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PYCARD: Function, Interactions & Overview

PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene. It is localized mainly in the nucleus of monocytes and macrophages. In case of pathogen infection, however, it relocalizes rapidly to the cytoplasm, perinuclear space, endoplasmic reticulum and…

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PYCARD topic overview

The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around PYCARD.

Related topics
21
Source areas
3
Connected nodes
24
Extracted relationships
169
Concept neighborhoods
12
Bridge connections
24

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 10 topics
Overview · 9 topics
Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UCP, 2KN6, 3J63, 5H8O
Band
16p11.2 · 7|7 F3
Bgee
monocyte · granulocyte · mucosa of transverse colon · blood · vulva
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 7 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PYCARD connects Entity context

The extracted context around PYCARD shows recurring relationship patterns in the source. For example, PYCARD → activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of innate immune response, AIM2 inflammasome complex, apoptotic process, azurophil granule lumen, BMP receptor binding, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to tumor necrosis factor, cysteine-type endopeptidase activator activity involved in apoptotic process, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cytoplasm, cytosol, defense response to Gram-negative bacterium, defense response to virus, endoplasmic reticulum, enzyme binding, extracellular region Another extracted example is PYCARD → blood, colon, crypt of lieberkuhn of small intestine, duodenum, epithelium of small intestine, esophagus, gingival epithelium, granulocyte, human penis, ileum, large intestine, left colon, migratory enteric neural crest cell, monocyte, mucosa of transverse colon, Paneth cell, skin of abdomen, skin of leg, spleen, vulva. Use these groups to spot repeated connection types before inspecting the individual relationships.

PYCARD

Top relations

Gene ontology · 92
PYCARD → activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of innate immune response, AIM2 inflammasome complex, apoptotic process, azurophil granule lumen, BMP receptor binding, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to tumor necrosis factor, cysteine-type endopeptidase activator activity involved in apoptotic process, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cytoplasm, cytosol, defense response to Gram-negative bacterium, defense response to virus, endoplasmic reticulum, enzyme binding, extracellular region
Bgee · 20
PYCARD → blood, colon, crypt of lieberkuhn of small intestine, duodenum, epithelium of small intestine, esophagus, gingival epithelium, granulocyte, human penis, ileum, large intestine, left colon, migratory enteric neural crest cell, monocyte, mucosa of transverse colon, Paneth cell, skin of abdomen, skin of leg, spleen, vulva
RNA expression pattern · 20
PYCARD → blood, colon, crypt of lieberkuhn of small intestine, duodenum, epithelium of small intestine, esophagus, gingival epithelium, granulocyte, human penis, ileum, large intestine, left colon, migratory enteric neural crest cell, monocyte, mucosa of transverse colon, Paneth cell, skin of abdomen, skin of leg, spleen, vulva
related to Function · 13
PYCARD → C-terminal, CARD, IL-1β, In, Isoform, N-terminal PYRIN-PAAD-DAPIN, NLR, NLRs, PYD, The PYD, They, This, Unlike
Band · 2
PYCARD → 16p11.2, 7|7 F3
Chr. · 2
PYCARD → Chromosome 16 (human), Chromosome 7 (mouse)
End · 2
PYCARD → 127,593,039 bp, 31,203,450 bp
Aliases · 1
PYCARD → PYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing
Available structures · 1
PYCARD → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UCP, 2KN6, 3J63, 5H8O
BioGPS · 1
PYCARD → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein bp gene chr human band card chromosome 16 asc cytoplasm activation location pyd nucleus isoform adaptor domain mitochondria inflammasome

PYCARD relationships Subject–Predicate–Object triples

TTTA extracted 169 structured relationships around PYCARD. Examples in this analysis include PYCARD → Aliases → PYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing and PYCARD → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UCP, 2KN6, 3J63, 5H8O. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PYCARDAliasesPYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing1.00infobox
PYCARDAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UCP, 2KN6, 3J63, 5H8O1.00infobox
PYCARDBand16p11.21.00infobox
PYCARDBand7|7 F31.00infobox
PYCARDBgeemonocyte1.00infobox
PYCARDBgeegranulocyte1.00infobox
PYCARDBgeemucosa of transverse colon1.00infobox
PYCARDBgeeblood1.00infobox
PYCARDBgeevulva1.00infobox
PYCARDBgeehuman penis1.00infobox
PYCARDBgeeskin of leg1.00infobox
PYCARDBgeeskin of abdomen1.00infobox
PYCARDBgeespleen1.00infobox
PYCARDBgeegingival epithelium1.00infobox
PYCARDBgeePaneth cell1.00infobox
PYCARDBgeemigratory enteric neural crest cell1.00infobox
PYCARDBgeeileum1.00infobox
PYCARDBgeecrypt of lieberkuhn of small intestine1.00infobox
PYCARDBgeeepithelium of small intestine1.00infobox
PYCARDBgeeduodenum1.00infobox
PYCARDBgeelarge intestine1.00infobox
PYCARDBgeecolon1.00infobox
PYCARDBgeeleft colon1.00infobox
PYCARDBgeeesophagus1.00infobox
PYCARDBioGPSMore reference expression data1.00infobox
PYCARDChr.Chromosome 16 (human)1.00infobox
PYCARDChr.Chromosome 7 (mouse)1.00infobox
PYCARDDatabasesNCBI: entry; OMA: entry1.00infobox
PYCARDEnd31,203,450 bp1.00infobox
PYCARDEnd127,593,039 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PYCARD bring nearby vocabulary together. In this analysis, examples include Card, Gene and Asc. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PYCARD
    • Card
    • Gene
    • Asc
    • Containing
    • Domain
    • Function
    • Referred
    • Search
    • Location
    • Pyd
    • Chromosome
    • Human
  • pycard
    • Card
    • Gene
    • Asc
    • Containing
    • Domain
    • Function
    • Referred
    • Search
    • Location
    • Pyd
    • Chromosome
    • Human
  • protein
    • Adaptor
    • Cytoplasm
    • Endoplasmic
    • However
    • Inflammasome
    • Mitochondria
    • Reticulum
    • Activation
    • Card
    • Gene
    • Pycard
    • Containing
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Domain
    • End
    • Function
    • Mouse
    • Search
    • Pycard
    • Pyd
  • cytoplasm
    • Endoplasmic
    • However
    • Inflammasome
    • Mitochondria
    • Reticulum
    • Protein
    • Activation
    • Adaptor
    • Domain
    • End
    • Function
    • Localized
  • card
    • Pyd
    • Gene
    • Containing
    • Domain
    • Function
    • Search
    • Pycard
    • Activation
    • Location
    • Chromosome
    • Human
    • Bp
  • endoplasmic reticulum
    • Inflammasome
    • Mitochondria
    • Reticulum
    • Activation
    • Adaptor
    • Protein
    • Domain
    • End
    • Function
    • However
    • Mouse
    • Nucleus
  • function
    • Domain
    • Search
    • Location
    • Pyd
    • Chromosome
    • Gene
    • Human
    • Id
    • Pdb
    • Bp
    • Chr
    • End

Connections between topic areas Semantic bridges

For PYCARD, one of the stronger structural bridges in this analysis connects PYCARD with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PYCARDFunction · splits 14 ⟂ 11
PYCARDOverview · splits 15 ⟂ 10
PYCARDInteractions · splits 22 ⟂ 3

Map overview Semantic statistics

PYCARD

Nodes25
Edges24
Triples169
Avg. degree1.92
Density0.08
Components1

Source & methodology

TTTA analyzes the structure around PYCARD to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PYCARD · EN edition · Analysis: TopicsToTalkAbout

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