Neurodegenerative disease

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Explore the main themes, entities and connections around Neurodegenerative disease. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Specific disorders

Synapses Cerebral cortex Atrophy Temporal Parietal lobe

68 related topics

Mechanisms

Genetic mutations Glutamine Trinucleotide repeat disorders Models Nematode

30 related topics

Overview

Neurons Death Amyotrophic lateral sclerosis Multiple sclerosis Parkinson's disease

59 related topics

Risk factors

Aging Mitochondrial DNA mutations Electronic health records UK Biobank

4 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Specialty: Neurology, Psychiatry

Topics to explore

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Management

Advanced semantic analysis

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Map overview Semantic statistics

Nodes171

Edges170

Triples95

Avg. degree1.99

Density0.011696

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Neurodegenerative disease

Top relations

related to Amyotrophic lateral sclerosis · 24

Neurodegenerative disease → ALS, Although, Amyotrophic, Astrocytes, C9orf72, Currently, Early, FUS, Fused, In, Independent, LMNs, Lou Gehrig, More, Neuron Score, PUMNS, Sarcoma, SOD1, TAR DNA-binding, TDP-43

related to Alzheimer's disease · 13

Neurodegenerative disease → A-beta, AD, Alzheimer's, Amyloid, APP, Aβ, Currently, Even, It, One, Plaques, Reasons, Within

related to Protein misfolding · 10

Neurodegenerative disease → Abeta, Alpha-synuclein, Alzheimer's, In, Lewy, NAC, Parkinson's, Pick, Protein, Several

related to Genetics · 9

Neurodegenerative disease → CAG, Diseases, Drosophila, Extensive, Extra, In, Many, Polyglutamine, PolyQ

related to Aging · 7

Neurodegenerative disease → About, DNA, It, Many, Mitochondrial DNA, One, The

related to Chronic traumatic encephalopathy · 7

Neurodegenerative disease → Chronic, Clinical, CTE, It, Symptoms, The, This

related to Programmed cell death · 6

Neurodegenerative disease → Alzheimer's, Huntington's, Parkinson's, PCD, Programmed, This

Specialty · 1

Neurodegenerative disease → Neurology, Psychiatry

related to Infections · 1

Neurodegenerative disease → UK Biobank

Important terminology Word statistics

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Important terminology

disease neurodegenerative diseases alzheimer's neurons protein neurodegeneration parkinson's brain proteins death huntington's cell also may damage research common cause form

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Neurodegenerative disease	Specialty	Neurology, Psychiatry	1.00	infobox
gamma secretase	instance of	APP is cleaved into smaller fragments by enzymes	0.80	text
beta secretase	instance of	APP is cleaved into smaller fragments by enzymes	0.80	text
α-synuclein	instance of	Mutations in genes	0.80	text
BDNF	instance of	leading to impaired transport of important cargoes	0.80	text
myelin oligodendrocyte glycoprotein	instance of	which is proposed to be due to the release of antigens	0.80	text
myelin basic protein	instance of	which is proposed to be due to the release of antigens	0.80	text
and proteolipid protein	instance of	which is proposed to be due to the release of antigens	0.80	text
causing an autoimmune response	instance of	which is proposed to be due to the release of antigens	0.80	text
manganese superoxide dismutase	instance of	ROS concentration is mediated by mitochondrial antioxidants	0.80	text
Alzheimer's disease	instance of	Defective DNA repair has been linked to neurodegenerative disorders	0.80	text
amyotrophic lateral sclerosis	instance of	Defective DNA repair has been linked to neurodegenerative disorders	0.80	text

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