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LGP2: Structure and function & Overview

Probable ATP-dependent RNA helicase DHX58 also known as RIG-I-like receptor 3 (RLR-3) or RIG-I-like receptor LGP2 (RLR) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the DHX58 gene. The protein encoded by the gene DHX58 is known as LGP2 (Laboratory of Genetics and Physiology 2).

Language: English [EN]
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LGP2 topic overview

The analysis highlights Structure and function and Overview as prominent areas in the source structure around LGP2.

Related topics
14
Source areas
2
Connected nodes
16
Extracted relationships
92
Concept neighborhoods
13
Bridge connections
16

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure and function · 8 topics
Overview · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.6.4.13
↗
Aliases
DHX58, D11LGP2, D11lgp2e, LGP2, RLR-3, DEXH-box helicase 58
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RQA, 2W4R, 3EQT
Band
17q21.2 · 11 D|11 63.52 cM
Bgee
granulocyte · right lobe of liver · right uterine tube · right adrenal gland · right adrenal cortex
BioGPS
More reference expression data

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure and function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How LGP2 connects Entity context

The extracted context around LGP2 shows recurring relationship patterns in the source. For example, LGP2 → ATP binding, cytoplasm, defense response to virus, DNA binding, double-stranded RNA binding, helicase activity, hydrolase activity, immune system process, innate immune response, metal ion binding, negative regulation of innate immune response, negative regulation of MDA-5 signaling pathway, negative regulation of RIG-I signaling pathway, negative regulation of type I interferon production, nucleotide binding, positive regulation of MDA-5 signaling pathway, positive regulation of RIG-I signaling pathway, positive regulation of type I interferon production, protein binding, regulation of innate immune response Another extracted example is LGP2 → adrenal gland, apex of heart, embryo, granulocyte, left adrenal cortex, left ovary, lumbar spinal ganglion, monocyte, mucous cell of stomach, right adrenal cortex, right adrenal gland, right lobe of liver, right uterine tube, seminiferous tubule, spermatid, spermatocyte, stroma of bone marrow, tibial nerve. Use these groups to spot repeated connection types before inspecting the individual relationships.

LGP2

Top relations

Gene ontology · 26
LGP2 → ATP binding, cytoplasm, defense response to virus, DNA binding, double-stranded RNA binding, helicase activity, hydrolase activity, immune system process, innate immune response, metal ion binding, negative regulation of innate immune response, negative regulation of MDA-5 signaling pathway, negative regulation of RIG-I signaling pathway, negative regulation of type I interferon production, nucleotide binding, positive regulation of MDA-5 signaling pathway, positive regulation of RIG-I signaling pathway, positive regulation of type I interferon production, protein binding, regulation of innate immune response
Bgee · 18
LGP2 → adrenal gland, apex of heart, embryo, granulocyte, left adrenal cortex, left ovary, lumbar spinal ganglion, monocyte, mucous cell of stomach, right adrenal cortex, right adrenal gland, right lobe of liver, right uterine tube, seminiferous tubule, spermatid, spermatocyte, stroma of bone marrow, tibial nerve
RNA expression pattern · 18
LGP2 → adrenal gland, apex of heart, embryo, granulocyte, left adrenal cortex, left ovary, lumbar spinal ganglion, monocyte, mucous cell of stomach, right adrenal cortex, right adrenal gland, right lobe of liver, right uterine tube, seminiferous tubule, spermatid, spermatocyte, stroma of bone marrow, tibial nerve
related to Structure and function · 5
LGP2 → CARD, MDA5, RIG-I, RLRs, Since LGP2
Band · 2
LGP2 → 11 D|11 63.52 cM, 17q21.2
Chr. · 2
LGP2 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
LGP2 → 100,595,097 bp, 42,112,714 bp
3.6.4.13 · 1
LGP2 → ↗
Aliases · 1
LGP2 → DHX58, D11LGP2, D11lgp2e, LGP2, RLR-3, DEXH-box helicase 58
Available structures · 1
LGP2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RQA, 2W4R, 3EQT

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

rig-i gene bp dhx58 chr helicase human band chromosome 17 signaling viral antiviral location dsrna function activity known encoded ligand

