Toll-like receptor 3

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Explore the main themes, entities and connections around Toll-like receptor 3. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

PAMPs Cytokines Placenta Pancreas Dendritic

15 related topics

Ligands

Poly(I:C)Poly(A:U)RGC100 NexaVant CU-CPT4a

6 related topics

Structure

Type I transmembrane Ectodomain Transmembrane helix Leucine-rich repeats

4 related topics

Overview

Cluster of differentiation Protein Gene Toll-like receptor Pattern recognition receptors

12 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: TLR3, CD283, IIAE2, toll like receptor 3, IMD83
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA
Band: 4q35.1 · 8|8 B1.1
Bgee: jejunal mucosa · palpebral conjunctiva · placenta · rectum · sperm
BioGPS: More reference expression data
Chr.: Chromosome 4 (human) · Chromosome 8 (mouse)

Topics to explore

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Overview

Cluster of differentiation
Protein
Gene
Toll-like receptor
Pattern recognition receptors Pattern recognition receptor
Innate immune system
RNA
Endosomes
Viral Virus
Genomes
Macrophages
Dendritic cells Dendritic cell

Structure

Type I transmembrane Type I transmembrane protein
Ectodomain
Transmembrane helix
Leucine-rich repeats

Function

PAMPs Pathogen-associated molecular pattern
Cytokines Cytokine
Placenta
Pancreas
Dendritic Dendrite (non-neuronal)
Leukocytes Leukocyte
IRF3
NF-κB
Interferons Interferon
Reoviruses Reovirus
Type I interferons Interferon type I
Double-stranded RNA
RIG-I DDX58
MDA-5 IFIH1
Atherosclerosis

Ligands

Poly(I:C)
Poly(A:U) Poly(A:U)?action=edit&redlink=1
RGC100
NexaVant NexaVant?action=edit&redlink=1
CU-CPT4a
MDA5

Advanced semantic analysis

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Map overview Semantic statistics

Nodes42

Edges41

Triples152

Avg. degree1.95

Density0.047619

Components1

How this topic connects Entity context

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Toll-like receptor 3

Top relations

Gene ontology · 76

Toll-like receptor 3 → activation of NF-kappaB-inducing kinase activity, apoptotic signaling pathway, cell surface, cellular response to dsRNA, cellular response to exogenous dsRNA, cellular response to interferon-beta, cellular response to interferon-gamma, cellular response to mechanical stimulus, cytoplasm, defense response, defense response to bacterium, defense response to virus, detection of virus, double-stranded RNA binding, early endosome, endolysosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane

Bgee · 20

Toll-like receptor 3 → Achilles tendon, conjunctival fornix, duodenum, Epithelium of choroid plexus, epithelium of colon, gallbladder, gastrula, jejunal mucosa, jejunum, lumbar subsegment of spinal cord, palpebral conjunctiva, pancreatic epithelial cell, placenta, rectum, secondary oocyte, sperm, stria vascularis, transitional epithelium of urinary bladder, vestibular membrane of cochlear duct, vestibular sensory epithelium

RNA expression pattern · 20

related to Structure · 11

Toll-like receptor 3 → C-terminal, Its, LRRs, PF01582, PF13516, PF13855, PF17968, TIR, TLR3, Toll-like, Toll/interleukin-1

Band · 2

Toll-like receptor 3 → 4q35.1, 8|8 B1.1

Chr. · 2

Toll-like receptor 3 → Chromosome 4 (human), Chromosome 8 (mouse)

End · 2

Toll-like receptor 3 → 186,088,073 bp, 45,864,117 bp

Aliases · 1

Toll-like receptor 3 → TLR3, CD283, IIAE2, toll like receptor 3, IMD83

Available structures · 1

Toll-like receptor 3 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA

BioGPS · 1

Toll-like receptor 3 → More reference expression data

Important terminology Word statistics

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Important terminology

tlr3 receptor bp activation human rna toll-like chr band gene dsrna double-stranded chromosome dendritic cells mouse production type innate location

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Toll-like receptor 3	Aliases	TLR3, CD283, IIAE2, toll like receptor 3, IMD83	1.00	infobox
Toll-like receptor 3	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA	1.00	infobox
Toll-like receptor 3	Band	4q35.1	1.00	infobox
Toll-like receptor 3	Band	8\|8 B1.1	1.00	infobox
Toll-like receptor 3	Bgee	jejunal mucosa	1.00	infobox
Toll-like receptor 3	Bgee	palpebral conjunctiva	1.00	infobox
Toll-like receptor 3	Bgee	placenta	1.00	infobox
Toll-like receptor 3	Bgee	rectum	1.00	infobox
Toll-like receptor 3	Bgee	sperm	1.00	infobox
Toll-like receptor 3	Bgee	duodenum	1.00	infobox
Toll-like receptor 3	Bgee	gallbladder	1.00	infobox
Toll-like receptor 3	Bgee	Achilles tendon	1.00	infobox
Toll-like receptor 3	Bgee	epithelium of colon	1.00	infobox
Toll-like receptor 3	Bgee	pancreatic epithelial cell	1.00	infobox
Toll-like receptor 3	Bgee	conjunctival fornix	1.00	infobox
Toll-like receptor 3	Bgee	gastrula	1.00	infobox
Toll-like receptor 3	Bgee	stria vascularis	1.00	infobox
Toll-like receptor 3	Bgee	transitional epithelium of urinary bladder	1.00	infobox
Toll-like receptor 3	Bgee	vestibular membrane of cochlear duct	1.00	infobox
Toll-like receptor 3	Bgee	vestibular sensory epithelium	1.00	infobox
Toll-like receptor 3	Bgee	secondary oocyte	1.00	infobox
Toll-like receptor 3	Bgee	lumbar subsegment of spinal cord	1.00	infobox
Toll-like receptor 3	Bgee	Epithelium of choroid plexus	1.00	infobox
Toll-like receptor 3	Bgee	jejunum	1.00	infobox
Toll-like receptor 3	BioGPS	More reference expression data	1.00	infobox
Toll-like receptor 3	Chr.	Chromosome 4 (human)	1.00	infobox
Toll-like receptor 3	Chr.	Chromosome 8 (mouse)	1.00	infobox
Toll-like receptor 3	Databases	NCBI: entry; OMA: entry	1.00	infobox
Toll-like receptor 3	End	186,088,073 bp	1.00	infobox
Toll-like receptor 3	End	45,864,117 bp	1.00	infobox

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