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EIF4EBP1: Function, Interactions & Overview

Eukaryotic translation initiation factor 4E-binding protein 1 (also known as 4E-BP1) is a protein that in humans is encoded by the EIF4EBP1 gene. It inhibits cap-dependent translation by binding to translation initiation factor eIF4E. Phosphorylation of 4E-BP1 results in its release from eIF4E, thereby allows cap-dependent translation to continue thereby…

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EIF4EBP1 topic overview

The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around EIF4EBP1.

Related topics
11
Source areas
3
Connected nodes
14
Extracted relationships
87
Related term clusters
10
Bridge connections
14

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 5 topics
Interactions · 3 topics
Overview · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E binding protein 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EJ4, 1WKW, 2JGB, 2JGC, 2V8W, 2V8X, 2V8Y, 3HXG, 3HXI, 3M93, 3M94, 3U7X, 4UED, 5BXV
Band
8p11.23 · 8 A2|8 15.95 cM
Bgee
body of pancreas · parotid gland · muscle of thigh · gastrocnemius muscle · apex of heart
BioGPS
More reference expression data
Chr.
Chromosome 8 (human) · Chromosome 8 (mouse)

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EIF4EBP1
5Repressor · Eukaryotic translation · EIF4E
3Protein · Gene · Phosphorylation
3Protein-protein interaction · KIAA1303 · Mammalian target of rapamycin

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How EIF4EBP1 connects Entity context

The extracted context around EIF4EBP1 shows recurring relationship patterns in the source. For example, EIF4EBP1 → cellular response to dexamethasone stimulus, cellular response to hypoxia, cytoplasm, cytosol, eukaryotic initiation factor 4E binding, G1/S transition of mitotic cell cycle, glutamatergic synapse, insulin receptor signaling pathway, IRES-dependent translational initiation of linear mRNA, lung development, negative regulation of protein-containing complex assembly, negative regulation of translation, negative regulation of translational initiation, nucleus, positive regulation of mitotic cell cycle, postsynaptic cytosol, protein binding, protein phosphatase 2A binding, protein-containing complex, regulation of translation Another extracted example is EIF4EBP1 → apex of heart, body of pancreas, brown adipose tissue, cartilage tissue, embryo, endothelial cell of lymphatic vessel, gastrocnemius muscle, gastrula, granulocyte, lacrimal gland, minor salivary glands, muscle of thigh, olfactory zone of nasal mucosa, parotid gland, right lobe of liver, stromal cell of endometrium, submandibular gland, white adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.

EIF4EBP1

Top relations

Gene ontology · 26
EIF4EBP1 → cellular response to dexamethasone stimulus, cellular response to hypoxia, cytoplasm, cytosol, eukaryotic initiation factor 4E binding, G1/S transition of mitotic cell cycle, glutamatergic synapse, insulin receptor signaling pathway, IRES-dependent translational initiation of linear mRNA, lung development, negative regulation of protein-containing complex assembly, negative regulation of translation, negative regulation of translational initiation, nucleus, positive regulation of mitotic cell cycle, postsynaptic cytosol, protein binding, protein phosphatase 2A binding, protein-containing complex, regulation of translation
Bgee · 18
EIF4EBP1 → apex of heart, body of pancreas, brown adipose tissue, cartilage tissue, embryo, endothelial cell of lymphatic vessel, gastrocnemius muscle, gastrula, granulocyte, lacrimal gland, minor salivary glands, muscle of thigh, olfactory zone of nasal mucosa, parotid gland, right lobe of liver, stromal cell of endometrium, submandibular gland, white adipose tissue
RNA expression pattern · 18
EIF4EBP1 → apex of heart, body of pancreas, brown adipose tissue, cartilage tissue, embryo, endothelial cell of lymphatic vessel, gastrocnemius muscle, gastrula, granulocyte, lacrimal gland, minor salivary glands, muscle of thigh, olfactory zone of nasal mucosa, parotid gland, right lobe of liver, stromal cell of endometrium, submandibular gland, white adipose tissue
Band · 2
EIF4EBP1 → 8 A2|8 15.95 cM, 8p11.23
Chr. · 2
EIF4EBP1 → Chromosome 8 (human), Chromosome 8 (mouse)
End · 2
EIF4EBP1 → 27,766,702 bp, 38,060,365 bp
related to Interactions · 2
EIF4EBP1 → EIF4E, KIAA1303
Aliases · 1
EIF4EBP1 → EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E binding protein 1
Available structures · 1
EIF4EBP1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EJ4, 1WKW, 2JGB, 2JGC, 2V8W, 2V8X, 2V8Y, 3HXG, 3HXI, 3M93, 3M94, 3U7X, 4UED, 5BXV
BioGPS · 1
EIF4EBP1 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

translation protein eif4e 4e-bp1 initiation bp human factor gene chr band eukaryotic chromosome cap-dependent binding phosphorylation location 4e end mouse

