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Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.
The analysis highlights Regions, Genetics and Protein structure as prominent areas in the source structure around Tissue factor pathway inhibitor.
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The extracted context around Tissue factor pathway inhibitor shows recurring relationship patterns in the source. For example, Tissue factor pathway inhibitor → anchored component of membrane, blood coagulation, blood coagulation, extrinsic pathway, caveola, cell surface, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to steroid hormone stimulus, endopeptidase inhibitor activity, endoplasmic reticulum, extracellular region, extracellular space, hemostasis, intracellular membrane-bounded organelle, membrane, negative regulation of blood coagulation, negative regulation of endopeptidase activity, negative regulation of peptidase activity, organelle membrane, peptidase inhibitor activity Another extracted example is Tissue factor pathway inhibitor → atrioventricular valve, decidua, dermis, efferent ductule, endocardial cushion, endothelial cell of lymphatic vessel, gastrula, liver, lower lobe of lung, pericardium, placenta, right lobe of liver, right lung, stromal cell of endometrium, umbilical cord, upper lobe of left lung, upper lobe of lung, vas deferens, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.
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tfpi bp human inhibitor chromosome factor chr band pathway gene xa tissue also location inhibit mouse nm protein external 152310
TTTA extracted 87 structured relationships around Tissue factor pathway inhibitor. Examples in this analysis include Tissue factor pathway inhibitor → Aliases → TFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor and Tissue factor pathway inhibitor → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4DTG, 1ADZ, 1IRH, 1TFX, 4BQD. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Tissue factor pathway inhibitor | Aliases | TFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor | 1.00 | infobox |
| Tissue factor pathway inhibitor | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4DTG, 1ADZ, 1IRH, 1TFX, 4BQD | 1.00 | infobox |
| Tissue factor pathway inhibitor | Band | 2q32.1 | 1.00 | infobox |
| Tissue factor pathway inhibitor | Band | 2|2 D | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | right lung | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | lower lobe of lung | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | visceral pleura | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | upper lobe of lung | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | placenta | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | upper lobe of left lung | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | stromal cell of endometrium | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | liver | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | pericardium | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | right lobe of liver | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | gastrula | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | decidua | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | atrioventricular valve | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | vas deferens | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | dermis | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | endocardial cushion | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | efferent ductule | 1.00 | infobox |
| Tissue factor pathway inhibitor | Bgee | umbilical cord | 1.00 | infobox |
| Tissue factor pathway inhibitor | BioGPS | More reference expression data | 1.00 | infobox |
| Tissue factor pathway inhibitor | Chr. | Chromosome 2 (human) | 1.00 | infobox |
| Tissue factor pathway inhibitor | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| Tissue factor pathway inhibitor | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Tissue factor pathway inhibitor | End | 187,565,760 bp | 1.00 | infobox |
| Tissue factor pathway inhibitor | End | 84,307,119 bp | 1.00 | infobox |
| Tissue factor pathway inhibitor | Ensembl | ENSG00000003436 | 1.00 | infobox |
The concept neighborhoods around Tissue factor pathway inhibitor bring nearby vocabulary together. In this analysis, examples include Tissue, Pathway and Inhibitor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Tissue factor pathway inhibitor, one of the stronger structural bridges in this analysis connects Tissue factor pathway inhibitor with Genetics. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Tissue factor pathway inhibitor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Genetics & Protein structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Tissue factor pathway inhibitor · EN edition · Analysis: TopicsToTalkAbout