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CLEC7A

C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene. CLEC7A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with a partial…

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Aliases
CLEC7A, BGR, CANDF4, CLECSF12, DECTIN1, CD369, SCARE2, C-type lectin domain family 7 member A, C-type lectin domain containing 7A
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BPD, 2BPE, 2BPH, 2CL8
Band
12p13.2 · 6|6 F3
Bgee
monocyte · granulocyte · blood · buccal mucosa cell · periodontal fiber
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)

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Map overview Semantic statistics

CLEC7A

Nodes57
Edges56
Triples144
Avg. degree1.96
Density0.035088
Components1

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CLEC7A

Top relations

Gene ontology · 26
CLEC7A → carbohydrate binding, carbohydrate mediated signaling, cell recognition, cytoplasm, defense response to protozoan, immune system process, inflammatory response, innate immune response, integral component of membrane, intracellular membrane-bounded organelle, membrane, metal ion binding, MHC protein binding, nucleoplasm, pattern recognition receptor activity, pattern recognition receptor signaling pathway, phagocytosis, recognition, plasma membrane, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of cytokine production involved in inflammatory response
related to Function · 23
CLEC7A → As, BCL10, CARD-CC/BCL10/MALT1, CARD9, CBM, Dimerization, IL-2, IL-23, IL-6, ITAM-like, Ligand, MALT1, NF-κB, Other, PKC-δ, Src, Syk, T-cells, The C-type, This
Bgee · 17
CLEC7A → appendix, blood, bone marrow, buccal mucosa cell, granulocyte, left lung, mesenteric lymph nodes, monocyte, mucous cell of stomach, periodontal fiber, right lung, right lung lobe, spleen, subcutaneous adipose tissue, tendon of biceps brachii, tibiofemoral joint, upper lobe of left lung
RNA expression pattern · 17
CLEC7A → appendix, blood, bone marrow, buccal mucosa cell, granulocyte, left lung, mesenteric lymph nodes, monocyte, mucous cell of stomach, periodontal fiber, right lung, right lung lobe, spleen, subcutaneous adipose tissue, tendon of biceps brachii, tibiofemoral joint, upper lobe of left lung
related to Antifungal immunity · 17
CLEC7A → Activation, Candida, CCL3, Coccidioides, CXCL2, G-CSF, GM-CSF, Histoplasma, IL-1α, IL-1β, IL-6, Penicillium, Pneumocystis, Recognition, Saccharomyces, Th17, TNF
related to Structure · 7
CLEC7A → C-type, CRD, Dectin-1, Expression, ITAM, N-linked, The CRD
related to Co-stimulatory molecule · 4
CLEC7A → Also, CD4, CD8, T-cells
Band · 2
CLEC7A → 12p13.2, 6|6 F3
Chr. · 2
CLEC7A → Chromosome 12 (human), Chromosome 6 (mouse)
End · 2
CLEC7A → 10,130,258 bp, 129,449,742 bp

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Important terminology

gene c-type bp cells domain human chromosome activation chr band lectin member receptor dectin-1 12 recognition family immune expression complex

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CLEC7AAliasesCLEC7A, BGR, CANDF4, CLECSF12, DECTIN1, CD369, SCARE2, C-type lectin domain family 7 member A, C-type lectin domain containing 7A1.00infobox
CLEC7AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BPD, 2BPE, 2BPH, 2CL81.00infobox
CLEC7ABand12p13.21.00infobox
CLEC7ABand6|6 F31.00infobox
CLEC7ABgeemonocyte1.00infobox
CLEC7ABgeegranulocyte1.00infobox
CLEC7ABgeeblood1.00infobox
CLEC7ABgeebuccal mucosa cell1.00infobox
CLEC7ABgeeperiodontal fiber1.00infobox
CLEC7ABgeetendon of biceps brachii1.00infobox
CLEC7ABgeeright lung1.00infobox
CLEC7ABgeeappendix1.00infobox
CLEC7ABgeespleen1.00infobox
CLEC7ABgeeupper lobe of left lung1.00infobox
CLEC7ABgeeright lung lobe1.00infobox
CLEC7ABgeemesenteric lymph nodes1.00infobox
CLEC7ABgeetibiofemoral joint1.00infobox
CLEC7ABgeebone marrow1.00infobox
CLEC7ABgeeleft lung1.00infobox
CLEC7ABgeemucous cell of stomach1.00infobox
CLEC7ABgeesubcutaneous adipose tissue1.00infobox
CLEC7ABioGPSMore reference expression data1.00infobox
CLEC7AChr.Chromosome 12 (human)1.00infobox
CLEC7AChr.Chromosome 6 (mouse)1.00infobox
CLEC7ADatabasesNCBI: entry; OMA: entry1.00infobox
CLEC7AEnd10,130,258 bp1.00infobox
CLEC7AEnd129,449,742 bp1.00infobox
CLEC7AEnsemblENSG000001722431.00infobox
CLEC7AEntrez645811.00infobox
CLEC7AExternal IDsOMIM: 606264; MGI: 1861431; GeneCards: CLEC7A1.00infobox

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