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Dual-specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene.
The analysis highlights Interactions and Overview as prominent areas in the source structure around MAP2K4.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around MAP2K4 shows recurring relationship patterns in the source. For example, MAP2K4 → activation of protein kinase activity, apoptotic process, ATP binding, axon, cell growth involved in cardiac muscle cell development, cellular response to mechanical stimulus, cellular response to sorbitol, cytoplasm, cytosol, dendrite cytoplasm, Fc-epsilon receptor signaling pathway, JNK cascade, JUN kinase kinase activity, kinase activity, MAP kinase kinase activity, MAPK cascade, mitogen-activated protein kinase kinase kinase binding, negative regulation of motor neuron apoptotic process, nucleotide binding, nucleus Another extracted example is MAP2K4 → Achilles tendon, anterior horn of spinal cord, Brodmann area 23, Brodmann area 46, dentate gyrus of hippocampal formation granule cell, dorsomedial hypothalamic nucleus, facial motor nucleus, genital tubercle, granulocyte, lateral nuclear group of thalamus, middle temporal gyrus, orbitofrontal cortex, paraventricular nucleus of hypothalamus, pars compacta, postcentral gyrus, prefrontal cortex, primary visual cortex, secondary oocyte, superior frontal gyrus. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
kinase human bp chr band protein phosphorylated gene chromosome 17 mice mitogen-activated 12 location dual-specificity contains chimeric enzyme mouse mapk8
TTTA extracted 108 structured relationships around MAP2K4. Examples in this analysis include MAP2K4 → 2.7.12.2 → ↗ and MAP2K4 → Aliases → MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, mitogen-activated protein kinase kinase 4. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| MAP2K4 | 2.7.12.2 | ↗ | 1.00 | infobox |
| MAP2K4 | Aliases | MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, mitogen-activated protein kinase kinase 4 | 1.00 | infobox |
| MAP2K4 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3ALN, 3ALO, 3VUT | 1.00 | infobox |
| MAP2K4 | Band | 17p12 | 1.00 | infobox |
| MAP2K4 | Band | 11 B3|11 40.53 cM | 1.00 | infobox |
| MAP2K4 | Bgee | lateral nuclear group of thalamus | 1.00 | infobox |
| MAP2K4 | Bgee | Brodmann area 46 | 1.00 | infobox |
| MAP2K4 | Bgee | postcentral gyrus | 1.00 | infobox |
| MAP2K4 | Bgee | orbitofrontal cortex | 1.00 | infobox |
| MAP2K4 | Bgee | pars compacta | 1.00 | infobox |
| MAP2K4 | Bgee | middle temporal gyrus | 1.00 | infobox |
| MAP2K4 | Bgee | superior frontal gyrus | 1.00 | infobox |
| MAP2K4 | Bgee | prefrontal cortex | 1.00 | infobox |
| MAP2K4 | Bgee | Achilles tendon | 1.00 | infobox |
| MAP2K4 | Bgee | Brodmann area 23 | 1.00 | infobox |
| MAP2K4 | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| MAP2K4 | Bgee | genital tubercle | 1.00 | infobox |
| MAP2K4 | Bgee | facial motor nucleus | 1.00 | infobox |
| MAP2K4 | Bgee | primary visual cortex | 1.00 | infobox |
| MAP2K4 | Bgee | anterior horn of spinal cord | 1.00 | infobox |
| MAP2K4 | Bgee | secondary oocyte | 1.00 | infobox |
| MAP2K4 | Bgee | dorsomedial hypothalamic nucleus | 1.00 | infobox |
| MAP2K4 | Bgee | granulocyte | 1.00 | infobox |
| MAP2K4 | Bgee | paraventricular nucleus of hypothalamus | 1.00 | infobox |
| MAP2K4 | BioGPS | n/a | 1.00 | infobox |
| MAP2K4 | Chr. | Chromosome 17 (human) | 1.00 | infobox |
| MAP2K4 | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| MAP2K4 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| MAP2K4 | End | 12,143,830 bp | 1.00 | infobox |
| MAP2K4 | End | 65,679,123 bp | 1.00 | infobox |
The concept neighborhoods around MAP2K4 bring nearby vocabulary together. In this analysis, examples include Protein, Mitogen-activated and Phosphorylated. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For MAP2K4, one of the stronger structural bridges in this analysis connects MAP2K4 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around MAP2K4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — MAP2K4 · EN edition · Analysis: TopicsToTalkAbout