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MAP2K3: Interactions & Overview

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.

Language: English [EN]
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MAP2K3 topic overview

The analysis highlights Interactions and Overview as prominent areas in the source structure around MAP2K3.

Related topics
10
Source areas
2
Connected nodes
12
Extracted relationships
97
Concept neighborhoods
7
Bridge connections
12

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 7 topics
Interactions · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.12.2
Aliases
MAP2K3, MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2, mitogen-activated protein kinase kinase 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LEZ
Band
17p11.2 · 11|11 B2
Bgee
buccal mucosa cell · vena cava · blood · body of tongue · saphenous vein
BioGPS
n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MAP2K3 connects Entity context

The extracted context around MAP2K3 shows recurring relationship patterns in the source. For example, MAP2K3 → activation of protein kinase activity, ATP binding, cardiac muscle contraction, cellular response to vascular endothelial growth factor stimulus, cytoplasm, cytosol, inflammatory response, kinase activity, MAP kinase kinase activity, MAPK cascade, membrane, nucleoplasm, nucleotide binding, p38MAPK cascade, peptidyl-tyrosine phosphorylation, phosphorylation, positive regulation of blood vessel endothelial cell migration, positive regulation of protein kinase activity, positive regulation of transcription, DNA-templated, protein binding Another extracted example is MAP2K3 → ankle, blood, body of tongue, buccal mucosa cell, cardia, digastric muscle, esophagus, fetal liver hematopoietic progenitor cell, lip, monocyte, mucosa of pharynx, muscle of thigh, pylorus, saphenous vein, sternocleidomastoid muscle, superior surface of tongue, temporal muscle, triceps brachii muscle, vastus lateralis muscle, vena cava. Use these groups to spot repeated connection types before inspecting the individual relationships.

MAP2K3

Top relations

Gene ontology · 30
MAP2K3 → activation of protein kinase activity, ATP binding, cardiac muscle contraction, cellular response to vascular endothelial growth factor stimulus, cytoplasm, cytosol, inflammatory response, kinase activity, MAP kinase kinase activity, MAPK cascade, membrane, nucleoplasm, nucleotide binding, p38MAPK cascade, peptidyl-tyrosine phosphorylation, phosphorylation, positive regulation of blood vessel endothelial cell migration, positive regulation of protein kinase activity, positive regulation of transcription, DNA-templated, protein binding
Bgee · 20
MAP2K3 → ankle, blood, body of tongue, buccal mucosa cell, cardia, digastric muscle, esophagus, fetal liver hematopoietic progenitor cell, lip, monocyte, mucosa of pharynx, muscle of thigh, pylorus, saphenous vein, sternocleidomastoid muscle, superior surface of tongue, temporal muscle, triceps brachii muscle, vastus lateralis muscle, vena cava
RNA expression pattern · 20
MAP2K3 → ankle, blood, body of tongue, buccal mucosa cell, cardia, digastric muscle, esophagus, fetal liver hematopoietic progenitor cell, lip, monocyte, mucosa of pharynx, muscle of thigh, pylorus, saphenous vein, sternocleidomastoid muscle, superior surface of tongue, temporal muscle, triceps brachii muscle, vastus lateralis muscle, vena cava
Band · 2
MAP2K3 → 11|11 B2, 17p11.2
Chr. · 2
MAP2K3 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
MAP2K3 → 21,315,232 bp, 60,843,637 bp
related to Interactions · 2
MAP2K3 → PLCB2, TAOK2
2.7.12.2 · 1
MAP2K3 → ↗
Aliases · 1
MAP2K3 → MAP2K3, MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2, mitogen-activated protein kinase kinase 3
Available structures · 1
MAP2K3 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LEZ

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

kinase gene bp chr human band protein chromosome 17 map expression mapk14 location dual specificity encoded activated thus enzyme mouse

MAP2K3 relationships Subject–Predicate–Object triples

TTTA extracted 97 structured relationships around MAP2K3. Examples in this analysis include MAP2K3 → 2.7.12.2 → ↗ and MAP2K3 → Aliases → MAP2K3, MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2, mitogen-activated protein kinase kinase 3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MAP2K32.7.12.21.00infobox
MAP2K3AliasesMAP2K3, MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2, mitogen-activated protein kinase kinase 31.00infobox
MAP2K3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LEZ1.00infobox
MAP2K3Band17p11.21.00infobox
MAP2K3Band11|11 B21.00infobox
MAP2K3Bgeebuccal mucosa cell1.00infobox
MAP2K3Bgeevena cava1.00infobox
MAP2K3Bgeeblood1.00infobox
MAP2K3Bgeebody of tongue1.00infobox
MAP2K3Bgeesaphenous vein1.00infobox
MAP2K3Bgeemucosa of pharynx1.00infobox
MAP2K3Bgeepylorus1.00infobox
MAP2K3Bgeesuperior surface of tongue1.00infobox
MAP2K3Bgeecardia1.00infobox
MAP2K3Bgeemonocyte1.00infobox
MAP2K3Bgeetemporal muscle1.00infobox
MAP2K3Bgeesternocleidomastoid muscle1.00infobox
MAP2K3Bgeeankle1.00infobox
MAP2K3Bgeedigastric muscle1.00infobox
MAP2K3Bgeetriceps brachii muscle1.00infobox
MAP2K3Bgeemuscle of thigh1.00infobox
MAP2K3Bgeefetal liver hematopoietic progenitor cell1.00infobox
MAP2K3Bgeelip1.00infobox
MAP2K3Bgeeesophagus1.00infobox
MAP2K3Bgeevastus lateralis muscle1.00infobox
MAP2K3BioGPSn/a1.00infobox
MAP2K3Chr.Chromosome 17 (human)1.00infobox
MAP2K3Chr.Chromosome 11 (mouse)1.00infobox
MAP2K3DatabasesNCBI: entry; OMA: entry1.00infobox
MAP2K3End21,315,232 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MAP2K3 bring nearby vocabulary together. In this analysis, examples include Protein, Activity and Mitogen-activated. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Protein
    • Location
    • Map2k3
    • Chromosome
    • Human
    • Kinase
    • Bp
    • Chr
    • Activity
    • End
    • Mitogen-activated
    • Mouse
  • constitutive activation
    • Expression
    • Activity
    • Cascade
    • End
    • Mapk14
    • Mouse
    • Search
    • Signaling
    • Thus
    • Kinase
    • Location
    • Map
  • MAP2K3
    • Protein
    • Activity
    • Mitogen-activated
    • Search
    • Gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Activation
    • Cascade
  • map2k3
    • Protein
    • Activity
    • Mitogen-activated
    • Search
    • Gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Activation
    • Cascade
  • enzyme
    • Mitogen-activated
    • Map2k3
    • Humans
    • Protein
    • Activity
    • Encoded
    • Gene
    • Search
    • Specificity
    • Kinase
    • Location
    • Chromosome
  • mapk14
    • Thus
    • Activation
    • Expression
  • insulin
    • Expression
    • Kinase

Connections between topic areas Semantic bridges

For MAP2K3, one of the stronger structural bridges in this analysis connects MAP2K3 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MAP2K3Overview · splits 5 ⟂ 8
MAP2K3Interactions · splits 9 ⟂ 4

Map overview Semantic statistics

MAP2K3

Nodes13
Edges12
Triples97
Avg. degree1.85
Density0.153846
Components1

Source & methodology

TTTA analyzes the structure around MAP2K3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MAP2K3 · EN edition · Analysis: TopicsToTalkAbout

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