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MMP2: Clinical significance, Ligands & Overview

72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. The MMP2 gene is located on chromosome 16 at position 12.2.

Language: English [EN]
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MMP2 topic overview

The analysis highlights Clinical significance, Ligands and Overview as prominent areas in the source structure around MMP2.

Related topics
67
Source areas
6
Connected nodes
73
Extracted relationships
92
Concept neighborhoods
16
Bridge connections
73

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 21 topics
Clinical significance · 16 topics
Ligands · 14 topics
Function · 8 topics
Interactions · 6 topics
Activation · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
matrix metallopeptidase 2wu:fa99h12wu:fk89d01
Band
n/a · 8 C5|8 44.99 cM
Bgee
swim bladder · zone of skin · spleen · muscle tissue · bone
BioGPS
n/a
Chr.
Chromosome 7 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Activation

Clinical significance

Interactions

Ligands

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MMP2 connects Entity context

The extracted context around MMP2 shows recurring relationship patterns in the source. For example, MMP2 → Abnormal, Activity, Altered, Arthropathy, Bronchiectasis, Disease-causing, For, Furthermore, Haemophilus, Idiopathic, In, Increased MMP-2, MMP, MMP-2, MMP-9, MMPs, Mook, Multicentric Osteolysis, Nodulosis, Pseudomonas Another extracted example is MMP2 → ankle, body of femur, bone, brain, calvaria, condyle, conjunctival fornix, external carotid artery, fossa, head kidney, heart, internal carotid artery, larva, muscle tissue, spleen, swim bladder, vas deferens, ventricle of the heart, vestibular sensory epithelium, zone of skin. Use these groups to spot repeated connection types before inspecting the individual relationships.

MMP2

Top relations

related to Role of MMP-2 in chronic disease · 21
MMP2 → Abnormal, Activity, Altered, Arthropathy, Bronchiectasis, Disease-causing, For, Furthermore, Haemophilus, Idiopathic, In, Increased MMP-2, MMP, MMP-2, MMP-9, MMPs, Mook, Multicentric Osteolysis, Nodulosis, Pseudomonas
Bgee · 20
MMP2 → ankle, body of femur, bone, brain, calvaria, condyle, conjunctival fornix, external carotid artery, fossa, head kidney, heart, internal carotid artery, larva, muscle tissue, spleen, swim bladder, vas deferens, ventricle of the heart, vestibular sensory epithelium, zone of skin
RNA expression pattern · 20
MMP2 → ankle, body of femur, bone, brain, calvaria, condyle, conjunctival fornix, external carotid artery, fossa, head kidney, heart, internal carotid artery, larva, muscle tissue, spleen, swim bladder, vas deferens, ventricle of the heart, vestibular sensory epithelium, zone of skin
related to Interactions · 4
MMP2 → CCL7, THBS2, TIMP2, TIMP4
Band · 2
MMP2 → 8 C5|8 44.99 cM, n/a
Chr. · 2
MMP2 → Chromosome 7 (human), Chromosome 8 (mouse)
End · 2
MMP2 → 35,432,901 bp, 93,580,048 bp
related to Clinical significance · 2
MMP2 → Mutations, Torg-Winchester
Aliases · 1
MMP2 → matrix metallopeptidase 2wu:fa99h12wu:fk89d01
BioGPS · 1
MMP2 → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mmp-2 mmp cancer inhibitors mmps cells also gene cell metastasis tumor bp activation role tissue human activity type chromosome mmp-9

