CD44

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CD44 topic overview

The analysis highlights Function, CD44 in cancer and Interactions as prominent areas in the source structure around CD44.

Related topics: 75
Source areas: 6
Connected nodes: 81
Extracted relationships: 158
Concept neighborhoods: 34
Bridge connections: 81

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

CD44 in cancer · 22 topics

Function · 20 topics

Interactions · 14 topics

Clinical significance · 12 topics

Overview · 4 topics

Tissue distribution and isoforms · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 molecule (Indian blood group)
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1POZ, 1UUH, 2I83, 4PZ3, 4PZ4
Band: 11p13 · 2 E2|2 54.13 cM
Bgee: parotid gland · stromal cell of endometrium · vulva · gingival epithelium · skin of thigh
BioGPS: More reference expression data
Chr.: Chromosome 11 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Tissue distribution and isoforms

Isoform Protein isoform
Exons Exon
Epithelial cells Epithelium

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD44 connects Entity context

The extracted context around CD44 shows recurring relationship patterns in the source. For example, CD44 → apical plasma membrane, basolateral plasma membrane, cartilage development, cell adhesion, cell migration, cell projection, cell surface, cell-cell adhesion, cell-matrix adhesion, cellular response to fibroblast growth factor stimulus, collagen binding, cytokine receptor activity, cytosol, extracellular exosome, extracellular matrix disassembly, extracellular matrix organization, focal adhesion, Golgi apparatus, hyaluronan catabolic process, hyaluronic acid binding Another extracted example is CD44 → Achilles tendon, body of femur, calvaria, dermis, endothelial cell of lymphatic vessel, epithelium of lens, gingival epithelium, granulocyte, human penis, islet of Langerhans, molar, parotid gland, skin of abdomen, skin of hip, skin of thigh, stromal cell of endometrium, submandibular gland, tibiofemoral joint, vulva. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 48

CD44 → apical plasma membrane, basolateral plasma membrane, cartilage development, cell adhesion, cell migration, cell projection, cell surface, cell-cell adhesion, cell-matrix adhesion, cellular response to fibroblast growth factor stimulus, collagen binding, cytokine receptor activity, cytosol, extracellular exosome, extracellular matrix disassembly, extracellular matrix organization, focal adhesion, Golgi apparatus, hyaluronan catabolic process, hyaluronic acid binding

Bgee · 19

CD44 → Achilles tendon, body of femur, calvaria, dermis, endothelial cell of lymphatic vessel, epithelium of lens, gingival epithelium, granulocyte, human penis, islet of Langerhans, molar, parotid gland, skin of abdomen, skin of hip, skin of thigh, stromal cell of endometrium, submandibular gland, tibiofemoral joint, vulva

RNA expression pattern · 19

related to Interactions · 12

CD44 → ARHGEF1, CD74, Epidermal Growth Factor Receptor, Ezrin, Fibrin, Fibronectin, FYN, Hyaluronan, Hyaluronan-dependent, Lck, OsteopontinSelectins, PIP2

related to External links · 8

CD44 → BGMUT Blood Group Antigen, Gene Mutation Database, Human CD44, IHOP, Indian, NCBI, NIHArticles, UCSC Genome Browser

related to HCELL · 7

CD44 → E-selectin, Ex, HCELL, Hematopoietic Cell E-/L-selectin Ligand, It, L-selectin, The HCELL

related to Clinical significance · 6

CD44 → CD25, CFSE, Indian, Memory, T-cells, The

related to CD44 in cancer · 5

CD44 → All, CD44-soluble, Experiments, Furthermore, High

related to Tissue distribution and isoforms · 5

CD44 → CD44E, CD44s, CD44v, Some, The

related to Function · 4

CD44 → HCELL, Hematopoietic Cell E-selectin/L-selectin Ligand, MMPs, One

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cell cells gene human cancer hcell bp expression chromosome 11 adhesion chr band also antigen migration molecule receptor homing protein

