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Tissue inhibitor of metalloproteinases 2 (TIMP2) is a gene and a corresponding protein. The gene is a member of the TIMP gene family. The protein is thought to be a metastasis suppressor.[citation needed]
The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around TIMP2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around TIMP2 shows recurring relationship patterns in the source. For example, TIMP2 → ageing, cell surface, central nervous system development, collagen-containing extracellular matrix, enzyme inhibitor activity, extracellular exosome, extracellular matrix, extracellular matrix disassembly, extracellular region, extracellular space, ficolin-1-rich granule lumen, growth cone, integrin binding, metal ion binding, metalloendopeptidase inhibitor activity, negative regulation of cell population proliferation, negative regulation of endopeptidase activity, negative regulation of membrane protein ectodomain proteolysis, negative regulation of metallopeptidase activity, negative regulation of mitotic cell cycle Another extracted example is TIMP2 → ankle, anterior amygdaloid area, ascending aorta, body of femur, calvaria, Descending thoracic aorta, endothelial cell of lymphatic vessel, retinal pigment epithelium, right coronary artery, skin of external ear, stroma of bone marrow, stromal cell of endometrium, subiculum, synovial joint, tendon of biceps brachii, tibia, trigeminal ganglion, urethra, ventromedial nucleus, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene bp human protein chr band inhibitor chromosome 17 function timp external extracellular matrix location role metalloproteinases family mouse proliferation
TTTA extracted 119 structured relationships around TIMP2. Examples in this analysis include TIMP2 → Aliases → TIMP2, CSC-21K, DDC8, TIMP metallopeptidase inhibitor 2 and TIMP2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BR9, 1GXD, 2TMP, 4ILW. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TIMP2 | Aliases | TIMP2, CSC-21K, DDC8, TIMP metallopeptidase inhibitor 2 | 1.00 | infobox |
| TIMP2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BR9, 1GXD, 2TMP, 4ILW | 1.00 | infobox |
| TIMP2 | Band | 17q25.3 | 1.00 | infobox |
| TIMP2 | Band | 11 E2|11 83.09 cM | 1.00 | infobox |
| TIMP2 | Bgee | tendon of biceps brachii | 1.00 | infobox |
| TIMP2 | Bgee | synovial joint | 1.00 | infobox |
| TIMP2 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| TIMP2 | Bgee | tibia | 1.00 | infobox |
| TIMP2 | Bgee | urethra | 1.00 | infobox |
| TIMP2 | Bgee | Descending thoracic aorta | 1.00 | infobox |
| TIMP2 | Bgee | trigeminal ganglion | 1.00 | infobox |
| TIMP2 | Bgee | ascending aorta | 1.00 | infobox |
| TIMP2 | Bgee | right coronary artery | 1.00 | infobox |
| TIMP2 | Bgee | visceral pleura | 1.00 | infobox |
| TIMP2 | Bgee | calvaria | 1.00 | infobox |
| TIMP2 | Bgee | stroma of bone marrow | 1.00 | infobox |
| TIMP2 | Bgee | ankle | 1.00 | infobox |
| TIMP2 | Bgee | skin of external ear | 1.00 | infobox |
| TIMP2 | Bgee | body of femur | 1.00 | infobox |
| TIMP2 | Bgee | ventromedial nucleus | 1.00 | infobox |
| TIMP2 | Bgee | subiculum | 1.00 | infobox |
| TIMP2 | Bgee | anterior amygdaloid area | 1.00 | infobox |
| TIMP2 | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| TIMP2 | Bgee | retinal pigment epithelium | 1.00 | infobox |
| TIMP2 | BioGPS | More reference expression data | 1.00 | infobox |
| TIMP2 | Chr. | Chromosome 17 (human) | 1.00 | infobox |
| TIMP2 | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| TIMP2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TIMP2 | End | 78,925,387 bp | 1.00 | infobox |
| TIMP2 | End | 118,246,566 bp | 1.00 | infobox |
The concept neighborhoods around TIMP2 bring nearby vocabulary together. In this analysis, examples include Gene, Function and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For TIMP2, one of the stronger structural bridges in this analysis connects TIMP2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around TIMP2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TIMP2 · EN edition · Analysis: TopicsToTalkAbout