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Tissue factor pathway inhibitor: Regions, Genetics & Protein structure

Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.

Language: English [EN]
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Tissue factor pathway inhibitor topic overview

The analysis highlights Regions, Genetics and Protein structure as prominent areas in the source structure around Tissue factor pathway inhibitor.

Related topics
12
Source areas
4
Connected nodes
16
Extracted relationships
87
Related term clusters
11
Bridge connections
16

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Genetics · 4 topics
Overview · 3 topics
Protein structure · 3 topics
Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4DTG, 1ADZ, 1IRH, 1TFX, 4BQD
Band
2q32.1 · 2|2 D
Bgee
right lung · lower lobe of lung · visceral pleura · upper lobe of lung · placenta
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 2 (mouse)

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Genetics

Protein structure

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Tissue factor pathway inhibitor connects Entity context

The extracted context around Tissue factor pathway inhibitor shows recurring relationship patterns in the source. For example, Tissue factor pathway inhibitor → anchored component of membrane, blood coagulation, blood coagulation, extrinsic pathway, caveola, cell surface, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to steroid hormone stimulus, endopeptidase inhibitor activity, endoplasmic reticulum, extracellular region, extracellular space, hemostasis, intracellular membrane-bounded organelle, membrane, negative regulation of blood coagulation, negative regulation of endopeptidase activity, negative regulation of peptidase activity, organelle membrane, peptidase inhibitor activity Another extracted example is Tissue factor pathway inhibitor → atrioventricular valve, decidua, dermis, efferent ductule, endocardial cushion, endothelial cell of lymphatic vessel, gastrula, liver, lower lobe of lung, pericardium, placenta, right lobe of liver, right lung, stromal cell of endometrium, umbilical cord, upper lobe of left lung, upper lobe of lung, vas deferens, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

Tissue factor pathway inhibitor

Top relations

Gene ontology · 24
Tissue factor pathway inhibitor → anchored component of membrane, blood coagulation, blood coagulation, extrinsic pathway, caveola, cell surface, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to steroid hormone stimulus, endopeptidase inhibitor activity, endoplasmic reticulum, extracellular region, extracellular space, hemostasis, intracellular membrane-bounded organelle, membrane, negative regulation of blood coagulation, negative regulation of endopeptidase activity, negative regulation of peptidase activity, organelle membrane, peptidase inhibitor activity
Bgee · 19
Tissue factor pathway inhibitor → atrioventricular valve, decidua, dermis, efferent ductule, endocardial cushion, endothelial cell of lymphatic vessel, gastrula, liver, lower lobe of lung, pericardium, placenta, right lobe of liver, right lung, stromal cell of endometrium, umbilical cord, upper lobe of left lung, upper lobe of lung, vas deferens, visceral pleura
RNA expression pattern · 19
Tissue factor pathway inhibitor → atrioventricular valve, decidua, dermis, efferent ductule, endocardial cushion, endothelial cell of lymphatic vessel, gastrula, liver, lower lobe of lung, pericardium, placenta, right lobe of liver, right lung, stromal cell of endometrium, umbilical cord, upper lobe of left lung, upper lobe of lung, vas deferens, visceral pleura
Band · 2
Tissue factor pathway inhibitor → 2q32.1, 2|2 D
Chr. · 2
Tissue factor pathway inhibitor → Chromosome 2 (human), Chromosome 2 (mouse)
End · 2
Tissue factor pathway inhibitor → 187,565,760 bp, 84,307,119 bp
related to Interactions · 2
Tissue factor pathway inhibitor → Factor, Tissue
Aliases · 1
Tissue factor pathway inhibitor → TFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor
Available structures · 1
Tissue factor pathway inhibitor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4DTG, 1ADZ, 1IRH, 1TFX, 4BQD
BioGPS · 1
Tissue factor pathway inhibitor → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tfpi bp human inhibitor chromosome factor chr band pathway gene xa tissue also location inhibit mouse nm protein external 152310

