LRP1

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LRP1 topic overview

The analysis highlights Function, Clinical significance and Interactions as prominent areas in the source structure around LRP1.

Related topics: 144
Source areas: 5
Connected nodes: 149
Extracted relationships: 291
Concept neighborhoods: 41
Bridge connections: 149

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 62 topics

Function · 26 topics

Clinical significance · 24 topics

Structure · 18 topics

Overview · 14 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: LRP1, A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5, low density lipoprotein receptor-related protein 1, LDL receptor related protein 1, KPA, IGFBP3R1, IGFBP-3R
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CR8, 1D2L, 1J8E, 2FYJ, 2FYL, 2KNX, 2KNY
Band: 12q13.3 · 10|10 D3
Bgee: stromal cell of endometrium · Descending thoracic aorta · ascending aorta · right ovary · left ovary
BioGPS: More reference expression data
Chr.: Chromosome 12 (human) · Chromosome 10 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How LRP1 connects Entity context

The extracted context around LRP1 shows recurring relationship patterns in the source. For example, LRP1 → ageing, alpha-2 macroglobulin receptor activity, amyloid-beta binding, amyloid-beta clearance, amyloid-beta clearance by cellular catabolic process, amyloid-beta clearance by transcytosis, aorta morphogenesis, apical part of cell, apolipoprotein binding, apolipoprotein receptor activity, apoptotic cell clearance, astrocyte activation involved in immune response, axonal growth cone, basolateral plasma membrane, calcium ion binding, cargo receptor activity, cell population proliferation, cellular lipid catabolic process, cellular response to amyloid-beta, cerebral cortex development Another extracted example is LRP1 → A2-Macroglobulin, APBB1, APOE, Aprotinin, C1S/C1q, CALR, CD44, Chylomicron, Circumsporozoite, Collectin, Complement C3, CTGF, DLG4, Elastase, Factor IXa, Factor VIIa, Fibronectin, Gentamicin, GIPC1, Heat. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 99

LRP1 → ageing, alpha-2 macroglobulin receptor activity, amyloid-beta binding, amyloid-beta clearance, amyloid-beta clearance by cellular catabolic process, amyloid-beta clearance by transcytosis, aorta morphogenesis, apical part of cell, apolipoprotein binding, apolipoprotein receptor activity, apoptotic cell clearance, astrocyte activation involved in immune response, axonal growth cone, basolateral plasma membrane, calcium ion binding, cargo receptor activity, cell population proliferation, cellular lipid catabolic process, cellular response to amyloid-beta, cerebral cortex development

related to Interactions · 57

LRP1 → A2-Macroglobulin, APBB1, APOE, Aprotinin, C1S/C1q, CALR, CD44, Chylomicron, Circumsporozoite, Collectin, Complement C3, CTGF, DLG4, Elastase, Factor IXa, Factor VIIa, Fibronectin, Gentamicin, GIPC1, Heat

Bgee · 20

LRP1 → ankle, ascending aorta, canal of the cervix, cerebellar cortex, choroid plexus of fourth ventricle, Descending thoracic aorta, external carotid artery, internal carotid artery, left coronary artery, left ovary, lip, perirhinal cortex, primary visual cortex, right coronary artery, right ovary, stroma of bone marrow, stromal cell of endometrium, superior frontal gyrus, sural nerve, tibial nerve

RNA expression pattern · 20

related to Function · 14

LRP1 → ADAM10, ADAM12, ADAM17, APOE, ERK1/2, In, LDLR, MT1-MMP, Several, SMC, SMCs, Though, To, While

related to Structure · 14

LRP1 → As, EGF, Golgi, I-IV, II, IV, LDLR, NPxY, Of, The, The EGF, The LRP1, These, This

related to Cancer · 12

LRP1 → Alternatively, ERK, HCA, However, JNK, LRP1-dependent, MC, MCs, Moreover, Notably, One, PAI-1

related to Cardiovascular disease · 9

LRP1 → Atherosclerosis, Chylomicron, Expression, Finally, In, PDGFR-β, Single-cell, Studies, VLDL

related to Alzheimer's disease · 8

LRP1 → Alzheimer's, Aβ, Cholesterol, In, It, Neurons, The, This

Band · 2

LRP1 → 10|10 D3, 12q13.3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein lipoprotein gene metabolism bp cancer also cells human vascular endocytosis clearance cell involved atherosclerosis chr receptor band disease function

