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Integrin: Structure, Function & Overview

Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. The presence of…

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Integrin topic overview

The analysis highlights Structure, Function and Overview as prominent areas in the source structure around Integrin.

Related topics
88
Source areas
4
Connected nodes
92
Extracted relationships
114
Concept neighborhoods
28
Bridge connections
92

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 35 topics
Function · 29 topics
Overview · 20 topics
Integrins and nerve repair · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR013649 · PF08441
Available protein structures:
IPR013649 · PF08441
InterPro
IPR013649
Membranome
13
OPM protein
2knc
OPM superfamily
176

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Integrins and nerve repair

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Integrin connects Entity context

The extracted context around Integrin shows recurring relationship patterns in the source. For example, Integrin → A-domains, As, Caenorhabditis, Despite, Drosophila, ECM, GPIIbIIIa, In, Integrins, Low-resolution, NMR, Perhaps, RGD-ligand, RGD-sequence, RNA, Several, The, The X-ray, Through, V-shape Another extracted example is Integrin → Among, Cell, CRK, ECM, EGF, FAK, Integrins, Src, The, These, Thus, Together, VEGF, Which. Use these groups to spot repeated connection types before inspecting the individual relationships.

Integrin

Top relations

related to Structure · 21
Integrin → A-domains, As, Caenorhabditis, Despite, Drosophila, ECM, GPIIbIIIa, In, Integrins, Low-resolution, NMR, Perhaps, RGD-ligand, RGD-sequence, RNA, Several, The, The X-ray, Through, V-shape
related to Attachment of cell to the ECM · 14
Integrin → Among, Cell, CRK, ECM, EGF, FAK, Integrins, Src, The, These, Thus, Together, VEGF, Which
related to Activation · 13
Integrin → ECM, EM, In, Kindlin-1, Kindlin-2, Moreover, One, Recently, Talin, The, Therefore, Unfortunately, When
related to Signal transduction · 11
Integrin → Clustering, ECM, For, Gab1/Shp2, IGF1R, In, Integrins, RTK, Shp2, The, While
related to External links · 8
Integrin → Integrins, Media, Medicine Medical Subject Headings, MeSH, National Library, PMAP The Proteolysis Map, Wikimedia Commons Talin, Wiktionary-logo-en-v2
related to Function · 8
Integrin → ECM, GpIIb/IIIa, Integrins, Recently, These, They, This, Upon
related to Integrins and nerve repair · 6
Integrin → CNS, ECM, Integrins, It, PNS, There
related to Vertebrate integrins · 6
Integrin → Beta-1, Gene, Integrins, Once, Some, The
see also · 3
Integrin → D-dimerDisintegrinExopolymerExtracellular, EPS, XPS
AlphaFold · 2
Integrin → IPR013649, PF08441

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

integrins cell ecm membrane binding subunits ligands adhesion also ligand structure proteins extracellular signaling one surface interaction receptors signal transmembrane

Integrin relationships Subject–Predicate–Object triples

TTTA extracted 114 structured relationships around Integrin. Examples in this analysis include Integrin → AlphaFold → IPR013649 and Integrin → AlphaFold → PF08441. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
IntegrinAlphaFoldIPR0136491.00infobox
IntegrinAlphaFoldPF084411.00infobox
IntegrinAvailable protein structures:IPR0136491.00infobox
IntegrinAvailable protein structures:PF084411.00infobox
IntegrinInterProIPR0136491.00infobox
IntegrinMembranome131.00infobox
IntegrinOPM protein2knc1.00infobox
IntegrinOPM superfamily1761.00infobox
IntegrinPDBIPR013649 PF08441 (ECOD; PDBsum)1.00infobox
IntegrinPfamPF084411.00infobox
IntegrinPfam clanCL01591.00infobox
IntegrinSCOP21jv2 / SCOPe / SUPFAM1.00infobox
IntegrinSymbolIntegrin_alphaVbeta31.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Integrin bring nearby vocabulary together. In this analysis, examples include Membrane, Ligand and Surface. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • transmembrane receptors
    • Transduction
    • Signal
    • Extracellular
    • Membrane
    • Ligand
    • Proteins
    • Also
    • Attachment
    • Binding
    • Cytoplasmic
    • Kinases
    • Matrix
  • extracellular matrix
    • Matrix
    • Complexes
    • Transmembrane
    • Ecm
    • Membrane
    • Structure
    • Integrin
    • Also
    • Receptors
    • Integrins
    • Bind
    • Changes
  • cell cycle
    • Integrins
    • Signaling
    • Ecm
    • Adhesion
    • Membrane
    • Surface
    • Integrin
    • Interaction
    • Binding
    • Also
    • Matrix
    • Cytoplasmic
  • cell adhesion molecules
    • Integrins
    • Complexes
    • Signaling
    • Ecm
    • Adhesion
    • Cell
    • Membrane
    • Surface
    • Integrin
    • Proteins
    • Interaction
    • Kinases
  • cell membrane
    • Integrins
    • Integrin
    • Cytoplasmic
    • Proteins
    • Signaling
    • Ecm
    • Adhesion
    • Membrane
    • Surface
    • Interaction
    • Transmembrane
    • Binding
  • cell adhesion
    • Integrins
    • Complexes
    • Signaling
    • Ecm
    • Adhesion
    • Cell
    • Membrane
    • Surface
    • Integrin
    • Proteins
    • Interaction
    • Kinases
  • cell migration
    • Integrins
    • Signaling
    • Ecm
    • Adhesion
    • Membrane
    • Surface
    • Integrin
    • Interaction
    • Binding
    • Also
    • Matrix
    • Cytoplasmic
  • cell growth
    • Integrins
    • Signaling
    • Ecm
    • Adhesion
    • Membrane
    • Surface
    • Integrin
    • Interaction
    • Binding
    • Also
    • Matrix
    • Cytoplasmic

Connections between topic areas Semantic bridges

For Integrin, one of the stronger structural bridges in this analysis connects Integrin with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
IntegrinStructure · splits 57 ⟂ 36
IntegrinFunction · splits 63 ⟂ 30
IntegrinOverview · splits 72 ⟂ 21
IntegrinIntegrins and nerve repair · splits 88 ⟂ 5

Map overview Semantic statistics

Integrin

Nodes93
Edges92
Triples114
Avg. degree1.98
Density0.021505
Components1

Source & methodology

TTTA analyzes the structure around Integrin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Integrin · EN edition · Analysis: TopicsToTalkAbout

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