Furin

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Clinical significance

Gp160 Gp120 Gp41 Golgi apparatus HIV

18 related topics

Function

Protein Proprotein convertases Endoprotease Parathyroid hormone Transforming growth factor beta 1

11 related topics

Interactions

Interact PACS1

2 related topics

Overview

Protease Enzyme Substrate presentation Gene Oncogene

8 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.21.75: ↗
Aliases: FURIN, FUR, PACE, PCSK3, SPC1, furin, paired basic amino acid cleaving enzyme
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4OMC, 4OMD, 4RYD, 4Z2A
Band: 15q26.1 · 7 D2|7 45.65 cM
Bgee: right lobe of liver · body of pancreas · right lung · right lobe of thyroid gland · left lobe of thyroid gland
BioGPS: More reference expression data

Topics to explore

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Interactions

Interact Protein-protein interaction
PACS1

Advanced semantic analysis

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Map overview Semantic statistics

Nodes44

Edges43

Triples168

Avg. degree1.95

Density0.045455

Components1

How this topic connects Entity context

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Furin

Top relations

Gene ontology · 57

Furin → cell population proliferation, cell surface, collagen catabolic process, cornification, dibasic protein processing, endopeptidase activity, endoplasmic reticulum, endosome, endosome membrane, extracellular exosome, extracellular matrix disassembly, extracellular matrix organization, extracellular region, extracellular space, Golgi apparatus, Golgi lumen, Golgi membrane, hydrolase activity, integral component of Golgi membrane, integral component of membrane

Bgee · 20

Furin → anterior pituitary, apex of heart, body of pancreas, corneal stroma, epithelium of stomach, extensor digitorum longus muscle, granulocyte, Ileal epithelium, lactiferous gland, left lobe of thyroid gland, lip, parotid gland, right kidney, right lobe of liver, right lobe of thyroid gland, right lung, salivary gland, secondary oocyte, skin of leg, upper lobe of left lung

RNA expression pattern · 20

related to Function · 15

Furin → Both, COOH-terminus, Ganz, HJV, HJV/hemojuvelin, PiTou, PPC, ProP, RGMc, RNRR, Rotwein, Some, The, This, Willebrand

related to Clinical significance · 13

Furin → Arg, Arg-X, Arg/Lys, For, Golgi, HIV, In, S1, S2, SARS-CoV-2, The, This, When SARS-CoV-2

related to External links · 8

Furin → Human Furin, Mouse Furin, Overview, P09958, P23188, PDB, PDBe-KB, UniProt

Band · 2

Furin → 15q26.1, 7 D2|7 45.65 cM

Chr. · 2

Furin → Chromosome 15 (human), Chromosome 7 (mouse)

End · 2

Furin → 80,055,184 bp, 90,883,458 bp

is a · 2

Furin → protease, subtilisin-like peptidase

Important terminology Word statistics

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Important terminology

gene protein proteins bp human chr enzyme band region chromosome 15 known basic amino acid precursor also protease mouse fes

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Furin	3.4.21.75	↗	1.00	infobox
Furin	Aliases	FURIN, FUR, PACE, PCSK3, SPC1, furin, paired basic amino acid cleaving enzyme	1.00	infobox
Furin	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4OMC, 4OMD, 4RYD, 4Z2A	1.00	infobox
Furin	Band	15q26.1	1.00	infobox
Furin	Band	7 D2\|7 45.65 cM	1.00	infobox
Furin	Bgee	right lobe of liver	1.00	infobox
Furin	Bgee	body of pancreas	1.00	infobox
Furin	Bgee	right lung	1.00	infobox
Furin	Bgee	right lobe of thyroid gland	1.00	infobox
Furin	Bgee	left lobe of thyroid gland	1.00	infobox
Furin	Bgee	apex of heart	1.00	infobox
Furin	Bgee	skin of leg	1.00	infobox
Furin	Bgee	upper lobe of left lung	1.00	infobox
Furin	Bgee	salivary gland	1.00	infobox
Furin	Bgee	anterior pituitary	1.00	infobox
Furin	Bgee	epithelium of stomach	1.00	infobox
Furin	Bgee	Ileal epithelium	1.00	infobox
Furin	Bgee	parotid gland	1.00	infobox
Furin	Bgee	granulocyte	1.00	infobox
Furin	Bgee	lip	1.00	infobox
Furin	Bgee	right kidney	1.00	infobox
Furin	Bgee	lactiferous gland	1.00	infobox
Furin	Bgee	corneal stroma	1.00	infobox
Furin	Bgee	extensor digitorum longus muscle	1.00	infobox
Furin	Bgee	secondary oocyte	1.00	infobox
Furin	BioGPS	More reference expression data	1.00	infobox
Furin	Chr.	Chromosome 15 (human)	1.00	infobox
Furin	Chr.	Chromosome 7 (mouse)	1.00	infobox
Furin	Databases	NCBI: entry; OMA: entry	1.00	infobox
Furin	End	90,883,458 bp	1.00	infobox

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