Tissue factor pathway inhibitor relationships Subject–Predicate–Object triples

TTTA extracted 87 structured relationships around Tissue factor pathway inhibitor. Examples in this analysis include Tissue factor pathway inhibitor → Aliases → TFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor and Tissue factor pathway inhibitor → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4DTG, 1ADZ, 1IRH, 1TFX, 4BQD. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Tissue factor pathway inhibitorAliasesTFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor1.00infobox
Tissue factor pathway inhibitorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4DTG, 1ADZ, 1IRH, 1TFX, 4BQD1.00infobox
Tissue factor pathway inhibitorBand2q32.11.00infobox
Tissue factor pathway inhibitorBand2|2 D1.00infobox
Tissue factor pathway inhibitorBgeeright lung1.00infobox
Tissue factor pathway inhibitorBgeelower lobe of lung1.00infobox
Tissue factor pathway inhibitorBgeevisceral pleura1.00infobox
Tissue factor pathway inhibitorBgeeupper lobe of lung1.00infobox
Tissue factor pathway inhibitorBgeeplacenta1.00infobox
Tissue factor pathway inhibitorBgeeupper lobe of left lung1.00infobox
Tissue factor pathway inhibitorBgeestromal cell of endometrium1.00infobox
Tissue factor pathway inhibitorBgeeliver1.00infobox
Tissue factor pathway inhibitorBgeepericardium1.00infobox
Tissue factor pathway inhibitorBgeeright lobe of liver1.00infobox
Tissue factor pathway inhibitorBgeegastrula1.00infobox
Tissue factor pathway inhibitorBgeedecidua1.00infobox
Tissue factor pathway inhibitorBgeeatrioventricular valve1.00infobox
Tissue factor pathway inhibitorBgeevas deferens1.00infobox
Tissue factor pathway inhibitorBgeedermis1.00infobox
Tissue factor pathway inhibitorBgeeendocardial cushion1.00infobox
Tissue factor pathway inhibitorBgeeendothelial cell of lymphatic vessel1.00infobox
Tissue factor pathway inhibitorBgeeefferent ductule1.00infobox
Tissue factor pathway inhibitorBgeeumbilical cord1.00infobox
Tissue factor pathway inhibitorBioGPSMore reference expression data1.00infobox
Tissue factor pathway inhibitorChr.Chromosome 2 (human)1.00infobox
Tissue factor pathway inhibitorChr.Chromosome 2 (mouse)1.00infobox
Tissue factor pathway inhibitorDatabasesNCBI: entry; OMA: entry1.00infobox
Tissue factor pathway inhibitorEnd187,565,760 bp1.00infobox
Tissue factor pathway inhibitorEnd84,307,119 bp1.00infobox
Tissue factor pathway inhibitorEnsemblENSG000000034361.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Tissue factor pathway inhibitor bring nearby vocabulary together. In this analysis, examples include Tissue, Pathway and Inhibitor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Tissue factor pathway inhibitor
    • Tissue
    • Pathway
    • Inhibitor
    • Available
    • Omim
    • Pdb
    • Tfpi1
    • Inhibit
    • External
    • Hemostasis
    • P10646
    • Protein
  • tissue factor pathway inhibitor
    • Inhibitor
    • Pathway
    • Tissue
    • Available
    • Omim
    • Pdb
    • Tfpi1
    • Tfpi
    • Hemostasis
    • Inhibit
    • P10646
    • Protein
  • factor xa
    • Tissue
    • Inhibit
    • Pathway
    • Inhibitor
    • Available
    • Omim
    • Pdb
    • Tfpi1
    • Also
    • Factor
    • Xa
    • Nm
  • tissue factor
    • Tissue
    • Pathway
    • Inhibitor
    • Available
    • Omim
    • Pdb
    • Tfpi1
    • Inhibit
    • Also
    • Xa
    • External
    • Hemostasis
  • chromosome 7
    • Gene
    • Bp
    • Human
    • Location
    • Band
    • Activity
    • Cell
    • End
    • Molecular
    • Mouse
    • Protein
    • Region
  • inter-alpha-trypsin inhibitor
    • Pathway
    • Tissue
    • Tfpi
    • Human
    • Available
    • Hemostasis
    • Omim
    • P10646
    • Pdb
    • Protein
    • Search
    • Tfpi1
  • basic pancreatic trypsin inhibitor
    • Pathway
    • Tissue
    • Tfpi
    • Human
    • Available
    • Hemostasis
    • Omim
    • P10646
    • Pdb
    • Protein
    • Search
    • Tfpi1
  • factor x
    • Tissue
    • Pathway
    • Inhibitor
    • Available
    • Inhibit
    • Omim
    • Pdb
    • Tfpi1
    • Also
    • Xa
    • External
    • Tfpi

Connections between topic areas Semantic bridges

For Tissue factor pathway inhibitor, one of the stronger structural bridges in this analysis connects Tissue factor pathway inhibitor with Genetics. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Tissue factor pathway inhibitor — Genetics · splits 12 ⟂ 5
Tissue factor pathway inhibitor — Overview · splits 13 ⟂ 4
Tissue factor pathway inhibitor — Protein structure · splits 13 ⟂ 4
Tissue factor pathway inhibitor — Interactions · splits 14 ⟂ 3

Map overview Semantic statistics

Tissue factor pathway inhibitor

Nodes17
Edges16
Triples87
Avg. degree1.88
Density0.117647
Components1

Source & methodology

TTTA analyzes the structure around Tissue factor pathway inhibitor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Genetics & Protein structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Tissue factor pathway inhibitor · EN edition · Analysis: TopicsToTalkAbout

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