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MAP2K4

Dual-specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene.

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2.7.12.2
Aliases
MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, mitogen-activated protein kinase kinase 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3ALN, 3ALO, 3VUT
Band
17p12 · 11 B3|11 40.53 cM
Bgee
lateral nuclear group of thalamus · Brodmann area 46 · postcentral gyrus · orbitofrontal cortex · pars compacta
BioGPS
n/a

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MAP2K4

Nodes22
Edges21
Triples108
Avg. degree1.91
Density0.090909
Components1

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MAP2K4

Top relations

Gene ontology · 40
MAP2K4 → activation of protein kinase activity, apoptotic process, ATP binding, axon, cell growth involved in cardiac muscle cell development, cellular response to mechanical stimulus, cellular response to sorbitol, cytoplasm, cytosol, dendrite cytoplasm, Fc-epsilon receptor signaling pathway, JNK cascade, JUN kinase kinase activity, kinase activity, MAP kinase kinase activity, MAPK cascade, mitogen-activated protein kinase kinase kinase binding, negative regulation of motor neuron apoptotic process, nucleotide binding, nucleus
Bgee · 19
MAP2K4 → Achilles tendon, anterior horn of spinal cord, Brodmann area 23, Brodmann area 46, dentate gyrus of hippocampal formation granule cell, dorsomedial hypothalamic nucleus, facial motor nucleus, genital tubercle, granulocyte, lateral nuclear group of thalamus, middle temporal gyrus, orbitofrontal cortex, paraventricular nucleus of hypothalamus, pars compacta, postcentral gyrus, prefrontal cortex, primary visual cortex, secondary oocyte, superior frontal gyrus
RNA expression pattern · 19
MAP2K4 → Achilles tendon, anterior horn of spinal cord, Brodmann area 23, Brodmann area 46, dentate gyrus of hippocampal formation granule cell, dorsomedial hypothalamic nucleus, facial motor nucleus, genital tubercle, granulocyte, lateral nuclear group of thalamus, middle temporal gyrus, orbitofrontal cortex, paraventricular nucleus of hypothalamus, pars compacta, postcentral gyrus, prefrontal cortex, primary visual cortex, secondary oocyte, superior frontal gyrus
related to Interactions · 5
MAP2K4 → FLNC, ITCH, MAP3K1, MAPK8, MAPK8IP3
Band · 2
MAP2K4 → 11 B3|11 40.53 cM, 17p12
Chr. · 2
MAP2K4 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
MAP2K4 → 12,143,830 bp, 65,679,123 bp
2.7.12.2 · 1
MAP2K4 → ↗
Aliases · 1
MAP2K4 → MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, mitogen-activated protein kinase kinase 4
Available structures · 1
MAP2K4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3ALN, 3ALO, 3VUT

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Important terminology

kinase human bp chr band protein phosphorylated gene chromosome 17 mice mitogen-activated 12 location dual-specificity contains chimeric enzyme mouse mapk8

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MAP2K42.7.12.21.00infobox
MAP2K4AliasesMAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, mitogen-activated protein kinase kinase 41.00infobox
MAP2K4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3ALN, 3ALO, 3VUT1.00infobox
MAP2K4Band17p121.00infobox
MAP2K4Band11 B3|11 40.53 cM1.00infobox
MAP2K4Bgeelateral nuclear group of thalamus1.00infobox
MAP2K4BgeeBrodmann area 461.00infobox
MAP2K4Bgeepostcentral gyrus1.00infobox
MAP2K4Bgeeorbitofrontal cortex1.00infobox
MAP2K4Bgeepars compacta1.00infobox
MAP2K4Bgeemiddle temporal gyrus1.00infobox
MAP2K4Bgeesuperior frontal gyrus1.00infobox
MAP2K4Bgeeprefrontal cortex1.00infobox
MAP2K4BgeeAchilles tendon1.00infobox
MAP2K4BgeeBrodmann area 231.00infobox
MAP2K4Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
MAP2K4Bgeegenital tubercle1.00infobox
MAP2K4Bgeefacial motor nucleus1.00infobox
MAP2K4Bgeeprimary visual cortex1.00infobox
MAP2K4Bgeeanterior horn of spinal cord1.00infobox
MAP2K4Bgeesecondary oocyte1.00infobox
MAP2K4Bgeedorsomedial hypothalamic nucleus1.00infobox
MAP2K4Bgeegranulocyte1.00infobox
MAP2K4Bgeeparaventricular nucleus of hypothalamus1.00infobox
MAP2K4BioGPSn/a1.00infobox
MAP2K4Chr.Chromosome 17 (human)1.00infobox
MAP2K4Chr.Chromosome 11 (mouse)1.00infobox
MAP2K4DatabasesNCBI: entry; OMA: entry1.00infobox
MAP2K4End12,143,830 bp1.00infobox
MAP2K4End65,679,123 bp1.00infobox

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