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TIMP2

Tissue inhibitor of metalloproteinases 2 (TIMP2) is a gene and a corresponding protein. The gene is a member of the TIMP gene family. The protein is thought to be a metastasis suppressor.[citation needed]

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Aliases
TIMP2, CSC-21K, DDC8, TIMP metallopeptidase inhibitor 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BR9, 1GXD, 2TMP, 4ILW
Band
17q25.3 · 11 E2|11 83.09 cM
Bgee
tendon of biceps brachii · synovial joint · stromal cell of endometrium · tibia · urethra
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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TIMP2

Nodes22
Edges21
Triples119
Avg. degree1.91
Density0.090909
Components1

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TIMP2

Top relations

Gene ontology · 39
TIMP2 → ageing, cell surface, central nervous system development, collagen-containing extracellular matrix, enzyme inhibitor activity, extracellular exosome, extracellular matrix, extracellular matrix disassembly, extracellular region, extracellular space, ficolin-1-rich granule lumen, growth cone, integrin binding, metal ion binding, metalloendopeptidase inhibitor activity, negative regulation of cell population proliferation, negative regulation of endopeptidase activity, negative regulation of membrane protein ectodomain proteolysis, negative regulation of metallopeptidase activity, negative regulation of mitotic cell cycle
Bgee · 20
TIMP2 → ankle, anterior amygdaloid area, ascending aorta, body of femur, calvaria, Descending thoracic aorta, endothelial cell of lymphatic vessel, retinal pigment epithelium, right coronary artery, skin of external ear, stroma of bone marrow, stromal cell of endometrium, subiculum, synovial joint, tendon of biceps brachii, tibia, trigeminal ganglion, urethra, ventromedial nucleus, visceral pleura
RNA expression pattern · 20
TIMP2 → ankle, anterior amygdaloid area, ascending aorta, body of femur, calvaria, Descending thoracic aorta, endothelial cell of lymphatic vessel, retinal pigment epithelium, right coronary artery, skin of external ear, stroma of bone marrow, stromal cell of endometrium, subiculum, synovial joint, tendon of biceps brachii, tibia, trigeminal ganglion, urethra, ventromedial nucleus, visceral pleura
related to Function · 16
TIMP2 → As, For, In, MITF, MMP, MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMPs, The, TIMP, TIMP-1, TIMP-2, TIMPs
Band · 2
TIMP2 → 11 E2|11 83.09 cM, 17q25.3
Chr. · 2
TIMP2 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
TIMP2 → 118,246,566 bp, 78,925,387 bp
Aliases · 1
TIMP2 → TIMP2, CSC-21K, DDC8, TIMP metallopeptidase inhibitor 2
Available structures · 1
TIMP2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BR9, 1GXD, 2TMP, 4ILW
BioGPS · 1
TIMP2 → More reference expression data

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Important terminology

gene bp human protein chr band inhibitor chromosome 17 function timp external extracellular matrix location role metalloproteinases family mouse proliferation

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TIMP2AliasesTIMP2, CSC-21K, DDC8, TIMP metallopeptidase inhibitor 21.00infobox
TIMP2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BR9, 1GXD, 2TMP, 4ILW1.00infobox
TIMP2Band17q25.31.00infobox
TIMP2Band11 E2|11 83.09 cM1.00infobox
TIMP2Bgeetendon of biceps brachii1.00infobox
TIMP2Bgeesynovial joint1.00infobox
TIMP2Bgeestromal cell of endometrium1.00infobox
TIMP2Bgeetibia1.00infobox
TIMP2Bgeeurethra1.00infobox
TIMP2BgeeDescending thoracic aorta1.00infobox
TIMP2Bgeetrigeminal ganglion1.00infobox
TIMP2Bgeeascending aorta1.00infobox
TIMP2Bgeeright coronary artery1.00infobox
TIMP2Bgeevisceral pleura1.00infobox
TIMP2Bgeecalvaria1.00infobox
TIMP2Bgeestroma of bone marrow1.00infobox
TIMP2Bgeeankle1.00infobox
TIMP2Bgeeskin of external ear1.00infobox
TIMP2Bgeebody of femur1.00infobox
TIMP2Bgeeventromedial nucleus1.00infobox
TIMP2Bgeesubiculum1.00infobox
TIMP2Bgeeanterior amygdaloid area1.00infobox
TIMP2Bgeeendothelial cell of lymphatic vessel1.00infobox
TIMP2Bgeeretinal pigment epithelium1.00infobox
TIMP2BioGPSMore reference expression data1.00infobox
TIMP2Chr.Chromosome 17 (human)1.00infobox
TIMP2Chr.Chromosome 11 (mouse)1.00infobox
TIMP2DatabasesNCBI: entry; OMA: entry1.00infobox
TIMP2End78,925,387 bp1.00infobox
TIMP2End118,246,566 bp1.00infobox

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