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Autophagy

Autophagy (or autophagocytosis; from the Greek αὐτόφαγος, autóphagos, meaning "self-devouring" and κύτος, kýtos, meaning "hollow") is the natural, conserved degradation of a biological cell that removes unnecessary or dysfunctional components through a lysosome-dependent regulated mechanism. It allows the orderly degradation and recycling of cellular…

History, Molecular biology & Functions

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History

Molecular biology

Functions

Exercise

Osteoarthritis

Cancer

Type 2 diabetes

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Autophagy

Nodes141
Edges140
Triples178
Avg. degree1.99
Density0.014184
Components1

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Autophagy

Top relations

related to history · 22
Autophagy → Alex, Ashford, Christian, Duve, German, However Porter, Hruban, In, In January, Inspired, Keith, Lysosomes, Novikoff, Porter, Rockefeller Institute, Russell Deter, Spargo, They, This, Thomas Ashford
related to External links · 11
Autophagy → BodyThe AIM, Cells May Hold Key, DatabaseAutophagy DB, Destructive Behavior, DJ KlionskyLongevityMeme, Drugs, Housecleaning, Human Autophagy, Landes Bioscience, Longer LifeExercise, PubMed
related to Exercise · 10
Autophagy → Another, BCL2, Both, Dallas, Exercise-induced, In, Results, Texas Southwestern Medical Center, University, VI
related to Targeted interplay between bacterial pathogens and host autophagy · 10
Autophagy → And, But, CALCOCO2/NDP52, MAP1LC3/LC3, Moreover, On, Some, The, There, While SQSTM1/p62
related to Tumor suppressor · 10
Autophagy → Atg5, Atg7, Beclin, Beclin1, Care, However, In, Necrosis, Several, When
related to Tumor cell survival · 9
Autophagy → Alternatively, ATP, By, Furthermore, In, Induction, Once, The, These
related to Molecular biology · 8
Autophagy → ATG, ATG13, ATG7, Autophagy-related, There, To, UKL1, ULK1
related to Programmed cell death · 8
Autophagy → Although, In, Morphological, One, PCD, Recent, Studies, This
related to Interface between inflammation and autophagy · 7
Autophagy → Cells, In, Proteins, Regulators, The, Therefore, This
related to Nutrient starvation · 7
Autophagy → APG, ATG7, In, Mutant, One, Studies, This

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Important terminology

proteins cell cells protein cancer survival genes degradation death also organelles autophagosome lysosome complex cellular mitochondria tumor autophagic pathway yeast

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Autophagyis aautophagy of organelles0.90text
Autophagyis asurvival pathway that is constitutively present in apoptosis-resistant colon cancer cells0.90text
Autophagyis aprotein degradation system used to maintain homeostasis and the findings that inhibition of autophagy often leads to apoptosis0.90text
mitochondriainstance ofand that some displaced lysosomes towards the centre of the cell contained other cell organelles0.80text
mitochondriainstance ofbut part of cytoplasm0.80text
and that hydrolytic enzymes were produced by microbodies.In 1963 Hrubaninstance ofbut part of cytoplasm0.80text
Spargoinstance ofbut part of cytoplasm0.80text
colleagues published a detailed ultrastructural description ofinstance ofbut part of cytoplasm0.80text
nutrient acquisitioninstance ofautophagy targets virulence factors and virulence factors responsible for more general functions0.80text
motility are recognized by multiple autophagy targeting proteinsinstance ofautophagy targets virulence factors and virulence factors responsible for more general functions0.80text
autolysinsinstance ofAnd the specialized virulence factors0.80text
and iron sequestering proteins are potentially recognized uniquely by a single autophagy targeting proteininstance ofAnd the specialized virulence factors0.80text

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