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Proteolysis

Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Protein degradation is a major regulatory mechanism of gene expression and contributes substantially to shaping mammalian proteomes. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular…

Applications, Laboratory applications & Proteolysis and diseases

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Overview

Biological functions

Autoproteolysis

Proteolysis and diseases

Non-enzymatic processes

Laboratory applications

Protease enzymes

Advanced semantic analysis

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Map overview Semantic statistics

Proteolysis

Nodes176
Edges175
Triples91
Avg. degree1.99
Density0.011364
Components1

How this topic connects Entity context

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Proteolysis

Top relations

has application · 16
Proteolysis → Analysis, Cleavage, Complete, Digestion, DNA, For, Increasing, Klenow, LC-MS, Lysogeny Broth, Partial, RNA, SDS, TEV, The, This
related to Autoproteolysis · 14
Proteolysis → Asn-Pro, Asp-Pro, Autoproteolysis, Examples, FrpC, Gly-Ser, In, Neisseria, Salmonella FlhB, SEA, Unlike, VWD, Willebrand, Yersinia YscU
related to Proteolysis and diseases · 10
Proteolysis → Abnormal, Alzheimer's, Chronic, In, MMPs, Other, People, Proteases, Smoking, TIMPs
related to Venoms · 7
Proteolysis → Certain, Cytotoxic, Hemorrhagic, Hemotoxic, Myotoxic, Proteolytic, These
related to Post-translational proteolytic processing · 5
Proteolysis → For, Limited, N-terminal, The, This
related to External links · 4
Proteolysis → Center, Proteolysis MAP, Proteolytic Pathways, The Journal
is a · 2
Proteolysis → breakdown of proteins into smaller polypeptides or amino acids, open access journal that provides an international forum for the electronic publication of the whole spectrum of high-quality articles and reviews in all areas of proteolysis an…
related to Cellular regulation · 2
Proteolysis → Other, Some
see also · 2
Proteolysis → Biology, The Proteolysis MapPROTOMAP

Important terminology Word statistics

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Important terminology

proteins may protein also peptide example degradation enzymes proteolytic proteases acids many used polypeptide amino cleavage rate digestion form cleaved

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Proteolysisis abreakdown of proteins into smaller polypeptides or amino acids0.90text
Proteolysisis aopen access journal that provides an international forum for the electronic publication of the whole spectrum of high-quality articles and reviews in all areas of proteolysis an…0.90text
cathepsins.The ubiquitin-mediated process is selectiveinstance ofThe lysosome contains a large number of proteases0.80text
pepsininstance ofproteins in food are broken down into smaller peptide chains by digestive enzymes0.80text
trypsininstance ofproteins in food are broken down into smaller peptide chains by digestive enzymes0.80text
chymotrypsininstance ofproteins in food are broken down into smaller peptide chains by digestive enzymes0.80text
and elastaseinstance ofproteins in food are broken down into smaller peptide chains by digestive enzymes0.80text
and into amino acids by various enzymes such as carboxypeptidaseinstance ofproteins in food are broken down into smaller peptide chains by digestive enzymes0.80text
aminopeptidaseinstance ofproteins in food are broken down into smaller peptide chains by digestive enzymes0.80text
and dipeptidaseinstance ofproteins in food are broken down into smaller peptide chains by digestive enzymes0.80text
alanine or glycine.In order to prevent inappropriate or premature activation of the digestive enzymesinstance ofelastase cleaves the bond after a small non-polar residue0.80text
trypsininstance ofThe pancreas secretes the precursors of a number of proteases0.80text

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