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APBB1: Interactions & Overview

Amyloid beta A4 precursor protein-binding family B member 1 is a protein that in humans is encoded by the APBB1 gene.

Language: English [EN]
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APBB1 topic overview

The analysis highlights Interactions and Overview as prominent areas in the source structure around APBB1.

Related topics
7
Source areas
2
Connected nodes
9
Extracted relationships
114
Concept neighborhoods
5
Bridge connections
9

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 5 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
APBB1, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65), FE65, MGC:9072, RIR, amyloid beta precursor protein binding family B member 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E45, 2HO2, 2IDH, 3D8D, 3D8E, 3D8F, 3DXC, 3DXD, 3DXE
Band
11p15.4 · 7 E3|7 55.9 cM
Bgee
right hemisphere of cerebellum · right frontal lobe · C1 segment · ganglionic eminence · prefrontal cortex
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 7 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How APBB1 connects Entity context

The extracted context around APBB1 shows recurring relationship patterns in the source. For example, APBB1 → amyloid-beta binding, apoptotic process, axonogenesis, cell projection, cellular response to DNA damage stimulus, chromatin binding, chromatin organization, cytoplasm, dendritic spine, double-strand break repair, growth cone, growth cone filopodium, growth cone lamellipodium, histone binding, histone H4 acetylation, lamellipodium, main axon, membrane, negative regulation of cell growth, negative regulation of transcription by RNA polymerase II Another extracted example is APBB1 → amygdala, anterior cingulate cortex, anterior pituitary, Brodmann area 9, C1 segment, CA3 field, cerebellar cortex, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, ganglionic eminence, habenula, perirhinal cortex, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, superior frontal gyrus. Use these groups to spot repeated connection types before inspecting the individual relationships.

APBB1

Top relations

Gene ontology · 47
APBB1 → amyloid-beta binding, apoptotic process, axonogenesis, cell projection, cellular response to DNA damage stimulus, chromatin binding, chromatin organization, cytoplasm, dendritic spine, double-strand break repair, growth cone, growth cone filopodium, growth cone lamellipodium, histone binding, histone H4 acetylation, lamellipodium, main axon, membrane, negative regulation of cell growth, negative regulation of transcription by RNA polymerase II
Bgee · 19
APBB1 → amygdala, anterior cingulate cortex, anterior pituitary, Brodmann area 9, C1 segment, CA3 field, cerebellar cortex, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, ganglionic eminence, habenula, perirhinal cortex, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, superior frontal gyrus
RNA expression pattern · 19
APBB1 → amygdala, anterior cingulate cortex, anterior pituitary, Brodmann area 9, C1 segment, CA3 field, cerebellar cortex, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, ganglionic eminence, habenula, perirhinal cortex, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, superior frontal gyrus
related to Interactions · 4
APBB1 → Amyloid, APLP2, LRP1, TFCP2
Band · 2
APBB1 → 11p15.4, 7 E3|7 55.9 cM
Chr. · 2
APBB1 → Chromosome 11 (human), Chromosome 7 (mouse)
End · 2
APBB1 → 105,230,860 bp, 6,419,414 bp
related to External links · 2
APBB1 → Human APBB1, UCSC Genome Browser
Aliases · 1
APBB1 → APBB1, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65), FE65, MGC:9072, RIR, amyloid beta precursor protein binding family B member 1
Available structures · 1
APBB1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E45, 2HO2, 2IDH, 3D8D, 3D8E, 3D8F, 3DXC, 3DXD, 3DXE

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein bp human chr band chromosome 11 amyloid precursor location family member encoded mouse transcription beta a4 protein-binding function

APBB1 relationships Subject–Predicate–Object triples

TTTA extracted 114 structured relationships around APBB1. Examples in this analysis include APBB1 → Aliases → APBB1, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65), FE65, MGC:9072, RIR, amyloid beta precursor protein binding family B member 1 and APBB1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E45, 2HO2, 2IDH, 3D8D, 3D8E, 3D8F, 3DXC, 3DXD, 3DXE. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
APBB1AliasesAPBB1, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65), FE65, MGC:9072, RIR, amyloid beta precursor protein binding family B member 11.00infobox
APBB1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E45, 2HO2, 2IDH, 3D8D, 3D8E, 3D8F, 3DXC, 3DXD, 3DXE1.00infobox
APBB1Band11p15.41.00infobox
APBB1Band7 E3|7 55.9 cM1.00infobox
APBB1Bgeeright hemisphere of cerebellum1.00infobox
APBB1Bgeeright frontal lobe1.00infobox
APBB1BgeeC1 segment1.00infobox
APBB1Bgeeganglionic eminence1.00infobox
APBB1Bgeeprefrontal cortex1.00infobox
APBB1Bgeeanterior pituitary1.00infobox
APBB1Bgeecingulate gyrus1.00infobox
APBB1BgeeBrodmann area 91.00infobox
APBB1Bgeeanterior cingulate cortex1.00infobox
APBB1Bgeeamygdala1.00infobox
APBB1Bgeeentorhinal cortex1.00infobox
APBB1Bgeeperirhinal cortex1.00infobox
APBB1Bgeeprimary visual cortex1.00infobox
APBB1BgeeCA3 field1.00infobox
APBB1Bgeesuperior frontal gyrus1.00infobox
APBB1Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
APBB1Bgeehabenula1.00infobox
APBB1Bgeeprimary motor cortex1.00infobox
APBB1Bgeecerebellar cortex1.00infobox
APBB1BioGPSMore reference expression data1.00infobox
APBB1Chr.Chromosome 11 (human)1.00infobox
APBB1Chr.Chromosome 7 (mouse)1.00infobox
APBB1DatabasesNCBI: entry; OMA: entry1.00infobox
APBB1End6,419,414 bp1.00infobox
APBB1End105,230,860 bp1.00infobox
APBB1EnsemblENSG000001663131.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around APBB1 bring nearby vocabulary together. In this analysis, examples include Family, Member and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • APBB1
    • Family
    • Member
    • Gene
    • Location
    • Precursor
    • Protein
    • Human
    • Beta
    • Binding
    • Fe65
    • Function
    • Protein-binding
  • apbb1
    • Family
    • Member
    • Gene
    • Location
    • Precursor
    • Protein
    • Human
    • Beta
    • Binding
    • Fe65
    • Function
    • Protein-binding
  • protein
    • Alzheimer's
    • Binding
    • Disease
    • Factor
    • Fe65
    • Function
    • Nucleus
    • Protein-binding
    • Search
    • Transcription
    • Chromosome
    • Location
  • gene
    • Location
    • Human
    • Member
    • Chromosome
    • Bp
    • Chr
    • Binding
    • E3
    • End
    • Fe65
    • Function
    • Mouse
  • amyloid precursor protein
    • Precursor
    • Protein
    • A4
    • Apbb1
    • Beta
    • Protein-binding
    • Family
    • Member
    • Alzheimer's
    • Binding
    • Disease
    • Factor

Connections between topic areas Semantic bridges

For APBB1, one of the stronger structural bridges in this analysis connects APBB1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
APBB1Interactions · splits 4 ⟂ 6
APBB1Overview · splits 7 ⟂ 3

Map overview Semantic statistics

APBB1

Nodes10
Edges9
Triples114
Avg. degree1.8
Density0.2
Components1

Source & methodology

TTTA analyzes the structure around APBB1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — APBB1 · EN edition · Analysis: TopicsToTalkAbout

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