LGP2 relationships Subject–Predicate–Object triples

TTTA extracted 92 structured relationships around LGP2. Examples in this analysis include LGP2 → 3.6.4.13 → ↗ and LGP2 → Aliases → DHX58, D11LGP2, D11lgp2e, LGP2, RLR-3, DEXH-box helicase 58. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
LGP23.6.4.13↗1.00infobox
LGP2AliasesDHX58, D11LGP2, D11lgp2e, LGP2, RLR-3, DEXH-box helicase 581.00infobox
LGP2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RQA, 2W4R, 3EQT1.00infobox
LGP2Band17q21.21.00infobox
LGP2Band11 D|11 63.52 cM1.00infobox
LGP2Bgeegranulocyte1.00infobox
LGP2Bgeeright lobe of liver1.00infobox
LGP2Bgeeright uterine tube1.00infobox
LGP2Bgeeright adrenal gland1.00infobox
LGP2Bgeeright adrenal cortex1.00infobox
LGP2Bgeeleft adrenal cortex1.00infobox
LGP2Bgeeapex of heart1.00infobox
LGP2Bgeemonocyte1.00infobox
LGP2Bgeeleft ovary1.00infobox
LGP2Bgeetibial nerve1.00infobox
LGP2Bgeespermatocyte1.00infobox
LGP2Bgeespermatid1.00infobox
LGP2Bgeeseminiferous tubule1.00infobox
LGP2Bgeeadrenal gland1.00infobox
LGP2Bgeemucous cell of stomach1.00infobox
LGP2Bgeelumbar spinal ganglion1.00infobox
LGP2Bgeestroma of bone marrow1.00infobox
LGP2Bgeeembryo1.00infobox
LGP2BioGPSMore reference expression data1.00infobox
LGP2Chr.Chromosome 17 (human)1.00infobox
LGP2Chr.Chromosome 11 (mouse)1.00infobox
LGP2DatabasesNCBI: entry; OMA: entry1.00infobox
LGP2End42,112,714 bp1.00infobox
LGP2End100,595,097 bp1.00infobox
LGP2EnsemblENSG000001087711.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around LGP2 bring nearby vocabulary together. In this analysis, examples include Rig-i, Antiviral and Signaling. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • LGP2
    • Rig-i
    • Antiviral
    • Signaling
    • Viral
    • Gene
    • Activity
    • Dsrna
    • Found
    • Ligand
    • Ligands
    • Card
    • Encoded
  • lgp2
    • Rig-i
    • Antiviral
    • Signaling
    • Viral
    • Gene
    • Activity
    • Dsrna
    • Found
    • Ligand
    • Ligands
    • Card
    • Encoded
  • helicase
    • Activity
    • Dhx58
    • Gene
    • Enzyme
    • Function
    • Rlr-3
    • Rna
    • Search
    • Lgp2
    • Found
    • Location
    • Rig-i
  • innate antiviral immunity
    • Viral
    • Rig-i
    • Signaling
    • Mda5
    • Lgp2
    • Found
    • Ligand
    • Card
    • End
    • Function
    • Mouse
    • Protein
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Helicase
    • End
    • Function
    • Known
    • Mouse
    • Protein
    • Rlr-3
  • structure and function
    • Search
    • Activity
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Gene
    • Helicase
    • End
    • Mouse
    • Protein
  • dsrna
    • Card
    • Encoded
    • Enzyme
    • Known
    • Mda5
    • Rlr-3
    • Rna
    • Lgp2
    • Ligand
    • Ligands
    • Antiviral
    • Gene
  • enzyme
    • Rlr-3
    • Gene
    • Helicase
    • Encoded
    • Function
    • Known
    • Rna
    • Search
    • Activity
    • Location
    • Chromosome
    • Human

Connections between topic areas Semantic bridges

For LGP2, one of the stronger structural bridges in this analysis connects LGP2 with Structure and function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
LGP2 — Structure and function · splits 8 ⟂ 9
LGP2 — Overview · splits 10 ⟂ 7

Map overview Semantic statistics

LGP2

Nodes17
Edges16
Triples92
Avg. degree1.88
Density0.117647
Components1

Source & methodology

TTTA analyzes the structure around LGP2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure and function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — LGP2 · EN edition · Analysis: TopicsToTalkAbout

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