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LRP1

Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, the LRP1 protein is encoded by the LRP1 gene.…

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Aliases
LRP1, A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5, low density lipoprotein receptor-related protein 1, LDL receptor related protein 1, KPA, IGFBP3R1, IGFBP-3R
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CR8, 1D2L, 1J8E, 2FYJ, 2FYL, 2KNX, 2KNY
Band
12q13.3 · 10|10 D3
Bgee
stromal cell of endometrium · Descending thoracic aorta · ascending aorta · right ovary · left ovary
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 10 (mouse)

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Structure

Function

Clinical significance

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Map overview Semantic statistics

LRP1

Nodes150
Edges149
Triples291
Avg. degree1.99
Density0.013333
Components1

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LRP1

Top relations

Gene ontology · 99
LRP1 → ageing, alpha-2 macroglobulin receptor activity, amyloid-beta binding, amyloid-beta clearance, amyloid-beta clearance by cellular catabolic process, amyloid-beta clearance by transcytosis, aorta morphogenesis, apical part of cell, apolipoprotein binding, apolipoprotein receptor activity, apoptotic cell clearance, astrocyte activation involved in immune response, axonal growth cone, basolateral plasma membrane, calcium ion binding, cargo receptor activity, cell population proliferation, cellular lipid catabolic process, cellular response to amyloid-beta, cerebral cortex development
related to Interactions · 57
LRP1 → A2-Macroglobulin, APBB1, APOE, Aprotinin, C1S/C1q, CALR, CD44, Chylomicron, Circumsporozoite, Collectin, Complement C3, CTGF, DLG4, Elastase, Factor IXa, Factor VIIa, Fibronectin, Gentamicin, GIPC1, Heat
Bgee · 20
LRP1 → ankle, ascending aorta, canal of the cervix, cerebellar cortex, choroid plexus of fourth ventricle, Descending thoracic aorta, external carotid artery, internal carotid artery, left coronary artery, left ovary, lip, perirhinal cortex, primary visual cortex, right coronary artery, right ovary, stroma of bone marrow, stromal cell of endometrium, superior frontal gyrus, sural nerve, tibial nerve
RNA expression pattern · 20
LRP1 → ankle, ascending aorta, canal of the cervix, cerebellar cortex, choroid plexus of fourth ventricle, Descending thoracic aorta, external carotid artery, internal carotid artery, left coronary artery, left ovary, lip, perirhinal cortex, primary visual cortex, right coronary artery, right ovary, stroma of bone marrow, stromal cell of endometrium, superior frontal gyrus, sural nerve, tibial nerve
related to Function · 14
LRP1 → ADAM10, ADAM12, ADAM17, APOE, ERK1/2, In, LDLR, MT1-MMP, Several, SMC, SMCs, Though, To, While
related to Structure · 14
LRP1 → As, EGF, Golgi, I-IV, II, IV, LDLR, NPxY, Of, The, The EGF, The LRP1, These, This
related to Cancer · 12
LRP1 → Alternatively, ERK, HCA, However, JNK, LRP1-dependent, MC, MCs, Moreover, Notably, One, PAI-1
related to Cardiovascular disease · 9
LRP1 → Atherosclerosis, Chylomicron, Expression, Finally, In, PDGFR-β, Single-cell, Studies, VLDL
related to Alzheimer's disease · 8
LRP1 → Alzheimer's, Aβ, Cholesterol, In, It, Neurons, The, This
Band · 2
LRP1 → 10|10 D3, 12q13.3

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Important terminology

protein lipoprotein gene metabolism bp cancer also cells human vascular endocytosis clearance cell involved atherosclerosis chr receptor band disease function

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
LRP1AliasesLRP1, A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5, low density lipoprotein receptor-related protein 1, LDL receptor related protein 1, KPA, IGFBP3R1, IGFBP-3R1.00infobox
LRP1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CR8, 1D2L, 1J8E, 2FYJ, 2FYL, 2KNX, 2KNY1.00infobox
LRP1Band12q13.31.00infobox
LRP1Band10|10 D31.00infobox
LRP1Bgeestromal cell of endometrium1.00infobox
LRP1BgeeDescending thoracic aorta1.00infobox
LRP1Bgeeascending aorta1.00infobox
LRP1Bgeeright ovary1.00infobox
LRP1Bgeeleft ovary1.00infobox
LRP1Bgeeright coronary artery1.00infobox
LRP1Bgeetibial nerve1.00infobox
LRP1Bgeecanal of the cervix1.00infobox
LRP1Bgeesural nerve1.00infobox
LRP1Bgeeleft coronary artery1.00infobox
LRP1Bgeestroma of bone marrow1.00infobox
LRP1Bgeesuperior frontal gyrus1.00infobox
LRP1Bgeeinternal carotid artery1.00infobox
LRP1Bgeeexternal carotid artery1.00infobox
LRP1Bgeeankle1.00infobox
LRP1Bgeeprimary visual cortex1.00infobox
LRP1Bgeelip1.00infobox
LRP1Bgeechoroid plexus of fourth ventricle1.00infobox
LRP1Bgeecerebellar cortex1.00infobox
LRP1Bgeeperirhinal cortex1.00infobox
LRP1BioGPSMore reference expression data1.00infobox
LRP1Chr.Chromosome 12 (human)1.00infobox
LRP1Chr.Chromosome 10 (mouse)1.00infobox
LRP1DatabasesNCBI: entry; OMA: entry1.00infobox
LRP1End57,213,361 bp1.00infobox
LRP1End127,457,017 bp1.00infobox

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