LRP1 relationships Subject–Predicate–Object triples

TTTA extracted 291 structured relationships around LRP1. Examples in this analysis include LRP1 → Aliases → LRP1, A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5, low density lipoprotein receptor-related protein 1, LDL receptor related protein 1, KPA, IGFBP3R1, IGFBP-3R and LRP1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CR8, 1D2L, 1J8E, 2FYJ, 2FYL, 2KNX, 2KNY. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
LRP1	Aliases	LRP1, A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5, low density lipoprotein receptor-related protein 1, LDL receptor related protein 1, KPA, IGFBP3R1, IGFBP-3R	1.00	infobox
LRP1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CR8, 1D2L, 1J8E, 2FYJ, 2FYL, 2KNX, 2KNY	1.00	infobox
LRP1	Band	12q13.3	1.00	infobox
LRP1	Band	10\|10 D3	1.00	infobox
LRP1	Bgee	stromal cell of endometrium	1.00	infobox
LRP1	Bgee	Descending thoracic aorta	1.00	infobox
LRP1	Bgee	ascending aorta	1.00	infobox
LRP1	Bgee	right ovary	1.00	infobox
LRP1	Bgee	left ovary	1.00	infobox
LRP1	Bgee	right coronary artery	1.00	infobox
LRP1	Bgee	tibial nerve	1.00	infobox
LRP1	Bgee	canal of the cervix	1.00	infobox
LRP1	Bgee	sural nerve	1.00	infobox
LRP1	Bgee	left coronary artery	1.00	infobox
LRP1	Bgee	stroma of bone marrow	1.00	infobox
LRP1	Bgee	superior frontal gyrus	1.00	infobox
LRP1	Bgee	internal carotid artery	1.00	infobox
LRP1	Bgee	external carotid artery	1.00	infobox
LRP1	Bgee	ankle	1.00	infobox
LRP1	Bgee	primary visual cortex	1.00	infobox
LRP1	Bgee	lip	1.00	infobox
LRP1	Bgee	choroid plexus of fourth ventricle	1.00	infobox
LRP1	Bgee	cerebellar cortex	1.00	infobox
LRP1	Bgee	perirhinal cortex	1.00	infobox
LRP1	BioGPS	More reference expression data	1.00	infobox
LRP1	Chr.	Chromosome 12 (human)	1.00	infobox
LRP1	Chr.	Chromosome 10 (mouse)	1.00	infobox
LRP1	Databases	NCBI: entry; OMA: entry	1.00	infobox
LRP1	End	57,213,361 bp	1.00	infobox
LRP1	End	127,457,017 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around LRP1 bring nearby vocabulary together. In this analysis, examples include Protein, Cancer and Cell. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

LRP1
- Protein
- Cancer
- Cell
- Metabolism
- Vascular
- Clearance
- Activity
- Cellular
- Membrane
- Atherosclerosis
- Barrier
- Factor
lrp1
- Protein
- Cancer
- Cell
- Metabolism
- Vascular
- Clearance
- Activity
- Cellular
- Membrane
- Atherosclerosis
- Barrier
- Factor
protein
- Metabolism
- Activity
- Membrane
- Pathway
- Factor
- Receptor
- Gene
- External
- Alzheimer's
- Apoe
- Cholesterol
- Chromosome
plasma membrane
- Activity
- Protein
- Receptor
- Cell
- External
- Band
- Cellular
- Cholesterol
- Chromosome
- Extracellular
- Growth
- Muscle
endocytosis
- Function
- Receptor
- Cellular
- Growth
- Membrane
- Lipoprotein
- Factor
- Involved
- Resulting
- Cell
- Metabolism
- Vascular
gene
- Chromosome
- Bp
- Chr
- Human
- Receptor
- External
- Band
- Lipoprotein
- Low
- Pathway
- Protein
- Function
lipoprotein
- Receptor
- Metabolism
- Protein
- Involved
- Growth
- Low
- Pathway
- Endocytosis
- Factor
- Also
- Cell
- Gene
metabolism
- Growth
- Factor
- Protein
- Vascular
- Activity
- Cellular
- Cholesterol
- Extracellular
- Pathway
- Receptor
- External
- Alzheimer's

Connections between topic areas Semantic bridges

For LRP1, one of the stronger structural bridges in this analysis connects LRP1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

LRP1 — Interactions · splits 87 ⟂ 63

LRP1 — Function · splits 123 ⟂ 27

LRP1 — Clinical significance · splits 125 ⟂ 25

LRP1 — Structure · splits 131 ⟂ 19

LRP1 — Overview · splits 135 ⟂ 15

Map overview Semantic statistics

LRP1

Nodes150

Edges149

Triples291

Avg. degree1.99

Density0.013333

Components1

Source & methodology

TTTA analyzes the structure around LRP1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — LRP1 · EN edition · Analysis: TopicsToTalkAbout