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NF-κB

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stressful stimuli like cytokines, free radicals, heavy metals…

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Signaling

62 related topics

Clinical significance

33 related topics

As a drug target

13 related topics

Species distribution and evolution

11 related topics

Key facts & relationships

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Domains
InterPro
HGNC
7794
Locus
Chr. 4 q24
NCBI gene
4790
OMIM
164011
RefSeq
NM_003998

Topics to explore

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Overview

Discovery

Structure

Members

Species distribution and evolution

Signaling

Clinical significance

Non-drug inhibitors

As a drug target

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Map overview Semantic statistics

NF-κB

Nodes167
Edges166
Triples226
Avg. degree1.99
Density0.011976
Components1

How this topic connects Entity context

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NF-κB

Top relations

related to Non-canonical/alternate pathway · 27
NF-κB → BAFF, DNA, Given, However, IKK1/IKKa, IKK2-IκB-RelA, In, It, IκBα, LTβR, Mechanistically, Moreover, Most, NEMO-IKK2, NF-κB/RelB, NF-κB2, Nfkb2, Nfkb2-mediated, NIK, On
related to Activation process (canonical/classical) · 20
NF-κB → Activation, AIDS, DNA-binding, HIV, HIV-1, IKK, IKKα, IKKβ, IKKγ, In, IκB, IκBα, NEMO, The, This, Translocation, When, With, Yersinia, YopP
related to Inhibition · 19
NF-κB → Although, Bcl-3, By, C-terminal, Due, In, Inhibitor, IκB, IκBs, IκBα, IκBβ, IκBδ, IκBε, LTβR, N-terminal, NIK, NLS, PEST, The
related to External links · 16
NF-κB → Boca Raton, Boston University, CRC, Gilmore, Handbook, ISBN, Medicine Medical Subject Headings, MeSH, National Library, NF-kappa, Pathway, Retrieved, Sankar Ghosh, The Rel/NF-κB Signal Transduction, Thomas, Transcription Factor NF-κB
related to Discovery · 15
NF-κB → Alexander Poltorak, Bruce Beutler, Bruno Lemaitre, David Baltimore, Drosophila, Hoffmann, Jules, Later, Medicine, Nobel, Nobel Prize, Physiology, Ranjan Sen, These, Toll-like
related to Non-drug inhibitors · 15
NF-κB → Ariad, Ashwagandha, Ben-Neriah, Extracts, IκBα, Karin, Likewise, Lilly, Many, Nobiletin, Recent, There, This, US, Withania
related to Structure · 15
NF-κB → All, C-terminal, C-termini, In, Indeed, IκB, N-terminus, NF-κB1, NF-κB2, Rel, RelA, RelA-p50, RelB, The, Whereas
related to Inflammation · 12
NF-κB → Additionally, Because NF-κB, Elevated NF-κB, Elevation, Fidelity, In, Inflammation, OPG, Particularly, Recently, Research, This
related to In immunity · 11
NF-κB → B-cell, CD3, ITAMs, LAT, Lck, PKC, PLC-γ, T-cell, Through, Upon, ZAP70
related to Effect of activation · 10
NF-κB → IL-1β, JNKs, Jun, Jun N-terminal, Known, LPS, ROS, STATs, This, TNFα

Important terminology Word statistics

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Important terminology

activation cells cell activity genes pathway p52 cancer immune also protein transcription proteins relb response canonical system p100 expression non-canonical

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
NF-κBDomainsInterPro1.00infobox
NF-κBHGNC77941.00infobox
NF-κBLocusChr. 4 q241.00infobox
NF-κBNCBI gene47901.00infobox
NF-κBOMIM1640111.00infobox
NF-κBRefSeqNM_0039981.00infobox
NF-κBSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
NF-κBStructuresSwiss-model1.00infobox
NF-κBSymbolNFKB11.00infobox
NF-κBUniProtP198381.00infobox
NF-κBis asubject of much active research among pharmaceutical companies as a target for anti-cancer therapy.However0.90text
NF-κBis aFas transcription activator and the alternative NF-κB is a Fas transcription repressor0.90text
NF-κBis acentral component of the cellular response to damage0.90text
NF-κBis akey player in the inflammatory response0.90text

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