Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

DC-SIGN: Gene family, Clinical significance & Function

DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene.

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

DC-SIGN topic overview

The analysis highlights Gene family, Clinical significance and Function as prominent areas in the source structure around DC-SIGN.

Related topics
36
Source areas
4
Connected nodes
40
Extracted relationships
172
Concept neighborhoods
17
Bridge connections
40

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 12 topics
Gene family · 9 topics
Clinical significance · 8 topics
Function · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CD209, CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CD209 molecule, hDC-SIGN
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1K9I, 1SL4, 1SL5, 2B6B, 2IT5, 2IT6, 2XR5, 2XR6
Band
19p13.2 · 8|8 A1.1
Bgee
lymph node · superficial temporal artery · decidua · rectum · right coronary artery
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 8 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Gene family

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How DC-SIGN connects Entity context

The extracted context around DC-SIGN shows recurring relationship patterns in the source. For example, DC-SIGN → adaptive immune response, antigen processing and presentation, B cell adhesion, carbohydrate binding, cell adhesion, cell surface, cell-cell recognition, cytoplasm, endocytosis, external side of plasma membrane, extracellular exosome, extracellular region, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, host cell, immune system process, innate immune response, integral component of membrane, intracellular signal transduction, intracellular transport of virus, leukocyte cell-cell adhesion Another extracted example is DC-SIGN → Among, ASGR, C-lectin, C-lectins, C57BL/6, CD209, CD23, CLEC4G, DC Receptor, DC-SIGN/CD209, DC-SIGNL1, DC-SIGNL2, DC-SIGNR, DC-SIGNR1, DC-SIGNR2, DC-SIGNR6, DC-SIGNR8, Eight, For, Higher. Use these groups to spot repeated connection types before inspecting the individual relationships.

DC-SIGN

Top relations

Gene ontology · 37
DC-SIGN → adaptive immune response, antigen processing and presentation, B cell adhesion, carbohydrate binding, cell adhesion, cell surface, cell-cell recognition, cytoplasm, endocytosis, external side of plasma membrane, extracellular exosome, extracellular region, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, host cell, immune system process, innate immune response, integral component of membrane, intracellular signal transduction, intracellular transport of virus, leukocyte cell-cell adhesion
related to Gene family · 26
DC-SIGN → Among, ASGR, C-lectin, C-lectins, C57BL/6, CD209, CD23, CLEC4G, DC Receptor, DC-SIGN/CD209, DC-SIGNL1, DC-SIGNL2, DC-SIGNR, DC-SIGNR1, DC-SIGNR2, DC-SIGNR6, DC-SIGNR8, Eight, For, Higher
Bgee · 20
DC-SIGN → apex of heart, blastocyst, decidua, duodenum, gallbladder, jejunal mucosa, lip, lymph node, mesenteric lymph nodes, morula, mucosa of ileum, muscle of thigh, rectum, right coronary artery, skin of abdomen, skin of back, skin of external ear, superficial temporal artery, thymus, white adipose tissue
RNA expression pattern · 20
DC-SIGN → apex of heart, blastocyst, decidua, duodenum, gallbladder, jejunal mucosa, lip, lymph node, mesenteric lymph nodes, morula, mucosa of ileum, muscle of thigh, rectum, right coronary artery, skin of abdomen, skin of back, skin of external ear, superficial temporal artery, thymus, white adipose tissue
related to SARS-CoV-2 · 19
DC-SIGN → ACE2, Angiotensin-converting, C-lectin, CD209L, CD209L-ACE2, CD299, DC/L-SIGN, Ebola, HIV, HIV-1, It, L-SIGN, PRR, SARS-CoV-2, SARS-CoV-2 Spike, Severe, Significant CD209L, Similarly, This
related to Function · 8
DC-SIGN → Besides, Binding, C-type, Hepatitis, HIV, ICAM3, It, T-cells
related to External links · 6
DC-SIGN → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
related to HIV infection · 6
DC-SIGN → CD4, DC-SIGN/HIV, HIV, ICAM-3, The, This
related to Ebola infection · 4
DC-SIGN → Different, European, In, These
Band · 2
DC-SIGN → 19p13.2, 8|8 A1.1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dendritic cells human gene cd209 cell bp infection hiv molecule receptor chr band also mouse virus chromosome 19 protein macrophages

