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Platelet-derived growth factor

Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In particular, PDGF plays a significant role in blood vessel formation, the growth of blood vessels from already-existing blood vessel tissue, mitogenesis, i.e. proliferation, of mesenchymal cells such as fibroblasts, osteoblasts, tenocytes…

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Explore the main themes, entities and connections around Platelet-derived growth factor. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Mechanisms

Cell surfacePhosphorylationCytosolicSignal transductionPI3K
12 related topics

Types and classification

IsoformsReceptorsLigandsPDGFAPDGFB
11 related topics

Function

MesenchymeProgenitorEmbryonicDiseasesAtherosclerosis
7 related topics

History

Signaling pathways
1 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR000072 · PF00341
Available protein structures:
IPR000072 · PF00341
InterPro
IPR000072
PDB
IPR000072 PF00341 (ECOD; PDBsum)
Pfam
PF00341
PROSITE
PDOC00222

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Overview

Types and classification

Mechanisms

Function

History

Research

Family members

  • PGF Placental growth factor
  • VEGF Vascular endothelial growth factor
  • VEGFB Vascular endothelial growth factor B
  • VEGFC Vascular endothelial growth factor C
  • VEGFD Vascular endothelial growth factor D

Advanced semantic analysis

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Map overview Semantic statistics

Platelet-derived growth factor

Nodes65
Edges64
Triples36
Avg. degree1.97
Density0.030769
Components1

How this topic connects Entity context

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Platelet-derived growth factor

Top relations

related to Family members · 8
Platelet-derived growth factor → Human, PDGFA, PDGFB, PDGFC, PDGFDPGFVEGF, VEGFB, VEGFC, VEGFD
AlphaFold · 2
Platelet-derived growth factor → IPR000072, PF00341
Available protein structures: · 2
Platelet-derived growth factor → IPR000072, PF00341
InterPro · 1
Platelet-derived growth factor → IPR000072
PDB · 1
Platelet-derived growth factor → IPR000072 PF00341 (ECOD; PDBsum)
Pfam · 1
Platelet-derived growth factor → PF00341
PROSITE · 1
Platelet-derived growth factor → PDOC00222
SCOP2 · 1
Platelet-derived growth factor → 1pdg / SCOPe / SUPFAM
Symbol · 1
Platelet-derived growth factor → PDGF
is a · 1
Platelet-derived growth factor → dimeric glycoprotein that can be composed of two A subunits

Important terminology Word statistics

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Important terminology

pdgf growth cells cell factor proliferation factors also two receptor receptors fibroblasts bone smooth muscle including mesenchymal human platelet-derived shown

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Platelet-derived growth factorAlphaFoldIPR0000721.00infobox
Platelet-derived growth factorAlphaFoldPF003411.00infobox
Platelet-derived growth factorAvailable protein structures:IPR0000721.00infobox
Platelet-derived growth factorAvailable protein structures:PF003411.00infobox
Platelet-derived growth factorInterProIPR0000721.00infobox
Platelet-derived growth factorPDBIPR000072 PF00341 (ECOD; PDBsum)1.00infobox
Platelet-derived growth factorPfamPF003411.00infobox
Platelet-derived growth factorPROSITEPDOC002221.00infobox
Platelet-derived growth factorSCOP21pdg / SCOPe / SUPFAM1.00infobox
Platelet-derived growth factorSymbolPDGF1.00infobox
Platelet-derived growth factoris adimeric glycoprotein that can be composed of two A subunits0.90text
fibroblastsinstance ofof mesenchymal cells0.80text

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    Min side: 3
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