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Apolipoprotein E (Apo-E) is a protein involved in the transport of fats in the body of mammals. A subtype is implicated in Alzheimer's disease and cardiovascular diseases. It is encoded in humans by the gene APOE.
The analysis highlights Structure, Function and Overview as prominent areas in the source structure around Apolipoprotein E.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Apolipoprotein E shows recurring relationship patterns in the source. For example, Apolipoprotein E → AMPA glutamate receptor clustering, amyloid-beta binding, antioxidant activity, artery morphogenesis, blood microparticle, cellular calcium ion homeostasis, cellular oxidant detoxification, cGMP-mediated signaling, cholesterol binding, cholesterol catabolic process, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process, cholesterol transfer activity, chylomicron, chylomicron remnant clearance, cytoplasm, cytoskeleton organization, dendrite, early endosome Another extracted example is Apolipoprotein E → amygdala, C1 segment, CA3 field, caudate nucleus, choroid plexus of fourth ventricle, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, gallbladder, hypothalamus, left adrenal cortex, left adrenal gland, left lobe of liver, nucleus accumbens, perirhinal cortex, putamen, right adrenal cortex, right lobe of liver, stroma of bone marrow, superior frontal gyrus, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
apoe gene disease alzheimer's cholesterol apo-e allele ad apoe4 risk lipoprotein human alleles odds bp receptor protein transport liver apolipoprotein
TTTA extracted 224 structured relationships around Apolipoprotein E. Examples in this analysis include Apolipoprotein E → Aliases → APOE, AD2, APO-E, LDLCQ5, LPG, apolipoprotein E, ApoE4 and Apolipoprotein E → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B68, 1BZ4, 1EA8, 1GS9, 1H7I, 1LE2, 1LE4, 1LPE, 1NFN, 1NFO, 1OEF, 1OEG, 1OR2, 1OR3, 2KC3, 2KNY, 2L7B. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Apolipoprotein E | Aliases | APOE, AD2, APO-E, LDLCQ5, LPG, apolipoprotein E, ApoE4 | 1.00 | infobox |
| Apolipoprotein E | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B68, 1BZ4, 1EA8, 1GS9, 1H7I, 1LE2, 1LE4, 1LPE, 1NFN, 1NFO, 1OEF, 1OEG, 1OR2, 1OR3, 2KC3, 2KNY, 2L7B | 1.00 | infobox |
| Apolipoprotein E | Band | 19q13.32 | 1.00 | infobox |
| Apolipoprotein E | Band | 7 A3|7 9.94 cM | 1.00 | infobox |
| Apolipoprotein E | Bgee | right adrenal cortex | 1.00 | infobox |
| Apolipoprotein E | Bgee | left adrenal gland | 1.00 | infobox |
| Apolipoprotein E | Bgee | left adrenal cortex | 1.00 | infobox |
| Apolipoprotein E | Bgee | right lobe of liver | 1.00 | infobox |
| Apolipoprotein E | Bgee | nucleus accumbens | 1.00 | infobox |
| Apolipoprotein E | Bgee | amygdala | 1.00 | infobox |
| Apolipoprotein E | Bgee | hypothalamus | 1.00 | infobox |
| Apolipoprotein E | Bgee | caudate nucleus | 1.00 | infobox |
| Apolipoprotein E | Bgee | C1 segment | 1.00 | infobox |
| Apolipoprotein E | Bgee | putamen | 1.00 | infobox |
| Apolipoprotein E | Bgee | entorhinal cortex | 1.00 | infobox |
| Apolipoprotein E | Bgee | stroma of bone marrow | 1.00 | infobox |
| Apolipoprotein E | Bgee | choroid plexus of fourth ventricle | 1.00 | infobox |
| Apolipoprotein E | Bgee | perirhinal cortex | 1.00 | infobox |
| Apolipoprotein E | Bgee | CA3 field | 1.00 | infobox |
| Apolipoprotein E | Bgee | left lobe of liver | 1.00 | infobox |
| Apolipoprotein E | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| Apolipoprotein E | Bgee | yolk sac | 1.00 | infobox |
| Apolipoprotein E | Bgee | gallbladder | 1.00 | infobox |
| Apolipoprotein E | Bgee | superior frontal gyrus | 1.00 | infobox |
| Apolipoprotein E | BioGPS | More reference expression data | 1.00 | infobox |
| Apolipoprotein E | Chr. | Chromosome 19 (human) | 1.00 | infobox |
| Apolipoprotein E | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| Apolipoprotein E | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Apolipoprotein E | End | 44,909,393 bp | 1.00 | infobox |
| Apolipoprotein E | End | 19,433,113 bp | 1.00 | infobox |
The concept neighborhoods around Apolipoprotein E bring nearby vocabulary together. In this analysis, examples include Chromosome, Protein and Alzheimer's. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Apolipoprotein E, one of the stronger structural bridges in this analysis connects Apolipoprotein E with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Apolipoprotein E to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Apolipoprotein E · EN edition · Analysis: TopicsToTalkAbout