NOD2

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NOD2 topic overview

The analysis highlights Structure, Function and Clinical significance as prominent areas in the source structure around NOD2.

Related topics: 29
Source areas: 5
Connected nodes: 34
Extracted relationships: 151
Concept neighborhoods: 15
Bridge connections: 34

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 9 topics

Structure · 7 topics

Clinical significance · 5 topics

Function · 5 topics

Interactions · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5IRL, 5IRM, 5IRN
Band: 16q12.1 · 8|8 C3
Bgee: monocyte · granulocyte · blood · skin of leg · skin of abdomen
BioGPS: More reference expression data
Chr.: Chromosome 16 (human) · Chromosome 8 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Interactions

Interact Protein–protein interaction
NLRC4
MAVS VISA (gene)

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NOD2 connects Entity context

The extracted context around NOD2 shows recurring relationship patterns in the source. For example, NOD2 → actin binding, ATP binding, basolateral plasma membrane, CARD domain binding, cell surface, cellular response to lipopolysaccharide, cellular response to muramyl dipeptide, cellular response to organic cyclic compound, cellular response to peptidoglycan, COP9 signalosome, cytokine production involved in immune response, cytoplasm, cytoskeleton, cytosol, defense response, defense response to bacterium, detection of bacterium, detection of biotic stimulus, detection of muramyl dipeptide, enzyme binding Another extracted example is NOD2 → blood, bone marrow cell, cartilage tissue, duodenum, embryo, esophagus, granulocyte, human penis, lip, monocyte, primary oocyte, quadriceps femoris muscle, secondary oocyte, skin of abdomen, skin of leg, vagina, vulva, zone of skin, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 77

NOD2 → actin binding, ATP binding, basolateral plasma membrane, CARD domain binding, cell surface, cellular response to lipopolysaccharide, cellular response to muramyl dipeptide, cellular response to organic cyclic compound, cellular response to peptidoglycan, COP9 signalosome, cytokine production involved in immune response, cytoplasm, cytoskeleton, cytosol, defense response, defense response to bacterium, detection of bacterium, detection of biotic stimulus, detection of muramyl dipeptide, enzyme binding

Bgee · 19

NOD2 → blood, bone marrow cell, cartilage tissue, duodenum, embryo, esophagus, granulocyte, human penis, lip, monocyte, primary oocyte, quadriceps femoris muscle, secondary oocyte, skin of abdomen, skin of leg, vagina, vulva, zone of skin, zygote

RNA expression pattern · 19

related to Clinical significance · 6

NOD2 → Blau, Crohn's, Graft-versus-host, Loss, Mutations, PD-1/PD-L1

related to Interactions · 5

NOD2 → IFN, MAVS, NLRC4, RNA, This

Band · 2

NOD2 → 16q12.1, 8|8 C3

Chr. · 2

NOD2 → Chromosome 16 (human), Chromosome 8 (mouse)

End · 2

NOD2 → 50,734,041 bp, 89,415,102 bp

Aliases · 1

NOD2 → NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS

Available structures · 1

NOD2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5IRL, 5IRM, 5IRN

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp protein gene chromosome 16 immune chr human band also known role domain oligomerization molecules containing response muramyl dipeptide location

NOD2 relationships Subject–Predicate–Object triples

TTTA extracted 151 structured relationships around NOD2. Examples in this analysis include NOD2 → Aliases → NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS and NOD2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5IRL, 5IRM, 5IRN. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
NOD2	Aliases	NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS	1.00	infobox
NOD2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5IRL, 5IRM, 5IRN	1.00	infobox
NOD2	Band	16q12.1	1.00	infobox
NOD2	Band	8\|8 C3	1.00	infobox
NOD2	Bgee	monocyte	1.00	infobox
NOD2	Bgee	granulocyte	1.00	infobox
NOD2	Bgee	blood	1.00	infobox
NOD2	Bgee	skin of leg	1.00	infobox
NOD2	Bgee	skin of abdomen	1.00	infobox
NOD2	Bgee	vulva	1.00	infobox
NOD2	Bgee	human penis	1.00	infobox
NOD2	Bgee	cartilage tissue	1.00	infobox
NOD2	Bgee	bone marrow cell	1.00	infobox
NOD2	Bgee	vagina	1.00	infobox
NOD2	Bgee	secondary oocyte	1.00	infobox
NOD2	Bgee	primary oocyte	1.00	infobox
NOD2	Bgee	zygote	1.00	infobox
NOD2	Bgee	embryo	1.00	infobox
NOD2	Bgee	esophagus	1.00	infobox
NOD2	Bgee	zone of skin	1.00	infobox
NOD2	Bgee	lip	1.00	infobox
NOD2	Bgee	quadriceps femoris muscle	1.00	infobox
NOD2	Bgee	duodenum	1.00	infobox
NOD2	BioGPS	More reference expression data	1.00	infobox
NOD2	Chr.	Chromosome 16 (human)	1.00	infobox
NOD2	Chr.	Chromosome 8 (mouse)	1.00	infobox
NOD2	Databases	NCBI: entry; OMA: entry	1.00	infobox
NOD2	End	50,734,041 bp	1.00	infobox
NOD2	End	89,415,102 bp	1.00	infobox
NOD2	Ensembl	ENSG00000167207	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NOD2 bring nearby vocabulary together. In this analysis, examples include Containing, Function and Oligomerization. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

NOD2
- Containing
- Function
- Oligomerization
- Also
- Response
- Chromosome
- Immune
- Gene
- Card15
- Ibd1
- Inflammatory
- Intracellular
nod2
- Containing
- Function
- Oligomerization
- Also
- Response
- Chromosome
- Immune
- Gene
- Card15
- Ibd1
- Inflammatory
- Intracellular
protein
- Recruitment
- Dipeptide
- Domain
- Muramyl
- Response
- Role
- Immune
- Bacterial
- Intracellular
- Mdp
- Mouse
- Nucleotide
gene
- Chromosome
- Location
- Oligomerization
- Human
- Known
- Bp
- Chr
- Ibd1
- Inflammatory
- Mouse
- Nucleotide
- Nucleotide-binding
chromosome 16
- Human
- Bp
- Chr
- Location
- Oligomerization
- Gene
- Band
- Ibd1
- Inflammatory
- Mouse
- Nucleotide
- Nucleotide-binding
immune system
- Response
- Role
- Bacterial
- Immune
- Plays
- System
- Dipeptide
- Function
- Inflammatory
- Intracellular
- Molecules
- Mouse
muramyl dipeptide
- Dipeptide
- Muramyl
- Intracellular
- Mdp
- Pattern
- Molecules
- Response
- Role
- Immune
- Protein
- Inflammatory
- Mouse
nod domain
- Nucleotide
- Function
- Location
- Oligomerization
- Human
- Bp
- Chr
- Gene
- Protein
- Ibd1
- Inflammatory
- Intracellular

Connections between topic areas Semantic bridges

For NOD2, one of the stronger structural bridges in this analysis connects NOD2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

NOD2 — Overview · splits 25 ⟂ 10

NOD2 — Structure · splits 27 ⟂ 8

NOD2 — Function · splits 29 ⟂ 6

NOD2 — Clinical significance · splits 29 ⟂ 6

NOD2 — Interactions · splits 31 ⟂ 4

Map overview Semantic statistics

NOD2

Nodes35

Edges34

Triples151

Avg. degree1.94

Density0.057143

Components1

Source & methodology

TTTA analyzes the structure around NOD2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NOD2 · EN edition · Analysis: TopicsToTalkAbout