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Langerin: Art & Standards

Langerin (CD207) is a type II transmembrane protein which is encoded by the CD207 gene in humans. It was discovered by scientists Sem Saeland and Jenny Valladeau as a main part of Birbeck granules. Langerin is C-type lectin receptor on Langerhans cells (LCs) and in mice also on dermal interstitial CD103+ dendritic cells (DC) and on resident CD8+ DC in…

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Langerin topic overview

The analysis highlights Art and Standards as prominent areas in the source structure around Langerin.

Related topics
65
Source areas
5
Connected nodes
70
Extracted relationships
135
Concept neighborhoods
17
Bridge connections
70

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 24 topics
Structure · 13 topics
Clinical significance · 11 topics
Overview · 9 topics
Polymorphism · 8 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CD207, CLEC4K, CD207 molecule
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3C22, 3KQG, 3P5D, 3P5E, 3P5F, 3P5G, 3P5H, 3P5I, 3P7F, 3P7G, 3P7H, 4AK8, 4N32, 4N33, 4N34, 4N35, 4N36, 4N37,…
Band
2p13.3 · 6|6 C3
Bgee
skin of thigh · skin of hip · skin of abdomen · skin of arm · vulva
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 6 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Polymorphism

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Langerin connects Entity context

The extracted context around Langerin shows recurring relationship patterns in the source. For example, Langerin → epithelium of esophagus, gingival epithelium, gums, left lobe of liver, lip, liver, neural layer of retina, nipple, oral cavity, right lung lobe, skin of abdomen, skin of arm, skin of back, skin of external ear, skin of hip, skin of thigh, spleen, thymus, vulva Another extracted example is Langerin → After, Birbeck, Candida, CD1a, For, HIV-1, In, It, LCs, MHC, MHC II, Mycobacterium, N-acetylglucosamine, Rab11a, Src, T-cells, There, These, Thus. Use these groups to spot repeated connection types before inspecting the individual relationships.

Langerin

Top relations

Bgee · 19
Langerin → epithelium of esophagus, gingival epithelium, gums, left lobe of liver, lip, liver, neural layer of retina, nipple, oral cavity, right lung lobe, skin of abdomen, skin of arm, skin of back, skin of external ear, skin of hip, skin of thigh, spleen, thymus, vulva
RNA expression pattern · 19
Langerin → epithelium of esophagus, gingival epithelium, gums, left lobe of liver, lip, liver, neural layer of retina, nipple, oral cavity, right lung lobe, skin of abdomen, skin of arm, skin of back, skin of external ear, skin of hip, skin of thigh, spleen, thymus, vulva
related to Function · 19
Langerin → After, Birbeck, Candida, CD1a, For, HIV-1, In, It, LCs, MHC, MHC II, Mycobacterium, N-acetylglucosamine, Rab11a, Src, T-cells, There, These, Thus
related to Structure · 18
Langerin → All, C-type, Ca2, CRD, CRDs, DC-SIGN, DC-SIGNR, EPN, Glu-Pro-Asn, In, It, K299, K313, MBP, PRD, The, The CRD, These
related to Clinical significance · 15
Langerin → Birbeck, By, Candida, CD4, Furthermore, Gal-6-sulfated, HIV-1, If, In, LCs, Malassezia, Saccharomyces, Subsequently, T-cells, Thus
Gene ontology · 12
Langerin → antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, carbohydrate binding, clathrin-coated endocytic vesicle membrane, defense response to virus, early endosome membrane, endocytic vesicle, integral component of membrane, mannose binding, membrane, plasma membrane, protein binding, receptor-mediated endocytosis
related to Polymorphism · 7
Langerin → Allelic, Birbeck, BSA, Single, SNP, Substitution, The
Band · 2
Langerin → 2p13.3, 6|6 C3
Chr. · 2
Langerin → Chromosome 2 (human), Chromosome 6 (mouse)
End · 2
Langerin → 70,835,816 bp, 83,654,839 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

binding human bp lcs hiv-1 gene chr band birbeck antigen cd207 protein chromosome via virus dc-sign function granules polymorphism also

