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Furin is a protease, a proteolytic enzyme activated by substrate presentation that in humans and other animals is encoded by the FURIN gene. Some proteins are inactive when they are first synthesized, and must have sections removed in order to become active. Furin cleaves these sections and activates the proteins. It was named furin because it was in the…
The analysis highlights Regions, Clinical significance and Function as prominent areas in the source structure around Furin.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Furin shows recurring relationship patterns in the source. For example, Furin → cell population proliferation, cell surface, collagen catabolic process, cornification, dibasic protein processing, endopeptidase activity, endoplasmic reticulum, endosome, endosome membrane, extracellular exosome, extracellular matrix disassembly, extracellular matrix organization, extracellular region, extracellular space, Golgi apparatus, Golgi lumen, Golgi membrane, hydrolase activity, integral component of Golgi membrane, integral component of membrane Another extracted example is Furin → anterior pituitary, apex of heart, body of pancreas, corneal stroma, epithelium of stomach, extensor digitorum longus muscle, granulocyte, Ileal epithelium, lactiferous gland, left lobe of thyroid gland, lip, parotid gland, right kidney, right lobe of liver, right lobe of thyroid gland, right lung, salivary gland, secondary oocyte, skin of leg, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene protein proteins bp human chr enzyme band region chromosome 15 known basic amino acid precursor also protease mouse fes
TTTA extracted 168 structured relationships around Furin. Examples in this analysis include Furin → 3.4.21.75 → ↗ and Furin → Aliases → FURIN, FUR, PACE, PCSK3, SPC1, furin, paired basic amino acid cleaving enzyme. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Furin | 3.4.21.75 | ↗ | 1.00 | infobox |
| Furin | Aliases | FURIN, FUR, PACE, PCSK3, SPC1, furin, paired basic amino acid cleaving enzyme | 1.00 | infobox |
| Furin | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4OMC, 4OMD, 4RYD, 4Z2A | 1.00 | infobox |
| Furin | Band | 15q26.1 | 1.00 | infobox |
| Furin | Band | 7 D2|7 45.65 cM | 1.00 | infobox |
| Furin | Bgee | right lobe of liver | 1.00 | infobox |
| Furin | Bgee | body of pancreas | 1.00 | infobox |
| Furin | Bgee | right lung | 1.00 | infobox |
| Furin | Bgee | right lobe of thyroid gland | 1.00 | infobox |
| Furin | Bgee | left lobe of thyroid gland | 1.00 | infobox |
| Furin | Bgee | apex of heart | 1.00 | infobox |
| Furin | Bgee | skin of leg | 1.00 | infobox |
| Furin | Bgee | upper lobe of left lung | 1.00 | infobox |
| Furin | Bgee | salivary gland | 1.00 | infobox |
| Furin | Bgee | anterior pituitary | 1.00 | infobox |
| Furin | Bgee | epithelium of stomach | 1.00 | infobox |
| Furin | Bgee | Ileal epithelium | 1.00 | infobox |
| Furin | Bgee | parotid gland | 1.00 | infobox |
| Furin | Bgee | granulocyte | 1.00 | infobox |
| Furin | Bgee | lip | 1.00 | infobox |
| Furin | Bgee | right kidney | 1.00 | infobox |
| Furin | Bgee | lactiferous gland | 1.00 | infobox |
| Furin | Bgee | corneal stroma | 1.00 | infobox |
| Furin | Bgee | extensor digitorum longus muscle | 1.00 | infobox |
| Furin | Bgee | secondary oocyte | 1.00 | infobox |
| Furin | BioGPS | More reference expression data | 1.00 | infobox |
| Furin | Chr. | Chromosome 15 (human) | 1.00 | infobox |
| Furin | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| Furin | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Furin | End | 90,883,458 bp | 1.00 | infobox |
The concept neighborhoods around Furin bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Proteins. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Furin, one of the stronger structural bridges in this analysis connects Furin with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Furin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Furin · EN edition · Analysis: TopicsToTalkAbout