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Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response to an array of…
Art, Interactions & Mechanism of activation
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protein kinase map3k5 human bp gene chromosome mitogen-activated chr band activation location external also activity trx tnf-α traf2 mouse binding
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| ASK1 | 2.7.11.25 | ↗ | 1.00 | infobox |
| ASK1 | Aliases | MAP3K5, ASK1, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5 | 1.00 | infobox |
| ASK1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CLQ, 3VW6, 4BF2, 4BHN, 4BIB, 4BIC, 4BID, 4BIE | 1.00 | infobox |
| ASK1 | Band | 6q23.3 | 1.00 | infobox |
| ASK1 | Band | 10|10 A3 | 1.00 | infobox |
| ASK1 | Bgee | endothelial cell | 1.00 | infobox |
| ASK1 | Bgee | Brodmann area 23 | 1.00 | infobox |
| ASK1 | Bgee | decidua | 1.00 | infobox |
| ASK1 | Bgee | pancreatic ductal cell | 1.00 | infobox |
| ASK1 | Bgee | adrenal cortex | 1.00 | infobox |
| ASK1 | Bgee | left adrenal gland | 1.00 | infobox |
| ASK1 | Bgee | right adrenal gland | 1.00 | infobox |
| ASK1 | Bgee | left adrenal cortex | 1.00 | infobox |
| ASK1 | Bgee | right adrenal cortex | 1.00 | infobox |
| ASK1 | Bgee | dorsal motor nucleus of vagus nerve | 1.00 | infobox |
| ASK1 | Bgee | ciliary body | 1.00 | infobox |
| ASK1 | Bgee | cumulus cell | 1.00 | infobox |
| ASK1 | Bgee | pineal gland | 1.00 | infobox |
| ASK1 | Bgee | retinal pigment epithelium | 1.00 | infobox |
| ASK1 | Bgee | hair follicle | 1.00 | infobox |
| ASK1 | Bgee | granulocyte | 1.00 | infobox |
| ASK1 | Bgee | iris | 1.00 | infobox |
| ASK1 | Bgee | transitional epithelium of urinary bladder | 1.00 | infobox |
| ASK1 | Bgee | ascending aorta | 1.00 | infobox |
| ASK1 | Bgee | vestibular membrane of cochlear duct | 1.00 | infobox |
| ASK1 | BioGPS | More reference expression data | 1.00 | infobox |
| ASK1 | Chr. | Chromosome 6 (human) | 1.00 | infobox |
| ASK1 | Chr. | Chromosome 10 (mouse) | 1.00 | infobox |
| ASK1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| ASK1 | End | 136,792,477 bp | 1.00 | infobox |
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