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PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene. It is localized mainly in the nucleus of monocytes and macrophages. In case of pathogen infection, however, it relocalizes rapidly to the cytoplasm, perinuclear space, endoplasmic reticulum and…
The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around PYCARD.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around PYCARD shows recurring relationship patterns in the source. For example, PYCARD → activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of innate immune response, AIM2 inflammasome complex, apoptotic process, azurophil granule lumen, BMP receptor binding, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to tumor necrosis factor, cysteine-type endopeptidase activator activity involved in apoptotic process, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cytoplasm, cytosol, defense response to Gram-negative bacterium, defense response to virus, endoplasmic reticulum, enzyme binding, extracellular region Another extracted example is PYCARD → blood, colon, crypt of lieberkuhn of small intestine, duodenum, epithelium of small intestine, esophagus, gingival epithelium, granulocyte, human penis, ileum, large intestine, left colon, migratory enteric neural crest cell, monocyte, mucosa of transverse colon, Paneth cell, skin of abdomen, skin of leg, spleen, vulva. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
protein bp gene chr human band card chromosome 16 asc cytoplasm activation location pyd nucleus isoform adaptor domain mitochondria inflammasome
TTTA extracted 169 structured relationships around PYCARD. Examples in this analysis include PYCARD → Aliases → PYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing and PYCARD → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UCP, 2KN6, 3J63, 5H8O. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| PYCARD | Aliases | PYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing | 1.00 | infobox |
| PYCARD | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UCP, 2KN6, 3J63, 5H8O | 1.00 | infobox |
| PYCARD | Band | 16p11.2 | 1.00 | infobox |
| PYCARD | Band | 7|7 F3 | 1.00 | infobox |
| PYCARD | Bgee | monocyte | 1.00 | infobox |
| PYCARD | Bgee | granulocyte | 1.00 | infobox |
| PYCARD | Bgee | mucosa of transverse colon | 1.00 | infobox |
| PYCARD | Bgee | blood | 1.00 | infobox |
| PYCARD | Bgee | vulva | 1.00 | infobox |
| PYCARD | Bgee | human penis | 1.00 | infobox |
| PYCARD | Bgee | skin of leg | 1.00 | infobox |
| PYCARD | Bgee | skin of abdomen | 1.00 | infobox |
| PYCARD | Bgee | spleen | 1.00 | infobox |
| PYCARD | Bgee | gingival epithelium | 1.00 | infobox |
| PYCARD | Bgee | Paneth cell | 1.00 | infobox |
| PYCARD | Bgee | migratory enteric neural crest cell | 1.00 | infobox |
| PYCARD | Bgee | ileum | 1.00 | infobox |
| PYCARD | Bgee | crypt of lieberkuhn of small intestine | 1.00 | infobox |
| PYCARD | Bgee | epithelium of small intestine | 1.00 | infobox |
| PYCARD | Bgee | duodenum | 1.00 | infobox |
| PYCARD | Bgee | large intestine | 1.00 | infobox |
| PYCARD | Bgee | colon | 1.00 | infobox |
| PYCARD | Bgee | left colon | 1.00 | infobox |
| PYCARD | Bgee | esophagus | 1.00 | infobox |
| PYCARD | BioGPS | More reference expression data | 1.00 | infobox |
| PYCARD | Chr. | Chromosome 16 (human) | 1.00 | infobox |
| PYCARD | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| PYCARD | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| PYCARD | End | 31,203,450 bp | 1.00 | infobox |
| PYCARD | End | 127,593,039 bp | 1.00 | infobox |
The concept neighborhoods around PYCARD bring nearby vocabulary together. In this analysis, examples include Card, Gene and Asc. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For PYCARD, one of the stronger structural bridges in this analysis connects PYCARD with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around PYCARD to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — PYCARD · EN edition · Analysis: TopicsToTalkAbout