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Small interfering RNA

Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded non-coding RNA molecules, typically 20–24 base pairs in length, similar to microRNA (miRNA), and operating within the RNA interference (RNAi) pathway. It interferes with the expression of specific genes with complementary nucleotide…

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Overview

Structure

History

Mechanism

  • RISC RNA-induced silencing complex

RNAi induction using siRNAs or their biosynthetic precursors

RNA activation

Post-transcriptional gene silencing

Applications

Challenges

Therapeutic applications

Intracellular delivery

Therapies

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Map overview Semantic statistics

Small interfering RNA

Nodes137
Edges136
Triples18
Avg. degree1.99
Density0.014599
Components1

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Small interfering RNA

Top relations

related to Intracellular delivery · 14
Small interfering RNA → As, ASGPR, But, For RNAi, GalNAc, LNP, N-acetylgalactosamine, Onpattro, Patisiran, RNA, RNAi, The, There, Unmodified

Important terminology Word statistics

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Important terminology

sirna rnai gene rna sirnas target mrna silencing also needed delivery expression source risc small may genes transcriptional therapies cells

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
an siRNAinstance ofWhen a mammalian cell encounters a double-stranded RNA0.80text
it may mistake it as a viral by-productinstance ofWhen a mammalian cell encounters a double-stranded RNA0.80text
mount an immune responseinstance ofWhen a mammalian cell encounters a double-stranded RNA0.80text
cyclodextrin based nanoparticles.siRNAs delivered via lipid based nanoparticles have been shown to have therapeutic potential for central nervous systeminstance ofbut other cancers may require different non-lipid based organic nanovectors0.80text
Small interfering RNArelated to Intracellular deliveryThere0.60section
Small interfering RNArelated to Intracellular deliveryRNA0.60section
Small interfering RNArelated to Intracellular deliveryRNAi0.60section
Small interfering RNArelated to Intracellular deliveryFor RNAi0.60section
Small interfering RNArelated to Intracellular deliveryBut0.60section
Small interfering RNArelated to Intracellular deliveryUnmodified0.60section
Small interfering RNArelated to Intracellular deliveryAs0.60section
Small interfering RNArelated to Intracellular deliveryThe0.60section

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