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Fibronectin: Structure, Function & Role in cancer

Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).

Language: English [EN]
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Fibronectin topic overview

The analysis highlights Structure, Function and Role in cancer as prominent areas in the source structure around Fibronectin.

Related topics
127
Source areas
7
Connected nodes
134
Extracted relationships
186
Concept neighborhoods
37
Bridge connections
134

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 34 topics
Function · 21 topics
Structure · 21 topics
Role in cancer · 20 topics
Interactions · 12 topics
Matrix assembly · 10 topics
Role in wound healing · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, fibronectin 1, SMDCF
Available structures
Available structuresPDBOrtholog search: H0Y7Z1%20or%20B7ZLE5 PDBe H0Y7Z1,B7ZLE5 RCSB List of PDB id codes1E88, 1E8B, 1FBR, 1FNA, 1FNF, 1FNH, 1J8K, 1O9A, 1OWW, 1Q38, 1QGB, 1QO6,…
Band
2q35 · 1 C3|1 36.05 cM
Bgee
synovial joint · right coronary artery · decidua · Descending thoracic aorta · synovial membrane
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Matrix assembly

Role in cancer

Role in wound healing

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Fibronectin connects Entity context

The extracted context around Fibronectin shows recurring relationship patterns in the source. For example, Fibronectin → acute-phase response, angiogenesis, apical plasma membrane, basement membrane, blood microparticle, calcium-independent cell-matrix adhesion, cell adhesion, cell-matrix adhesion, cell-substrate junction assembly, collagen binding, endodermal cell differentiation, endoplasmic reticulum-Golgi intermediate compartment, extracellular exosome, extracellular fluid, extracellular matrix, extracellular matrix disassembly, extracellular matrix organization, extracellular region, fibrinogen complex, heparin binding Another extracted example is Fibronectin → ankle, ascending aorta, atrium, calvaria, decidua, Descending thoracic aorta, endothelial cell of lymphatic vessel, left coronary artery, left lung lobe, right coronary artery, stroma of bone marrow, stromal cell of endometrium, synovial joint, synovial membrane, tail of embryo, tendon of biceps brachii, tibia, tibiofemoral joint, tunica media of zone of aorta, umbilical cord. Use these groups to spot repeated connection types before inspecting the individual relationships.

Fibronectin

Top relations

Gene ontology · 42
Fibronectin → acute-phase response, angiogenesis, apical plasma membrane, basement membrane, blood microparticle, calcium-independent cell-matrix adhesion, cell adhesion, cell-matrix adhesion, cell-substrate junction assembly, collagen binding, endodermal cell differentiation, endoplasmic reticulum-Golgi intermediate compartment, extracellular exosome, extracellular fluid, extracellular matrix, extracellular matrix disassembly, extracellular matrix organization, extracellular region, fibrinogen complex, heparin binding
Bgee · 20
Fibronectin → ankle, ascending aorta, atrium, calvaria, decidua, Descending thoracic aorta, endothelial cell of lymphatic vessel, left coronary artery, left lung lobe, right coronary artery, stroma of bone marrow, stromal cell of endometrium, synovial joint, synovial membrane, tail of embryo, tendon of biceps brachii, tibia, tibiofemoral joint, tunica media of zone of aorta, umbilical cord
RNA expression pattern · 20
Fibronectin → ankle, ascending aorta, atrium, calvaria, decidua, Descending thoracic aorta, endothelial cell of lymphatic vessel, left coronary artery, left lung lobe, right coronary artery, stroma of bone marrow, stromal cell of endometrium, synovial joint, synovial membrane, tail of embryo, tendon of biceps brachii, tibia, tibiofemoral joint, tunica media of zone of aorta, umbilical cord
related to Structure · 15
Fibronectin → All, Beta-sandwich, C-terminal, Each, EIIIA, EIIIB, II, III, III14, It, One, The, The V-region, Three, V-region
related to External links · 13
Fibronectin → Extracellular Adhesion MoleculeThe Fibronectin, Human Fibronectin, Medicine Medical Subject Headings, MeSH, Mouse Fibronectin, National Library, Overview, P02751, P11276, PDB, PDBe-KB, ProteinFibronectin, UniProt
related to Role in wound healing · 11
Fibronectin → An, Based, Collagen, During, Factor XIII, Fibroblast, Fibroblasts, III, Patients, Plasma, The
related to Function · 9
Fibronectin → Along, As, Cellular, Fibroblasts, Fragmentation, Fragmenting, It, These, V-region
related to Interactions · 8
Fibronectin → Besides, BMP-1, FBP-A, FBP-B, For, N-terminal, NSP-4, TNF-α
related to Matrix assembly · 8
Fibronectin → As, Cells, Cellular, Fibronectin's, Short, The, These, This
related to Role in cancer · 4
Fibronectin → In, Several, The, These

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

matrix protein fibroblasts insoluble wound cell extracellular cells healing soluble plasma cellular human fibrin gene modules type iii collagen adhesion

