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Lactoferrin: History & Technology

Lactoferrin (LF), also known as lactotransferrin (LTF), is a multifunctional protein of the transferrin family. Lactoferrin is a globular glycoprotein with a molecular mass of about 80 kDa that is widely represented in various secretory fluids, such as milk, saliva, tears, and nasal secretions. Lactoferrin is also present in secondary granules of PMNs…

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Lactoferrin topic overview

The analysis highlights History and Technology as prominent areas in the source structure around Lactoferrin.

Related topics
141
Source areas
6
Connected nodes
147
Extracted relationships
260
Concept neighborhoods
24
Bridge connections
147

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 56 topics
Structure · 36 topics
Function · 23 topics
Overview · 22 topics
History · 2 topics
Technology · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
LTF, GIG12, HEL110, HLF2, LF, lactotransferrin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2PMS, 1B0L, 1BKA, 1CB6, 1DSN, 1EH3, 1FCK, 1H43, 1H44, 1H45, 1HSE, 1L5T, 1LCF, 1LCT, 1LFG, 1LFH, 1LFI, 1LGB,…
Band
3p21.31 · 9 F2|9 60.79 cM
Bgee
trachea · trabecular bone · olfactory zone of nasal mucosa · parotid gland · bone marrow cell
BioGPS
n/a
Chr.
Chromosome 3 (human) · Chromosome 9 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Structure

Function

Clinical significance

Technology

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Lactoferrin connects Entity context

The extracted context around Lactoferrin shows recurring relationship patterns in the source. For example, Lactoferrin → antibacterial humoral response, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, antimicrobial humoral response, bone morphogenesis, cell surface, cysteine-type endopeptidase inhibitor activity, cytoplasm, defense response to bacterium, DNA binding, extracellular exosome, extracellular region, extracellular space, heparin binding, humoral immune response, hydrolase activity, immune system process, innate immune response, innate immune response in mucosa, ion transport Another extracted example is Lactoferrin → body of femur, bone marrow cell, cervix, corpus epididymis, epithelium of lactiferous gland, femur, granulocyte, lacrimal gland, lactiferous duct, lactiferous gland, olfactory epithelium, olfactory zone of nasal mucosa, parotid gland, pylorus, seminal vesicula, superior surface of tongue, tibiofemoral joint, trabecular bone, trachea. Use these groups to spot repeated connection types before inspecting the individual relationships.

Lactoferrin

Top relations

Gene ontology · 65
Lactoferrin → antibacterial humoral response, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, antimicrobial humoral response, bone morphogenesis, cell surface, cysteine-type endopeptidase inhibitor activity, cytoplasm, defense response to bacterium, DNA binding, extracellular exosome, extracellular region, extracellular space, heparin binding, humoral immune response, hydrolase activity, immune system process, innate immune response, innate immune response in mucosa, ion transport
Bgee · 19
Lactoferrin → body of femur, bone marrow cell, cervix, corpus epididymis, epithelium of lactiferous gland, femur, granulocyte, lacrimal gland, lactiferous duct, lactiferous gland, olfactory epithelium, olfactory zone of nasal mucosa, parotid gland, pylorus, seminal vesicula, superior surface of tongue, tibiofemoral joint, trabecular bone, trachea
RNA expression pattern · 19
Lactoferrin → body of femur, bone marrow cell, cervix, corpus epididymis, epithelium of lactiferous gland, femur, granulocyte, lacrimal gland, lactiferous duct, lactiferous gland, olfactory epithelium, olfactory zone of nasal mucosa, parotid gland, pylorus, seminal vesicula, superior surface of tongue, tibiofemoral joint, trabecular bone, trachea
related to Genes of lactoferrin · 17
Lactoferrin → At, Bos, Capra, Deletions, Exons, Gene, Homo, In, LTF, Mus, Similarity, Study, Sus, TAA, TGA, There, This
related to history · 14
Lactoferrin → All, Aspergillus, China, In, Its, November, Occurrence, Pichia, Recombinant, Sydney-based, The, Therefore, They, Yeast
related to Antifungal activity · 13
Lactoferrin → Administration, Antifungal, Candida, Contrary, Fluconazole, HIV-infected, HIV-positive, However, In, Oral, Such, The, Trichophyton
related to Molecular structure · 12
Lactoferrin → C-lobe, C1, C2, Concentration, Each, It, N-and C-lobes, N-lobe, N1, N2, The, X-ray
related to Antiviral activity · 9
Lactoferrin → Activity, COVID-19, DNA, HIV, Iron-free, Many, Mayaro, RNA, The
related to Polymeric forms · 8
Lactoferrin → Both, Ca2, DNA, In, It, Many, Several, Titer
related to Antibacterial activity · 7
Lactoferrin → Although, Antibacterial, ATPase, Its, Lactoferrin's, N-lobe, This

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

iron human also activity milk protein gene antibacterial cell bovine candida rna bp transferrin membrane system bone antifungal two one