DC-SIGN relationships Subject–Predicate–Object triples

TTTA extracted 172 structured relationships around DC-SIGN. Examples in this analysis include DC-SIGN → Aliases → CD209, CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CD209 molecule, hDC-SIGN and DC-SIGN → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1K9I, 1SL4, 1SL5, 2B6B, 2IT5, 2IT6, 2XR5, 2XR6. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DC-SIGNAliasesCD209, CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CD209 molecule, hDC-SIGN1.00infobox
DC-SIGNAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1K9I, 1SL4, 1SL5, 2B6B, 2IT5, 2IT6, 2XR5, 2XR61.00infobox
DC-SIGNBand19p13.21.00infobox
DC-SIGNBand8|8 A1.11.00infobox
DC-SIGNBgeelymph node1.00infobox
DC-SIGNBgeesuperficial temporal artery1.00infobox
DC-SIGNBgeedecidua1.00infobox
DC-SIGNBgeerectum1.00infobox
DC-SIGNBgeeright coronary artery1.00infobox
DC-SIGNBgeemucosa of ileum1.00infobox
DC-SIGNBgeejejunal mucosa1.00infobox
DC-SIGNBgeegallbladder1.00infobox
DC-SIGNBgeeapex of heart1.00infobox
DC-SIGNBgeeduodenum1.00infobox
DC-SIGNBgeemorula1.00infobox
DC-SIGNBgeeskin of abdomen1.00infobox
DC-SIGNBgeeblastocyst1.00infobox
DC-SIGNBgeemesenteric lymph nodes1.00infobox
DC-SIGNBgeelip1.00infobox
DC-SIGNBgeeskin of external ear1.00infobox
DC-SIGNBgeethymus1.00infobox
DC-SIGNBgeemuscle of thigh1.00infobox
DC-SIGNBgeeskin of back1.00infobox
DC-SIGNBgeewhite adipose tissue1.00infobox
DC-SIGNBioGPSMore reference expression data1.00infobox
DC-SIGNChr.Chromosome 19 (human)1.00infobox
DC-SIGNChr.Chromosome 8 (mouse)1.00infobox
DC-SIGNDatabasesNCBI: entry; OMA: entry1.00infobox
DC-SIGNEnd7,747,564 bp1.00infobox
DC-SIGNEnd3,904,309 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around DC-SIGN bring nearby vocabulary together. In this analysis, examples include Cells, Dendritic and Also. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DC-SIGN
    • Cells
    • Dendritic
    • Also
    • Molecule
    • Receptor
    • Virus
    • Human
    • Cell
    • Infection
    • Hiv
    • Cd209
    • Adhesion
  • dc-sign
    • Cells
    • Dendritic
    • Also
    • Molecule
    • Receptor
    • Virus
    • Human
    • Cell
    • Infection
    • Hiv
    • Cd209
    • Adhesion
  • c-type lectin
    • Lectin
    • Surface
    • Recognition
    • External
    • Receptor
    • Function
    • Location
    • Macrophages
    • Affinity
    • Band
    • Binding
    • Cells
  • dendritic cells
    • Cells
    • Dendritic
    • Dc-sign
    • Cell
    • C-type
    • Binding
    • Recognition
    • Surface
    • Expressed
    • Hiv
    • Receptor
    • Virus
  • adhesion
    • Known
    • Protein
    • Also
    • Gene
    • Molecule
    • Cd209
    • External
    • Lectin
    • C-type
    • Function
    • Location
    • Affinity
  • ebola virus
    • Ebola
    • Virus
    • Hiv
    • Infection
    • Molecule
    • Receptor
    • Binding
    • Process
    • Recognition
    • Dc-sign
    • External
    • Human
  • sars-cov-2 spike protein
    • Entry
    • Process
    • Also
    • Human
    • External
    • Infection
    • Function
    • Location
    • Binding
    • Chromosome
    • Ebola
    • Interaction
  • gene family
    • Location
    • Chromosome
    • Bp
    • Chr
    • Mouse
    • External
    • Human
    • Function
    • Band
    • Protein
    • Expressed
    • Molecule

Connections between topic areas Semantic bridges

For DC-SIGN, one of the stronger structural bridges in this analysis connects DC-SIGN with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DC-SIGNOverview · splits 28 ⟂ 13
DC-SIGNGene family · splits 31 ⟂ 10
DC-SIGNClinical significance · splits 32 ⟂ 9
DC-SIGNFunction · splits 33 ⟂ 8

Map overview Semantic statistics

DC-SIGN

Nodes41
Edges40
Triples172
Avg. degree1.95
Density0.04878
Components1

Source & methodology

TTTA analyzes the structure around DC-SIGN to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Gene family, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DC-SIGN · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.