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Explore the main themes, entities and connections around RIG-I. Start with the topic map, then use the sections below for research and deeper semantic analysis.
Explore this topic
Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.
Overview
28 related topics
Structure
8 related topics
Function
7 related topics
History
1 related topics
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
- 3.6.4.13
- ↗
- Aliases
- RIGI, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RLR-1, SGMRT2, RIG-I, DEXD/H-box helicase 58, RIG1, DDX58, RNA sensor RIG-I
- Available structures
- Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LWD, 2LWE, 2QFB, 2QFD, 2RMJ, 2YKG, 3LRN, 3LRR, 3NCU, 3OG8, 3ZD6, 3ZD7, 4AY2, 4BPB, 4NQK, 4ON9, 4P4H, 5E3H,…
- Band
- 9p21.1 · 4|4 A5
- Bgee
- buccal mucosa cell · skin of thigh · tendon of biceps brachii · white blood cell · monocyte
- BioGPS
- More reference expression data
Topics to explore
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.Browse the full topic structure. Each item opens a new analysis centered on that subject.
Overview
- DEAD box
- Cytosolic Cytosol
- Pattern recognition receptor
- Type-I interferon Interferon type I
- Innate immune system
- West Nile virus
- Japanese Encephalitis virus Japanese encephalitis
- Influenza A
- Sendai virus
- Flavivirus
- Coronaviruses Coronavirus
- DExD/H box DExD/H box proteins
- RNA helicase
- Double-stranded RNA
- 5' 7-methyl guanosine (m7G) cap Five-prime cap
- MAVS MAVS (gene)
- CARD domains CARD domain
- Adaptive immune system
- Orthologs Ortholog
- Knockout mice Knockout mouse
- DNA-dependent RNA polymerase III RNA polymerase III
- Breast cancer
- Myeloid leukemia
- Hepatocellular carcinoma
- Oncoviruses Oncovirus
- Apoptosis
- Caspase-3 Caspase 3
- Natural killer cells Natural killer cell
Structure
- Gene
- RNA helicase
- C-terminus
- N-terminus
- RIG-I like receptors RIG-I-like receptor
- Melanoma Differentiation-Associated protein 5 MDA5
- LGP2
- MAVS VISA (gene)
Regulation
Function
- Virus
- Pathogen-associated molecular patterns Pathogen-associated molecular pattern
- Type-I interferon Type-I interferon?action=edit&redlink=1
- Proinflammatory cytokines Inflammatory cytokine
- IFNα
- IFNβ) IFN-β
- JAK-STAT JAK-STAT signaling pathway
History
- All-trans retinoic acid Tretinoin
Advanced semantic analysis
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.RIG-I
Nodes52
Edges51
Triples191
Avg. degree1.96
Density0.038462
Components1
How this topic connects Entity context
Quick relationship hints grouped by predicate. Useful for spotting recurring semantic connections around the current entity.See the strongest relationship patterns around the current topic before diving into the raw triples.
RIG-I
Top relations
Gene ontology · 49
RIG-I → actin cytoskeleton, ATP binding, bicellular tight junction, cell junction, cell projection, cellular response to exogenous dsRNA, cytoplasm, cytoplasmic pattern recognition receptor signaling pathway in response to virus, cytoskeleton, cytosol, defense response to virus, detection of virus, double-stranded DNA binding, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, immune system process, innate immune response, membrane
related to Type-1 interferon pathway · 21
RIG-I → Although RIG-I, CARD, CARDs, IFN-stimulated, IFN1, IFN1s, IFNα, IFNβ, Interferon, ISGs, JAK-STAT, MAVS, MAVS CARD, Once, Once RIG-I, PACT, PAMP, RIG-I CARD, The, This
Bgee · 19
RIG-I → Achilles tendon, blood, buccal mucosa cell, calvaria, epithelium of small intestine, granulocyte, internal globus pallidus, jejunum, lumbar spinal ganglion, mesenteric lymph nodes, monocyte, otolith organ, skin of thigh, spleen, superficial temporal artery, tendon of biceps brachii, utricle, white blood cell, zygote
