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TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a two-domain glycoprotein with a molecular weight of 28 kDa. TIMP1 is expressed in several tissues of organisms.
The analysis highlights Regulation of TIMP expression, Cell-surface receptor binding and Function as prominent areas in the source structure around TIMP1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around TIMP1 shows recurring relationship patterns in the source. For example, TIMP1 → ageing, basement membrane, cartilage development, cell activation, collagen, connective tissue replacement involved in inflammatory response wound healing, cytokine activity, cytokine-mediated signaling pathway, endoplasmic reticulum lumen, enzyme inhibitor activity, extracellular exosome, extracellular matrix, extracellular matrix disassembly, extracellular region, extracellular space, growth factor activity, metal ion binding, metalloendopeptidase inhibitor activity, negative regulation of apoptotic process, negative regulation of catalytic activity Another extracted example is TIMP1 → ankle, ankle joint, ascending aorta, beta cell, body of femur, calvaria, Descending thoracic aorta, endothelial cell of lymphatic vessel, fossa, gallbladder, gastrula, islet of Langerhans, lactiferous gland, left coronary artery, pericardium, right adrenal gland, right coronary artery, stroma of bone marrow, stromal cell of endometrium, umbilical cord. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
human inhibitor bp gene timp also chr band expression role mmps chromosome matrix protein function metallopeptidase metalloproteinases glycoprotein activity extracellular
TTTA extracted 123 structured relationships around TIMP1. Examples in this analysis include TIMP1 → Aliases → TIMP1, CLGI, EPA, EPO, HCI, TIMP, TIMP-1, TIMP metallopeptidase inhibitor 1 and TIMP1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D2B, 1OO9, 1UEA, 2J0T, 3MA2, 3V96. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TIMP1 | Aliases | TIMP1, CLGI, EPA, EPO, HCI, TIMP, TIMP-1, TIMP metallopeptidase inhibitor 1 | 1.00 | infobox |
| TIMP1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D2B, 1OO9, 1UEA, 2J0T, 3MA2, 3V96 | 1.00 | infobox |
| TIMP1 | Band | Xp11.3 | 1.00 | infobox |
| TIMP1 | Band | X A1.3|X 16.38 cM | 1.00 | infobox |
| TIMP1 | Bgee | right coronary artery | 1.00 | infobox |
| TIMP1 | Bgee | gallbladder | 1.00 | infobox |
| TIMP1 | Bgee | left coronary artery | 1.00 | infobox |
| TIMP1 | Bgee | Descending thoracic aorta | 1.00 | infobox |
| TIMP1 | Bgee | ascending aorta | 1.00 | infobox |
| TIMP1 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| TIMP1 | Bgee | islet of Langerhans | 1.00 | infobox |
| TIMP1 | Bgee | pericardium | 1.00 | infobox |
| TIMP1 | Bgee | beta cell | 1.00 | infobox |
| TIMP1 | Bgee | right adrenal gland | 1.00 | infobox |
| TIMP1 | Bgee | calvaria | 1.00 | infobox |
| TIMP1 | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| TIMP1 | Bgee | stroma of bone marrow | 1.00 | infobox |
| TIMP1 | Bgee | body of femur | 1.00 | infobox |
| TIMP1 | Bgee | ankle joint | 1.00 | infobox |
| TIMP1 | Bgee | ankle | 1.00 | infobox |
| TIMP1 | Bgee | gastrula | 1.00 | infobox |
| TIMP1 | Bgee | lactiferous gland | 1.00 | infobox |
| TIMP1 | Bgee | fossa | 1.00 | infobox |
| TIMP1 | Bgee | umbilical cord | 1.00 | infobox |
| TIMP1 | BioGPS | More reference expression data | 1.00 | infobox |
| TIMP1 | Chr. | X chromosome (human) | 1.00 | infobox |
| TIMP1 | Chr. | X chromosome (mouse) | 1.00 | infobox |
| TIMP1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TIMP1 | End | 47,586,789 bp | 1.00 | infobox |
| TIMP1 | End | 20,740,974 bp | 1.00 | infobox |
The concept neighborhoods around TIMP1 bring nearby vocabulary together. In this analysis, examples include Domain, Regulation and Expression. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For TIMP1, one of the stronger structural bridges in this analysis connects TIMP1 with Regulation of TIMP expression. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around TIMP1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regulation of TIMP expression, Cell-surface receptor binding & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TIMP1 · EN edition · Analysis: TopicsToTalkAbout