics
21
Source areas
4
Connected nodes
25
Extracted relationships
154
Concept neighborhoods
12
Bridge connections
25

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 9 topics
Interactions · 6 topics
Role in disease · 5 topics
Modulators · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
BECN1, ATG6, VPS30, beclin1, beclin 1
Available structures
Available structuresPDBOrtholog search: K7ER46 PDBe K7ER46 RCSB List of PDB id codes2P1L, 2PON, 3DVU, 4DDP, 4MI8
Band
17q21.31 · 11|11 D
Bgee
rectum · epithelium of colon · monocyte · Achilles tendon · gastric mucosa
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Role in disease

Interactions

Modulators

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How BECN1 connects Entity context

The extracted context around BECN1 shows recurring relationship patterns in the source. For example, BECN1 → ageing, amyloid-beta metabolic process, apoptotic process, autophagosome, autophagosome assembly, autophagy, autophagy of mitochondrion, autophagy of nucleus, cell cycle, cell division, cellular defense response, cellular response to aluminum ion, cellular response to amino acid starvation, cellular response to copper ion, cellular response to epidermal growth factor stimulus, cellular response to glucose starvation, cellular response to hydrogen peroxide, cellular response to nitrogen starvation, cytokinesis, cytoplasm Another extracted example is BECN1 → Achilles tendon, aortic valve, ascending aorta, blood, ciliary body, endocardial cushion, endothelial cell of lymphatic vessel, epithelium of colon, gastric mucosa, gastrocnemius muscle, hair follicle, medullary collecting duct, monocyte, muscle layer of sigmoid colon, olfactory zone of nasal mucosa, Paneth cell, rectum, retinal pigment epithelium, Skeletal muscle tissue of rectus abdominis, stromal cell of endometrium. Use these groups to spot repeated connection types before inspecting the individual relationships.

BECN1

Top relations

Gene ontology · 82
BECN1 → ageing, amyloid-beta metabolic process, apoptotic process, autophagosome, autophagosome assembly, autophagy, autophagy of mitochondrion, autophagy of nucleus, cell cycle, cell division, cellular defense response, cellular response to aluminum ion, cellular response to amino acid starvation, cellular response to copper ion, cellular response to epidermal growth factor stimulus, cellular response to glucose starvation, cellular response to hydrogen peroxide, cellular response to nitrogen starvation, cytokinesis, cytoplasm
Bgee · 20
BECN1 → Achilles tendon, aortic valve, ascending aorta, blood, ciliary body, endocardial cushion, endothelial cell of lymphatic vessel, epithelium of colon, gastric mucosa, gastrocnemius muscle, hair follicle, medullary collecting duct, monocyte, muscle layer of sigmoid colon, olfactory zone of nasal mucosa, Paneth cell, rectum, retinal pigment epithelium, Skeletal muscle tissue of rectus abdominis, stromal cell of endometrium
RNA expression pattern · 20
BECN1 → Achilles tendon, aortic valve, ascending aorta, blood, ciliary body, endocardial cushion, endothelial cell of lymphatic vessel, epithelium of colon, gastric mucosa, gastrocnemius muscle, hair follicle, medullary collecting duct, monocyte, muscle layer of sigmoid colon, olfactory zone of nasal mucosa, Paneth cell, rectum, retinal pigment epithelium, Skeletal muscle tissue of rectus abdominis, stromal cell of endometrium
related to External links · 8
BECN1 → Beclin-1, Human BECN1, Overview, PDB, PDBe-KB, Q14457, UCSC Genome Browser, UniProt
Band · 2
BECN1 → 11|11 D, 17q21.31
Chr. · 2
BECN1 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
BECN1 → 101,193,112 bp, 42,833,350 bp
Aliases · 1
BECN1 → BECN1, ATG6, VPS30, beclin1, beclin 1
Available structures · 1
BECN1 → Available structuresPDBOrtholog search: K7ER46 PDBe K7ER46 RCSB List of PDB id codes2P1L, 2PON, 3DVU, 4DDP, 4MI8
BioGPS · 1
BECN1 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp human chr band beclin-1 autophagy protein chromosome 17 cell death location role ortholog mouse bcl-2 atg6 class iii

