Toll-like receptor 4

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Explore the main themes, entities and connections around Toll-like receptor 4. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Drugs targeting TLR4

Opioids Analgesic Μ-opioid Receptor (+)-morphine

40 related topics

Signaling

MyD88 TRIF TIRAP IRAKs TRAF6

13 related topics

Clinical significance

Inflammation Infection Sepsis Septic shock Escherichia coli

10 related topics

Overview

Cluster of differentiation Innate immune Transmembrane protein KDa Gene

17 related topics

Key facts & relationships

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Aliases: TLR4, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4G8A, 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA
Band: 9q33.1 · 4 C1|4 34.66 cM
Bgee: monocyte · Achilles tendon · blood · bone marrow · trabecular bone
BioGPS: More reference expression data
Chr.: Chromosome 9 (human) · Chromosome 4 (mouse)

Topics to explore

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Overview

Cluster of differentiation
Innate immune Innate immune system
Transmembrane protein
KDa Dalton (unit)
Gene
Toll-like receptor
Pattern recognition receptors Pattern recognition receptor
Pathogen-associated molecular patterns Pathogen-associated molecular pattern
Myeloid Myeloid-derived suppressor cell
CD14
Lipopolysaccharides Lipopolysaccharide
Gram-negative bacteria
Gram-positive bacteria
DAMPs
HMGB1
S100 S100 protein
Histones Histone

Function

Innate immunity
LPS-binding protein Lipopolysaccharide binding protein
Leucine-rich repeat domain Leucine-rich repeat
Toll/interleukin-1 receptor Toll-Interleukin receptor
MD-2 protein Lymphocyte antigen 96

Signaling

MyD88
TRIF TICAM1
TIRAP
IRAKs Interleukin-1 receptor-associated kinase
TRAF6
TAK1 MAP3K7
MAPK cascades MAPK/ERK pathway
IKK IκB kinase
NF-κB
AP-1 AP-1 transcription factor
TRIF
IRF3
Type I IFN Interferon type I

Immune cell activation

CD40 CD40 (protein)
CD80
CD86
MHC MHC class II
Endosomes Endosome
Phagosomes Phagosome

Clinical significance

Drugs targeting TLR4

Opioids Opioid
Analgesic
Μ-opioid Mu opioid receptor
Receptor Receptor (biochemistry)
(+)-morphine
TNF-α Tumor necrosis factor-alpha
Interleukin-1 IL1B
Tolerance Drug tolerance
Hyperalgesia
Allodynia
Enantiomer
(-)-morphine (-)-morphine?action=edit&redlink=1
(+)-naloxone
Morphine
Pain
Addiction
Drug abuse
Respiratory depression
Pain management
Molecular docking
Amitriptyline
Cyclobenzaprine
CyRL-QN15
Eritoran
Ketotifen
Imipramine
Mianserin
Ibudilast
Pinocembrin
Resatorvid

Advanced semantic analysis

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Map overview Semantic statistics

Nodes98

Edges97

Triples191

Avg. degree1.98

Density0.020408

Components1

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Toll-like receptor 4

Top relations

Gene ontology · 84

Toll-like receptor 4 → activation of innate immune response, apoptotic signaling pathway, astrocyte development, B cell proliferation involved in immune response, cell surface, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to mechanical stimulus, cytoplasm, defense response to bacterium, defense response to Gram-negative bacterium, detection of fungus, detection of lipopolysaccharide, endosome membrane, external side of plasma membrane, I-kappaB kinase/NF-kappaB signaling, I-kappaB phosphorylation, immune response, immune system process, inflammatory response

Bgee · 19

Toll-like receptor 4 → Achilles tendon, aortic valve, ascending aorta, blood, bone marrow, bone marrow cell, cervix, decidua, endothelial cell of lymphatic vessel, epithelium of stomach, gallbladder, granulocyte, lumbar spinal ganglion, monocyte, mucous cell of stomach, right lung, spleen, stroma of bone marrow, trabecular bone

RNA expression pattern · 19

related to External links · 10

Toll-like receptor 4 → Medicine Medical Subject Headings, MeSH, National Library, O00206, Overview, PDB, PDBe-KB, Receptor, Toll-Like, UniProt

Band · 2

Toll-like receptor 4 → 4 C1|4 34.66 cM, 9q33.1

Chr. · 2

Toll-like receptor 4 → Chromosome 4 (mouse), Chromosome 9 (human)

End · 2

Toll-like receptor 4 → 117,724,735 bp, 66,848,521 bp

Aliases · 1

Toll-like receptor 4 → TLR4, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4

Available structures · 1

Toll-like receptor 4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4G8A, 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA

BioGPS · 1

Toll-like receptor 4 → More reference expression data

Important terminology Word statistics

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Important terminology

tlr4 lps activation also signaling cells receptor human pathway trif protein immune pathways agonists innate myd88 however tumor molecules role

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Toll-like receptor 4	Aliases	TLR4, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4	1.00	infobox
Toll-like receptor 4	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4G8A, 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA	1.00	infobox
Toll-like receptor 4	Band	9q33.1	1.00	infobox
Toll-like receptor 4	Band	4 C1\|4 34.66 cM	1.00	infobox
Toll-like receptor 4	Bgee	monocyte	1.00	infobox
Toll-like receptor 4	Bgee	Achilles tendon	1.00	infobox
Toll-like receptor 4	Bgee	blood	1.00	infobox
Toll-like receptor 4	Bgee	bone marrow	1.00	infobox
Toll-like receptor 4	Bgee	trabecular bone	1.00	infobox
Toll-like receptor 4	Bgee	spleen	1.00	infobox
Toll-like receptor 4	Bgee	granulocyte	1.00	infobox
Toll-like receptor 4	Bgee	right lung	1.00	infobox
Toll-like receptor 4	Bgee	gallbladder	1.00	infobox
Toll-like receptor 4	Bgee	bone marrow cell	1.00	infobox
Toll-like receptor 4	Bgee	lumbar spinal ganglion	1.00	infobox
Toll-like receptor 4	Bgee	aortic valve	1.00	infobox
Toll-like receptor 4	Bgee	ascending aorta	1.00	infobox
Toll-like receptor 4	Bgee	decidua	1.00	infobox
Toll-like receptor 4	Bgee	epithelium of stomach	1.00	infobox
Toll-like receptor 4	Bgee	stroma of bone marrow	1.00	infobox
Toll-like receptor 4	Bgee	endothelial cell of lymphatic vessel	1.00	infobox
Toll-like receptor 4	Bgee	cervix	1.00	infobox
Toll-like receptor 4	Bgee	mucous cell of stomach	1.00	infobox
Toll-like receptor 4	BioGPS	More reference expression data	1.00	infobox
Toll-like receptor 4	Chr.	Chromosome 9 (human)	1.00	infobox
Toll-like receptor 4	Chr.	Chromosome 4 (mouse)	1.00	infobox
Toll-like receptor 4	Databases	NCBI: entry; OMA: entry	1.00	infobox
Toll-like receptor 4	End	117,724,735 bp	1.00	infobox
Toll-like receptor 4	End	66,848,521 bp	1.00	infobox
Toll-like receptor 4	Ensembl	ENSG00000136869	1.00	infobox

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