EIF4EBP1 relationships Subject–Predicate–Object triples

TTTA extracted 87 structured relationships around EIF4EBP1. Examples in this analysis include EIF4EBP1 → Aliases → EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E binding protein 1 and EIF4EBP1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EJ4, 1WKW, 2JGB, 2JGC, 2V8W, 2V8X, 2V8Y, 3HXG, 3HXI, 3M93, 3M94, 3U7X, 4UED, 5BXV. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
EIF4EBP1AliasesEIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E binding protein 11.00infobox
EIF4EBP1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EJ4, 1WKW, 2JGB, 2JGC, 2V8W, 2V8X, 2V8Y, 3HXG, 3HXI, 3M93, 3M94, 3U7X, 4UED, 5BXV1.00infobox
EIF4EBP1Band8p11.231.00infobox
EIF4EBP1Band8 A2|8 15.95 cM1.00infobox
EIF4EBP1Bgeebody of pancreas1.00infobox
EIF4EBP1Bgeeparotid gland1.00infobox
EIF4EBP1Bgeemuscle of thigh1.00infobox
EIF4EBP1Bgeegastrocnemius muscle1.00infobox
EIF4EBP1Bgeeapex of heart1.00infobox
EIF4EBP1Bgeeminor salivary glands1.00infobox
EIF4EBP1Bgeeolfactory zone of nasal mucosa1.00infobox
EIF4EBP1Bgeeright lobe of liver1.00infobox
EIF4EBP1Bgeestromal cell of endometrium1.00infobox
EIF4EBP1Bgeecartilage tissue1.00infobox
EIF4EBP1Bgeeendothelial cell of lymphatic vessel1.00infobox
EIF4EBP1Bgeelacrimal gland1.00infobox
EIF4EBP1Bgeewhite adipose tissue1.00infobox
EIF4EBP1Bgeebrown adipose tissue1.00infobox
EIF4EBP1Bgeeembryo1.00infobox
EIF4EBP1Bgeegranulocyte1.00infobox
EIF4EBP1Bgeegastrula1.00infobox
EIF4EBP1Bgeesubmandibular gland1.00infobox
EIF4EBP1BioGPSMore reference expression data1.00infobox
EIF4EBP1Chr.Chromosome 8 (human)1.00infobox
EIF4EBP1Chr.Chromosome 8 (mouse)1.00infobox
EIF4EBP1DatabasesNCBI: entry; OMA: entry1.00infobox
EIF4EBP1End38,060,365 bp1.00infobox
EIF4EBP1End27,766,702 bp1.00infobox
EIF4EBP1EnsemblENSG000001878401.00infobox
EIF4EBP1Entrez19781.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around EIF4EBP1 bring nearby vocabulary together. In this analysis, examples include Eukaryotic, Factor and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • EIF4EBP1
    • Eukaryotic
    • Factor
    • Function
    • Gene
    • Search
    • Initiation
    • 4e
    • Binding
    • Location
    • Chromosome
    • Protein
    • Bp
  • eif4ebp1
    • Eukaryotic
    • Factor
    • Function
    • Gene
    • Search
    • Initiation
    • 4e
    • Binding
    • Location
    • Chromosome
    • Protein
    • Bp
  • protein
    • Translation
    • Eif4e
    • 4e
    • Complex
    • Mrna
    • Phosphorylation
    • Gene
    • Function
    • Insulin
    • Rate
    • Search
    • Signaling
  • eukaryotic translation
    • Factor
    • Protein
    • 4e
    • Initiation
    • Eif4ebp1
    • Function
    • Gene
    • Search
    • Eif4e
    • 4e-bp1
    • Binding
    • Complex
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Human
    • A2
    • Function
    • Mouse
    • Repressor
    • Search
    • Initiation
    • Translation
  • function
    • Search
    • 4e
    • Location
    • Chromosome
    • Bp
    • Chr
    • Gene
    • Human
    • A2
    • Initiation
    • Insulin
    • Mouse
  • eif4e
    • Translation
    • Protein
    • Inhibits
    • Complex
    • Factor
    • Initiation
    • Insulin
    • Rate
    • Signaling
    • Synthesis
    • 4e
    • End
  • phosphorylation
    • Rate
    • Synthesis
    • Protein
    • Translation
    • Function
    • Search
    • 4e
    • Location
    • Mrna
    • Chromosome
    • Bp
    • Chr

Connections between topic areas Semantic bridges

For EIF4EBP1, one of the stronger structural bridges in this analysis connects EIF4EBP1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
EIF4EBP1 — Function · splits 9 ⟂ 6
EIF4EBP1 — Overview · splits 11 ⟂ 4
EIF4EBP1 — Interactions · splits 11 ⟂ 4

Map overview Semantic statistics

EIF4EBP1

Nodes15
Edges14
Triples87
Avg. degree1.87
Density0.133333
Components1

Source & methodology

TTTA analyzes the structure around EIF4EBP1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — EIF4EBP1 · EN edition · Analysis: TopicsToTalkAbout

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