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Complement system

The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. Despite being part of the innate immune system, the…

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Overview

History

Functions

Activation of complements by antigen-associated antibody

Regulation

Role in disease

Modulation of the body by complement with infection

  • HIV Human Immunodeficiency Virus
  • AIDS Acquired Immunodeficiency Syndrome

Role in the brain

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Map overview Semantic statistics

Complement system

Nodes147
Edges146
Triples59
Avg. degree1.99
Density0.013605
Components1

How this topic connects Entity context

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Complement system

Top relations

related to overview · 25
Complement system → As, ASP, Bb, Both C3a, But, C2b, C3, C3-convertase, C3a, C3b, C4b, C5, C5a, C5b, C6, C7, C8, C9, Factor, Factor Ba
related to Regulation · 16
Complement system → Another, C1, C1-inhibitor, C3, C3-convertase, C3b, C9, CD59, DAF, Factor, FH, GPI, One, Some, The, This
related to Complement deficiency · 5
Complement system → Barraquer, Complement, Improper, It, Simons
related to Modulation of the body by complement with infection · 5
Complement system → Although, COVID-19, Excessive, HIV/AIDS, Research
related to External links · 4
Complement system → Complement, Media, Wikimedia Commons, Wiktionary-logo-en-v2

Important terminology Word statistics

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Important terminology

complement pathway system c3b c3 proteins c2b classical activation alternative immune factor also cells complex cell membrane blood surface c4b

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
spinal cord injuries.Deficiencies of the terminal pathway predispose to both autoimmune diseaseinstance ofImproper alternative complement pathway activation may mediate recurrent immune-mediated fetal loss.The complement system is also becoming increasingly implicated in diseases of…0.80text
infectionsinstance ofImproper alternative complement pathway activation may mediate recurrent immune-mediated fetal loss.The complement system is also becoming increasingly implicated in diseases of…0.80text
DAF.Diagnostic toolsDiagnostic tools to measure complement activity include the total complement activity test.The presence or absence of complement fixation upon a challenge can indicate whether particular antigens or antibodies are present in the bloodinstance ofThus the RBCs are not protected by GPI anchored proteins0.80text
DAFinstance ofThus the RBCs are not protected by GPI anchored proteins0.80text
Complement systemrelated to Complement deficiencyIt0.60section
Complement systemrelated to Complement deficiencyBarraquer0.60section
Complement systemrelated to Complement deficiencySimons0.60section
Complement systemrelated to Complement deficiencyComplement0.60section
Complement systemrelated to Complement deficiencyImproper0.60section
Complement systemrelated to External linksWiktionary-logo-en-v20.60section
Complement systemrelated to External linksMedia0.60section
Complement systemrelated to External linksComplement0.60section

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    Min side: 3
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