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RIG-I: History, Overview & Structure

RIG-I (retinoic acid-inducible gene I), encoded by the gene DDX58 (DEAD box polypeptide 58), is a cytosolic pattern recognition receptor (PRR) that can mediate induction of a type-I interferon (IFN1) response. RIG-I is an essential molecule in the innate immune system for recognizing cells that have been infected with a virus, including but not limited…

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RIG-I topic overview

The analysis highlights History, Overview and Structure as prominent areas in the source structure around RIG-I. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics: 45
Source areas: 5
Connected nodes: 51
Extracted relationships: 191
Concept neighborhoods: 23
Bridge connections: 51

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 28 topics

Structure · 8 topics

Function · 7 topics

Regulation · 2 topics

History · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.6.4.13: ↗
Aliases: RIGI, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RLR-1, SGMRT2, RIG-I, DEXD/H-box helicase 58, RIG1, DDX58, RNA sensor RIG-I
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LWD, 2LWE, 2QFB, 2QFD, 2RMJ, 2YKG, 3LRN, 3LRR, 3NCU, 3OG8, 3ZD6, 3ZD7, 4AY2, 4BPB, 4NQK, 4ON9, 4P4H, 5E3H,…
Band: 9p21.1 · 4|4 A5
Bgee: buccal mucosa cell · skin of thigh · tendon of biceps brachii · white blood cell · monocyte
BioGPS: More reference expression data

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Connections across areas

RNA helicaseOverview · Structure

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

DEAD box
Cytosolic Cytosol
Pattern recognition receptor
Type-I interferon Interferon type I
Innate immune system
West Nile virus
Japanese Encephalitis virus Japanese encephalitis
Influenza A
Sendai virus
Flavivirus
Coronaviruses Coronavirus
DExD/H box DExD/H box proteins
RNA helicase
Double-stranded RNA
5' 7-methyl guanosine (m7G) cap Five-prime cap
MAVS MAVS (gene)
CARD domains CARD domain
Adaptive immune system
Orthologs Ortholog
Knockout mice Knockout mouse
DNA-dependent RNA polymerase III RNA polymerase III
Breast cancer
Myeloid leukemia
Hepatocellular carcinoma
Oncoviruses Oncovirus
Apoptosis
Caspase-3 Caspase 3
Natural killer cells Natural killer cell

Structure

Gene
RNA helicase
C-terminus
N-terminus
RIG-I like receptors RIG-I-like receptor
Melanoma Differentiation-Associated protein 5 MDA5
LGP2
MAVS VISA (gene)

Regulation

Function

Virus
Pathogen-associated molecular patterns Pathogen-associated molecular pattern
Type-I interferon Type-I interferon?action=edit&redlink=1
Proinflammatory cytokines Inflammatory cytokine
IFNα
IFNβ) IFN-β
JAK-STAT JAK-STAT signaling pathway

History

All-trans retinoic acid Tretinoin

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How RIG-I connects Entity context

The extracted context around RIG-I shows recurring relationship patterns in the source. For example, RIG-I → actin cytoskeleton, ATP binding, bicellular tight junction, cell junction, cell projection, cellular response to exogenous dsRNA, cytoplasm, cytoplasmic pattern recognition receptor signaling pathway in response to virus, cytoskeleton, cytosol, defense response to virus, detection of virus, double-stranded DNA binding, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, immune system process, innate immune response, membrane Another extracted example is RIG-I → Although RIG-I, CARD, CARDs, IFN-stimulated, IFN1, IFN1s, IFNα, IFNβ, Interferon, ISGs, JAK-STAT, MAVS, MAVS CARD, Once, Once RIG-I, PACT, PAMP, RIG-I CARD, The, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

RIG-I

Top relations

Gene ontology · 49

RIG-I → actin cytoskeleton, ATP binding, bicellular tight junction, cell junction, cell projection, cellular response to exogenous dsRNA, cytoplasm, cytoplasmic pattern recognition receptor signaling pathway in response to virus, cytoskeleton, cytosol, defense response to virus, detection of virus, double-stranded DNA binding, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, immune system process, innate immune response, membrane

related to Type-1 interferon pathway · 21

RIG-I → Although RIG-I, CARD, CARDs, IFN-stimulated, IFN1, IFN1s, IFNα, IFNβ, Interferon, ISGs, JAK-STAT, MAVS, MAVS CARD, Once, Once RIG-I, PACT, PAMP, RIG-I CARD, The, This

Bgee · 19

RIG-I → Achilles tendon, blood, buccal mucosa cell, calvaria, epithelium of small intestine, granulocyte, internal globus pallidus, jejunum, lumbar spinal ganglion, mesenteric lymph nodes, monocyte, otolith organ, skin of thigh, spleen, superficial temporal artery, tendon of biceps brachii, utricle, white blood cell, zygote

RNA expression pattern · 19

related to Structure · 14

RIG-I → ATP-dependent DExD/H, C-terminus, CARDs, DDX58, Laboratory, LGP2, MAVS, MDA5, Melanoma Differentiation-Associated, N-terminus, On, RD, RLRs, RNA

related to Ligands · 9

RIG-I → As, Cells, It, N1, Native RNA, O-methyl, RNA, RNAs, The PAMP

related to history · 7

RIG-I → ATRA, Hematology, In, RIG, RIG-A, RIG-B, Shanghai Institute

related to Regulation · 6

RIG-I → For, LGP2, N-terminus, RIG-I-mediated, STING, The

related to Function · 5

RIG-I → In, Once, PAMP, PRR's, PRRs

related to Mechanism · 5

RIG-I → It, Less, O-methyl, On, RNA

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

rna gene cells dsrna system also cell response immune interferon virus signaling innate bp mavs pathway ifn1 helicase binding viral