RNA expression pattern · 19
RIG-I → Achilles tendon, blood, buccal mucosa cell, calvaria, epithelium of small intestine, granulocyte, internal globus pallidus, jejunum, lumbar spinal ganglion, mesenteric lymph nodes, monocyte, otolith organ, skin of thigh, spleen, superficial temporal artery, tendon of biceps brachii, utricle, white blood cell, zygote
related to Structure · 14
RIG-I → ATP-dependent DExD/H, C-terminus, CARDs, DDX58, Laboratory, LGP2, MAVS, MDA5, Melanoma Differentiation-Associated, N-terminus, On, RD, RLRs, RNA
related to Ligands · 9
RIG-I → As, Cells, It, N1, Native RNA, O-methyl, RNA, RNAs, The PAMP
related to history · 7
RIG-I → ATRA, Hematology, In, RIG, RIG-A, RIG-B, Shanghai Institute
related to Regulation · 6
RIG-I → For, LGP2, N-terminus, RIG-I-mediated, STING, The
related to Function · 5
RIG-I → In, Once, PAMP, PRR's, PRRs
related to Mechanism · 5
RIG-I → It, Less, O-methyl, On, RNA
Important terminology Word statistics
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Important terminology
rna gene cells dsrna system also cell response immune interferon virus signaling innate bp mavs pathway ifn1 helicase binding viral
Entity relationships Subject–Predicate–Object triples
Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| RIG-I | 3.6.4.13 | ↗ | 1.00 | infobox |
| RIG-I | Aliases | RIGI, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RLR-1, SGMRT2, RIG-I, DEXD/H-box helicase 58, RIG1, DDX58, RNA sensor RIG-I | 1.00 | infobox |
| RIG-I | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LWD, 2LWE, 2QFB, 2QFD, 2RMJ, 2YKG, 3LRN, 3LRR, 3NCU, 3OG8, 3ZD6, 3ZD7, 4AY2, 4BPB, 4NQK, 4ON9, 4P4H, 5E3H,… | 1.00 | infobox |
| RIG-I | Band | 9p21.1 | 1.00 | infobox |
| RIG-I | Band | 4|4 A5 | 1.00 | infobox |
| RIG-I | Bgee | buccal mucosa cell | 1.00 | infobox |
| RIG-I | Bgee | skin of thigh | 1.00 | infobox |
| RIG-I | Bgee | tendon of biceps brachii | 1.00 | infobox |
| RIG-I | Bgee | white blood cell | 1.00 | infobox |
| RIG-I | Bgee | monocyte | 1.00 | infobox |
| RIG-I | Bgee | blood | 1.00 | infobox |
| RIG-I | Bgee | Achilles tendon | 1.00 | infobox |
| RIG-I | Bgee | granulocyte | 1.00 | infobox |
| RIG-I | Bgee | internal globus pallidus | 1.00 | infobox |
| RIG-I | Bgee | superficial temporal artery | 1.00 | infobox |
| RIG-I | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| RIG-I | Bgee | lumbar spinal ganglion | 1.00 | infobox |
| RIG-I | Bgee | otolith organ | 1.00 | infobox |
| RIG-I | Bgee | utricle | 1.00 | infobox |
| RIG-I | Bgee | jejunum | 1.00 | infobox |
| RIG-I | Bgee | spleen | 1.00 | infobox |
| RIG-I | Bgee | calvaria | 1.00 | infobox |
| RIG-I | Bgee | epithelium of small intestine | 1.00 | infobox |
| RIG-I | Bgee | zygote | 1.00 | infobox |
| RIG-I | BioGPS | More reference expression data | 1.00 | infobox |
| RIG-I | Chr. | Chromosome 9 (human) | 1.00 | infobox |
| RIG-I | Chr. | Chromosome 4 (mouse) | 1.00 | infobox |
| RIG-I | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| RIG-I | End | 32,526,208 bp | 1.00 | infobox |
| RIG-I | End | 40,239,828 bp | 1.00 | infobox |
No triples extracted yet.
Related concept clusters Concept neighborhoods
Clusters of nearby vocabulary surrounding the topic. Scan them for adjacent concepts and language you may have missed.These clusters group vocabulary that occurs around closely connected concepts in the source material.
Connections between topic areas Semantic bridges
Bridge nodes connect otherwise separate parts of the map. Expand a row to inspect the topic groups on each side.Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.
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