Lactoferrin relationships Subject–Predicate–Object triples

TTTA extracted 260 structured relationships around Lactoferrin. Examples in this analysis include Lactoferrin → Aliases → LTF, GIG12, HEL110, HLF2, LF, lactotransferrin and Lactoferrin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2PMS, 1B0L, 1BKA, 1CB6, 1DSN, 1EH3, 1FCK, 1H43, 1H44, 1H45, 1HSE, 1L5T, 1LCF, 1LCT, 1LFG, 1LFH, 1LFI, 1LGB,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
LactoferrinAliasesLTF, GIG12, HEL110, HLF2, LF, lactotransferrin1.00infobox
LactoferrinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2PMS, 1B0L, 1BKA, 1CB6, 1DSN, 1EH3, 1FCK, 1H43, 1H44, 1H45, 1HSE, 1L5T, 1LCF, 1LCT, 1LFG, 1LFH, 1LFI, 1LGB,…1.00infobox
LactoferrinBand3p21.311.00infobox
LactoferrinBand9 F2|9 60.79 cM1.00infobox
LactoferrinBgeetrachea1.00infobox
LactoferrinBgeetrabecular bone1.00infobox
LactoferrinBgeeolfactory zone of nasal mucosa1.00infobox
LactoferrinBgeeparotid gland1.00infobox
LactoferrinBgeebone marrow cell1.00infobox
LactoferrinBgeepylorus1.00infobox
LactoferrinBgeeseminal vesicula1.00infobox
LactoferrinBgeecorpus epididymis1.00infobox
LactoferrinBgeeepithelium of lactiferous gland1.00infobox
LactoferrinBgeelactiferous duct1.00infobox
LactoferrinBgeegranulocyte1.00infobox
LactoferrinBgeetibiofemoral joint1.00infobox
LactoferrinBgeelacrimal gland1.00infobox
LactoferrinBgeecervix1.00infobox
LactoferrinBgeelactiferous gland1.00infobox
LactoferrinBgeeolfactory epithelium1.00infobox
LactoferrinBgeesuperior surface of tongue1.00infobox
LactoferrinBgeefemur1.00infobox
LactoferrinBgeebody of femur1.00infobox
LactoferrinBioGPSn/a1.00infobox
LactoferrinChr.Chromosome 3 (human)1.00infobox
LactoferrinChr.Chromosome 9 (mouse)1.00infobox
LactoferrinDatabasesNCBI: entry; OMA: entry1.00infobox
LactoferrinEnd46,485,234 bp1.00infobox
LactoferrinEnd110,871,835 bp1.00infobox
LactoferrinEnsemblENSG000000122231.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Lactoferrin bring nearby vocabulary together. In this analysis, examples include Activity, Iron and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Lactoferrin
    • Activity
    • Iron
    • Human
    • Antibacterial
    • Protein
    • Milk
    • Antifungal
    • Antiviral
    • Bind
    • Bovine
    • Forms
    • System
  • lactoferrin
    • Activity
    • Iron
    • Human
    • Antibacterial
    • Protein
    • Milk
    • Antifungal
    • Antiviral
    • Bind
    • Bovine
    • Forms
    • System
  • protein
    • Molecular
    • Binding
    • Milk
    • Dna
    • Rna
    • Transferrin
    • Iron
    • Two
    • Gene
    • Band
    • Bp
    • Chr
  • milk
    • Protein
    • Rna
    • Human
    • Saliva
    • Molecular
    • Dna
    • Iron
    • Bovine
    • Membrane
    • Band
    • Bp
    • Chr
  • immune system
    • Antimicrobial
    • Ltf
    • Bovine
    • Activity
    • Human
    • Band
    • Saliva
    • Bp
    • Chr
    • Chromosome
    • Function
    • Molecular
  • antibacterial
    • Function
    • Antifungal
    • Antiviral
    • Iron
    • Bp
    • Chr
    • Chromosome
    • Ltf
    • Molecular
    • Binding
    • Bone
    • Human
  • dna
    • Rna
    • Bind
    • Protein
    • Band
    • Milk
    • Human
    • Bp
    • Chr
    • Chromosome
    • Function
    • Ltf
    • Molecular
  • human milk
    • Bp
    • Chr
    • Chromosome
    • Activity
    • Band
    • Protein
    • Rna
    • Human
    • Milk
    • Bovine
    • Forms
    • System

Connections between topic areas Semantic bridges

For Lactoferrin, one of the stronger structural bridges in this analysis connects Lactoferrin with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
LactoferrinClinical significance · splits 91 ⟂ 57
LactoferrinStructure · splits 111 ⟂ 37
LactoferrinFunction · splits 124 ⟂ 24
LactoferrinOverview · splits 125 ⟂ 23
LactoferrinHistory · splits 145 ⟂ 3
LactoferrinTechnology · splits 145 ⟂ 3

Map overview Semantic statistics

Lactoferrin

Nodes148
Edges147
Triples260
Avg. degree1.99
Density0.013514
Components1

Source & methodology

TTTA analyzes the structure around Lactoferrin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Technology, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Lactoferrin · EN edition · Analysis: TopicsToTalkAbout

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