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Galectin-3 is a protein that in humans is encoded by the LGALS3 gene. Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have been identified.
The analysis highlights Applications, Clinical significance and Function as prominent areas in the source structure around Galectin-3.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around Galectin-3 shows recurring relationship patterns in the source. For example, Galectin-3 → antimicrobial humoral immune response mediated by antimicrobial peptide, carbohydrate binding, cell differentiation, cell surface, chemoattractant activity, collagen-containing extracellular matrix, cytoplasm, eosinophil chemotaxis, epithelial cell differentiation, extracellular exosome, extracellular matrix, extracellular region, extracellular space, ficolin-1-rich granule membrane, galectin complex, IgE binding, immune system process, immunological synapse, innate immune response, laminin binding Another extracted example is Galectin-3 → amniotic fluid, bronchial epithelial cell, calvaria, decidua, gastrula, granulocyte, jejunal mucosa, left colon, lip, mucosa of colon, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, nasal epithelium, palpebral conjunctiva, skin of abdomen, skin of external ear, stroma of bone marrow, transitional epithelium of urinary bladder. Use these groups to spot repeated connection types before inspecting the individual relationships.
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fibrosis also cancer expression human gene 14 galectins lgals3 bp cell shown binding chromosome angiogenesis chr protein band heart cells
TTTA extracted 157 structured relationships around Galectin-3. Examples in this analysis include Galectin-3 → Aliases → LGALS3, CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2, lectin, galactoside binding soluble 3, galectin 3 and Galectin-3 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A3K, 1KJL, 1KJR, 2NMN, 2NMO, 2NN8, 2XG3, 3AYA, 3AYC, 3AYD, 3AYE, 3T1L, 3T1M, 3ZSJ, 3ZSK, 3ZSL, 3ZSM, 4BLI,…. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Galectin-3 | Aliases | LGALS3, CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2, lectin, galactoside binding soluble 3, galectin 3 | 1.00 | infobox |
| Galectin-3 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A3K, 1KJL, 1KJR, 2NMN, 2NMO, 2NN8, 2XG3, 3AYA, 3AYC, 3AYD, 3AYE, 3T1L, 3T1M, 3ZSJ, 3ZSK, 3ZSL, 3ZSM, 4BLI,… | 1.00 | infobox |
| Galectin-3 | Band | 14q22.3 | 1.00 | infobox |
| Galectin-3 | Band | 14|14 C1 | 1.00 | infobox |
| Galectin-3 | Bgee | mucosa of colon | 1.00 | infobox |
| Galectin-3 | Bgee | palpebral conjunctiva | 1.00 | infobox |
| Galectin-3 | Bgee | mucosa of sigmoid colon | 1.00 | infobox |
| Galectin-3 | Bgee | bronchial epithelial cell | 1.00 | infobox |
| Galectin-3 | Bgee | nasal epithelium | 1.00 | infobox |
| Galectin-3 | Bgee | decidua | 1.00 | infobox |
| Galectin-3 | Bgee | mucosa of ileum | 1.00 | infobox |
| Galectin-3 | Bgee | jejunal mucosa | 1.00 | infobox |
| Galectin-3 | Bgee | mucosa of transverse colon | 1.00 | infobox |
| Galectin-3 | Bgee | amniotic fluid | 1.00 | infobox |
| Galectin-3 | Bgee | skin of external ear | 1.00 | infobox |
| Galectin-3 | Bgee | left colon | 1.00 | infobox |
| Galectin-3 | Bgee | transitional epithelium of urinary bladder | 1.00 | infobox |
| Galectin-3 | Bgee | calvaria | 1.00 | infobox |
| Galectin-3 | Bgee | granulocyte | 1.00 | infobox |
| Galectin-3 | Bgee | gastrula | 1.00 | infobox |
| Galectin-3 | Bgee | stroma of bone marrow | 1.00 | infobox |
| Galectin-3 | Bgee | lip | 1.00 | infobox |
| Galectin-3 | Bgee | skin of abdomen | 1.00 | infobox |
| Galectin-3 | BioGPS | More reference expression data | 1.00 | infobox |
| Galectin-3 | Chr. | Chromosome 14 (human) | 1.00 | infobox |
| Galectin-3 | Chr. | Chromosome 14 (mouse) | 1.00 | infobox |
| Galectin-3 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Galectin-3 | End | 55,145,423 bp | 1.00 | infobox |
| Galectin-3 | End | 47,623,617 bp | 1.00 | infobox |
| Galectin-3 | Ensembl | ENSG00000131981 | 1.00 | infobox |
The concept neighborhoods around Galectin-3 bring nearby vocabulary together. In this analysis, examples include Expression, Also and Fibrosis. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Galectin-3, one of the stronger structural bridges in this analysis connects Galectin-3 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Galectin-3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Galectin-3 · EN edition · Analysis: TopicsToTalkAbout
