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PYCARD

PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene. It is localized mainly in the nucleus of monocytes and macrophages. In case of pathogen infection, however, it relocalizes rapidly to the cytoplasm, perinuclear space, endoplasmic reticulum and…

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Function

10 related topics

Interactions

2 related topics

Overview

9 related topics

Key facts & relationships

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Aliases
PYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UCP, 2KN6, 3J63, 5H8O
Band
16p11.2 · 7|7 F3
Bgee
monocyte · granulocyte · mucosa of transverse colon · blood · vulva
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 7 (mouse)

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Overview

Function

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Map overview Semantic statistics

PYCARD

Nodes25
Edges24
Triples169
Avg. degree1.92
Density0.08
Components1

How this topic connects Entity context

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PYCARD

Top relations

Gene ontology · 92
PYCARD → activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of innate immune response, AIM2 inflammasome complex, apoptotic process, azurophil granule lumen, BMP receptor binding, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to tumor necrosis factor, cysteine-type endopeptidase activator activity involved in apoptotic process, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cytoplasm, cytosol, defense response to Gram-negative bacterium, defense response to virus, endoplasmic reticulum, enzyme binding, extracellular region
Bgee · 20
PYCARD → blood, colon, crypt of lieberkuhn of small intestine, duodenum, epithelium of small intestine, esophagus, gingival epithelium, granulocyte, human penis, ileum, large intestine, left colon, migratory enteric neural crest cell, monocyte, mucosa of transverse colon, Paneth cell, skin of abdomen, skin of leg, spleen, vulva
RNA expression pattern · 20
PYCARD → blood, colon, crypt of lieberkuhn of small intestine, duodenum, epithelium of small intestine, esophagus, gingival epithelium, granulocyte, human penis, ileum, large intestine, left colon, migratory enteric neural crest cell, monocyte, mucosa of transverse colon, Paneth cell, skin of abdomen, skin of leg, spleen, vulva
related to Function · 13
PYCARD → C-terminal, CARD, IL-1β, In, Isoform, N-terminal PYRIN-PAAD-DAPIN, NLR, NLRs, PYD, The PYD, They, This, Unlike
Band · 2
PYCARD → 16p11.2, 7|7 F3
Chr. · 2
PYCARD → Chromosome 16 (human), Chromosome 7 (mouse)
End · 2
PYCARD → 127,593,039 bp, 31,203,450 bp
Aliases · 1
PYCARD → PYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing
Available structures · 1
PYCARD → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UCP, 2KN6, 3J63, 5H8O
BioGPS · 1
PYCARD → More reference expression data

Important terminology Word statistics

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Important terminology

protein bp gene chr human band card chromosome 16 asc cytoplasm activation location pyd nucleus isoform adaptor domain mitochondria inflammasome

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PYCARDAliasesPYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing1.00infobox
PYCARDAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UCP, 2KN6, 3J63, 5H8O1.00infobox
PYCARDBand16p11.21.00infobox
PYCARDBand7|7 F31.00infobox
PYCARDBgeemonocyte1.00infobox
PYCARDBgeegranulocyte1.00infobox
PYCARDBgeemucosa of transverse colon1.00infobox
PYCARDBgeeblood1.00infobox
PYCARDBgeevulva1.00infobox
PYCARDBgeehuman penis1.00infobox
PYCARDBgeeskin of leg1.00infobox
PYCARDBgeeskin of abdomen1.00infobox
PYCARDBgeespleen1.00infobox
PYCARDBgeegingival epithelium1.00infobox
PYCARDBgeePaneth cell1.00infobox
PYCARDBgeemigratory enteric neural crest cell1.00infobox
PYCARDBgeeileum1.00infobox
PYCARDBgeecrypt of lieberkuhn of small intestine1.00infobox
PYCARDBgeeepithelium of small intestine1.00infobox
PYCARDBgeeduodenum1.00infobox
PYCARDBgeelarge intestine1.00infobox
PYCARDBgeecolon1.00infobox
PYCARDBgeeleft colon1.00infobox
PYCARDBgeeesophagus1.00infobox
PYCARDBioGPSMore reference expression data1.00infobox
PYCARDChr.Chromosome 16 (human)1.00infobox
PYCARDChr.Chromosome 7 (mouse)1.00infobox
PYCARDDatabasesNCBI: entry; OMA: entry1.00infobox
PYCARDEnd31,203,450 bp1.00infobox
PYCARDEnd127,593,039 bp1.00infobox

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