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Factor IX

Factor IX (EC 3.4.21.22) is one of the serine proteases involved in coagulation; it belongs to peptidase family S1. Deficiency of this protein causes haemophilia B.

Physiology, Genetics & Domain architecture

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3.4.21.22
Aliases
F9, F9 p22, FIX, HEMB, P19, PTC, THPH8, coagulation factor IX, Blood coagulation factor IX, Christmas Factor
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CFH, 1CFI, 1EDM, 1IXA, 1MGX, 1NL0, 1RFN, 2WPH, 2WPI, 2WPJ, 2WPK, 2WPL, 2WPM, 3KCG, 3LC3, 3LC5, 4YZU, 4Z0K,…
Band
Xq27.1 · X A6|X 33.5 cM
Bgee
right lobe of liver · secondary oocyte · gonad · pancreatic ductal cell · skin of thigh
BioGPS
More reference expression data

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Physiology

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Genetics

Role in disease

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Factor IX

Nodes42
Edges41
Triples145
Avg. degree1.95
Density0.047619
Components1

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Factor IX

Top relations

Gene ontology · 24
Factor IX → blood coagulation, blood coagulation, extrinsic pathway, blood coagulation, intrinsic pathway, calcium ion binding, collagen-containing extracellular matrix, endopeptidase activity, endoplasmic reticulum lumen, endoplasmic reticulum to Golgi vesicle-mediated transport, extracellular exosome, extracellular region, extracellular space, Golgi lumen, hemostasis, hydrolase activity, metal ion binding, peptidase activity, peptidyl-glutamic acid carboxylation, plasma membrane, protein binding, proteolysis
Bgee · 20
Factor IX → blood, dentate gyrus, gallbladder, gonad, human musculoskeletal system, jejunum, kidney, left lobe of liver, lumbar spinal ganglion, medial head of gastrocnemius muscle, muscle, muscular system, nucleus of stria terminalis, pancreatic ductal cell, piriform cortex, right lobe of liver, secondary oocyte, sexually immature organism, skin of thigh, thoracic diaphragm
RNA expression pattern · 20
Factor IX → blood, dentate gyrus, gallbladder, gonad, human musculoskeletal system, jejunum, kidney, left lobe of liver, lumbar spinal ganglion, medial head of gastrocnemius muscle, muscle, muscular system, nucleus of stria terminalis, pancreatic ductal cell, piriform cortex, right lobe of liver, secondary oocyte, sexually immature organism, skin of thigh, thoracic diaphragm
related to Role in disease · 15
Factor IX → Alphanine SD, Alprolix, Benefix, Christmas, Deficiency, Fc, Idelvion, IX, Ixinity, Named, Rebinyn, Recombinant, Refixia, Rixubis, Stephen Christmas
related to External links · 12
Factor IX → Archived, Coagulation, GeneReviews/NCBI/NIH/UW, Hemophilia BThe MEROPS, IX, Overview, P00740, PDB, PDBe-KB, S01, UniProt, Wayback Machine
related to Genetics · 12
Factor IX → At, Because, Dr Ian Wilmut, Earl Davie, IX, Kotoku Kurachi, Poll Dorset, Polly, Roslin Institute, The F9, X-linked, Xq27
related to Domain architecture · 8
Factor IX → C-terminal, EGF, Factors VII, Gla, IX, The, The N-terminal EGF, Wilkinson
related to Physiology · 8
Factor IX → Ca2, Factor VIII, It, IXa, VIIa, When, Xa, XIa
Band · 2
Factor IX → X A6|X 33.5 cM, Xq27.1
Chr. · 2
Factor IX → X chromosome (human), X chromosome (mouse)

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Important terminology

factor ix coagulation gene bp human domain protein chr band chromosome haemophilia list mutations deficiency blood f9 mouse binding peptidase

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Factor IX3.4.21.221.00infobox
Factor IXAliasesF9, F9 p22, FIX, HEMB, P19, PTC, THPH8, coagulation factor IX, Blood coagulation factor IX, Christmas Factor1.00infobox
Factor IXAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CFH, 1CFI, 1EDM, 1IXA, 1MGX, 1NL0, 1RFN, 2WPH, 2WPI, 2WPJ, 2WPK, 2WPL, 2WPM, 3KCG, 3LC3, 3LC5, 4YZU, 4Z0K,…1.00infobox
Factor IXBandXq27.11.00infobox
Factor IXBandX A6|X 33.5 cM1.00infobox
Factor IXBgeeright lobe of liver1.00infobox
Factor IXBgeesecondary oocyte1.00infobox
Factor IXBgeegonad1.00infobox
Factor IXBgeepancreatic ductal cell1.00infobox
Factor IXBgeeskin of thigh1.00infobox
Factor IXBgeekidney1.00infobox
Factor IXBgeeblood1.00infobox
Factor IXBgeehuman musculoskeletal system1.00infobox
Factor IXBgeemuscular system1.00infobox
Factor IXBgeemuscle1.00infobox
Factor IXBgeeleft lobe of liver1.00infobox
Factor IXBgeelumbar spinal ganglion1.00infobox
Factor IXBgeegallbladder1.00infobox
Factor IXBgeesexually immature organism1.00infobox
Factor IXBgeethoracic diaphragm1.00infobox
Factor IXBgeemedial head of gastrocnemius muscle1.00infobox
Factor IXBgeedentate gyrus1.00infobox
Factor IXBgeenucleus of stria terminalis1.00infobox
Factor IXBgeepiriform cortex1.00infobox
Factor IXBgeejejunum1.00infobox
Factor IXBioGPSMore reference expression data1.00infobox
Factor IXChr.X chromosome (human)1.00infobox
Factor IXChr.X chromosome (mouse)1.00infobox
Factor IXDatabasesNCBI: entry; OMA: entry1.00infobox
Factor IXEnd139,563,459 bp1.00infobox

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