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Furin: Regions, Clinical significance & Function

Furin is a protease, a proteolytic enzyme activated by substrate presentation that in humans and other animals is encoded by the FURIN gene. Some proteins are inactive when they are first synthesized, and must have sections removed in order to become active. Furin cleaves these sections and activates the proteins. It was named furin because it was in the…

Language: English [EN]
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Furin topic overview

The analysis highlights Regions, Clinical significance and Function as prominent areas in the source structure around Furin.

Related topics
39
Source areas
4
Connected nodes
43
Extracted relationships
168
Concept neighborhoods
9
Bridge connections
43

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 18 topics
Function · 11 topics
Overview · 8 topics
Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.21.75
Aliases
FURIN, FUR, PACE, PCSK3, SPC1, furin, paired basic amino acid cleaving enzyme
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4OMC, 4OMD, 4RYD, 4Z2A
Band
15q26.1 · 7 D2|7 45.65 cM
Bgee
right lobe of liver · body of pancreas · right lung · right lobe of thyroid gland · left lobe of thyroid gland
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Furin connects Entity context

The extracted context around Furin shows recurring relationship patterns in the source. For example, Furin → cell population proliferation, cell surface, collagen catabolic process, cornification, dibasic protein processing, endopeptidase activity, endoplasmic reticulum, endosome, endosome membrane, extracellular exosome, extracellular matrix disassembly, extracellular matrix organization, extracellular region, extracellular space, Golgi apparatus, Golgi lumen, Golgi membrane, hydrolase activity, integral component of Golgi membrane, integral component of membrane Another extracted example is Furin → anterior pituitary, apex of heart, body of pancreas, corneal stroma, epithelium of stomach, extensor digitorum longus muscle, granulocyte, Ileal epithelium, lactiferous gland, left lobe of thyroid gland, lip, parotid gland, right kidney, right lobe of liver, right lobe of thyroid gland, right lung, salivary gland, secondary oocyte, skin of leg, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.

Furin

Top relations

Gene ontology · 57
Furin → cell population proliferation, cell surface, collagen catabolic process, cornification, dibasic protein processing, endopeptidase activity, endoplasmic reticulum, endosome, endosome membrane, extracellular exosome, extracellular matrix disassembly, extracellular matrix organization, extracellular region, extracellular space, Golgi apparatus, Golgi lumen, Golgi membrane, hydrolase activity, integral component of Golgi membrane, integral component of membrane
Bgee · 20
Furin → anterior pituitary, apex of heart, body of pancreas, corneal stroma, epithelium of stomach, extensor digitorum longus muscle, granulocyte, Ileal epithelium, lactiferous gland, left lobe of thyroid gland, lip, parotid gland, right kidney, right lobe of liver, right lobe of thyroid gland, right lung, salivary gland, secondary oocyte, skin of leg, upper lobe of left lung
RNA expression pattern · 20
Furin → anterior pituitary, apex of heart, body of pancreas, corneal stroma, epithelium of stomach, extensor digitorum longus muscle, granulocyte, Ileal epithelium, lactiferous gland, left lobe of thyroid gland, lip, parotid gland, right kidney, right lobe of liver, right lobe of thyroid gland, right lung, salivary gland, secondary oocyte, skin of leg, upper lobe of left lung
related to Function · 15
Furin → Both, COOH-terminus, Ganz, HJV, HJV/hemojuvelin, PiTou, PPC, ProP, RGMc, RNRR, Rotwein, Some, The, This, Willebrand
related to Clinical significance · 13
Furin → Arg, Arg-X, Arg/Lys, For, Golgi, HIV, In, S1, S2, SARS-CoV-2, The, This, When SARS-CoV-2
related to External links · 8
Furin → Human Furin, Mouse Furin, Overview, P09958, P23188, PDB, PDBe-KB, UniProt
Band · 2
Furin → 15q26.1, 7 D2|7 45.65 cM
Chr. · 2
Furin → Chromosome 15 (human), Chromosome 7 (mouse)
End · 2
Furin → 80,055,184 bp, 90,883,458 bp
is a · 2
Furin → protease, subtilisin-like peptidase

