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Toll-like receptor

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have reached physical barriers such as the skin or…

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Membranome
7
Symbol
Toll-like receptor

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Overview

Function

Superfamily

Extended family

Summary of known mammalian TLRs

Ligands

Signaling

Medical relevance

Discovery

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Map overview Semantic statistics

Toll-like receptor

Nodes189
Edges188
Triples90
Avg. degree1.99
Density0.010582
Components1

How this topic connects Entity context

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Toll-like receptor

Top relations

related to Discovery · 25
Toll-like receptor → Christiane Nüsslein-Volhard's, Das, DNA, Drosophila, Eric Wieschaus, Gram-negative, Hoffmann, However, In, It, Jules, Kathryn Anderson, LPS, More, Nobel Laureates Christiane Nüsslein-Volhard, Other, P08953, Richard Pfeiffer, Robert Koch, That's
related to Ligands · 13
Toll-like receptor → As TLR, Because, CpG, DNA, For, LPS, MMR, Pathogen-associated, RNA, See, Somewhat, TLR, TLRs
related to Superfamily · 13
Toll-like receptor → DAMPs, HSPs, Ig, IL-1, Immunoglobulin, In, Interleukin-1, PAMPs, Proteins, PRR, Three, TIR, TLRs
related to External links · 12
Toll-like receptor → Drosophila, Family, Innate Immune Receptors, LMU MunichThe Toll-Like Receptor, Medicine Medical Subject Headings, MeSH, National Library, PathwayBioScience Animations, Receptors, Toll, Toll-Like, TollML
related to Endogenous ligands · 8
Toll-like receptor → DNA, HMGB1, HSPs, The, These, TLR7, TLR9, TLRs
related to Function · 3
Toll-like receptor → The, TLR, TLRs
related to Summary of known mammalian TLRs · 3
Toll-like receptor → Furthermore, They, Toll-like
Membranome · 1
Toll-like receptor → 7
Symbol · 1
Toll-like receptor → Toll-like receptor

Important terminology Word statistics

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Important terminology

tlrs receptors molecules toll receptor tlr immune tlr4 tlr3 also pathway toll-like proteins activation cells genes mice signaling tlr11 protein

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Toll-like receptorMembranome71.00infobox
Toll-like receptorSymbolToll-like receptor1.00infobox
macrophagesinstance ofThey are single-spanning receptors usually expressed on sentinel cells0.80text
dendritic cellsinstance ofThey are single-spanning receptors usually expressed on sentinel cells0.80text
that recognize structurally conserved molecules derived from microbesinstance ofThey are single-spanning receptors usually expressed on sentinel cells0.80text
the skin or intestinal tract mucosainstance ofOnce these microbes have reached physical barriers0.80text
they are recognized by TLRsinstance ofOnce these microbes have reached physical barriers0.80text
which activate immune cell responsesinstance ofOnce these microbes have reached physical barriers0.80text
interferons.Toll-like receptors have also been shown to be an important link between Innate immune systeminstance ofImmune cells that have detected a virus may also release anti-viral factors0.80text
adaptive immune system through their presence in dendritic cellsinstance ofImmune cells that have detected a virus may also release anti-viral factors0.80text
flagellin from bacterial flagellainstance ofproteins0.80text
respiratory depressioninstance ofand other negative side effects0.80text

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