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DLG4: Interactions, MAGUK superfamily and constituent domains & Overview

PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs large homolog 4) gene.

Language: English [EN]
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DLG4 topic overview

The analysis highlights Interactions, MAGUK superfamily and constituent domains and Overview as prominent areas in the source structure around DLG4.

Related topics
57
Source areas
3
Connected nodes
60
Extracted relationships
174
Concept neighborhoods
16
Bridge connections
60

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 34 topics
Overview · 14 topics
MAGUK superfamily and constituent domains · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DLG4, PSD95, SAP-90, SAP90, Dlgh4, PSD-95, SAP90A, discs large homolog 4, discs large MAGUK scaffold protein 4, MRD62
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KEF, 3I4W, 3K82, 3ZRT
Band
17p13.1 · 11|11 B3
Bgee
right hemisphere of cerebellum · right frontal lobe · nucleus accumbens · cingulate gyrus · anterior cingulate cortex
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

MAGUK superfamily and constituent domains

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How DLG4 connects Entity context

The extracted context around DLG4 shows recurring relationship patterns in the source. For example, DLG4 → acetylcholine receptor binding, AMPA glutamate receptor clustering, AMPA glutamate receptor complex, axon, basolateral plasma membrane, beta-1 adrenergic receptor binding, cell junction, cell periphery, cell projection, cell-cell adhesion, cellular response to potassium ion, cerebellar mossy fiber, chemical synaptic transmission, cortical cytoskeleton, cytoplasm, cytosol, D1 dopamine receptor binding, dendrite, dendrite cytoplasm, dendritic spine Another extracted example is DLG4 → ATP, C-terminus, CaMKII, GUK, GUK-SH3, It, Its, L27, MAGUK, MAGUKs, One, P-Loop, PDZ, PSD-93, PSD-95, PXXP, SAP102, SAP97, SH3, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

DLG4

Top relations

Gene ontology · 83
DLG4 → acetylcholine receptor binding, AMPA glutamate receptor clustering, AMPA glutamate receptor complex, axon, basolateral plasma membrane, beta-1 adrenergic receptor binding, cell junction, cell periphery, cell projection, cell-cell adhesion, cellular response to potassium ion, cerebellar mossy fiber, chemical synaptic transmission, cortical cytoskeleton, cytoplasm, cytosol, D1 dopamine receptor binding, dendrite, dendrite cytoplasm, dendritic spine
related to MAGUK superfamily and constituent domains · 25
DLG4 → ATP, C-terminus, CaMKII, GUK, GUK-SH3, It, Its, L27, MAGUK, MAGUKs, One, P-Loop, PDZ, PSD-93, PSD-95, PXXP, SAP102, SAP97, SH3, The
Bgee · 20
DLG4 → amygdala, anterior cingulate cortex, anterior pituitary, Brodmann area 9, CA3 field, caudate nucleus, cerebellar cortex, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, genital tubercle, neural layer of retina, nucleus accumbens, perirhinal cortex, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, superior frontal gyrus, tail of embryo
RNA expression pattern · 20
DLG4 → amygdala, anterior cingulate cortex, anterior pituitary, Brodmann area 9, CA3 field, caudate nucleus, cerebellar cortex, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, genital tubercle, neural layer of retina, nucleus accumbens, perirhinal cortex, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, superior frontal gyrus, tail of embryo
related to External links · 3
DLG4 → Medicine Medical Subject Headings, MeSH, National Library
Band · 2
DLG4 → 11|11 B3, 17p13.1
Chr. · 2
DLG4 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
DLG4 → 69,938,348 bp, 7,219,841 bp
Aliases · 1
DLG4 → DLG4, PSD95, SAP-90, SAP90, Dlgh4, PSD-95, SAP90A, discs large homolog 4, discs large MAGUK scaffold protein 4, MRD62
Available structures · 1
DLG4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KEF, 3I4W, 3K82, 3ZRT

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

psd-95 proteins pdz bp gene domain human maguk chr protein band binding postsynaptic density guanylate chromosome 17 also domains nmda