MMP2 relationships Subject–Predicate–Object triples

TTTA extracted 92 structured relationships around MMP2. Examples in this analysis include MMP2 → Aliases → matrix metallopeptidase 2wu:fa99h12wu:fk89d01 and MMP2 → Band → n/a. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MMP2Aliasesmatrix metallopeptidase 2wu:fa99h12wu:fk89d011.00infobox
MMP2Bandn/a1.00infobox
MMP2Band8 C5|8 44.99 cM1.00infobox
MMP2Bgeeswim bladder1.00infobox
MMP2Bgeezone of skin1.00infobox
MMP2Bgeespleen1.00infobox
MMP2Bgeemuscle tissue1.00infobox
MMP2Bgeebone1.00infobox
MMP2Bgeeheart1.00infobox
MMP2Bgeelarva1.00infobox
MMP2Bgeehead kidney1.00infobox
MMP2Bgeeventricle of the heart1.00infobox
MMP2Bgeebrain1.00infobox
MMP2Bgeevestibular sensory epithelium1.00infobox
MMP2Bgeeexternal carotid artery1.00infobox
MMP2Bgeecalvaria1.00infobox
MMP2Bgeeinternal carotid artery1.00infobox
MMP2Bgeebody of femur1.00infobox
MMP2Bgeecondyle1.00infobox
MMP2Bgeevas deferens1.00infobox
MMP2Bgeeconjunctival fornix1.00infobox
MMP2Bgeefossa1.00infobox
MMP2Bgeeankle1.00infobox
MMP2BioGPSn/a1.00infobox
MMP2Chr.Chromosome 7 (human)1.00infobox
MMP2Chr.Chromosome 8 (mouse)1.00infobox
MMP2DatabasesNCBI: entry; OMA: entry1.00infobox
MMP2End35,432,901 bp1.00infobox
MMP2End93,580,048 bp1.00infobox
MMP2EnsemblENSDARG000000176761.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MMP2 bring nearby vocabulary together. In this analysis, examples include Gene, Chromosome and Type. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • matrix metalloproteinase
    • Bp
    • Chr
    • Chromosome
    • Human
    • Signaling
    • Gene
    • Mmp2
    • Cell
    • Band
    • Clinical
    • Collagen
    • Ecm
  • extracellular matrix
    • Bp
    • Chr
    • Chromosome
    • Human
    • Signaling
    • Gene
    • Mmp2
    • Cell
    • Band
    • Clinical
    • Collagen
    • Ecm
  • type iv collagen
    • Collagen
    • Type
    • Gene
    • Basement
    • Membrane
    • Mmp2
    • Cells
    • Mmp-2
    • Matrix
    • Human
    • Signaling
    • Degradation
  • collagen type i
    • Collagen
    • Type
    • Gene
    • Basement
    • Membrane
    • Mmp2
    • Cells
    • Mmp-2
    • Matrix
    • Human
    • Signaling
    • Degradation
  • activation
    • Mmp-2
    • Inhibitors
    • Matrix
    • Bp
    • Chr
    • Chromosome
    • Clinical
    • Human
    • Invasion
    • Signaling
    • Furthermore
    • Mmp
  • gene
    • Mmp2
    • Chromosome
    • Type
    • Matrix
    • Bp
    • Chr
    • Human
    • Band
    • Basement
    • Clinical
    • Collagen
    • Invasion
  • MMP2
    • Gene
    • Chromosome
    • Type
    • Band
    • Bp
    • Chr
    • Ecm
    • Human
    • Angiogenesis
    • Shown
    • Metastasis
    • Tissue
  • mmp2
    • Gene
    • Chromosome
    • Type
    • Band
    • Bp
    • Chr
    • Ecm
    • Human
    • Angiogenesis
    • Shown
    • Metastasis
    • Tissue

Connections between topic areas Semantic bridges

For MMP2, one of the stronger structural bridges in this analysis connects MMP2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MMP2Overview · splits 52 ⟂ 22
MMP2Clinical significance · splits 57 ⟂ 17
MMP2Ligands · splits 59 ⟂ 15
MMP2Function · splits 65 ⟂ 9
MMP2Interactions · splits 67 ⟂ 7
MMP2Activation · splits 71 ⟂ 3

Map overview Semantic statistics

MMP2

Nodes74
Edges73
Triples92
Avg. degree1.97
Density0.027027
Components1

Source & methodology

TTTA analyzes the structure around MMP2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Ligands & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MMP2 · EN edition · Analysis: TopicsToTalkAbout

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