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein proteins bp human chr enzyme band region chromosome 15 known basic amino acid precursor also protease mouse fes

Furin relationships Subject–Predicate–Object triples

TTTA extracted 168 structured relationships around Furin. Examples in this analysis include Furin → 3.4.21.75 → ↗ and Furin → Aliases → FURIN, FUR, PACE, PCSK3, SPC1, furin, paired basic amino acid cleaving enzyme. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Furin3.4.21.751.00infobox
FurinAliasesFURIN, FUR, PACE, PCSK3, SPC1, furin, paired basic amino acid cleaving enzyme1.00infobox
FurinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4OMC, 4OMD, 4RYD, 4Z2A1.00infobox
FurinBand15q26.11.00infobox
FurinBand7 D2|7 45.65 cM1.00infobox
FurinBgeeright lobe of liver1.00infobox
FurinBgeebody of pancreas1.00infobox
FurinBgeeright lung1.00infobox
FurinBgeeright lobe of thyroid gland1.00infobox
FurinBgeeleft lobe of thyroid gland1.00infobox
FurinBgeeapex of heart1.00infobox
FurinBgeeskin of leg1.00infobox
FurinBgeeupper lobe of left lung1.00infobox
FurinBgeesalivary gland1.00infobox
FurinBgeeanterior pituitary1.00infobox
FurinBgeeepithelium of stomach1.00infobox
FurinBgeeIleal epithelium1.00infobox
FurinBgeeparotid gland1.00infobox
FurinBgeegranulocyte1.00infobox
FurinBgeelip1.00infobox
FurinBgeeright kidney1.00infobox
FurinBgeelactiferous gland1.00infobox
FurinBgeecorneal stroma1.00infobox
FurinBgeeextensor digitorum longus muscle1.00infobox
FurinBgeesecondary oocyte1.00infobox
FurinBioGPSMore reference expression data1.00infobox
FurinChr.Chromosome 15 (human)1.00infobox
FurinChr.Chromosome 7 (mouse)1.00infobox
FurinDatabasesNCBI: entry; OMA: entry1.00infobox
FurinEnd90,883,458 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Furin bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Proteins. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Furin
    • Gene
    • Protein
    • Proteins
    • Enzyme
    • Region
    • Available
    • Known
    • Pdb
    • Uniprot
    • Acid
    • Amino
    • Basic
  • furin
    • Gene
    • Protein
    • Proteins
    • Enzyme
    • Region
    • Available
    • Known
    • Pdb
    • Uniprot
    • Acid
    • Amino
    • Basic
  • enzyme
    • Cleaving
    • Pace
    • Encoded
    • Location
    • Paired
    • Protease
    • Gene
    • Acid
    • Amino
    • Basic
    • Chromosome
    • Bp
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Human
    • Fur
    • Mouse
    • Protease
    • Band
    • Processing
    • Region
    • Protein
  • protein
    • Furin-like
    • Processing
    • Region
    • Proteins
    • Peptidase
    • Upstream
    • Family
    • Location
    • Mouse
    • Paired
    • Protease
    • Uniprot
  • spike protein
    • Furin-like
    • Processing
    • Region
    • Proteins
    • Peptidase
    • Upstream
    • Family
    • Location
    • Mouse
    • Paired
    • Protease
    • Uniprot
  • family s8
    • Peptidase
    • Location
    • Mouse
    • Protease
    • Uniprot
    • Band
    • Chromosome
    • Processing
    • Region
    • Bp
    • Chr
    • Human
  • fes
    • Named
    • Upstream
    • Known
    • Region
    • Fur
    • Gene
    • Protein
    • Furin

Connections between topic areas Semantic bridges

For Furin, one of the stronger structural bridges in this analysis connects Furin with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
FurinClinical significance · splits 25 ⟂ 19
FurinFunction · splits 32 ⟂ 12
FurinOverview · splits 35 ⟂ 9
FurinInteractions · splits 41 ⟂ 3

Map overview Semantic statistics

Furin

Nodes44
Edges43
Triples168
Avg. degree1.95
Density0.045455
Components1

Source & methodology

TTTA analyzes the structure around Furin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Furin · EN edition · Analysis: TopicsToTalkAbout

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