CD44 relationships Subject–Predicate–Object triples

TTTA extracted 158 structured relationships around CD44. Examples in this analysis include CD44 → Aliases → CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 molecule (Indian blood group) and CD44 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1POZ, 1UUH, 2I83, 4PZ3, 4PZ4. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
CD44	Aliases	CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 molecule (Indian blood group)	1.00	infobox
CD44	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1POZ, 1UUH, 2I83, 4PZ3, 4PZ4	1.00	infobox
CD44	Band	11p13	1.00	infobox
CD44	Band	2 E2\|2 54.13 cM	1.00	infobox
CD44	Bgee	parotid gland	1.00	infobox
CD44	Bgee	stromal cell of endometrium	1.00	infobox
CD44	Bgee	vulva	1.00	infobox
CD44	Bgee	gingival epithelium	1.00	infobox
CD44	Bgee	skin of thigh	1.00	infobox
CD44	Bgee	human penis	1.00	infobox
CD44	Bgee	skin of abdomen	1.00	infobox
CD44	Bgee	Achilles tendon	1.00	infobox
CD44	Bgee	skin of hip	1.00	infobox
CD44	Bgee	islet of Langerhans	1.00	infobox
CD44	Bgee	molar	1.00	infobox
CD44	Bgee	granulocyte	1.00	infobox
CD44	Bgee	calvaria	1.00	infobox
CD44	Bgee	dermis	1.00	infobox
CD44	Bgee	submandibular gland	1.00	infobox
CD44	Bgee	epithelium of lens	1.00	infobox
CD44	Bgee	tibiofemoral joint	1.00	infobox
CD44	Bgee	endothelial cell of lymphatic vessel	1.00	infobox
CD44	Bgee	body of femur	1.00	infobox
CD44	BioGPS	More reference expression data	1.00	infobox
CD44	Chr.	Chromosome 11 (human)	1.00	infobox
CD44	Chr.	Chromosome 2 (mouse)	1.00	infobox
CD44	Databases	NCBI: entry; OMA: entry	1.00	infobox
CD44	End	35,232,402 bp	1.00	infobox
CD44	End	102,732,010 bp	1.00	infobox
CD44	Ensembl	ENSG00000026508	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD44 bring nearby vocabulary together. In this analysis, examples include Cell, Cells and Expression. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

CD44
- Cell
- Cells
- Expression
- Gene
- Cancer
- Adhesion
- Molecule
- Variants
- Hcell
- Surface
- Receptor
- Also
cd44
- Cell
- Cells
- Expression
- Gene
- Cancer
- Adhesion
- Molecule
- Variants
- Hcell
- Surface
- Receptor
- Also
cell
- Surface
- Migration
- Involved
- L-selectin
- Molecule
- Hcell
- E-selectin
- Isoforms
- Cells
- Binding
- Hematopoietic
- Homing
cell adhesion molecule
- Molecule
- Involved
- Surface
- Antigen
- Cell
- Migration
- Protein
- Receptor
- L-selectin
- Hcell
- Cd44
- E-selectin
epithelial cells
- Stem
- Hcell
- Expression
- Surface
- Human
- Hematopoietic
- Increased
- Migration
- Receptor
- Variants
- Also
- E-selectin
adhesion molecule
- Molecule
- Involved
- Antigen
- Cell
- Migration
- Protein
- Receptor
- Hcell
- Cd44
- Function
- Isoforms
- L-selectin
mesenchymal stem cells
- Stem
- Hcell
- Expression
- Surface
- Human
- Hematopoietic
- Increased
- Migration
- Receptor
- Variants
- Also
- E-selectin
t cell
- Surface
- Migration
- Involved
- L-selectin
- Molecule
- Hcell
- E-selectin
- Isoforms
- Cells
- Binding
- Hematopoietic
- Homing

Connections between topic areas Semantic bridges

For CD44, one of the stronger structural bridges in this analysis connects CD44 with CD44 in cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

CD44 — CD44 in cancer · splits 59 ⟂ 23

CD44 — Function · splits 61 ⟂ 21

CD44 — Interactions · splits 67 ⟂ 15

CD44 — Clinical significance · splits 69 ⟂ 13

CD44 — Overview · splits 77 ⟂ 5

CD44 — Tissue distribution and isoforms · splits 78 ⟂ 4

Map overview Semantic statistics

CD44

Nodes82

Edges81

Triples158

Avg. degree1.98

Density0.02439

Components1

Source & methodology

TTTA analyzes the structure around CD44 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, CD44 in cancer & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD44 · EN edition · Analysis: TopicsToTalkAbout