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Pattern recognition receptor

Pattern recognition receptors (PRRs) play a crucial role in the proper function of the innate immune system. PRRs are germline-encoded host sensors, which detect molecules typical for the pathogens. They are proteins expressed mainly by cells of the innate immune system, such as dendritic cells, macrophages, monocytes, neutrophils, as well as by…

Types and signaling, Clinical significance & Overview

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Pattern recognition receptor

Nodes144
Edges143
Triples19
Avg. degree1.99
Density0.013889
Components1

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Important terminology

prrs immune proteins also receptors recognition tlrs system signaling response called molecules activation prr innate nod2 mannose receptor cytokines associated

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Dectin 1instance ofTLR-independent signaling0.80text
and Dectin 2instance ofTLR-independent signaling0.80text
IPAFinstance ofwhich binds more limited number and variety of ligands and works in a complex with NAIP protein.Other NLRs0.80text
NAIP5/Birc1e have also been shown to activate caspase-1 in response to Salmonellainstance ofwhich binds more limited number and variety of ligands and works in a complex with NAIP protein.Other NLRs0.80text
Legionella.NLR signalingSome of these proteins recognize endogenous or microbial molecules or stress responsesinstance ofwhich binds more limited number and variety of ligands and works in a complex with NAIP protein.Other NLRs0.80text
form oligomers thatinstance ofwhich binds more limited number and variety of ligands and works in a complex with NAIP protein.Other NLRs0.80text
in animalsinstance ofwhich binds more limited number and variety of ligands and works in a complex with NAIP protein.Other NLRs0.80text
activate inflammatory caspasesinstance ofwhich binds more limited number and variety of ligands and works in a complex with NAIP protein.Other NLRs0.80text
TLRsinstance ofThey sense the conserved microbial peptidoglycans in the cytoplasm of the cell and therefore represent another level of immune response after membrane-bound receptors0.80text
CLRsinstance ofThey sense the conserved microbial peptidoglycans in the cytoplasm of the cell and therefore represent another level of immune response after membrane-bound receptors0.80text
serum amyloidinstance ofpentraxins0.80text
C-reactive proteininstance ofpentraxins0.80text

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