RIG-I relationships Subject–Predicate–Object triples

TTTA extracted 191 structured relationships around RIG-I. Examples in this analysis include RIG-I → 3.6.4.13 → ↗ and RIG-I → Aliases → RIGI, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RLR-1, SGMRT2, RIG-I, DEXD/H-box helicase 58, RIG1, DDX58, RNA sensor RIG-I. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
RIG-I	3.6.4.13	↗	1.00	infobox
RIG-I	Aliases	RIGI, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RLR-1, SGMRT2, RIG-I, DEXD/H-box helicase 58, RIG1, DDX58, RNA sensor RIG-I	1.00	infobox
RIG-I	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LWD, 2LWE, 2QFB, 2QFD, 2RMJ, 2YKG, 3LRN, 3LRR, 3NCU, 3OG8, 3ZD6, 3ZD7, 4AY2, 4BPB, 4NQK, 4ON9, 4P4H, 5E3H,…	1.00	infobox
RIG-I	Band	9p21.1	1.00	infobox
RIG-I	Band	4\|4 A5	1.00	infobox
RIG-I	Bgee	buccal mucosa cell	1.00	infobox
RIG-I	Bgee	skin of thigh	1.00	infobox
RIG-I	Bgee	tendon of biceps brachii	1.00	infobox
RIG-I	Bgee	white blood cell	1.00	infobox
RIG-I	Bgee	monocyte	1.00	infobox
RIG-I	Bgee	blood	1.00	infobox
RIG-I	Bgee	Achilles tendon	1.00	infobox
RIG-I	Bgee	granulocyte	1.00	infobox
RIG-I	Bgee	internal globus pallidus	1.00	infobox
RIG-I	Bgee	superficial temporal artery	1.00	infobox
RIG-I	Bgee	mesenteric lymph nodes	1.00	infobox
RIG-I	Bgee	lumbar spinal ganglion	1.00	infobox
RIG-I	Bgee	otolith organ	1.00	infobox
RIG-I	Bgee	utricle	1.00	infobox
RIG-I	Bgee	jejunum	1.00	infobox
RIG-I	Bgee	spleen	1.00	infobox
RIG-I	Bgee	calvaria	1.00	infobox
RIG-I	Bgee	epithelium of small intestine	1.00	infobox
RIG-I	Bgee	zygote	1.00	infobox
RIG-I	BioGPS	More reference expression data	1.00	infobox
RIG-I	Chr.	Chromosome 9 (human)	1.00	infobox
RIG-I	Chr.	Chromosome 4 (mouse)	1.00	infobox
RIG-I	Databases	NCBI: entry; OMA: entry	1.00	infobox
RIG-I	End	32,526,208 bp	1.00	infobox
RIG-I	End	40,239,828 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around RIG-I bring nearby vocabulary together. In this analysis, examples include Rna, Dsrna and Also. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

RIG-I
- Rna
- Dsrna
- Also
- Activated
- Signaling
- System
- Cells
- Cancer
- Card
- Helicase
- Mavs
- Binding
rig-i
- Rna
- Dsrna
- Also
- Activated
- Signaling
- System
- Cells
- Cancer
- Card
- Helicase
- Mavs
- Binding
pattern recognition receptor
- Recognition
- Receptor
- Helicase
- Interferon
- Response
- Band
- Chromosome
- Cytosol
- Human
- Bp
- Chr
- End
type-i interferon
- Response
- Pathway
- Signaling
- Chromosome
- Cytosol
- Human
- Pattern
- Recognition
- Bp
- Cancer
- Chr
- Receptor
innate immune system
- Immune
- Innate
- System
- Including
- Virus
- Cells
- Cell
- Card
- Response
- Band
- Chromosome
- Cytosol
west nile virus
- Immune
- System
- Innate
- Viral
- Including
- Cell
- Response
- Cells
- Band
- Chromosome
- Cytosol
- Human
japanese encephalitis virus
- Immune
- System
- Innate
- Viral
- Including
- Cell
- Response
- Cells
- Band
- Chromosome
- Cytosol
- Human
sendai virus
- Immune
- System
- Innate
- Viral
- Including
- Cell
- Response
- Cells
- Band
- Chromosome
- Cytosol
- Human

Connections between topic areas Semantic bridges

For RIG-I, one of the stronger structural bridges in this analysis connects RIG-I with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

RIG-I — Overview · splits 23 ⟂ 29

RIG-I — Structure · splits 43 ⟂ 9

RIG-I — Function · splits 44 ⟂ 8

RIG-I — Regulation · splits 49 ⟂ 3

Map overview Semantic statistics

RIG-I

Nodes52

Edges51

Triples191

Avg. degree1.96

Density0.038462

Components1

Source & methodology

TTTA analyzes the structure around RIG-I to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Overview & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — RIG-I · EN edition · Analysis: TopicsToTalkAbout

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