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Integrin: Structure, Function & Overview

Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. The presence of…

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Integrin topic overview

The analysis highlights Structure, Function and Overview as prominent areas in the source structure around Integrin.

Related topics
87
Source areas
4
Connected nodes
91
Extracted relationships
81
Related term clusters
28
Bridge connections
91

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 34 topics
Function · 29 topics
Overview · 20 topics
Integrins and nerve repair · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR013649 · PF08441
Available protein structures:
IPR013649 · PF08441
InterPro
IPR013649
Membranome
13
OPM protein
2knc
OPM superfamily
176

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Integrin
7Transmembrane receptors · Extracellular matrix · Signal transduction
7Microfilament · Ligand · Fibronectin
5Cell membrane · Nanometre · N-terminus
6Cadherin · Immunoglobulin superfamily · Cell adhesion molecule

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Integrins and nerve repair

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Integrin connects Entity context

The extracted context around Integrin shows recurring relationship patterns in the source. For example, Integrin → A-domains, Caenorhabditis, Despite, Drosophila, ECM, GPIIbIIIa, Integrins, Low-resolution, NMR, Perhaps, RGD-ligand, RGD-sequence, RNA, Several, The X-ray, V-shape, Variants Another extracted example is Integrin → Among, Cell, CRK, ECM, EGF, FAK, Integrins, Src, Thus, Together, VEGF. Use these groups to spot repeated connection types before inspecting the individual relationships.

Integrin

Top relations

related to Structure · 17
Integrin → A-domains, Caenorhabditis, Despite, Drosophila, ECM, GPIIbIIIa, Integrins, Low-resolution, NMR, Perhaps, RGD-ligand, RGD-sequence, RNA, Several, The X-ray, V-shape, Variants
related to Attachment of cell to the ECM · 11
Integrin → Among, Cell, CRK, ECM, EGF, FAK, Integrins, Src, Thus, Together, VEGF
related to Activation · 10
Integrin → ECM, EM, Kindlin-1, Kindlin-2, Moreover, One, Recently, Talin, Therefore, Unfortunately
related to Signal transduction · 7
Integrin → Clustering, ECM, Gab1/Shp2, IGF1R, Integrins, RTK, Shp2
related to Function · 5
Integrin → ECM, GpIIb/IIIa, Integrins, Recently, Upon
related to Integrins and nerve repair · 4
Integrin → CNS, ECM, Integrins, PNS
related to Vertebrate integrins · 3
Integrin → Beta-1, Gene, Integrins
AlphaFold · 2
Integrin → IPR013649, PF08441
Available protein structures: · 2
Integrin → IPR013649, PF08441
InterPro · 1
Integrin → IPR013649

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

integrins cell ecm membrane binding subunits ligands adhesion also ligand structure proteins extracellular signaling one surface interaction receptors signal transmembrane

Integrin relationships Subject–Predicate–Object triples

TTTA extracted 81 structured relationships around Integrin. Examples in this analysis include Integrin → AlphaFold → IPR013649 and Integrin → AlphaFold → PF08441. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
IntegrinAlphaFoldIPR0136491.00infobox
IntegrinAlphaFoldPF084411.00infobox
IntegrinAvailable protein structures:IPR0136491.00infobox
IntegrinAvailable protein structures:PF084411.00infobox
IntegrinInterProIPR0136491.00infobox
IntegrinMembranome131.00infobox
IntegrinOPM protein2knc1.00infobox
IntegrinOPM superfamily1761.00infobox
IntegrinPDBIPR013649 PF08441 (ECOD; PDBsum)1.00infobox
IntegrinPfamPF084411.00infobox
IntegrinPfam clanCL01591.00infobox
IntegrinSCOP21jv2 / SCOPe / SUPFAM1.00infobox
IntegrinSymbolIntegrin_alphaVbeta31.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Integrin bring nearby vocabulary together. In this analysis, examples include Membrane, Ligand and Surface. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • transmembrane receptors
    • Transduction
    • Signal
    • Extracellular
    • Membrane
    • Ligand
    • Proteins
    • Also
    • Attachment
    • Binding
    • Cytoplasmic
    • Kinases
    • Matrix
  • extracellular matrix
    • Matrix
    • Complexes
    • Transmembrane
    • Ecm
    • Membrane
    • Structure
    • Integrin
    • Also
    • Receptors
    • Integrins
    • Bind
    • Changes
  • cell cycle
    • Integrins
    • Signaling
    • Ecm
    • Adhesion
    • Membrane
    • Surface
    • Integrin
    • Interaction
    • Binding
    • Also
    • Matrix
    • Cytoplasmic
  • cell adhesion molecules
    • Integrins
    • Complexes
    • Signaling
    • Ecm
    • Adhesion
    • Cell
    • Membrane
    • Surface
    • Integrin
    • Proteins
    • Interaction
    • Kinases
  • cell membrane
    • Integrins
    • Integrin
    • Cytoplasmic
    • Proteins
    • Signaling
    • Ecm
    • Adhesion
    • Membrane
    • Surface
    • Interaction
    • Transmembrane
    • Binding
  • cell adhesion
    • Integrins
    • Complexes
    • Signaling
    • Ecm
    • Adhesion
    • Cell
    • Membrane
    • Surface
    • Integrin
    • Proteins
    • Interaction
    • Kinases
  • cell migration
    • Integrins
    • Signaling
    • Ecm
    • Adhesion
    • Membrane
    • Surface
    • Integrin
    • Interaction
    • Binding
    • Also
    • Matrix
    • Cytoplasmic
  • cell growth
    • Integrins
    • Signaling
    • Ecm
    • Adhesion
    • Membrane
    • Surface
    • Integrin
    • Interaction
    • Binding
    • Also
    • Matrix
    • Cytoplasmic

Connections between topic areas Semantic bridges

For Integrin, one of the stronger structural bridges in this analysis connects Integrin with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Integrin — Structure · splits 57 ⟂ 35
Integrin — Function · splits 62 ⟂ 30
Integrin — Overview · splits 71 ⟂ 21
Integrin — Integrins and nerve repair · splits 87 ⟂ 5

Map overview Semantic statistics

Integrin

Nodes92
Edges91
Triples81
Avg. degree1.98
Density0.021739
Components1

Source & methodology

TTTA analyzes the structure around Integrin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Integrin · EN edition · Analysis: TopicsToTalkAbout

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