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TIMP1

TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a two-domain glycoprotein with a molecular weight of 28 kDa. TIMP1 is expressed in several tissues of organisms.

Regulation of TIMP expression, Cell-surface receptor binding & Function

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Regulation of TIMP expression

10 related topics

Cell-surface receptor binding

4 related topics

Function

1 related topics

Overview

7 related topics

Key facts & relationships

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Aliases
TIMP1, CLGI, EPA, EPO, HCI, TIMP, TIMP-1, TIMP metallopeptidase inhibitor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D2B, 1OO9, 1UEA, 2J0T, 3MA2, 3V96
Band
Xp11.3 · X A1.3|X 16.38 cM
Bgee
right coronary artery · gallbladder · left coronary artery · Descending thoracic aorta · ascending aorta
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

Topics to explore

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Overview

Function

Cell-surface receptor binding

Regulation of TIMP expression

Advanced semantic analysis

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Map overview Semantic statistics

TIMP1

Nodes27
Edges26
Triples123
Avg. degree1.93
Density0.074074
Components1

How this topic connects Entity context

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TIMP1

Top relations

Gene ontology · 40
TIMP1 → ageing, basement membrane, cartilage development, cell activation, collagen, connective tissue replacement involved in inflammatory response wound healing, cytokine activity, cytokine-mediated signaling pathway, endoplasmic reticulum lumen, enzyme inhibitor activity, extracellular exosome, extracellular matrix, extracellular matrix disassembly, extracellular region, extracellular space, growth factor activity, metal ion binding, metalloendopeptidase inhibitor activity, negative regulation of apoptotic process, negative regulation of catalytic activity
Bgee · 20
TIMP1 → ankle, ankle joint, ascending aorta, beta cell, body of femur, calvaria, Descending thoracic aorta, endothelial cell of lymphatic vessel, fossa, gallbladder, gastrula, islet of Langerhans, lactiferous gland, left coronary artery, pericardium, right adrenal gland, right coronary artery, stroma of bone marrow, stromal cell of endometrium, umbilical cord
RNA expression pattern · 20
TIMP1 → ankle, ankle joint, ascending aorta, beta cell, body of femur, calvaria, Descending thoracic aorta, endothelial cell of lymphatic vessel, fossa, gallbladder, gastrula, islet of Langerhans, lactiferous gland, left coronary artery, pericardium, right adrenal gland, right coronary artery, stroma of bone marrow, stromal cell of endometrium, umbilical cord
related to Function · 14
TIMP1 → Accordingly, ADAMs, ADAMTSs, Additionally, C-terminal, ECM, In, It, MMP-2, MMP-9, MMPs, Studies, The, TIMP1 N-terminal
related to Cell-surface receptor binding · 6
TIMP1 → C-terminal, CD63, CD82, MAPK, These, While
Band · 2
TIMP1 → X A1.3|X 16.38 cM, Xp11.3
Chr. · 2
TIMP1 → X chromosome (human), X chromosome (mouse)
End · 2
TIMP1 → 20,740,974 bp, 47,586,789 bp
Aliases · 1
TIMP1 → TIMP1, CLGI, EPA, EPO, HCI, TIMP, TIMP-1, TIMP metallopeptidase inhibitor 1
Available structures · 1
TIMP1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D2B, 1OO9, 1UEA, 2J0T, 3MA2, 3V96

Important terminology Word statistics

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Important terminology

human inhibitor bp gene timp also chr band expression role mmps chromosome matrix protein function metallopeptidase metalloproteinases glycoprotein activity extracellular

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TIMP1AliasesTIMP1, CLGI, EPA, EPO, HCI, TIMP, TIMP-1, TIMP metallopeptidase inhibitor 11.00infobox
TIMP1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D2B, 1OO9, 1UEA, 2J0T, 3MA2, 3V961.00infobox
TIMP1BandXp11.31.00infobox
TIMP1BandX A1.3|X 16.38 cM1.00infobox
TIMP1Bgeeright coronary artery1.00infobox
TIMP1Bgeegallbladder1.00infobox
TIMP1Bgeeleft coronary artery1.00infobox
TIMP1BgeeDescending thoracic aorta1.00infobox
TIMP1Bgeeascending aorta1.00infobox
TIMP1Bgeestromal cell of endometrium1.00infobox
TIMP1Bgeeislet of Langerhans1.00infobox
TIMP1Bgeepericardium1.00infobox
TIMP1Bgeebeta cell1.00infobox
TIMP1Bgeeright adrenal gland1.00infobox
TIMP1Bgeecalvaria1.00infobox
TIMP1Bgeeendothelial cell of lymphatic vessel1.00infobox
TIMP1Bgeestroma of bone marrow1.00infobox
TIMP1Bgeebody of femur1.00infobox
TIMP1Bgeeankle joint1.00infobox
TIMP1Bgeeankle1.00infobox
TIMP1Bgeegastrula1.00infobox
TIMP1Bgeelactiferous gland1.00infobox
TIMP1Bgeefossa1.00infobox
TIMP1Bgeeumbilical cord1.00infobox
TIMP1BioGPSMore reference expression data1.00infobox
TIMP1Chr.X chromosome (human)1.00infobox
TIMP1Chr.X chromosome (mouse)1.00infobox
TIMP1DatabasesNCBI: entry; OMA: entry1.00infobox
TIMP1End47,586,789 bp1.00infobox
TIMP1End20,740,974 bp1.00infobox

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