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Extracellular signal-regulated kinases: Overview, Mitogen-activated protein kinase 1 & Clinical significance

In molecular biology, extracellular signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines…

Language: English [EN]
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Extracellular signal-regulated kinases topic overview

The analysis highlights Overview, Mitogen-activated protein kinase 1 and Clinical significance as prominent areas in the source structure around Extracellular signal-regulated kinases.

Related topics
40
Source areas
5
Connected nodes
45
Extracted relationships
25
Concept neighborhoods
23
Bridge connections
45

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 24 topics
Mitogen-activated protein kinase 1 · 9 topics
Clinical significance · 4 topics
Mitogen-activated protein kinase 3 · 2 topics
Mitogen-activated protein kinase 7 · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Alt. symbols
PRKM2, PRKM1
Domains
InterPro
HGNC
6871
Locus
Chr. 22 q11.2
NCBI gene
5594
OMIM
176948

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Mitogen-activated protein kinase 1

Mitogen-activated protein kinase 3

Mitogen-activated protein kinase 7

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Extracellular signal-regulated kinases connects Entity context

The extracted context around Extracellular signal-regulated kinases shows recurring relationship patterns in the source. For example, Extracellular signal-regulated kinases → Cell Migration Gateway Archived, Extracellular, Kinase Resource Archived, Kinases, MAP, MAPK1MAPK3 Info, Medicine Medical Subject Headings, MeSH, National Library, Signal-Regulated, The Extracellular Signal-Regulated KinasesMAP, Wayback Machine Another extracted example is Extracellular signal-regulated kinases → PRKM2, PRKM1. Use these groups to spot repeated connection types before inspecting the individual relationships.

Extracellular signal-regulated kinases

Top relations

related to External links · 12
Extracellular signal-regulated kinases → Cell Migration Gateway Archived, Extracellular, Kinase Resource Archived, Kinases, MAP, MAPK1MAPK3 Info, Medicine Medical Subject Headings, MeSH, National Library, Signal-Regulated, The Extracellular Signal-Regulated KinasesMAP, Wayback Machine
Alt. symbols · 1
Extracellular signal-regulated kinases → PRKM2, PRKM1
Domains · 1
Extracellular signal-regulated kinases → InterPro
HGNC · 1
Extracellular signal-regulated kinases → 6871
Locus · 1
Extracellular signal-regulated kinases → Chr. 22 q11.2
NCBI gene · 1
Extracellular signal-regulated kinases → 5594
OMIM · 1
Extracellular signal-regulated kinases → 176948
RefSeq · 1
Extracellular signal-regulated kinases → NM_002745
Search for · 1
Extracellular signal-regulated kinases → Search forStructuresSwiss-modelDomainsInterPro
Structures · 1
Extracellular signal-regulated kinases → Swiss-model

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein kinases mapk1 kinase ras extracellular signal-regulated erks mapk mitogen-activated activation map cells erk pathway mapk3 cell also growth receptors

Extracellular signal-regulated kinases relationships Subject–Predicate–Object triples

TTTA extracted 25 structured relationships around Extracellular signal-regulated kinases. Examples in this analysis include Extracellular signal-regulated kinases → Alt. symbols → PRKM2, PRKM1 and Extracellular signal-regulated kinases → Domains → InterPro. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Extracellular signal-regulated kinasesAlt. symbolsPRKM2, PRKM11.00infobox
Extracellular signal-regulated kinasesDomainsInterPro1.00infobox
Extracellular signal-regulated kinasesHGNC68711.00infobox
Extracellular signal-regulated kinasesLocusChr. 22 q11.21.00infobox
Extracellular signal-regulated kinasesNCBI gene55941.00infobox
Extracellular signal-regulated kinasesOMIM1769481.00infobox
Extracellular signal-regulated kinasesRefSeqNM_0027451.00infobox
Extracellular signal-regulated kinasesSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
Extracellular signal-regulated kinasesStructuresSwiss-model1.00infobox
Extracellular signal-regulated kinasesSymbolMAPK11.00infobox
Extracellular signal-regulated kinasesUniProtP284821.00infobox
HER2instance ofor receptors0.80text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Extracellular signal-regulated kinases bring nearby vocabulary together. In this analysis, examples include Signal-regulated, Kinase and Mitogen-activated. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Extracellular signal-regulated kinases
    • Signal-regulated
    • Kinase
    • Mitogen-activated
    • Kinases
    • Protein
    • Known
    • Also
    • Tyrosine
    • Map
    • Including
    • Mek
    • Mapk
  • extracellular signal-regulated kinases
    • Signal-regulated
    • Kinase
    • Mitogen-activated
    • Known
    • Kinases
    • Protein
    • Also
    • Growth
    • Tyrosine
    • Map
    • Erks
    • Including
  • protein kinase
    • Signal-regulated
    • Protein
    • Mitogen-activated
    • Map
    • Known
    • Also
    • Factors
    • Including
    • Many
    • Kinases
    • Mapk1
    • Activate
  • mitogen-activated protein kinase
    • Known
    • Signal-regulated
    • Protein
    • Also
    • Mitogen-activated
    • Map
    • Mapk1
    • Factors
    • Including
    • Many
    • Kinases
    • Activate
  • mapk/erk pathway
    • Mek
    • Pathway
    • C-raf
    • Mapk
    • Ras
    • Leads
    • Receptors
    • Sometimes
    • Factors
    • Including
    • Many
    • Signalling
  • mitogen-activated protein kinase kinase
    • Known
    • Signal-regulated
    • Protein
    • Also
    • Mitogen-activated
    • Map
    • Mapk1
    • Factors
    • Including
    • Many
    • Kinases
    • Activate
  • receptor tyrosine kinases
    • Growth
    • Protein
    • Kinases
    • Signal-regulated
    • Tyrosine
    • Activation
    • Ras
    • Map
    • Erks
    • Factors
    • Including
    • Many
  • mitogen-activated protein kinase 1
    • Known
    • Signal-regulated
    • Protein
    • Also
    • Mitogen-activated
    • Map
    • Mapk1
    • Factors
    • Including
    • Many
    • Kinases
    • Activate

Connections between topic areas Semantic bridges

For Extracellular signal-regulated kinases, one of the stronger structural bridges in this analysis connects Extracellular signal-regulated kinases with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Extracellular signal-regulated kinases — Overview · splits 21 ⟂ 25
Extracellular signal-regulated kinases — Mitogen-activated protein kinase 1 · splits 36 ⟂ 10
Extracellular signal-regulated kinases — Clinical significance · splits 41 ⟂ 5
Extracellular signal-regulated kinases — Mitogen-activated protein kinase 3 · splits 43 ⟂ 3

Map overview Semantic statistics

Extracellular signal-regulated kinases

Nodes46
Edges45
Triples25
Avg. degree1.96
Density0.043478
Components1

Source & methodology

TTTA analyzes the structure around Extracellular signal-regulated kinases to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Mitogen-activated protein kinase 1 & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Extracellular signal-regulated kinases · EN edition · Analysis: TopicsToTalkAbout

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