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Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).
The analysis highlights Structure, Function and Role in cancer as prominent areas in the source structure around Fibronectin.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Fibronectin shows recurring relationship patterns in the source. For example, Fibronectin → acute-phase response, angiogenesis, apical plasma membrane, basement membrane, blood microparticle, calcium-independent cell-matrix adhesion, cell adhesion, cell-matrix adhesion, cell-substrate junction assembly, collagen binding, endodermal cell differentiation, endoplasmic reticulum-Golgi intermediate compartment, extracellular exosome, extracellular fluid, extracellular matrix, extracellular matrix disassembly, extracellular matrix organization, extracellular region, fibrinogen complex, heparin binding Another extracted example is Fibronectin → ankle, ascending aorta, atrium, calvaria, decidua, Descending thoracic aorta, endothelial cell of lymphatic vessel, left coronary artery, left lung lobe, right coronary artery, stroma of bone marrow, stromal cell of endometrium, synovial joint, synovial membrane, tail of embryo, tendon of biceps brachii, tibia, tibiofemoral joint, tunica media of zone of aorta, umbilical cord. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
matrix protein fibroblasts insoluble wound cell extracellular cells healing soluble plasma cellular human fibrin gene modules type iii collagen adhesion
TTTA extracted 186 structured relationships around Fibronectin. Examples in this analysis include Fibronectin → Aliases → FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, fibronectin 1, SMDCF and Fibronectin → Available structures → Available structuresPDBOrtholog search: H0Y7Z1%20or%20B7ZLE5 PDBe H0Y7Z1,B7ZLE5 RCSB List of PDB id codes1E88, 1E8B, 1FBR, 1FNA, 1FNF, 1FNH, 1J8K, 1O9A, 1OWW, 1Q38, 1QGB, 1QO6,…. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Fibronectin | Aliases | FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, fibronectin 1, SMDCF | 1.00 | infobox |
| Fibronectin | Available structures | Available structuresPDBOrtholog search: H0Y7Z1%20or%20B7ZLE5 PDBe H0Y7Z1,B7ZLE5 RCSB List of PDB id codes1E88, 1E8B, 1FBR, 1FNA, 1FNF, 1FNH, 1J8K, 1O9A, 1OWW, 1Q38, 1QGB, 1QO6,… | 1.00 | infobox |
| Fibronectin | Band | 2q35 | 1.00 | infobox |
| Fibronectin | Band | 1 C3|1 36.05 cM | 1.00 | infobox |
| Fibronectin | Bgee | synovial joint | 1.00 | infobox |
| Fibronectin | Bgee | right coronary artery | 1.00 | infobox |
| Fibronectin | Bgee | decidua | 1.00 | infobox |
| Fibronectin | Bgee | Descending thoracic aorta | 1.00 | infobox |
| Fibronectin | Bgee | synovial membrane | 1.00 | infobox |
| Fibronectin | Bgee | ascending aorta | 1.00 | infobox |
| Fibronectin | Bgee | tibia | 1.00 | infobox |
| Fibronectin | Bgee | tendon of biceps brachii | 1.00 | infobox |
| Fibronectin | Bgee | stromal cell of endometrium | 1.00 | infobox |
| Fibronectin | Bgee | left coronary artery | 1.00 | infobox |
| Fibronectin | Bgee | calvaria | 1.00 | infobox |
| Fibronectin | Bgee | stroma of bone marrow | 1.00 | infobox |
| Fibronectin | Bgee | tunica media of zone of aorta | 1.00 | infobox |
| Fibronectin | Bgee | umbilical cord | 1.00 | infobox |
| Fibronectin | Bgee | left lung lobe | 1.00 | infobox |
| Fibronectin | Bgee | ankle | 1.00 | infobox |
| Fibronectin | Bgee | tail of embryo | 1.00 | infobox |
| Fibronectin | Bgee | tibiofemoral joint | 1.00 | infobox |
| Fibronectin | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| Fibronectin | Bgee | atrium | 1.00 | infobox |
| Fibronectin | BioGPS | More reference expression data | 1.00 | infobox |
| Fibronectin | Chr. | Chromosome 2 (human) | 1.00 | infobox |
| Fibronectin | Chr. | Chromosome 1 (mouse) | 1.00 | infobox |
| Fibronectin | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Fibronectin | End | 215,436,073 bp | 1.00 | infobox |
| Fibronectin | End | 71,692,359 bp | 1.00 | infobox |
The concept neighborhoods around Fibronectin bring nearby vocabulary together. In this analysis, examples include Matrix, Cells and Wound. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Fibronectin, one of the stronger structural bridges in this analysis connects Fibronectin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Fibronectin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Role in cancer, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Fibronectin · EN edition · Analysis: TopicsToTalkAbout