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Midkine (MK or MDK), also known as neurite growth-promoting factor 2 (NEGF2), is a protein that in humans is encoded by the MDK gene.
The analysis highlights Overview, Role in cancer and Trivia as prominent areas in the source structure around Midkine.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Midkine shows recurring relationship patterns in the source. For example, Midkine → adrenal gland development, behavioral fear response, cell differentiation, cell migration, cell projection, cerebellar granular layer development, cerebral cortex development, collagen-containing extracellular matrix, cytoplasm, defecation, dentate gyrus development, extracellular region, growth factor activity, heparin binding, hippocampus development, multicellular organism development, negative regulation of neuron apoptotic process, negative regulation of neuron death, nervous system development, Notch signaling pathway Another extracted example is Midkine → anterior pituitary, canal of the cervix, duodenum, embryo, epiblast, ganglionic eminence, genital tubercle, left ovary, neural tube, pituitary gland, right ovary, right uterine tube, stromal cell of endometrium, tail of embryo, uterus, ventricular zone, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
mk cells protein cell gene cancer bp factor neuroblastoma mdk chr human band resistant wt chromosome 11 molecular chemotherapeutic also
TTTA extracted 102 structured relationships around Midkine. Examples in this analysis include Midkine → Aliases → MDK, ARAP, MK, NEGF2, midkine (neurite growth-promoting factor 2), midkine and Midkine → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MKC, 1MKN. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Midkine | Aliases | MDK, ARAP, MK, NEGF2, midkine (neurite growth-promoting factor 2), midkine | 1.00 | infobox |
| Midkine | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MKC, 1MKN | 1.00 | infobox |
| Midkine | Band | 11p11.2 | 1.00 | infobox |
| Midkine | Band | 2 E1|2 50.63 cM | 1.00 | infobox |
| Midkine | Bgee | ventricular zone | 1.00 | infobox |
| Midkine | Bgee | stromal cell of endometrium | 1.00 | infobox |
| Midkine | Bgee | pituitary gland | 1.00 | infobox |
| Midkine | Bgee | left ovary | 1.00 | infobox |
| Midkine | Bgee | canal of the cervix | 1.00 | infobox |
| Midkine | Bgee | anterior pituitary | 1.00 | infobox |
| Midkine | Bgee | right uterine tube | 1.00 | infobox |
| Midkine | Bgee | ganglionic eminence | 1.00 | infobox |
| Midkine | Bgee | duodenum | 1.00 | infobox |
| Midkine | Bgee | right ovary | 1.00 | infobox |
| Midkine | Bgee | genital tubercle | 1.00 | infobox |
| Midkine | Bgee | tail of embryo | 1.00 | infobox |
| Midkine | Bgee | yolk sac | 1.00 | infobox |
| Midkine | Bgee | epiblast | 1.00 | infobox |
| Midkine | Bgee | uterus | 1.00 | infobox |
| Midkine | Bgee | neural tube | 1.00 | infobox |
| Midkine | Bgee | embryo | 1.00 | infobox |
| Midkine | BioGPS | More reference expression data | 1.00 | infobox |
| Midkine | Chr. | Chromosome 11 (human) | 1.00 | infobox |
| Midkine | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| Midkine | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Midkine | End | 46,383,837 bp | 1.00 | infobox |
| Midkine | End | 91,762,642 bp | 1.00 | infobox |
| Midkine | Ensembl | ENSG00000110492 | 1.00 | infobox |
| Midkine | Entrez | 4192 | 1.00 | infobox |
| Midkine | External IDs | OMIM: 162096; MGI: 96949; GeneCards: MDK | 1.00 | infobox |
The concept neighborhoods around Midkine bring nearby vocabulary together. In this analysis, examples include Factor, Mdk and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Midkine, one of the stronger structural bridges in this analysis connects Midkine with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Midkine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Role in cancer & Trivia, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Midkine · EN edition · Analysis: TopicsToTalkAbout