DLG4 relationships Subject–Predicate–Object triples

TTTA extracted 174 structured relationships around DLG4. Examples in this analysis include DLG4 → Aliases → DLG4, PSD95, SAP-90, SAP90, Dlgh4, PSD-95, SAP90A, discs large homolog 4, discs large MAGUK scaffold protein 4, MRD62 and DLG4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KEF, 3I4W, 3K82, 3ZRT. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DLG4AliasesDLG4, PSD95, SAP-90, SAP90, Dlgh4, PSD-95, SAP90A, discs large homolog 4, discs large MAGUK scaffold protein 4, MRD621.00infobox
DLG4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KEF, 3I4W, 3K82, 3ZRT1.00infobox
DLG4Band17p13.11.00infobox
DLG4Band11|11 B31.00infobox
DLG4Bgeeright hemisphere of cerebellum1.00infobox
DLG4Bgeeright frontal lobe1.00infobox
DLG4Bgeenucleus accumbens1.00infobox
DLG4Bgeecingulate gyrus1.00infobox
DLG4Bgeeanterior cingulate cortex1.00infobox
DLG4Bgeeprefrontal cortex1.00infobox
DLG4Bgeeanterior pituitary1.00infobox
DLG4BgeeBrodmann area 91.00infobox
DLG4Bgeeamygdala1.00infobox
DLG4Bgeecaudate nucleus1.00infobox
DLG4Bgeeneural layer of retina1.00infobox
DLG4Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
DLG4Bgeesuperior frontal gyrus1.00infobox
DLG4Bgeeprimary visual cortex1.00infobox
DLG4BgeeCA3 field1.00infobox
DLG4Bgeetail of embryo1.00infobox
DLG4Bgeeperirhinal cortex1.00infobox
DLG4Bgeecerebellar cortex1.00infobox
DLG4Bgeeentorhinal cortex1.00infobox
DLG4Bgeegenital tubercle1.00infobox
DLG4BioGPSMore reference expression data1.00infobox
DLG4Chr.Chromosome 17 (human)1.00infobox
DLG4Chr.Chromosome 11 (mouse)1.00infobox
DLG4DatabasesNCBI: entry; OMA: entry1.00infobox
DLG4End7,219,841 bp1.00infobox
DLG4End69,938,348 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around DLG4 bring nearby vocabulary together. In this analysis, examples include Protein, Postsynaptic and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DLG4
    • Protein
    • Postsynaptic
    • Human
    • Gene
    • Location
    • Scaffold
    • Chromosome
    • Maguk
    • Psd-95
    • Bp
    • Chr
    • Clustering
  • dlg4
    • Protein
    • Postsynaptic
    • Human
    • Gene
    • Location
    • Scaffold
    • Chromosome
    • Maguk
    • Psd-95
    • Bp
    • Chr
    • Clustering
  • protein
    • Dlg4
    • Gene
    • Also
    • Psd-95
    • Human
    • Location
    • Scaffold
    • Chromosome
    • Maguk
    • Binding
    • Bp
    • Chr
  • gene
    • Protein
    • Location
    • Chromosome
    • Psd-95
    • Binding
    • Bp
    • Chr
    • Human
    • Mouse
    • Scaffold
    • Band
    • Maguk
  • membrane-associated guanylate kinase
    • Family
    • Member
    • Domain
    • Maguk
    • Pdz
    • Clustering
    • Maguk-family
    • Mouse
    • Neuroligin
    • Psd-95
    • Location
    • Nmda
  • potassium channels
    • Receptors
    • Neuroligin
    • Receptor
    • Binding
    • Clustering
    • Channels
    • Form
    • Mouse
    • Nmda
    • Potassium
    • Scaffold
    • Location
  • clustering
    • Scaffold
    • Maguk
    • Postsynaptic
    • Channels
    • Mouse
    • Neuroligin
    • Receptors
    • Family
    • Form
    • Location
    • Member
    • Nmda
  • pdz domain
    • Domains
    • Guanylate
    • Guk
    • Proteins
    • Domain
    • Pdz
    • Sh3
    • Three
    • Psd-95
    • Form
    • Maguks
    • Binding

Connections between topic areas Semantic bridges

For DLG4, one of the stronger structural bridges in this analysis connects DLG4 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DLG4Interactions · splits 26 ⟂ 35
DLG4Overview · splits 46 ⟂ 15
DLG4MAGUK superfamily and constituent domains · splits 51 ⟂ 10

Map overview Semantic statistics

DLG4

Nodes61
Edges60
Triples174
Avg. degree1.97
Density0.032787
Components1

Source & methodology

TTTA analyzes the structure around DLG4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, MAGUK superfamily and constituent domains & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DLG4 · EN edition · Analysis: TopicsToTalkAbout

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