DC-SIGN

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Gene family

Prokaryotes Eukaryotes Lectins Ligands Asialoglycoprotein receptors

9 related topics

Clinical significance

Molecule Gp120 Ebola virus L-SIGN (CD209L or CD299)Severe acute respiratory syndrome coronavirus 2

8 related topics

Function

ICAM3 Mannose Glycoproteins HIV Hepatitis C

7 related topics

Overview

Cluster of Differentiation Protein C-type lectin Macrophages Dendritic cells

12 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: CD209, CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CD209 molecule, hDC-SIGN
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1K9I, 1SL4, 1SL5, 2B6B, 2IT5, 2IT6, 2XR5, 2XR6
Band: 19p13.2 · 8|8 A1.1
Bgee: lymph node · superficial temporal artery · decidua · rectum · right coronary artery
BioGPS: More reference expression data
Chr.: Chromosome 19 (human) · Chromosome 8 (mouse)

Topics to explore

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Gene family

Prokaryotes Prokaryote
Eukaryotes Eukaryote
Lectins
Ligands Ligand (biochemistry)
Asialoglycoprotein receptors Asialoglycoprotein receptor
Innate immunity
CD23
B lymphocytes B lymphocyte
Orthologous Homology (biology)

Advanced semantic analysis

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Map overview Semantic statistics

Nodes41

Edges40

Triples172

Avg. degree1.95

Density0.04878

Components1

How this topic connects Entity context

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DC-SIGN

Top relations

Gene ontology · 37

DC-SIGN → adaptive immune response, antigen processing and presentation, B cell adhesion, carbohydrate binding, cell adhesion, cell surface, cell-cell recognition, cytoplasm, endocytosis, external side of plasma membrane, extracellular exosome, extracellular region, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, host cell, immune system process, innate immune response, integral component of membrane, intracellular signal transduction, intracellular transport of virus, leukocyte cell-cell adhesion

related to Gene family · 26

DC-SIGN → Among, ASGR, C-lectin, C-lectins, C57BL/6, CD209, CD23, CLEC4G, DC Receptor, DC-SIGN/CD209, DC-SIGNL1, DC-SIGNL2, DC-SIGNR, DC-SIGNR1, DC-SIGNR2, DC-SIGNR6, DC-SIGNR8, Eight, For, Higher

Bgee · 20

DC-SIGN → apex of heart, blastocyst, decidua, duodenum, gallbladder, jejunal mucosa, lip, lymph node, mesenteric lymph nodes, morula, mucosa of ileum, muscle of thigh, rectum, right coronary artery, skin of abdomen, skin of back, skin of external ear, superficial temporal artery, thymus, white adipose tissue

RNA expression pattern · 20

related to SARS-CoV-2 · 19

DC-SIGN → ACE2, Angiotensin-converting, C-lectin, CD209L, CD209L-ACE2, CD299, DC/L-SIGN, Ebola, HIV, HIV-1, It, L-SIGN, PRR, SARS-CoV-2, SARS-CoV-2 Spike, Severe, Significant CD209L, Similarly, This

related to Function · 8

DC-SIGN → Besides, Binding, C-type, Hepatitis, HIV, ICAM3, It, T-cells

related to External links · 6

DC-SIGN → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library

related to HIV infection · 6

DC-SIGN → CD4, DC-SIGN/HIV, HIV, ICAM-3, The, This

related to Ebola infection · 4

DC-SIGN → Different, European, In, These

Band · 2

DC-SIGN → 19p13.2, 8|8 A1.1

Important terminology Word statistics

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Important terminology

dendritic cells human gene cd209 cell bp infection hiv molecule receptor chr band also mouse virus chromosome 19 protein macrophages

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
DC-SIGN	Aliases	CD209, CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CD209 molecule, hDC-SIGN	1.00	infobox
DC-SIGN	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1K9I, 1SL4, 1SL5, 2B6B, 2IT5, 2IT6, 2XR5, 2XR6	1.00	infobox
DC-SIGN	Band	19p13.2	1.00	infobox
DC-SIGN	Band	8\|8 A1.1	1.00	infobox
DC-SIGN	Bgee	lymph node	1.00	infobox
DC-SIGN	Bgee	superficial temporal artery	1.00	infobox
DC-SIGN	Bgee	decidua	1.00	infobox
DC-SIGN	Bgee	rectum	1.00	infobox
DC-SIGN	Bgee	right coronary artery	1.00	infobox
DC-SIGN	Bgee	mucosa of ileum	1.00	infobox
DC-SIGN	Bgee	jejunal mucosa	1.00	infobox
DC-SIGN	Bgee	gallbladder	1.00	infobox
DC-SIGN	Bgee	apex of heart	1.00	infobox
DC-SIGN	Bgee	duodenum	1.00	infobox
DC-SIGN	Bgee	morula	1.00	infobox
DC-SIGN	Bgee	skin of abdomen	1.00	infobox
DC-SIGN	Bgee	blastocyst	1.00	infobox
DC-SIGN	Bgee	mesenteric lymph nodes	1.00	infobox
DC-SIGN	Bgee	lip	1.00	infobox
DC-SIGN	Bgee	skin of external ear	1.00	infobox
DC-SIGN	Bgee	thymus	1.00	infobox
DC-SIGN	Bgee	muscle of thigh	1.00	infobox
DC-SIGN	Bgee	skin of back	1.00	infobox
DC-SIGN	Bgee	white adipose tissue	1.00	infobox
DC-SIGN	BioGPS	More reference expression data	1.00	infobox
DC-SIGN	Chr.	Chromosome 19 (human)	1.00	infobox
DC-SIGN	Chr.	Chromosome 8 (mouse)	1.00	infobox
DC-SIGN	Databases	NCBI: entry; OMA: entry	1.00	infobox
DC-SIGN	End	7,747,564 bp	1.00	infobox
DC-SIGN	End	3,904,309 bp	1.00	infobox

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