BECN1 relationships Subject–Predicate–Object triples

TTTA extracted 154 structured relationships around BECN1. Examples in this analysis include BECN1 → Aliases → BECN1, ATG6, VPS30, beclin1, beclin 1 and BECN1 → Available structures → Available structuresPDBOrtholog search: K7ER46 PDBe K7ER46 RCSB List of PDB id codes2P1L, 2PON, 3DVU, 4DDP, 4MI8. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
BECN1AliasesBECN1, ATG6, VPS30, beclin1, beclin 11.00infobox
BECN1Available structuresAvailable structuresPDBOrtholog search: K7ER46 PDBe K7ER46 RCSB List of PDB id codes2P1L, 2PON, 3DVU, 4DDP, 4MI81.00infobox
BECN1Band17q21.311.00infobox
BECN1Band11|11 D1.00infobox
BECN1Bgeerectum1.00infobox
BECN1Bgeeepithelium of colon1.00infobox
BECN1Bgeemonocyte1.00infobox
BECN1BgeeAchilles tendon1.00infobox
BECN1Bgeegastric mucosa1.00infobox
BECN1BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
BECN1Bgeegastrocnemius muscle1.00infobox
BECN1Bgeeolfactory zone of nasal mucosa1.00infobox
BECN1Bgeemuscle layer of sigmoid colon1.00infobox
BECN1Bgeestromal cell of endometrium1.00infobox
BECN1Bgeemedullary collecting duct1.00infobox
BECN1BgeePaneth cell1.00infobox
BECN1Bgeeblood1.00infobox
BECN1Bgeeendothelial cell of lymphatic vessel1.00infobox
BECN1Bgeeretinal pigment epithelium1.00infobox
BECN1Bgeeendocardial cushion1.00infobox
BECN1Bgeeaortic valve1.00infobox
BECN1Bgeeascending aorta1.00infobox
BECN1Bgeehair follicle1.00infobox
BECN1Bgeeciliary body1.00infobox
BECN1BioGPSMore reference expression data1.00infobox
BECN1Chr.Chromosome 17 (human)1.00infobox
BECN1Chr.Chromosome 11 (mouse)1.00infobox
BECN1DatabasesNCBI: entry; OMA: entry1.00infobox
BECN1End42,833,350 bp1.00infobox
BECN1End101,193,112 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around BECN1 bring nearby vocabulary together. In this analysis, examples include Gene, Location and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • BECN1
    • Gene
    • Location
    • Human
    • Search
    • Ucsc
    • Protein
    • Role
    • Chromosome
    • Bp
    • Chr
    • External
    • Humans
  • becn1
    • Gene
    • Location
    • Human
    • Search
    • Ucsc
    • Protein
    • Role
    • Chromosome
    • Bp
    • Chr
    • External
    • Humans
  • gene
    • Location
    • Human
    • Chromosome
    • Bp
    • Chr
    • Atg6
    • End
    • Mouse
    • Ortholog
    • Search
    • Ucsc
    • Protein
  • autophagy
    • Cell
    • Death
    • Class
    • Iii
    • Levels
    • Regulation
    • Protein
    • Role
    • Beclin-1
    • Pi3k
    • Bcl-2
    • End
  • cell death
    • Death
    • Class
    • Iii
    • Levels
    • Regulation
    • Protein
    • Role
    • Pi3k
    • End
    • Mouse
    • Q14457
    • Search
  • programmed cell death
    • Death
    • Class
    • Iii
    • Levels
    • Regulation
    • Protein
    • Role
    • Pi3k
    • End
    • Mouse
    • Q14457
    • Search
  • protein
    • Regulation
    • Cell
    • Death
    • Role
    • Autophagy
    • End
    • Levels
    • Mouse
    • Q14457
    • Search
    • Ucsc
    • Uniprot
  • role in disease
    • Search
    • Chromosome
    • Location
    • Bp
    • Chr
    • Human
    • End
    • Levels
    • Mouse
    • Ortholog
    • Pdb
    • Q14457

Connections between topic areas Semantic bridges

For BECN1, one of the stronger structural bridges in this analysis connects BECN1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
BECN1 — Overview · splits 16 ⟂ 10
BECN1 — Interactions · splits 19 ⟂ 7
BECN1 — Role in disease · splits 20 ⟂ 6

Map overview Semantic statistics

BECN1

Nodes26
Edges25
Triples154
Avg. degree1.92
Density0.076923
Components1

Source & methodology

TTTA analyzes the structure around BECN1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Role in disease & Modulators, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — BECN1 · EN edition · Analysis: TopicsToTalkAbout

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