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LGP2

Probable ATP-dependent RNA helicase DHX58 also known as RIG-I-like receptor 3 (RLR-3) or RIG-I-like receptor LGP2 (RLR) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the DHX58 gene. The protein encoded by the gene DHX58 is known as LGP2 (Laboratory of Genetics and Physiology 2).

Structure and function & Overview

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Topic orientation

LGP2 at a glance

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Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.6.4.13
Aliases
DHX58, D11LGP2, D11lgp2e, LGP2, RLR-3, DEXH-box helicase 58
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RQA, 2W4R, 3EQT
Band
17q21.2 · 11 D|11 63.52 cM
Bgee
granulocyte · right lobe of liver · right uterine tube · right adrenal gland · right adrenal cortex
BioGPS
More reference expression data

Topics to explore

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Overview

Structure and function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How this topic connects Entity context

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LGP2

Top relations

Gene ontology · 26
LGP2 → ATP binding, cytoplasm, defense response to virus, DNA binding, double-stranded RNA binding, helicase activity, hydrolase activity, immune system process, innate immune response, metal ion binding, negative regulation of innate immune response, negative regulation of MDA-5 signaling pathway, negative regulation of RIG-I signaling pathway, negative regulation of type I interferon production, nucleotide binding, positive regulation of MDA-5 signaling pathway, positive regulation of RIG-I signaling pathway, positive regulation of type I interferon production, protein binding, regulation of innate immune response
Bgee · 18
LGP2 → adrenal gland, apex of heart, embryo, granulocyte, left adrenal cortex, left ovary, lumbar spinal ganglion, monocyte, mucous cell of stomach, right adrenal cortex, right adrenal gland, right lobe of liver, right uterine tube, seminiferous tubule, spermatid, spermatocyte, stroma of bone marrow, tibial nerve
RNA expression pattern · 18
LGP2 → adrenal gland, apex of heart, embryo, granulocyte, left adrenal cortex, left ovary, lumbar spinal ganglion, monocyte, mucous cell of stomach, right adrenal cortex, right adrenal gland, right lobe of liver, right uterine tube, seminiferous tubule, spermatid, spermatocyte, stroma of bone marrow, tibial nerve
related to Structure and function · 5
LGP2 → CARD, MDA5, RIG-I, RLRs, Since LGP2
Band · 2
LGP2 → 11 D|11 63.52 cM, 17q21.2
Chr. · 2
LGP2 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
LGP2 → 100,595,097 bp, 42,112,714 bp
3.6.4.13 · 1
LGP2 → ↗
Aliases · 1
LGP2 → DHX58, D11LGP2, D11lgp2e, LGP2, RLR-3, DEXH-box helicase 58
Available structures · 1
LGP2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RQA, 2W4R, 3EQT

Important terminology Word statistics

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Important terminology

rig-i gene bp dhx58 chr helicase human band chromosome 17 signaling viral antiviral location dsrna function activity known encoded ligand

Entity relationships Subject–Predicate–Object triples

Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.
SubjectPredicateObjectConfidenceSrc
LGP23.6.4.131.00infobox
LGP2AliasesDHX58, D11LGP2, D11lgp2e, LGP2, RLR-3, DEXH-box helicase 581.00infobox
LGP2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RQA, 2W4R, 3EQT1.00infobox
LGP2Band17q21.21.00infobox
LGP2Band11 D|11 63.52 cM1.00infobox
LGP2Bgeegranulocyte1.00infobox
LGP2Bgeeright lobe of liver1.00infobox
LGP2Bgeeright uterine tube1.00infobox
LGP2Bgeeright adrenal gland1.00infobox
LGP2Bgeeright adrenal cortex1.00infobox
LGP2Bgeeleft adrenal cortex1.00infobox
LGP2Bgeeapex of heart1.00infobox
LGP2Bgeemonocyte1.00infobox
LGP2Bgeeleft ovary1.00infobox
LGP2Bgeetibial nerve1.00infobox
LGP2Bgeespermatocyte1.00infobox
LGP2Bgeespermatid1.00infobox
LGP2Bgeeseminiferous tubule1.00infobox
LGP2Bgeeadrenal gland1.00infobox
LGP2Bgeemucous cell of stomach1.00infobox
LGP2Bgeelumbar spinal ganglion1.00infobox
LGP2Bgeestroma of bone marrow1.00infobox
LGP2Bgeeembryo1.00infobox
LGP2BioGPSMore reference expression data1.00infobox
LGP2Chr.Chromosome 17 (human)1.00infobox
LGP2Chr.Chromosome 11 (mouse)1.00infobox
LGP2DatabasesNCBI: entry; OMA: entry1.00infobox
LGP2End42,112,714 bp1.00infobox
LGP2End100,595,097 bp1.00infobox
LGP2EnsemblENSG000001087711.00infobox

Related concept clusters Concept neighborhoods

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    Connections between topic areas Semantic bridges

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    Map overview Semantic statistics

    Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.

    LGP2

    Nodes17
    Edges16
    Triples92
    Avg. degree1.88
    Density0.117647
    Components1
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