Langerin relationships Subject–Predicate–Object triples

TTTA extracted 135 structured relationships around Langerin. Examples in this analysis include Langerin → Aliases → CD207, CLEC4K, CD207 molecule and Langerin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3C22, 3KQG, 3P5D, 3P5E, 3P5F, 3P5G, 3P5H, 3P5I, 3P7F, 3P7G, 3P7H, 4AK8, 4N32, 4N33, 4N34, 4N35, 4N36, 4N37,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
LangerinAliasesCD207, CLEC4K, CD207 molecule1.00infobox
LangerinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3C22, 3KQG, 3P5D, 3P5E, 3P5F, 3P5G, 3P5H, 3P5I, 3P7F, 3P7G, 3P7H, 4AK8, 4N32, 4N33, 4N34, 4N35, 4N36, 4N37,…1.00infobox
LangerinBand2p13.31.00infobox
LangerinBand6|6 C31.00infobox
LangerinBgeeskin of thigh1.00infobox
LangerinBgeeskin of hip1.00infobox
LangerinBgeeskin of abdomen1.00infobox
LangerinBgeeskin of arm1.00infobox
LangerinBgeevulva1.00infobox
LangerinBgeenipple1.00infobox
LangerinBgeeepithelium of esophagus1.00infobox
LangerinBgeeoral cavity1.00infobox
LangerinBgeegums1.00infobox
LangerinBgeegingival epithelium1.00infobox
LangerinBgeeskin of external ear1.00infobox
LangerinBgeethymus1.00infobox
LangerinBgeelip1.00infobox
LangerinBgeeliver1.00infobox
LangerinBgeespleen1.00infobox
LangerinBgeeleft lobe of liver1.00infobox
LangerinBgeeright lung lobe1.00infobox
LangerinBgeeskin of back1.00infobox
LangerinBgeeneural layer of retina1.00infobox
LangerinBioGPSMore reference expression data1.00infobox
LangerinChr.Chromosome 2 (human)1.00infobox
LangerinChr.Chromosome 6 (mouse)1.00infobox
LangerinDatabasesNCBI: entry; OMA: entry1.00infobox
LangerinEnd70,835,816 bp1.00infobox
LangerinEnd83,654,839 bp1.00infobox
LangerinEnsemblENSG000001160311.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Langerin bring nearby vocabulary together. In this analysis, examples include Binding, Protein and Via. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Langerin
    • Binding
    • Protein
    • Via
    • Virus
    • Hiv-1
    • Lcs
    • Mannose
    • Dc-sign
    • Antigen
    • Gene
    • Mice
    • Also
  • langerin
    • Binding
    • Protein
    • Via
    • Virus
    • Hiv-1
    • Lcs
    • Mannose
    • Dc-sign
    • Antigen
    • Gene
    • Mice
    • Also
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Protein
    • External
    • Mouse
    • Human
    • Band
    • Function
    • Polymorphism
    • Pdb
  • antigen
    • Presentation
    • Binding
    • External
    • Mice
    • Mouse
    • Q9uj71
    • Uniprot
    • Formation
    • Intracellular
    • Lobe
    • Location
    • Mannose
  • measles virus
    • Presentation
    • Via
    • Hiv-1
    • External
    • Langerin
    • Mouse
    • Q9uj71
    • Uniprot
    • Binding
    • Cell
    • Intracellular
    • Lobe
  • function
    • External
    • Location
    • Chromosome
    • Bp
    • Chr
    • Gene
    • Protein
    • Human
    • Mouse
    • Pdb
    • Q9uj71
    • Uniprot
  • mannose
    • Mouse
    • Q9uj71
    • Uniprot
    • Intracellular
    • Presentation
    • Carbohydrates
    • Crd
    • Domain
    • Protein
    • Via
    • Virus
  • birbeck granules
    • Granules
    • Intracellular
    • Molecule
    • Formation
    • Presentation
    • Domain
    • Antigen
    • Virus
    • Langerin
    • Binding

Connections between topic areas Semantic bridges

For Langerin, one of the stronger structural bridges in this analysis connects Langerin with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
LangerinFunction · splits 46 ⟂ 25
LangerinStructure · splits 57 ⟂ 14
LangerinClinical significance · splits 59 ⟂ 12
LangerinOverview · splits 61 ⟂ 10
LangerinPolymorphism · splits 62 ⟂ 9

Map overview Semantic statistics

Langerin

Nodes71
Edges70
Triples135
Avg. degree1.97
Density0.028169
Components1

Source & methodology

TTTA analyzes the structure around Langerin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Langerin · EN edition · Analysis: TopicsToTalkAbout

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