Fibronectin relationships Subject–Predicate–Object triples

TTTA extracted 186 structured relationships around Fibronectin. Examples in this analysis include Fibronectin → Aliases → FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, fibronectin 1, SMDCF and Fibronectin → Available structures → Available structuresPDBOrtholog search: H0Y7Z1%20or%20B7ZLE5 PDBe H0Y7Z1,B7ZLE5 RCSB List of PDB id codes1E88, 1E8B, 1FBR, 1FNA, 1FNF, 1FNH, 1J8K, 1O9A, 1OWW, 1Q38, 1QGB, 1QO6,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
FibronectinAliasesFN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, fibronectin 1, SMDCF1.00infobox
FibronectinAvailable structuresAvailable structuresPDBOrtholog search: H0Y7Z1%20or%20B7ZLE5 PDBe H0Y7Z1,B7ZLE5 RCSB List of PDB id codes1E88, 1E8B, 1FBR, 1FNA, 1FNF, 1FNH, 1J8K, 1O9A, 1OWW, 1Q38, 1QGB, 1QO6,…1.00infobox
FibronectinBand2q351.00infobox
FibronectinBand1 C3|1 36.05 cM1.00infobox
FibronectinBgeesynovial joint1.00infobox
FibronectinBgeeright coronary artery1.00infobox
FibronectinBgeedecidua1.00infobox
FibronectinBgeeDescending thoracic aorta1.00infobox
FibronectinBgeesynovial membrane1.00infobox
FibronectinBgeeascending aorta1.00infobox
FibronectinBgeetibia1.00infobox
FibronectinBgeetendon of biceps brachii1.00infobox
FibronectinBgeestromal cell of endometrium1.00infobox
FibronectinBgeeleft coronary artery1.00infobox
FibronectinBgeecalvaria1.00infobox
FibronectinBgeestroma of bone marrow1.00infobox
FibronectinBgeetunica media of zone of aorta1.00infobox
FibronectinBgeeumbilical cord1.00infobox
FibronectinBgeeleft lung lobe1.00infobox
FibronectinBgeeankle1.00infobox
FibronectinBgeetail of embryo1.00infobox
FibronectinBgeetibiofemoral joint1.00infobox
FibronectinBgeeendothelial cell of lymphatic vessel1.00infobox
FibronectinBgeeatrium1.00infobox
FibronectinBioGPSMore reference expression data1.00infobox
FibronectinChr.Chromosome 2 (human)1.00infobox
FibronectinChr.Chromosome 1 (mouse)1.00infobox
FibronectinDatabasesNCBI: entry; OMA: entry1.00infobox
FibronectinEnd215,436,073 bp1.00infobox
FibronectinEnd71,692,359 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Fibronectin bring nearby vocabulary together. In this analysis, examples include Matrix, Cells and Wound. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Fibronectin
    • Matrix
    • Cells
    • Wound
    • Cellular
    • Plasma
    • Healing
    • Cell
    • Development
    • Fibronectin-binding
    • Insoluble
    • Protein
    • Also
  • fibronectin
    • Matrix
    • Cells
    • Wound
    • Cellular
    • Plasma
    • Healing
    • Cell
    • Development
    • Fibronectin-binding
    • Insoluble
    • Protein
    • Also
  • extracellular matrix
    • Matrix
    • Assembly
    • Cellular
    • Insoluble
    • Protein
    • Soluble
    • Cells
    • Two
    • Adhesion
    • Collagen
    • Fibroblasts
    • Blood
  • collagen
    • Fibrils
    • Extracellular
    • Iii
    • Type
    • Wound
    • Band
    • Bp
    • Chr
    • Expression
    • Integrin
    • Migration
    • Two
  • protein dimer
    • Blood
    • Two
    • Adhesion
    • Assembly
    • Gene
    • Matrix
    • Cellular
    • Human
    • Plasma
    • Soluble
    • Insoluble
    • Cells
  • blood plasma
    • Cellular
    • Protein
    • Two
    • Blood
    • Plasma
    • Assembly
    • Matrix
    • Fibrin
    • Human
    • Extracellular
    • Insoluble
    • Major
  • cell adhesion
    • Migration
    • Expression
    • Growth
    • Adhesion
    • Cell
    • Integrins
    • Extracellular
    • Protein
    • Healing
    • Integrin
    • Development
    • Fibronectin-binding
  • wound healing
    • Healing
    • Wound
    • Role
    • Migration
    • Major
    • Fibroblasts
    • Bp
    • Chr
    • Growth
    • Assembly
    • Adhesion
    • Collagen

Connections between topic areas Semantic bridges

For Fibronectin, one of the stronger structural bridges in this analysis connects Fibronectin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
FibronectinOverview · splits 100 ⟂ 35
FibronectinStructure · splits 113 ⟂ 22
FibronectinFunction · splits 113 ⟂ 22
FibronectinRole in cancer · splits 114 ⟂ 21
FibronectinInteractions · splits 122 ⟂ 13
FibronectinMatrix assembly · splits 124 ⟂ 11
FibronectinRole in wound healing · splits 125 ⟂ 10

Map overview Semantic statistics

Fibronectin

Nodes135
Edges134
Triples186
Avg. degree1.99
Density0.014815
Components1

Source & methodology

TTTA analyzes the structure around Fibronectin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Role in cancer, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Fibronectin · EN edition · Analysis: TopicsToTalkAbout

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