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C-Jun N-terminal kinases

c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock. They also…

Function, Roles in DNA repair & Overview

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Alt. symbols
JNK1, PRKM8
Domains
InterPro
HGNC
6881
Locus
Chr. 10 q11.2
NCBI gene
5599
OMIM
601158

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Overview

Isoforms

Function

Roles in DNA repair

In aging

Advanced semantic analysis

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Map overview Semantic statistics

C-Jun N-terminal kinases

Nodes66
Edges65
Triples23
Avg. degree1.97
Density0.030303
Components1

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C-Jun N-terminal kinases

Top relations

related to Isoforms · 12
C-Jun N-terminal kinases → Differences, Each, JNK1, JNK1-α, JNK1-β, JNK2, JNK2-α, JNK2-β, JNK3, Jun N-terminal, The, There
Alt. symbols · 1
C-Jun N-terminal kinases → JNK1, PRKM8
Domains · 1
C-Jun N-terminal kinases → InterPro
HGNC · 1
C-Jun N-terminal kinases → 6881
Locus · 1
C-Jun N-terminal kinases → Chr. 10 q11.2
NCBI gene · 1
C-Jun N-terminal kinases → 5599
OMIM · 1
C-Jun N-terminal kinases → 601158
RefSeq · 1
C-Jun N-terminal kinases → NM_002750
Search for · 1
C-Jun N-terminal kinases → Search forStructuresSwiss-modelDomainsInterPro
Structures · 1
C-Jun N-terminal kinases → Swiss-model

Important terminology Word statistics

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Important terminology

jnk protein activation apoptosis dna kinase kinases within jnk1 c-jun phosphorylation pathway repair also damage activity cell occurs 10 isoforms

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
C-Jun N-terminal kinasesAlt. symbolsJNK1, PRKM81.00infobox
C-Jun N-terminal kinasesDomainsInterPro1.00infobox
C-Jun N-terminal kinasesHGNC68811.00infobox
C-Jun N-terminal kinasesLocusChr. 10 q11.21.00infobox
C-Jun N-terminal kinasesNCBI gene55991.00infobox
C-Jun N-terminal kinasesOMIM6011581.00infobox
C-Jun N-terminal kinasesRefSeqNM_0027501.00infobox
C-Jun N-terminal kinasesSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
C-Jun N-terminal kinasesStructuresSwiss-model1.00infobox
C-Jun N-terminal kinasesSymbolMAPK81.00infobox
C-Jun N-terminal kinasesUniProtP459831.00infobox
C-Jun N-terminal kinasesrelated to IsoformsThe0.60section

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