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NOD2

Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1), is a protein that in humans is encoded by the NOD2 gene located on chromosome 16. NOD2 plays an important role in the immune system. It recognizes bacterial…

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Aliases
NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5IRL, 5IRM, 5IRN
Band
16q12.1 · 8|8 C3
Bgee
monocyte · granulocyte · blood · skin of leg · skin of abdomen
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)

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Map overview Semantic statistics

NOD2

Nodes35
Edges34
Triples151
Avg. degree1.94
Density0.057143
Components1

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NOD2

Top relations

Gene ontology · 77
NOD2 → actin binding, ATP binding, basolateral plasma membrane, CARD domain binding, cell surface, cellular response to lipopolysaccharide, cellular response to muramyl dipeptide, cellular response to organic cyclic compound, cellular response to peptidoglycan, COP9 signalosome, cytokine production involved in immune response, cytoplasm, cytoskeleton, cytosol, defense response, defense response to bacterium, detection of bacterium, detection of biotic stimulus, detection of muramyl dipeptide, enzyme binding
Bgee · 19
NOD2 → blood, bone marrow cell, cartilage tissue, duodenum, embryo, esophagus, granulocyte, human penis, lip, monocyte, primary oocyte, quadriceps femoris muscle, secondary oocyte, skin of abdomen, skin of leg, vagina, vulva, zone of skin, zygote
RNA expression pattern · 19
NOD2 → blood, bone marrow cell, cartilage tissue, duodenum, embryo, esophagus, granulocyte, human penis, lip, monocyte, primary oocyte, quadriceps femoris muscle, secondary oocyte, skin of abdomen, skin of leg, vagina, vulva, zone of skin, zygote
related to Clinical significance · 6
NOD2 → Blau, Crohn's, Graft-versus-host, Loss, Mutations, PD-1/PD-L1
related to Interactions · 5
NOD2 → IFN, MAVS, NLRC4, RNA, This
Band · 2
NOD2 → 16q12.1, 8|8 C3
Chr. · 2
NOD2 → Chromosome 16 (human), Chromosome 8 (mouse)
End · 2
NOD2 → 50,734,041 bp, 89,415,102 bp
Aliases · 1
NOD2 → NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS
Available structures · 1
NOD2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5IRL, 5IRM, 5IRN

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Important terminology

bp protein gene chromosome 16 immune chr human band also known role domain oligomerization molecules containing response muramyl dipeptide location

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
NOD2AliasesNOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS1.00infobox
NOD2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5IRL, 5IRM, 5IRN1.00infobox
NOD2Band16q12.11.00infobox
NOD2Band8|8 C31.00infobox
NOD2Bgeemonocyte1.00infobox
NOD2Bgeegranulocyte1.00infobox
NOD2Bgeeblood1.00infobox
NOD2Bgeeskin of leg1.00infobox
NOD2Bgeeskin of abdomen1.00infobox
NOD2Bgeevulva1.00infobox
NOD2Bgeehuman penis1.00infobox
NOD2Bgeecartilage tissue1.00infobox
NOD2Bgeebone marrow cell1.00infobox
NOD2Bgeevagina1.00infobox
NOD2Bgeesecondary oocyte1.00infobox
NOD2Bgeeprimary oocyte1.00infobox
NOD2Bgeezygote1.00infobox
NOD2Bgeeembryo1.00infobox
NOD2Bgeeesophagus1.00infobox
NOD2Bgeezone of skin1.00infobox
NOD2Bgeelip1.00infobox
NOD2Bgeequadriceps femoris muscle1.00infobox
NOD2Bgeeduodenum1.00infobox
NOD2BioGPSMore reference expression data1.00infobox
NOD2Chr.Chromosome 16 (human)1.00infobox
NOD2Chr.Chromosome 8 (mouse)1.00infobox
NOD2DatabasesNCBI: entry; OMA: entry1.00infobox
NOD2End50,734,041 bp1.00infobox
NOD2End89,415,102 bp1.00infobox
NOD2EnsemblENSG000001672071.00infobox

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